Evolutionary history of the monospecific Compsopogon genus (Compsopogonales, Rhodophyta)

Nan, Fangru,Feng, Jia,Lv, Junping,Liu, Qi,Xie, Shulian The Korean Society of Phycology 2016 ALGAE Vol.31 No.4

Compsopogon specimens collected in China were examined based on morphology and DNA sequences. Five molecular markers from different genome compartments including rbcL, COI, 18S rDNA, psbA, and UPA were identified and used to construct a phylogenetic relationship. Phylogenetic analyses indicated that two different morphological types from China clustered into an independent clade with Compsopogon specimens when compared to other global samples. The Compsopogon clade exhibited robust support values, revealing the affiliation of the samples to Compsopogon caeruleus. Although the samples were distributed in a close geographical area, unexpected sequence divergences between the Chinese samples implied that they were introduced by different dispersal events and from varied origins. It was speculated that Compsopogon originated in North America, a portion of the Laurentia landmass situated in the Rodinia supercontinent at approximately 573.89-1,701.50 million years ago during the Proterozoic era.Although Compsopogonhad evolved for a rather long time, genetic conservation had limited its variability and rate of evolution, resulting in the current monospecific global distribution. Additional global specimens and sequence information were required to increase our understanding of the evolutionary history of this ancient red algal lineage.

Experimental Study on Sedimentation and Consolidation of Soil Particles in Dredged Slurry

Nan Zhang,Wei Zhu,Hongtao He,Yiyan Lv 대한토목학회 2017 KSCE JOURNAL OF CIVIL ENGINEERING Vol.21 No.7

Sedimentation and consolidation of dredged slurry is very complex in practice. A new Multilayer Extraction Sampling (MES) method was developed in this study to better understand the underlying law of sedimentation and consolidation of soil particles in slurries. Comparing with previous methods, the advantages of this method include: (1) the equipment is easy to operate and the test procedures are simple; (2) the volume distribution and the settling velocity of soil particles can be measured and calculated by Volume Flux Function (VFF) approach at different time and heights during sedimentation and consolidation process; (3) soil formation from sedimentation of dredged slurry can be also further studied based on pore water pressure measurements in conjunction with the velocity and density distributions. The experimental results revealed that there were four different zones during sedimentation and consolidation process: water zone, hindered settling zone, consolidation zone and a new zone termed as “transition zone” where soil particles are in contact with each other but effective stress are not fully developed. It is concluded that the sedimentation and consolidation of soil particles in dredged slurry was studied successfully in a holistic manner using this new experimental method.

Evolutionary history of the monospecific Compsopogon genus (Compsopogonales, Rhodophyta)

Fangru Nan,Jia Feng,Junping Lv,Qi Liu,Shulian Xie 한국조류학회I 2016 ALGAE Vol.31 No.4

Compsopogon specimens collected in China were examined based on morphology and DNA sequences. Five molecularmarkers from different genome compartments including rbcL, COI, 18S rDNA, psbA, and UPA were identified andused to construct a phylogenetic relationship. Phylogenetic analyses indicated that two different morphological typesfrom China clustered into an independent clade with Compsopogon specimens when compared to other global samples. The Compsopogon clade exhibited robust support values, revealing the affiliation of the samples to Compsopogon caeruleus. Although the samples were distributed in a close geographical area, unexpected sequence divergences betweenthe Chinese samples implied that they were introduced by different dispersal events and from varied origins. It wasspeculated that Compsopogon originated in North America, a portion of the Laurentia landmass situated in the Rodiniasupercontinent at approximately 573.89-1,701.50 million years ago during the Proterozoic era. Although Compsopogonhad evolved for a rather long time, genetic conservation had limited its variability and rate of evolution, resulting in thecurrent monospecific global distribution. Additional global specimens and sequence information were required to increaseour understanding of the evolutionary history of this ancient red algal lineage.

Application of Lobaplatin in Trans-catheter Arterial Chemoembolization for Primary Hepatic Carcinoma

Wang, Nan,Lv, Yin-Zhang,Xu, An-Hui,Huang, Yan-Rong,Peng, Ling,Li, Jia-Rui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

Objective: To explore the efficiency of single application of lobaplatin in tran-scatheter arterial chemoembolization (TACE) for patients with a primary hepatic carcinoma who were unable or unwilling to undergo surgery. Methods: 173 patients with primary hepatic carcinoma diagnosed by imaging or pathology were randomly divided into experimental and control groups and respectively treated with lobaplatin and pirarubicin hydrochloride as chemotherapeutic drugs for TACE. The amount of iodipin was regulated according to the tumor number and size, and then gelatin sponge or polyvinyl alcohol particles were applied for embolisms. The efficiency of treatment in the two groups was compared with reference to survival time and therapeutic response. Results: The experimental group (single lobaplatin as chemotherapy drug) was superior to control group (single pirarubicin hydrochloride as chemotherapy drug) in the aspects of survival time and therapeutic response, with statistical significance. Conclusions: Single lobaplatin can be as a chemotherapy drug in TACE and has better efficiency in the aspects of mean survival time and therapeutic response, deserving to be popularized in the clinic.

FoxD2-AS1 is a prognostic factor in glioma and promotes temozolomide resistance in a O⁶-methylguanine-DNA methyltransferase-dependent manner

Shangguan, Wenbing,Lv, Xuyang,Tian, Nan The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.6

Glioma is the most common brain tumor with a dismal prognosis. While temozolomide (TMZ) based chemotherapy significantly improves survival in glioma patients, resistance against this compound commonly leads to glioma treatment failure. Overexpression of long-noncoding RNA (LncRNA) FoxD2 adjacent opposite strand RNA 1 (FoxD2-AS1) was identified to promote glioma development, but the role in TMZ resistance remains unclear. In this paper, we found that FoxD2-AS1 was overexpressed in recurrent glioma, high FoxD2-AS1 expression was significantly correlated with poor patient outcome. Methylation of $O^6$-methylguanine-DNA methyltransferase (MGMT) is significantly less frequent in high FoxD2-AS1 expression patients. Knockdown of FoxD2-AS1 decreased the proliferation, metastatic ability of glioma cells and promote the sensitivity to TMZ in glioma cells. Furthermore, knockdown of FoxD2-AS1 induced hypermethylation of the promoter region of MGMT. Our data suggested that FoxD2-AS1 is a clinical relevance LncRNA and mediates TMZ resistance by regulating the methylation status of the MGMT promoter region.

Hot Keyword Extraction of Sci-tech Periodicals Based on the Improved BERT Model

Bing Liu,Zhijun Lv,Nan Zhu,Dongyu Chang,Mengxin Lu 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.6

With the development of the economy and the improvement of living standards, the hot issues in the subject area have become the main research direction, and the mining of the hot issues in the subject currently has problems such as a large amount of data and a complex algorithm structure. Therefore, in response to this problem, this study proposes a method for extracting hot keywords in scientific journals based on the improved BERT model.It can also provide reference for researchers,and the research method improves the overall similarity measure of the ensemble,introducing compound keyword word density, combining word segmentation, word sense set distance, and density clustering to construct an improved BERT framework, establish a composite keyword heat analysis model based on I-BERT framework.Taking the 14420 articles published in 21 kinds of social science management periodicals collected by CNKI(China National Knowledge Infrastructure) in 2017-2019 as the experimental data, the superiority of the proposed method is verified by the data of word spacing, class spacing, extraction accuracy and recall of hot keywords. In the experimental process of this research, it can be found that the method proposed in this paper has a higher accuracy than other methods in extracting hot keywords, which can ensure the timeliness and accuracy of scientific journals in capturing hot topics in the discipline, and finally pass Use information technology to master popular key words.

Application of near-infrared spectroscopy for screening the potato flour content in Chinese steamed bread

Hui Wang,Du Lv,Nan Dong,Sijie Wang,Jia Liu 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.4

Near-infrared (NIR) spectroscopy combinedwith chemometrics was used as a technique to predict thepotato flour content in Chinese steamed bread (CSB). Theinner core of CSB was chosen as the measuring position foracquiring the NIR spectra. Spectra between 4000 and10,000 cm-1 were analysed using a partial least-squaresregression. The coefficient of determination (RCV2 ) and theroot mean square error of cross-validation in the calibrationset were found to be 0.7940–0.8955 and 4.22–5.93,depending on the pre-treatment of the spectra. The externalvalidation set gave an R2 and a ratio to performancedeviation of 0.8865 and 3.07. Reasonable recovery(93.1–102.5%) and good intra-assay (3.3–8.3%) and interassay(7.6–17.2%) precision illustrated the feasibility ofthis method. The result of this study reveals that NIRspectroscopy could be used as rapid tool to determine thepotato flour content in CSB ([20%).

Energy Efficient Air-to-Ground Communication Networks with Reconfigurable Intelligent Surface

Yuanyuan Yao,Ke Lv,Nan Ma,Xinwei Yue,Xiaoqi Qin,Xiang Yun 한국통신학회 2022 Journal of communications and networks Vol.24 No.5

Reconfigurable intelligent surface (RIS) assisted air- to-ground wireless powered communication networks (WPCNs) are constructed to promote the energy efficiency of the system, in which unmanned aerial vehicles (UAV) reflects energy towards the energy-constrained hybrid access points (HAP) through RIS. Subsequently, HAP uses the collected energy to communicate with users in blind areas through the RIS-UAV. By optimizing parameters such as charging time ratio, transmit power and phase shifts matrix, the energy efficiency for single and multi- user scenarios are maximized, respectively. The energy efficiency is modeled as a non-convex quadratic programming problem with inequality constraints in the single-user scenario. Then the problem is converted into an equivalent convex problem by using the Taylor expansion and convex approximation method. A joint optimization algorithm of power and phase shifts is proposed to obtain a feasible solution. The energy efficiency is modeled as a fractional programming problem with non-convex inequality constraints in the multi-user scenario, and the feasible solution is obtained by proposing an alternating algorithm. Finally, both two scenarios are compared with the system of traditional amplify- and-forward (AF) relay, respectively. Finally, the simulation results show that the proposed algorithms can provide up with 150% and 160% improvement of the energy efficiency in the single and multi-user scenarios, respectively, compared to the traditional AF relay.

TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1

Fei Xiaowei,Dou Ya-nan,Sun Kai,Wei Jialiang,Guo Qingdong,Wang Li,Wu Xiuquan,Lv Weihao,Jiang Xiaofan,Fei Zhou 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

The tripartite motif (TRIM) 22 and mitogen-activated protein kinase (MAPK) signaling pathways play critical roles in the growth of glioblastoma (GBM). However, the molecular mechanism underlying the relationship between TRIM22 and MAPK signaling remains unclear. Here, we found that TRIM22 binds to exon 2 of the sphingosine kinase 2 (SPHK2) gene. An ERK1/2-driven luciferase reporter construct identified TRIM22 as a potential activator of MAPK signaling. Knockout and overexpression of TRIM22 regulate the inhibition and activation of MAPK signaling through the RING-finger domain. TRIM22 binds to Raf-1, a negative regulator of MAPK signaling, and accelerates its degradation by inducing K48-linked ubiquitination, which is related to the CC and SPRY domains of TRIM22 and the C1D domain of Raf-1. In vitro and in vivo, an SPHK2 inhibitor (K145), an ERK1/2 inhibitor (selumetinib), and the nonphosphorylated mutant Raf-1S338A inhibited GBM growth. In addition, deletion of the RING domain and the nuclear localization sequence of TRIM22 significantly inhibited TRIM22-induced proliferation of GBM cells in vivo and in vitro. In conclusion, our study showed that TRIM22 regulates SPHK2 transcription and activates MAPK signaling through posttranslational modification of two critical regulators of MAPK signaling in GBM cells.

An Optimized MPC Method for Restraining the Midpoint Voltage Fluctuation of 3-Level T-Type Grid-Connected Inverter

Dou Zhifeng,Wang Nan,Chen Zhinan,Zheng Anping,Lu Falong,Lv Zhongbin 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.2

Conventional Finite Control Set Model Predictive Control (FCS-MPC) suffers from large neutral point voltage fluctuation, cumbersome calculation process, as well as high current Total Harmonic Distortions for 3-level T-type grid-tied inverter. An improved FCS-MPC method is proposed in this paper by directly calculating the switch state’s cost function. This method uses the 3-phase switching state Sx to represent the load current i, the DC side neutral point voltage offset ΔUc, the load current prediction value i(k + 1), and establishes a real-time cost function g through 27 switching vectors. In the loop calculation, the switching vector is selected by minimizing the absolute value of the cost function g, and the output switching state is represented by the switching vector. Thus, the inverter can be switched ON or OFF depending on the stat of the next moment. The FCS-MPC of a 3-level T-type grid-tied inverter is also established by simulation, and the effectiveness of the proposed method is verified by experimental results.