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- 저자 : M . H . Tan (검색결과 3,378 건)
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Microstructural Stability and Creep Performance of a Novel Low-Cost Single Crystal Superalloy
Z. H. Tan,X. G. Wang,Y. L. Du,Y. M. Li,Y. H. Yang,J. L. Liu,J. D. Liu,J. G. Li,Y. Z. Zhou,X. F. Sun 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.7
The increasing pursuit of advanced aero-engines with lower ratio between the cost and performance has greatly promotedthe demanding of single crystal superalloys characterized by low cost and outstanding temperature capability. In this study,a novel low-cost single crystal superalloy was designed and the creep tests as well as micro-characterization were carried outon the experimental alloy. The results illustrated that the novel single crystal alloy exhibited an ideal microstructural stabilitywithout precipitating TCP phases, after long-term thermal exposure at the ultimate service temperature of third generationsingle crystal superalloys. Moreover, the experimental alloy with only 3 wt% Re addition demonstrated remarkable creepresistance and maintained a very low minimum creep rate at 1100 °C/137 MPa and 1120 °C/137 MPa, while the accumulationand coalescence of micro-pores had eventually led to the alloy fracture. Apart from that, the compact interfacial dislocationnetworks the 2nd γ′ phase were observed after high-temperature creep rupture, and the typical a < 010 > superdislocationswith relatively poor mobility was found at 1120 °C. At 760 °C/800 MPa, both the minimum creep velocity and entire creepstain was increased evidently, however, the ultimate creep rupture life of the alloy had still reached 200 h. The correspondingdeformation mechanism was identified as the combination of superdislocation pairs shearing and a/3 < 121 > partial dislocationcutting the γ′ phase with a SISF being generated. In general, the novel single crystal alloy characterized by remarkablemechanical properties and cost reduction possesses a great potential for future application in the advanced aircraft engines.
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In vitro shear bond strength between fluorinated zirconia ceramic and resin cements
Merve Çakırbay Tanış,Canan Akay,Turgut Cihan Akçaboy,Murat Şen,Pınar Akkaş Kavaklı,Kadriye Sapmaz 대한치과보철학회 2018 The Journal of Advanced Prosthodontics Vol.10 No.3
PURPOSE. The purpose of this study was to evaluate the efficiency of a gas-phase fluorination method under different fluorination periods through using two resin cements. MATERIALS AND METHODS. 84 zirconia specimens in dimensions of 5 mm × 5 mm × 2 mm were prepared and surface treated with 50 μm aluminum oxide particles or gas phase fluorination for 2 min, 5 min, or 10 min. One specimen in each group was surface analyzed under scanning electron microscope. The remaining specimens were bonded to composite cylinders in dimensions of 2 mm diameter and 3 mm high with Panavia SA Plus or Variolink N. Then, the specimens were stored in 37°C distilled water for 24 hours and shear bond strength test was applied at a speed of 1 mm/min. RESULTS. The highest shear bond strength values were observed in the samples fluorinated for 5 minutes and cemented with Panavia SA Plus. Variolink N did not elicit any statistical differences between surface treatments. Panavia SA Plus resin cement and Variolink N resin cements featured statistically significant difference in shear bond strength values only in the case of 5 minutes of fluorination treatment. CONCLUSION. According to the results of this study, application of 5 minutes of fluorination with 10-methacryloyloxydecyl dihydrogen phosphate monomer (MDP) containing Panavia SA Plus resin cement increased the resin bond strength of zirconia. Fluorination of the zirconia surface using conventional resin cement, Variolink N, did not lead to an increase in bond strength.
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Chia, Sin-Eng,Wong, Kin-Yoke,Cheng, Christopher,Lau, Weber,Tan, Puay-Hoon Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
Background: Most of the epidemiology studies on the effects of sun exposure and prostate cancer were conducted among the temperate countries of North America and Europe. Little is known about the influence on Asian populations. The purpose of current study was to evaluate any association of sun exposure with risk of prostate cancer in Chinese, Malays and Indians who reside in the tropics. Methods: The Singapore Prostate Cancer Study is a hospital-based case-control study of 240 prostate cancer incident cases and 268 controls conducted in Singapore between April 2007 and May 2009. Detailed information on outdoor activities in the sun, skin colour, sun sensitivity and other possible risk factors were collected in personal interviews. Cases were further classified by Gleason scores and TNM staging. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression analysis, adjusted for age, ethnicity, education, family history of any cancers, BMI and skin colour. Results: We found that prostate cancer risk was increased in subjects with black/dark-brown eyes (OR 5.88, 95%CI 3.17-10.9), darker skin colour e.g. tan/dark brown/black (OR 7.62, 95%CI 3.41-17.0), frequent sunburn in lifetime (OR 4.30, 95%CI 1.7-11.2) and increased general sun exposure in adulthood per week (OR 2.03, 95%CI 1.09-3.81). The increased risk was consistent for high grade tumours and advanced stage prostate cancers. Conclusion: The findings from this study suggest that excessive sun exposure is a risk factor for prostate cancer in Asians.
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( Young-suk Lim ),( Henry Lik Yuen Chan ),( Yock Young Dan ),( Mei Hsuan Lee ),( Eliza Kruger ),( Seng Tan5,Zobair M. Younossi ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: To estimate the work productivity gains associated with LDV/SOF treatment for CHC in Hong Kong, Singapore, South Korea and Taiwan. Methods: The model captures anticipated impact of LDV/SOF on productivity loss over a one-year time horizon from a societal perspective for each country. A literature review was performed to identify country- specific inputs and expert advice was solicited to verify key variables. Patients enter the model post-treatment, having achieved SVR12, or not. Absenteeism and presenteeism rates were estimated based on the Work Productivity and Activity Index-Specific Health Problem (WPAI-SHP) data collected from the Phase III ION trials (US participants only) at baseline and at 12 weeks with rates assumed to remain unchanged from baseline for patients not achieving SVR. Sensitivity analyses were performed on key variables. Results: Total Work productivity loss due to not treating CHC was highest in Taiwan at US$349M ($355 per capita) given high prevalence of HCV, followed by US$146M ($358) in Korea, US$17M ($914) in Singapore and US$11M ($351) in Hong Kong. Treatment with LDV/SOF resulted in estimated productivity gains of $138 million, $58.7 million, $6.8 million and $4.5 million in Taiwan, Korea, Singapore and Hong Kong respectively. Conclusions: CHC imposes a significant indirect economic burden. Our model demonstrates that treatment of HCV GT1 patients with LDV/SOF is likely to result in significant cost savings due to an improvement in presenteeism versus no treatment across 4 Asian countries. This indirect economic gain should be considered when assessing the benefits of treating CHC.
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Zhu, Haiyan,Chen, Zhiwu,Ma, Zengchun,Tan, Hongling,Xiao, Chengrong,Tang, Xianglin,Zhang, Boli,Wang, Yuguang,Gao, Yue The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.6
Tanshinone IIA (Tan IIA) is a pharmacologically active substance extracted from the rhizome of Salvia miltiorrhiza Bunge (also known as the Chinese herb Danshen), and is widely used to treat atherosclerosis. The pregnane X receptor (PXR) is a nuclear receptor that is a key regulator of xenobiotic and endobiotic detoxification. Tan IIA is an efficacious PXR agonist that has a potential protective effect on endothelial injuries induced by xenobiotics and endobiotics via PXR activation. Previously numerous studies have demonstrated the possible effects of Tan IIA on human umbilical vein endothelial cells, but the further mechanism for its exerts the protective effect is not well established. To study the protective effects of Tan IIA against hydrogen peroxide ($H_2O_2$) in human umbilical vein endothelial cells (HUVECs), we pretreated cells with or without different concentrations of Tan IIA for 24 h, then exposed the cells to $400{\mu}M$ $H_2O_2$ for another 3 h. Therefore, our data strongly suggests that Tan IIA may lead to increased regeneration of glutathione (GSH) from the glutathione disulfide (GSSG) produced during the GSH peroxidase-catalyzed decomposition of $H_2O_2$ in HUVECs, and the PXR plays a significant role in this process. Tan IIA may also exert protective effects against $H_2O_2$-induced apoptosis through the mitochondrial apoptosis pathway associated with the participation of PXR. Tan IIA protected HUVECs from inflammatory mediators triggered by $H_2O_2$ via PXR activation. In conclusion, Tan IIA protected HUVECs against $H_2O_2$-induced cell injury through PXR-dependent mechanisms.
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Tanshinone IIA Protects Endothelial Cells from H2O2-Induced Injuries via PXR Activation
Haiyan Zhu,Zhiwu Chen,Zengchun Ma,Hongling Tan,Chengrong Xiao,Xianglin Tang,Boli Zhang,Yuguang Wang,Yue Gao 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.6
Tanshinone IIA (Tan IIA) is a pharmacologically active substance extracted from the rhizome of Salvia miltiorrhiza Bunge (also known as the Chinese herb Danshen), and is widely used to treat atherosclerosis. The pregnane X receptor (PXR) is a nuclear receptor that is a key regulator of xenobiotic and endobiotic detoxification. Tan IIA is an efficacious PXR agonist that has a potential protective effect on endothelial injuries induced by xenobiotics and endobiotics via PXR activation. Previously numerous studies have demonstrated the possible effects of Tan IIA on human umbilical vein endothelial cells, but the further mechanism for its exerts the protective effect is not well established. To study the protective effects of Tan IIA against hydrogen peroxide (H2O2) in human umbilical vein endothelial cells (HUVECs), we pretreated cells with or without different concentrations of Tan IIA for 24 h, then exposed the cells to 400 μM H2O2 for another 3 h. Therefore, our data strongly suggests that Tan IIA may lead to increased regeneration of glutathione (GSH) from the glutathione disulfide (GSSG) produced during the GSH peroxidase-catalyzed decomposition of H2O2 in HUVECs, and the PXR plays a significant role in this process. Tan IIA may also exert protective effects against H2O2-induced apoptosis through the mitochondrial apoptosis pathway associated with the participation of PXR. Tan IIA protected HUVECs from inflammatory mediators triggered by H2O2 via PXR activation. In conclusion, Tan IIA protected HUVECs against H2O2-induced cell injury through PXR-dependent mechanisms.
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( Haiyan Zhu ),( Zhiwu Chen ),( Zengchun Ma ),( Hongling Tan ),( Chengrong Xiao ),( Xianglin Tang ),( Boli Zhang ),( Yuguang Wang ),( Yue Gao ) 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.6
Tanshinone IIA (Tan IIA) is a pharmacologically active substance extracted from the rhizome of Salvia miltiorrhiza Bunge (also known as the Chinese herb Danshen), and is widely used to treat atherosclerosis. The pregnane X receptor (PXR) is a nuclear receptor that is a key regulator of xenobiotic and endobiotic detoxification. Tan IIA is an efficacious PXR agonist that has a potential protective effect on endothelial injuries induced by xenobiotics and endobiotics via PXR activation. Previously numerous studies have demonstrated the possible effects of Tan IIA on human umbilical vein endothelial cells, but the further mechanism for its exerts the protective effect is not well established. To study the protective effects of Tan IIA against hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) in human umbilical vein endothelial cells (HUVECs), we pretreated cells with or without different concentrations of Tan IIA for 24 h, then exposed the cells to 400 μM H<sub>2</sub>O<sub>2</sub> for another 3 h. Therefore, our data strongly suggests that Tan IIA may lead to increased regeneration of glutathione (GSH) from the glutathione disulfide (GSSG) produced during the GSH peroxidase-catalyzed decom position of H<sub>2</sub>O<sub>2</sub> in HUVECs, and the PXR plays a significant role in this process. Tan IIA may also exert protective effects against H<sub>2</sub>O<sub>2</sub>-induced apoptosis through the mitochondrial apoptosis pathway associated with the participation of PXR. Tan IIA protected HUVECs from inflammatory mediators triggered by H<sub>2</sub>O<sub>2</sub> via PXR activation. In conclusion, Tan IIA protected HUVECs against H<sub>2</sub>O<sub>2</sub>-induced cell injury through PXR-dependent mechanisms.
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Tan Tan Bui,Min Kyoung Shin,Seung Yong Jee,Jongin Hong,Myung Gil Kim 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
The significant public health concerns related to air pollution that contains particulate matter (PM) and the airborne transmission of severe acute respiratory syndrome coronavirus 2 raised considerable interest in high performance air filtration membranes. The highly ferroelectric polyvinylidene fluoride (PVDF) nanofiber filter membrane is successfully fabricated via the electrospinning process for high-performance low-cost air filtration. Spectroscopic and ferroelectric/piezoelectric analyses of PVDF NF show that a thinner PVDF NF typically forms a ferroelectric β phase with a confinement effect. A 70-nm PVDF NF membrane exhibits the highest fraction of β phase and the largest polarization behavior from piezoresponse force microscopy. An ultra-thin 70-nm PVDF NF membrane exhibits a high PM0.3 filtration efficiency of 97.4% with a low pressure drop of 5.2 mmH2O at an air flow of 5.3 cm/s owing to the synergetic combination of the slip effect and ferroelectric dipole interaction.
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