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- 저자 : Longfei Lin (검색결과 5 건)
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( Yanjie Liu ),( Longfei Chen ),( Qiaohong Xie ),( Xi Yu ),( Anqing Duan ),( Yamin Lin ),( Biyun Xiang ),( Xiaoran Hao ),( Wanwan Chen ),( Xudong Zhu ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.10
The fungal products dibenzodioxocinones promise a novel class of inhibitors against cholesterol ester transfer protein (CEPT). Knowledge as to their biosynthesis is scarce. In this report, we characterized four more dibenzodioxocinones, which along with a previously described member pestalotiollide B, delimit the dominant spectrum of secondary metabolites in P. microspora. Through mRNA-seq profiling in gα1Δ, a process that halts the production of the dibenzodioxocinones, a gene cluster harboring 21 genes including a polyketide synthase, designated as pks8, was defined. Disruption of genes in the cluster led to loss of the compounds, concluding the anticipated role in the biosynthesis of the chemicals. The biosynthetic route to dibenzodioxocinones was temporarily speculated. This study reveals the genetic basis underlying the biosynthesis of dibenzodioxocinone in fungi, and may facilitate the practice for yield improvement in the drug development arena.
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Yongkui Yang,Yifeng Ling,Longfei Wang,Peizhe Sun,Lin Zhao,Hongyang Wang 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.5
With rapid industrialization and population growth, sewage sludge generation has increased worldwide, and it needs to be treated properly. The pyrolysis of sewage sludge into biochar provides sustainable benefits for concomitant pollutant adsorption and waste treatment. Sulfamethoxazole (SMX) antibiotics are highly prevalent in waste-water owing to their widespread utilization and low metabolic rate and removal efficiency during conventional waste-water treatment. Biochar is known to effectively remove pollutants from wastewater. However, the adsorption capacity and mechanism of SMX adsorption onto sludge-based biochar are currently unclear. Therefore, the adsorption behavior of SMX on sludge-based biochar from three sources (raw sludge, compost sludge, and digested sludge) and ZnCl2-modified biochar was investigated. Among the unmodified biochars, raw sludge-based biochar exhibited the highest adsorption capacity, followed by compost sludge-based and digested sludge-based biochar. The pore-forming effect of ZnCl2 application significantly increased the biochar specific surface area, which increased the equilibrium adsorption of SMX from 6.1 mg/g to 49.3 mg/g. The adsorption mechanisms involved electrostatic interactions, pore filling, hydrophobic interactions, hydrogen bonding, and π-π interactions. The findings of this study demonstrate the development of sewage sludge biochar and its effectiveness for the treatment of antibiotics containing wastewater.
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Alterations of Amino Acid Level in Depressed Rat Brain
Yang, Pei,Li, Xuechun,Ni, Jian,Tian, Jingchen,Jing, Fu,Qu, Changhai,Lin, Longfei,Zhang, Hui The Korean Society of Pharmacology 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.5
Amino-acid neurotransmitter system dysfunction plays a major role in the pathophysiology of depression. Several studies have demonstrated the potential of amino acids as a source of neuro-specific biomarkers could be used in future diagnosis of depression. Only partial amino acids such as glycine and asparagine were determined from certain parts of rats' brain included hippocampi and cerebral cortex in previous studies. However, according to systematic biology, amino acids in different area of brain are interacted and interrelated. Hence, the determination of 34 amino acids through entire rats' brain was conducted in this study in order to demonstrate more possibilities for biomarkers of depression by discovering other potential amino acids in more areas of rats' brain. As a result, 4 amino acids (L-aspartic acid, L-glutamine, taurine and ${\gamma}$-amino-n-butyric acid) among 34 were typically identified as potentially primary biomarkers of depression by data statistics. Meanwhile, an antidepressant called Fluoxetine was employed to verify other potential amino acids which were not identified by data statistics. Eventually, we found L-${\alpha}$-amino-adipic acid could also become a new potentially secondary biomarker of depression after drug validation. In conclusion, we suggested that L-aspartic acid, L-glutamine, taurine, ${\gamma}$-amino-n-butyric acid and L-${\alpha}$-amino-adipic acid might become potential biomarkers for future diagnosis of depression and development of antidepressant.
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Alterations of Amino Acid Level in Depressed Rat Brain
Pei Yang,Xuechun Li,Jian Ni,Jingchen Tian,Fu Jing,Changhai Qu,Longfei Lin,Hui Zhang 대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.5
Amino-acid neurotransmitter system dysfunction plays a major role in the pathophysiology ofdepression. Several studies have demonstrated the potential of amino acids as a source of neuro-specificbiomarkers could be used in future diagnosis of depression. Only partial amino acids such as glycineand asparagine were determined from certain parts of rats’ brain included hippocampi and cerebralcortex in previous studies. However, according to systematic biology, amino acids in different areaof brain are interacted and interrelated. Hence, the determination of 34 amino acids through entirerats’ brain was conducted in this study in order to demonstrate more possibilities for biomarkers ofdepression by discovering other potential amino acids in more areas of rats’ brain. As a result, 4 aminoacids (L-aspartic acid, L-glutamine, taurine and γ -amino-n-butyric acid) among 34 were typicallyidentified as potentially primary biomarkers of depression by data statistics. Meanwhile, anantidepressant called Fluoxetine was employed to verify other potential amino acids which were notidentified by data statistics. Eventually, we found L-α -amino-adipic acid could also become a newpotentially secondary biomarker of depression after drug validation. In conclusion, we suggested thatL-aspartic acid, L-glutamine, taurine, γ-amino-n-butyric acid and L-α-amino-adipic acid might becomepotential biomarkers for future diagnosis of depression and development of antidepressant.
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Zhi Wang,Longxiang Wu,Shiyu Tong,Xiheng Hu,Xiongbing Zu,Yuan Li,Wei He,Longfei Liu,Minfeng Chen,Lin Qi 한국통합생물학회 2016 Animal cells and systems Vol.20 No.2
Resveratrol possesses a wide spectrum of pharmacological properties and has been an ideal alternative drug for the treatment of different cancers, including prostate cancer. However, the mechanisms by which resveratrol inhibits the growth of prostate cancer are still not fully elucidated. To understand the effect of resveratrol on the apoptosis and the epithelial-tomesenchymal transition (EMT) of prostate cancer as well as its related mechanism, we investigated the potential use of resveratrol in PC-3 prostate cancer cells in vitro using real-time PCR, fluorescence-activated cell sorting, Western blotting, etc. Resveratrol suppresses the PC-3 prostate cancer cell growth and induces apoptosis. Resveratrol also influences the expression of EMT-related proteins (increased E-cadherin and decreased Vimentin expression). Finally, resveratrol also suppressed Akt phosphorylation in PC-3 cells. This study indicates that resveratrol may be a potential anti-cancer treatment for prostate cancer; moreover, it provides new evidence that resveratrol suppresses prostate cancer growth and metastasis.
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