2001년에 1만 MW규모로 원자력개발

Srinivasan M.R. 한국원자력산업회의 1990 원자력산업 Vol.10 No.5

Development of Hybrid Artificial Neural Network–Particle Swarm Optimization Model and Comparison of Genetic and Particle Swarm Algorithms for Optimization of Machining Fixture Layout

M. Ramesh,K. A. Sundararaman,M. Sabareeswaran,R. Srinivasan 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.23 No.12

In this research paper, a methodology is proposed by combining taguchi’s parametric design, hybrid artificial neural network–particle swarm optimization (ANN–PSO) and evolutionary techniques to optimize the fixture layout by minimizing the maximum workpiece deformation on a 2D fixture workpiece system in end milling operation. Taguchi’s parametric design with five levels is utilized iteratively to estimate the potential range to place the fixture elements around the workpiece using the data obtained from finite element method. The hybrid ANN–PSO model is developed to predict the maximum workpiece deformation within the potential range in which PSO is utilized to optimize the weights and biases of the network. The diversity of data used for training the model is ensured by combining the experimental conditions of central composite design and Box Behnken design of response surface methodology. The developed model is tested using root mean square error, which exhibited better prediction accuracy. The hybrid ANN–PSO model is then optimized by genetic algorithm (GA) and PSO. The results clearly indicate that the PSO is capable of producing better fixture layouts with 0.1936% of superiority in solution quality than GA. Hence, the proposed approach is more viable to design the improved fixture layout with huge reduction in time and computational complexity.

Sphingopyxis panaciterrulae sp. nov., isolated from soil of a ginseng field

Srinivasan, S.,Kim, M.K.,Sathiyaraj, G.,Veena, V.,Mahalakshmi, M.,Kalaiselvi, S.,Kim, Y.-J.,Yang, D.-C. SOCIETY FOR GENERAL MICROBIOLOGY 2010 International journal of systematic and evolutiona Vol.60 No.10

Numerical Modelling on Stress and Dislocation Generation in Multi-Crystalline Silicon during Directional Solidification for PV Applications

M. Srinivasan,P. Karuppasamy,P. Ramasamy,A. K. Barua 대한금속·재료학회 2016 ELECTRONIC MATERIALS LETTERS Vol.12 No.4

Numerical modelling has emerged as a powerful tool for the development andoptimization of directional solidification process for mass production of multicrystallinesilicon. A transient global heat transfer model is performed to investigate theeffect of bottom grooved furnace upon the directional solidification (DS) process ofmulti-crystalline silicon (mc-Si). The temperature distribution, von Mises stress,residual stress and dislocation density rate in multi-crystalline silicon ingots grown bymodified directional solidification method have been investigated for five growth stagesusing finite volume method at the critical Prandtl number, Pr = 0.01. This paperdiscusses bottom groove furnace instead of seed crystal DS method. It achieves anadvanced understanding of the thermal and mechanical behaviour in grown multicrystallineingot by bottom grooved directional solidification method. The von Misesstress and dislocation density were reduced while using the bottom grooved furnace. This work was carried out in the different grooves of radius 30 mm, 60 mm and 90 mmof the heat exchanger block of the DS furnace. In this paper, the results are presented for60 mm radius groove only because it has got better results compared to the othergrooves. Also, the computational results of bottom grooved DS method show betterperformance compared the conventional DS method for stress and dislocation densityin grown ingot.

Deuterium ion irradiation impact on the current-carrying capacity of DI-BSCCO superconducting tape

Rajput M.,Swami H.L.,Kumar R.,Bano A.,Vala S.,Abhangi M.,Prasad Upendra,Kumar Rajesh,Srinivasan R. 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.7

In the present work, we have irradiated the DI-BSCCO superconducting tapes with the 100 keV deuterium ions to investigate the effect of ion irradiation on their critical current (Ic). The damage simulations are carried out using the binary collision approximation method to get the spatial distribution and depth profile of the damage events in the high temperature superconducting (HTS) tape. The point defects are formed near the surface of the HTS tape. These point defects change the vortex profile in the superconducting tape. Due to the long-range interaction of vortices with each other, the Ic of the tape degrades at the 77 K and self magnetic field. The radiation dose of 2.90 MGy degrades the 44% critical current of the tape. The results of the displacement per atom (dpa) and dose deposited by the deuterium ions are used to fit an empirical relation for predicting the degradation of the Ic of the tape. We include the dpa, dose and columnar defect terms produced by the incident particles in the empirical relation. The fitted empirical relation predicts that light ion irradiation degrades the Ic in the DI-BSCCO tape at the self field. This empirical relation can also be used in neutron irradiation to predict the lifetime of the DI-BSCCO tape. The change in the Ic of the DI-BSCCO tape due to deuterium irradiation is compared with the other second-generation HTS tape irradiated with energetic radiation

Nocardioides humi sp. nov., a -glucosidase-producing bacterium isolated from soil of a ginseng field

Kim, M. K.,Srinivasan, S.,Park, M.-J.,Sathiyaraj, G.,Kim, Y.-J.,Yang, D.-C. Microbiology Society 2009 International journal of systematic and evolutiona Vol.59 No.11

<P>Strain DCY24(T), a Gram-reaction-positive, aerobic, rod-shaped, motile bacterium, was isolated from soil of a ginseng field in South Korea. According to 16S rRNA gene sequence analysis, it was closely related to Nocardioides aromaticivorans DSM 15131(T) (95.1 % similarity), Nocardioides simplex KCTC 9106(T) (95.0 %), Nocardioides nitrophenolicus DSM 15529(T) (94.8 %) and Nocardioides kongjuensis DSM 19082(T) (94.7 %). Chemotaxonomic data revealed that strain DCY24(T) possessed MK-8(H(4)) as the predominant menaquinone, ll-2,6-diaminopimelic acid as the diagnostic diamino acid, phosphatidylglycerol and diphosphatidylglycerol as predominant polar lipids and iso-C(16 : 0), iso-C(17 : 0) and C(18 : 1)omega9c as predominant fatty acids. The DNA G+C content was 71.0 mol%. Based on evidence from this polyphasic study, strain DCY24(T) (=KCTC 19265(T) =LMG 24128(T)) should be classified as the type strain of a novel Nocardioides species, for which the name Nocardioides humi sp. nov. is proposed.</P>

Complete genome sequence of Deinococcus actinosclerus BM2^T, a bacterium with Gamma-radiation resistance isolated from soil in South Korea

Kim, M.K.,Kang, M.S.,Lee, D.H.,Joo, E.S.,Kim, E.B.,Jeon, S.H.,Jung, H.Y.,Srinivasan, S. Elsevier Science Publishers 2016 Journal of biotechnology Vol.224 No.-

<P>A Gram-positive, short-rod shaped and non-motile bacterium Deinococcus actinosclerus BM2(T), resistant to gamma and UV radiation, was isolated from a soil sample collected in South Korea. Strain BM2(T) showed high resistance to gamma radiation with D-10 value of 9 kGy. The complete genome of D. actinosclerus BM2(T) consists of a single chromosome (3,264,334 bp). The genome features showed the presence of intracellular proteases that help to eliminate radiation-induced ROS during recovery from ionizing radiation damage. (C) 2016 Elsevier B.V. All rights reserved.</P>

Complete genome sequence of Spirosoma pulveris JSH 5-14T, a bacterium isolated from a dust sample

Kim, M. K.,Kim, J. Y.,Kim, S. J.,Kim, M. J.,Lee, J. Y.,Kim, C. G.,Srinivasan, S. THE KOREAN SOCIETY OF TOXICOGENOMICS AND TOXICOPRP 2017 MOLECULAR AND CELLULAR TOXICOLOGY Vol. No.

Canine Model for Selective and Superselective Cerebral Intra-Arterial Therapy Testing

Camstra Kevin M.,Srinivasan Visish M.,Collins Dalis,Chen Stephen,Kan Peter,Johnson Jeremiah 대한신경중재치료의학회 2020 Neurointervention Vol.15 No.3

Purpose: With advancing endovascular technology and increasing interest in minimally invasive intra-arterial therapies such as stem cell and chemotherapy for cerebral disease, the establishment of a translational model with cerebral circulation accessible to microcatheters is needed. We report our experience catheterizing canine cerebral circulation with microcatheters, present high-resolution angiographic images of the canine vascular anatomy, describe arterial branch flow patterns and provide measurements of canine arterial conduits.Materials and Methods: Angiograms were performed on 10 intact purpose-bred hounds. Angiography, measurements of arterial conduits and catheterization information for intracranial arterial branches were obtained.Results: Selective and superselective cerebral angiography was successful in all subjects. Relevant arterial mean diameters include the femoral (4.64 mm), aorta (9.38 mm), external carotid (3.65 mm), internal carotid arteries (1.6 mm), vertebrobasilar system and Circle of Willis branches. Catheterization of the Circle of Willis was achieved via the posterior circulation in all subjects tested (n=3) and the use of flow directed microcatheters resulted in reduced arterial tree deformation and improved superselection of intracranial vessels. Catheterization of the intracranial circulation was attempted but not achieved via the internal carotid artery (n=7) due to its tortuosity and subsequent catheter related vasospasm.Conclusion: The canine cerebral vasculature is posterior circulation dominant. Anterior circulation angiography is achievable via the internal carotid artery, but direct cerebral arterial access is best achieved via the posterior circulation using flow-directed microcatheters. It is feasible to deliver intra-arterial therapies to selective vascular territories within the canine cerebral circulation, thus making it a viable animal model for testing novel intra-arterial cerebral treatments.

Carcinoma Thyroid-Have Turned Around the Corner?

N. Dorairajan,M.D.<SUP>1<.SUP>,Preetha Muthayya,M.D. and Srinivasan,M.D. 대한갑상선-내분비외과학회 2002 The Koreran journal of Endocrine Surgery Vol.2 No.1

Thyroid surgery was revolutionized by Theodre Kocher and his work earned him the Nobel Prize in 1909. The techniques laid down by him hold good even today, even in thyroid cancer surgery. William Halstead, Charles Mayo, George Crile, Frank Lahey and Thomas Dunhill also made significant contributions in vastly improving the outcome of surgery of Thyroid disease. FNAC, a technique first performed by Greig and Gray in 1904 to aspirate trypanosomes from the lymph nodes of patients with sleeping sickness, is the best modality for work up of thyroid nodules and has eclipsed Radio Active Iodine Uptake study. After the widespread use of FNAC in thyroid disease since 1970s a pre operative tissue diagnosis was possible in most thyroid nodules. The role of FNAC is further enhanced by combining Immuno Histo chemistry and nuclear DNA analysis (Petra Werga et al, Karolinska hospital, Sweden, 2000). Yield is highest when done by persons well versed with this technique. The only distinct failure of FNAC is its inability to distinguish between follicular adenoma and carcinoma. But even this has been overcome with the advent of techniques like the following. Two dimensional proton Magnetic Resonance Spectroscopic analysis has now enabled one to effectively identify malignancy as well as to differentiate between Follicular adenoma and carcinoma and is based increased cell surface fucosylation (Wanda. B Mackinnon et al, NSW, Australia). Molecular genetics in relation to thyroid disease especially in carcinoma thyroid had exploded many myths and realities. The relationship between RET-PTC oncogene and MTC is established beyond doubt and signaled the induction of "prophylactic thyroidectomy" in the realm of surgeons. Prophylactic thyroidectomy is ideally done in RET-PTC positive individuals at six years of age. Central compartment lymph node dissection is added if there is a raised serum calcium or if the patient is older than 10 years. Bilateral lymph node dissection is done in patents older than 15 with elevated serum calcitonin (Henning Dralle et al, Germany 1998). An Association between TSHR and Gs mutation with toxic adenosis has also been proven. P 53 mutation plays a dominant role in the development of anaplastic carcinoma (Diana Learoyd et al, NSW, Australia, 2000). Familial Papillary Thyroid Carcinoma [FPTC] and MNG has also been recognized as a distinct entity apart from other familial syndromes like Gardener's syndrome and Cowden's disease. Primary criteria for susceptibility to FPTC include PTC in two first degree relatives, MNG in three first or second degree relatives , patients younger than 33 years with multi focal, bilateral or metastatic PTC (Thomas.Musholt et al, Hannover, Germany 2000). Surgical techniques are opted based on various scoring systems like AMES, MACIS, AGES. These systems help prognosticate thyroid cancer based on age, size of tumor, extra thyroidal spread, metastasis and completeness of thyroidectomy. Sentinel lymph node mapping was first with isosulfan blue dye is safe and sentinel nodes even if present in the lateral cervical compartments and mediastinum are detected (Elijah Dixon et al, Alberta, Canada 2000). Microdissection with central compartment lymph nodal clearance has been shown to positively influence survival and decrease local recurrence in patients with PTC (Lars-Erik Tissel et al, Goteberg, Sweden 1996). Complications of surgery like permanent Recurrent laryngeal nerve palsy [1%] and hypo parathyroidism [2%] have been reduced and recurrence scaled down significantly because of well established endocrine centers and training of young surgeons (Tom Reeve, NSW Australia, 2000). Complications are higher in re operative thyroid surgeries with RLN palsy as high as 2% and hypoparathyroidism seen in almost 5% of the cases (Puzzolo et al, Italy 1997). (Korean J Endocrine Surg 2002;2:5-9)