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      • KCI등재
      • KCI등재

        Primary versus revision total shoulder arthroplasty: comparing relative value and reimbursement trends

        John Joseph Carney,Erik Gerlach,Mark Plantz,Peter Raymond Swiatek,Jeremy Marx,Matthew Saltzman,Guido Marra 대한견주관절학회 2022 대한견주관절의학회지 Vol.25 No.1

        Background: Total shoulder arthroplasty (TSA) has been demonstrated to be an effective treatment for multiple shoulder pathologies. The purpose of our study was to compare the relative value units (RVUs) per minute of surgical time for primary and revision TSA. Methods: The American College of Surgeons National Surgical Quality Improvement Program database was queried to identify patients that underwent primary TSA, one-component revision TSA, and two-component revision TSA between January 1, 2015 and December 31, 2017 using current procedure terminology codes. RVUs were divided by mean operative time for each procedure to determine the amount of revenue generated per minute. Rates were compared between the groups using a one-way analysis of variance with post-hoc Tukey test. Statistical significance was set at p<0.05. Results: When dividing compensation by surgical time, we found that two-component revision generated more compensation per minute compared to primary TSA (0.284±0.114 vs. 0.239±0.278 RVU per minute or $10.25±$4.11 vs. $8.64±$10.05 per minute, respectively; p=0.001). Conclusions: The relative value of revision TSA procedures is weighted to account for the increased technical challenges and time associated with these procedures. This study confirms that reimbursement is higher for revision TSA compared to primary TSA.

      • KCI등재후보

        Co-occurrence of heavy metals and antibiotics resistance in bacteria isolated from metal-polluted soil

        Oluwarotimi John Joseph,Gbemisola Elizabeth Ogunleye,Kubrat Abiola Oyinlola,Augustina I. Balogun,Damilola Tolulope Olumeko 환경독성보건학회 2023 환경독성보건학회지 Vol.38 No.4

        The indiscriminate deposition of metal-containing substances into the environment contributes significantly to high concentrations of metals in the soil resulting in resistance to metals and consequentially to antibiotics by inherent microbes which may eventually spread to other pathogenic microbes thereby elevating disease burden due to antibiotic resistance. The study aimed at determining the co-occurrence of resistance of bacteria isolated from metal-contaminated soil to heavy metals and subsequently, antibiotics. Metal-tolerant bacteria were randomly isolated from top soils from a battery waste site using the pour plate method. Selected isolates were identified using biochemical tests, then, subjected to elevating supplemented concentrations of different metal salts at 100-500 μg/mL to determine the minimum inhibitory concentration. Isolates tolerant to minimum three metals up to 400 μg/mL were subjected to Sulfamethoxazole-trimethoprim (25 μg), Imipenem (10 μg), Amoxicillin (30 μg), Ciprofloxacin (10 μg) and Tigecycline (15 μg) and observations interpreted using the guiding principle of the Clinical and Laboratory Standards Institute. Metal concentrations in the soils exceeded permissible limits. In total, 16 isolates were selected and identified as Proteus sp. (1), Pseudomonas spp. (5), Enterobacter spp. (2), Klebsiella spp. (2), Escherichia spp. (3), Raoultella spp. (2) and Rahnella sp. (1). Thirteen (81.25 %) of all isolates showed multi-resistance to the metals and seven exhibited multidrug-resistance, with 4 (57.1 %) showing resistance to three different classes of antibiotics and 3 (42.9 %) showed resistance to four antibiotic classes. Heavy metal-tolerant bacteria isolated from this study possess co-selection potentials as they showed resistance to different metals and antibiotics classes which is a concern to public health.

      • KCI등재

        George B. Shaw : Garnering Women’s Rights through His Female Characterizations

        Ball Joseph John(조셉 존 볼) 한국현대영미드라마학회 2009 현대영미드라마 Vol.22 No.3

        Since Shaw associated with many different styles of women, he formed unbiased ideas about how unique and special they are within society. From his mother and sisters with their never ending love for music and art, to married women with him as the third wheel and often as a marriage counselor, and to single women who he wooed, he learned a great deal. Particularly, his romances, whether literal or physical, impacted his views on women and their situation within the Victorian society. The objective of this piece is to establish Shaw’s relevance and contributions to bringing about equal rights to women through his characterizations of women in his plays. Shaw played a significant part in the equalization of rights for women in the passage of acts not only during his life, but posthumously by educating the audience and readers on the inequalities and falsehoods of society. Some of the most important acts of legislation for Shaw to see passed were of course those for women’s suffrage. Although many minor acts were passed from the 1870s onward, voting rights were not truly granted until 1928 with the Representation of the People Act. Shaw was well ahead of his time with female character development because he wrote about women having diverse personalities instead of pigeonholing women into the Victorian ideal. In making Victorians think about the society and its injustices through his plays, he indirectly initiated the call for reforms. Although he may have written some controversial plays for the time like Widower’s Houses (1892), The Philanderer (1893) Mrs Warren’s Profession (1894) Man and Superman (1903), and Major Barbara (1905), he mainly did it to stimulate a response about the problems people, and more particularly, women were up against. Unfortunately, some audiences may not have recognized his true designs for equality; however, they did see women become the central key figures in his plays, which would be a shock in itself. Thus, he started the ball rolling for people to look around and question whether or not society needed to be reevaluated. In Shaw’s representations of female characters in his plays, he established a precedence not only of women being the central role in his plays, but also of them being more realistic emotional portrayals of women. Especially, Shaw broke the mold in comparison to his contemporaries who mainly focused on traditional Victorian women. In analyzing the effeminizer, equalizer, and unadjusted or unruly, I have pointed out the wide range of attributes that Shaw gave to his female characters. With these characterizations, Shaw helped to awaken society to the inequalities between the genders which set the stage for change.

      • Electrocardiographic findings in systemic lupus erythematosus: data from an international inception cohort.

        Bourr?-Tessier, Josiane,Urowitz, Murray B,Clarke, Ann E,Bernatsky, Sasha,Krantz, Mori J,Huynh, Thao,Joseph, Lawrence,Belisle, Patrick,Bae, Sang-Cheol,Hanly, John G,Wallace, Daniel J,Gordon, Caroline,I John Wiley Sons 2015 Arthritis care & research Vol.67 No.1

        <P>To estimate the early prevalence of various electrocardiographic (EKG) abnormalities in patients with systemic lupus erythematosus (SLE) and to evaluate possible associations between repolarization changes (increased corrected QT [QTc] and QT dispersion [QTd]) and clinical and laboratory variables, including the anti-Ro/SSA level and specificity (52 or 60 kd).</P>

      • KCI등재

        Comparison of clinical outcomes following osteochondral allograft transplantation for osteochondral versus chondral defects in the knee

        ( John Reza Matthews ),( Joseph Brutico ),( Jeremy Heard ),( Kashyap Chauhan ),( Bradford Tucker ),( Kevin Blake Freedman ) 대한슬관절학회 2022 대한슬관절학회지 Vol.34 No.-

        Purpose: Osteochondral allograft (OCA) transplantation is a restorative technique for addressing articular cartilage defects by transferring mature viable chondrocytes with subchondral bone into size-matched lesions. The purpose of this study was to compare differences in clinical and functional outcomes in patients treated with OCA for osteochondral defects compared with isolated chondral pathology. Methods: A retrospective review identified patients who underwent OCA transplantation and grouped them into osteochondral or isolated chondral pathology. Demographic data, surgical history, lesion characteristics, complications, and rate of subsequent surgery were reviewed. The review included 86 patients (24 osteochondral, 62 chondral) with a mean follow-up of 5.4 ± 1.4 years. Outcome measures included the Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS, JR.), International Knee Documentation Committee (IKDC), and Short Form Health Survey (SF-12) physical scores. Failure was defined to include revision OCA, graft removal, conversion to ACI, or conversion to arthroplasty. Results: The average age at surgery was 32.3 and 37.3 years for the osteochondral and chondral groups, respectively (P = 0.056). The medial femoral condyle was the most common defect location in both groups. P < 0.05 was considered statistically significant. Patients with osteochondral pathology had significantly greater KOOS JR., IKDC, and SF-12 scores (P < 0.05), and fewer failures were reported in the osteochondral group (8.3% versus 32.3%, P = 0.045). When controlling for age, sex, laterality, BMI, and presence of a concomitant procedure, patients with osteochondral pathology were found to have better KOOS and IKDC scores, but there was no difference in SF12 scores or rates of failure between groups. Conclusion: The findings of this study indicate that patients undergoing OCA for osteochondral defects may have greater functional outcomes and similar failure rates compared with OCA transplantation for isolated chondral pathology.

      • KCI등재후보

        Associations of Depressive Symptoms and Brachial Artery Reactivity among Police Officers

        John M Violanti,Luenda E Charles,Ja K Gu,Cecil M Burchfiel,Michael E Andrew,Parveen N Joseph,Joan M Dorn 한국산업안전보건공단 산업안전보건연구원 2013 Safety and health at work Vol.4 No.1

        Objectives: Mental health has been shown to be linked with certain underlying physiological mechanisms. The objective of this cross sectional study was to investigate the relationship between depressive symptoms and brachial artery reactivity (BAR) in an understudied population: police officers. Methods: Participants were 351 police officers who were clinically examined in the Buffalo Cardio-Metabolic Police Stress (BCOPS) study. BAR was performed using standard B-Mode ultrasound procedures. Depressive symptoms were measured using the Center for Epidemiological Studies Depression (CES-D) scale. Mean values of the difference between the baseline and maximum diameters of the brachial artery were determined across three categories of CES-D score using the analysis of variance and the analysis of covariance. p-values for linear trends were obtained from linear regression models. Results: The mean age (± standard deviation) of all officers was 40.9 ± 7.2 years. Women had a slightly higher mean CES-D score than men (8.9 ± 8.9 vs. 7.4 ± 6.4) and a slightly higher percentage increase of BAR than men (6.90 vs. 5.26%). Smoking status significantly modified the associations between depressive symptoms and BAR. Among current smokers, mean absolute values of BAR significantly decreased as depressive symptoms increased after adjustment for age, gender, race/ethnicity, hypertension, and diabetes; the multivariate-adjusted p-values were 0.033 (absolute) and 0.040 (%). Associations between depressive symptoms and BAR were not statistically significant among former smokers or never smokers. Conclusion: Depressive symptoms were inversely associated with BAR among police officers who were current smokers and together may be considered a risk factor for cardiovascular disease among police officers. Further prospective research is warranted.

      • KCI등재
      • KCI등재

        Correlation of Early Outcomes and Intradiscal Interleukin-6 Expression in Lumbar Fusion Patients

        John D. Koerner,Dessislava Z. Markova,Greg D. Schroeder,Christopher L. Antonacci,Joseph Mendelis,Alexander R. Vaccaro,D. Greg Anderson,Chris K. Kepler 대한척추신경외과학회 2020 Neurospine Vol.17 No.1

        Objective: To determine if there is correlation between intradiscal levels of interleukin-6 (IL-6) and early outcome measures in patients undergoing lumbar fusion for painful disc degeneration. Methods: Intervertebral disc tissue was separated into annulus fibrosus/nucleus pulposus and cultured separately in vitro in serum-free medium (Opti-MEM). Conditioned media was collected after 48 hours. The concentration of IL-6 was quantified using enzyme-linked immunosorbent assay. Pearson correlation coefficients quantified relationships between IL-6 levels and pre- and postoperative visual analogue scale (VAS) back pain and Oswestry Disability Index (ODI), as well as change in VAS/ODI. Results: Sixteen discs were harvested from 9 patients undergoing anterior lumbar interbody fusion (mean age, 47.4 years; range, 21–70 years). Mean preoperative and 6-month postoperative VAS were 8.1 and 3.7, respectively. Mean preoperative and postoperative ODI were 56.2 and 25.6, respectively. There were significant positive correlations between IL-6 expression and postoperative VAS (ρ=0.38, p=0.048) and ODI (ρ=0.44, p=0.02). No significant correlations were found between intradiscal IL-6 expression and preoperative VAS (ρ=-0.12, p=0.54). Trends were seen associating IL-6 expression and change in VAS/ODI (ρ=-0.35 p=0.067; ρ=-0.34, p=0.08, respectively). A trend associated IL-6 and preoperative ODI (ρ=0.36, p=0.063). Conclusion: The direct association between IL-6 expression and VAS/ODI suggests patients with elevated intradiscal cytokine expression may have worse early outcomes than those with lower expression of IL-6 after surgery for symptomatic disc degeneration.

      • Polyphenolics in Grape Seeds―Biochemistry and Functionality

        John Shi,Jianmel Yu,Joseph E. Pohorly,Yukio Kakuda 한국식품영양과학회 2003 Journal of medicinal food Vol.6 No.4

        Grape seeds are waste products of the winery and grape juice industry. These seeds contain lipid, protein, car-bohydrates, and 5 8% polyphenols depending on the variety. Polyphenols in grape seeds are mainly flavonoids, including gal-lic acid, the monomeric flavan-3-ols catechin, epicatechin, gallocatechin, epigallocatechin, and epicatechin 3-O-gallate, andprocyanidin dimers, trimers, and more highly polymerized procyanidins. Grape seed extract is known as a powerful antioxi-dant that protects the body from premature aging, disease, and decay. Grape seeds contains mainly phenols such as proan-thocyanidins (oligomeric proanthocyanidins). Scientific studies have shown that the antioxidant power of proanthocyanidinsis 20 times greater than vitamin E and 50 times greater than vitamin C. Extensive research suggests that grape seed extractis beneficial in many areas of health because of its antioxidant effect to bond with collagen, promoting youthful skin, cellhealth, elasticity, and flexibility. Other studies have shown that proanthocyanidins help to protect the body from sun damage,to improve vision, to improve flexibility in joints, arteries, and body tissues such as the heart, and to improve blood circula-tion by strengthening capillaries, arteries, and veins. The most abundant phenolic compounds isolated from grape seed arecatechins, epicatechin, procyanidin, and some dimers and trimers.

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