Studies on Filariasis in Kinmen (Quemoy) Islands, Republic of China

Fan,P.C.,Wang,Y.C.,Liu,J.C.,Lo,H.S.,Hsu,Y.P.,Yen,C.H.,Lin,C.C.,Hsu,S.T. INSTITUTE OF TROPICAL MEDICINE YONSEI UNIVERSITY 1974 YONSEI REPORTS ON TROPICAL MEDICINE Vol.5 No.1

1972年 7月 1日부터 1973年 6月 30日까지 1年間 中華民國 臺?省 金門鳥에서 絲狀 症에 關한 調査硏究를 實施한 바 다음과 같은 結果를 얻었다. 1. 金門鳥 55村落에 居住하는 20,018 住民을 對象으로 調査한 바 血中 microfilariae (mf.) 兩性率은 8.8%였고 血液 20立方mm當 mf농도는 16.2였으며 絲狀 感染으로 因 臨床例 는 19.2%였다. 金門鳥 駐屯 軍人 2,428名에서 mf.양성율은 0.1%, mf. 감염농도는 20立方mm當 26.3이었으며 臨床例는 없었다. mf.感染濃度 및 臨床例에 있어 확실히 女性보다는 男性에서 高率을 보였으나 mf.陽性率은 兩性間에 差異가 없었다. mf.陽性率과 臨床例는 年齡의 增加와 一致하였으나 mf. 감렴농도는 年齡의 증가와 無關하였다. 2. 金文鳥 駐屯 軍人에 있어 주둔 其間과 絲狀 感染과는 關係가 없었으며 駐屯基地와 村落과의 距離와도 無關하였다. 軍人들은 모기에 물리지 않도록 잘 保護되어 있었고 주둔지역은 完全히 住民들과 격리되어 있었다. 3. 51村落으로부터의 血液檢査를 받은 1,470名의 絲狀 感染陽性者 中에서 臨床病勢르 보인 例는 19.2%였으며 女性보다는 男性에서 約 5倍가 많았다. 男性에 있어서의 大部分의 臨床例는 生殖器에 症狀을 보였는데 其中 10%는 象皮症을 가진 例는 2名뿐이었다. 4. 43村落의 家屋內에서 잡힌 모기는 4屬 14種(Culex 10種, Aedes 2種, Anopheles 1種, Armigeres 1種)이었으며 이들中 Cules P. fatigans와 Armigeres subalbatus가 大部分이었으나 其他 12種은 매우 적었다. Culcx mimesticus, C. (L) vorax, C. fuscocephala 및 Acdes nocturnus등 의 4新種은 처음으로 發見되었다. Culex p.fatigans는 現存「반크롭트」 絲狀 만을 옮기는 媒介昆 으로 알려져 있다. 治療前 8個 村落으로부터 잡은 438마리의 Culex p. fatigans에서 幼 을 內包하고 있는 모기는 1마리 平均 5.9마리의 絲狀 幼 을 갖고 있는 셈이었으며 全體 感染率은 11.9%, 感染期 幼 을 가진 모기는 10.5%이었다. 上記 8個 村落 住民을 治癒한 後의 樣狀은 治療前과 아주 달라서 모기 1마리當 平均 2.1마리의 幼 을 갖고 있었고 全體感染率은 2.2%, 感染期幼 內包率은 0.09%였다. 平均 pH가 7.4(6.4∼8.0)인 8個處의 모기 産卵場所에서 잡힌 모기 幼 은 모두 11種이었다. 有機燐劑의 一種인 Sumithion을 1平方m當 0.2gm의 농도로 모기 産卵場所 水面에 撒布하였던바 모든 모기 幼 에 對한 殺 果가 좋았다. 5. 總 1.590名의 絲狀 感染者에게 成人當 總量 5gm의 diethylcarbamazine을 10∼12日 間 服用시켜 보았다. 治療率은 80.6%, mf. 減少率은 96.9%였고 反應率는 67.2%였다. 여러 가지 副作用은 있었으나 一般的으로 輕微하였으며 患者가 참을 수 있었으므로 最高用量으로 投藥했을 경우에도 大部分 거절 하지 않았다. 8個 部落에서 捕獲된 Culex P. fatigans의 絲狀 幼 全體感染率, 感染期幼 內包率 및 感染濃度는 患者治療前에 各各 11.9%, 10.5%, 5.9였는데 治療後에는 2.2%, 0.09%, 2.1로 떨어져서 diethylcarbamazine은 microfilariae에 對한 殺충효果가 높을 뿐 아니라 絲狀충 만延을 組止시키는데 좋은 藥劑라고 思料된다 The present investigation is a serial study on “Filariasis in Kinmen (Quemoy) Islands”, which was performed from July 1, 1972 to June 30, 1973. The results are summarized as follows; 1. Parasitological investigation: Of 20,018 Kinmen Chinese in 55 villages examined, the microfilariae (mf.) rate of 8.8%, mf. density of 16.2 per 20cmm blood and clinical rate 19.2% were found: the corresponding figures for a total of 2,428 military personnel were 0.1%, 29.3 and 0.0% respectively. The mf. density and clinical rate were obviously higher in the males than in the females, but no difference was found for the microfilarial rate. The mf. rate and clinical rate were correspondingly increased with age, but there was no difference in mf. density. 2. Transmission of filariasis: It seems no any relation to the length of stationing of the Chinese troops on Kinmen Islands, and also no relation to the distance between the villages and camps; because the servicemen are well protected from the mosquito bites and bites and the camps are completely isolated, to and off limit to the villagers, though they have common places of entertainment. 3. Clinical investigation: Of 1,470 filarial carriers in 51 villages examined physically, the clinical rate of 19.2% was detected. It was about 5 times higher in males than in females. In the males, most of the cases the trouble in their reproductive organs, and 10% had elephantiasis; but in the females, the lymph nodes enlargement and chyluria were more common, only 2 cases had elephantiasis. The clinical rates increased corresponding with age. 4. Entomological investigation: Fourteen(14) species of 4 genera (10 Culex, 2 Aedes, 1 Anopheles and 1 Armigeres) of household mosquitoes were collected from indoor resting sites of 43 villages on kinmen Islands, in which, Cules P. fatigans and Armigeres subalbatus were the most common species, but the remaining 12 species are faily rare. Four (4) new species: Culex mimeticus, C. (L) vorax, C, fucocephala and Aedes noturnvs were found for the first time. Culex p.fatigans is still the only vector. in transmission of bancroftian filariasis. The infection rate of 11.9%, infective rate of 10.5% and 5.9 filarial larvae per infected mosquito were detected in 438 Culex p. fatigans from 8 villages before treatment. The corresponding figures were much lower in the above same villages after treatment (2.2%, 0.09% and 2.1). Eleven (11) species of moswquito larvae were collected from 8 kinds of breeding sites; where, the pH value of 7.4(ranged 6.4∼8.0) was measured. “Sumithion”is one of the organophosphorous compounds, which was first used on the water surface with the dosage of 0.2gm per square meter.A high insecticidal effect against different species of mosquito larvae was observed. 5. Chemotherapy of filariasis: Of 1.590 filarial carriers scheme, with a total does of 5 gm of diethylcarbamazine per adult case for a period of 10∼12 days schedule was performed. The cure rate of 80.6%, mf. reduction tate of 96.9% and reaction rate of 67.2% were found. Although many kinds of side effects were encountered, they were usually mild or transient and could be tolerated by the patients, thus there was almost no refused to the administration of the drug even if the drug was increased to the maximum dosage. The natural infection rate, infective rate and filarial larval density of Culex P. fatigans in 8 villages were found much higher before control measure (11.9%, 10.5% and 5.9%) than after control (2.2%, 0.09% and 2.1). It showed that diethylcarbamazine is a powerful microfilaricidal drug in eliminating the filarial infection and reducing this transmission.

A model-based Technique for Early and Robust Detection of Oscillatory Failure Case in A380 Actuators

Loïc Lavigne,Ali Zolghadri,Philippe Goupil,Pascal Simon 제어·로봇·시스템학회 2011 International Journal of Control, Automation, and Vol.9 No.1

This paper addresses the problem of Oscillatory Failure Cases (OFC) detection in the Electrical Flight Control System (EFCS) of the Airbus airplanes. OFC can lead to strong interactions with loads and aero-elasticity and consequently are to be detected very early in time. The work describes the status of on going research activity undertaken within a collaborative project between Bordeaux University (France) and Airbus. An hydraulic actuator model is currently used as the basis for a robust analytical redundancy-based technique implemented in A380 Flight Control Computer (FCC) for detecting unauthorized oscillatory events. For upcoming and future generation aircraft (A/C), it could be re-quired to detect OFC earlier with less important amplitude. The method presented here is based on nonlinear state space modeling, associated with the same decision test as used by in-service Airbus A/C. It is shown that the model quality could be improved significantly by reliable estimating of some physical parameters. The fault indicating signals are compared on data set obtained from A380 com-puters during flight tests.

Gel-type ion exchange resin stabilized Pd-Bi nanoparticles for the glycerol oxidation in liquid phase

Stanislav Vajı´cˇek,Magdale´na Sˇtolcova´,Alexander Kaszonyi,Matej Micˇusˇı´k,Pavel Alexy c, Patrizia Canton,Patrizia Canton,Gyo¨ rgy Onyestya´k,Szabolcs Harnos,Ferenc Lo´ nyi,Jo´ zsef Valyon 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.39 No.-

Palladium-bismuth nanoparticles were supported into strongly basic anion-exchange resin of gel-typeand tested as catalysts for the selective oxidation of glycerol with molecular oxygen at atmosphericpressure. Detailed study of the precursors preparation and reduction were undertaken. The catalyst3%Pd-1%Bi where the bismuth was deposited on the palladium particles (3.4 nm) exhibited at 95%glycerol conversion more than 63% yield toward glyceric acid and tartronic acid after 3 h of reaction. Thecatalyst maintains practically similar catalytic performance as in fresh state for at least five consecutivecatalytic cycles without extra catalyst treatment and reactivation.

Development of HPV16 mouse and dog models for more accurate prediction of human vaccine efficacy

Emmanuelle Totain,Loïc Lindner,Nicolas Martin,Yolande Misseri,Alexandra Iché,Marie-Christine Birling,Tania Sorg,Yann Herault,Alain Bousquet-Melou,Pascale Bouillé,Christine Duthoit,Guillaume Pavlovic,S 한국실험동물학회 2023 Laboratory Animal Research Vol.39 No.2

Background: Animal models are essential to understand the physiopathology of human diseases but also to evaluate new therapies. However, for several diseases there is no appropriate animal model, which complicates the development of effective therapies. HPV infections, responsible for carcinoma cancers, are among these. So far, the lack of relevant animal models has hampered the development of therapeutic vaccines. In this study, we used a candidate therapeutic vaccine named C216, similar to the ProCervix candidate therapeutic vaccine, to validate new mouse and dog HPV preclinical models. ProCervix has shown promising results with classical subcutaneous murine TC-1 cell tumor isografts but has failed in a phase II study. Results: We first generated E7/HPV16 syngeneic transgenic mice in which the expression of the E7 antigen could be switched on through the use of Cre–lox recombination. Non-integrative LentiFlash® viral particles were used to locally deliver Cre mRNA, resulting in E7/HPV16 expression and GFP reporter fluorescence. The expression of E7/HPV16 was monitored by in vivo fluorescence using Cellvizio imaging and by local mRNA expression quantification. In the experimental conditions used, we observed no differences in E7 expression between C216 vaccinated and control groups. To mimic the MHC diversity of humans, E7/HPV16 transgenes were locally delivered by injection of lentiviral particles in the muscle of dogs. Vaccination with C216, tested with two different adjuvants, induced a strong immune response in dogs. However, we detected no relationship between the level of cellular response against E7/HPV16 and the elimination of E7-expressing cells, either by fluorescence or by RT-ddPCR analysis. Conclusions: In this study, we have developed two animal models, with a genetic design that is easily transposable to different antigens, to validate the efficacy of candidate vaccines. Our results indicate that, despite being immunogenic, the C216 candidate vaccine did not induce a sufficiently strong immune response to eliminate infected cells. Our results are in line with the failure of the ProCervix vaccine that was observed at the end of the phase II clinical trial, reinforcing the relevance of appropriate animal models.

Optical Characterization of ZnMnO Thin Films on c-Al2O3

H. J. LIN,D. Y. Lin,J. S. Wu,W. C. CHOU,C. S. YANG,J. S. WANG,W. H. Lo 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.1

Various optical measurement technologies have ben used to characterize ZnMnO thin filmswith different Mn compositions grown by molecular beam epitaxy(MBE) on c-Al2O3 substrates. Thelat- tice constant and the crystalization quality have ben evaluated by using X-ray diraction (XRD). Photoluminescence (PL) has ben used to reveal the neutral-donor-bound exciton (D0X) and to checkthelm'squality. Defect-relatedabsorptionsignatures,inadditiontonear-band-edgeabsorp- tion, due to the zinc vacancy and the donor-aceptor pair (DAP) have ben found in the surface photovoltagespectra(SPS).Freexcitonictransitionsandtheirphonon-asistedreplicashaveben observed in the re ectance spectra. Our experimental results not only unveil specic optical tran- sitionenergies but also indicate arapid materiald deterioration whenMn incorporation goes beyond a certain amount to cause manganese segregation. Various optical measurement technologies have ben used to characterize ZnMnO thin filmswith different Mn compositions grown by molecular beam epitaxy(MBE) on c-Al2O3 substrates. Thelat- tice constant and the crystalization quality have ben evaluated by using X-ray diraction (XRD). Photoluminescence (PL) has ben used to reveal the neutral-donor-bound exciton (D0X) and to checkthelm'squality. Defect-relatedabsorptionsignatures,inadditiontonear-band-edgeabsorp- tion, due to the zinc vacancy and the donor-aceptor pair (DAP) have ben found in the surface photovoltagespectra(SPS).Freexcitonictransitionsandtheirphonon-asistedreplicashaveben observed in the re ectance spectra. Our experimental results not only unveil specic optical tran- sitionenergies but also indicate arapid materiald deterioration whenMn incorporation goes beyond a certain amount to cause manganese segregation.

Implications of a two-step procedure in surgical management of patients with early-stage endometrioid endometrial cancer

Emmanuelle Arsène,Géraldine Bleu,Benjamin Merlot,Loïc Boulanger,Denis Vinatier,Olivier Kerdraon,Pierre Collinet 대한부인종양학회 2015 Journal of Gynecologic Oncology Vol.26 No.2

Objective: Since European Society for Medical Oncology (ESMO) recommendations and French guidelines, pelvic lymphadenectomyshould not be systematically performed for women with early-stage endometrioid endometrial cancer (EEC) preoperativelyassessed at presumed low- or intermediate-risk. The aim of our study was to evaluate the change of our surgical practices afterESMO recommendations, and to evaluate the rate and morbidity of second surgical procedure in case of understaging after thefirst surgery. Methods: This retrospective single-center study included women with EEC preoperatively assessed at presumed low- orintermediate-risk who had surgery between 2006 and 2013. Two periods were defined the times before and after ESMOrecommendations. Demographics characteristics, surgical management, operative morbidity, and rate of understaging werecompared. The rate of second surgical procedure required for lymph node resection during the second period and its morbiditywere also studied. Results: Sixty-one and sixty-two patients were operated for EEC preoperatively assessed at presumed low-or intermediate-riskbefore and after ESMO recommendations, respectively. Although immediate pelvic lymphadenectomy was performed morefrequently during the first period than the second period (88.5% vs. 19.4%; p<0.001), the rate of postoperative risk-elevating orupstaging were comparable between the two periods (31.1% vs. 27.4%; p=0.71). Among the patients requiring second surgicalprocedure during the second period (21.0%), 30.8% did not undergo the second surgery due to their comorbidity or old age. For the patients who underwent second surgical procedure, mean operative time of the second procedure was 246.1±117.8minutes. Third operation was required in 33.3% of them because of postoperative complications. Conclusion: Since ESMO recommendations, second surgical procedure for lymph node resection is often required for womenwith EEC presumed at low- or intermediate-risk. This reoperation is not always performed due to age/comorbidity of thepatients, and presents a significant morbidity.

Correlation between Carbon Steel Corrosion and Atmospheric Factors in Taiwan

( C. M. Lo ),( L. H. Tsai ),( C. W. Hu ),( M. D. Lin ) 한국부식방식학회(구 한국부식학회) 2018 Corrosion Science and Technology Vol.17 No.2

Taiwan has a typical marine climate featuring perennial high-temperature and dampness. This climate, together with the emission of various industrial corrosive waste gases in recent years, contributes a lot to the corrosion of metal materials. In this study, samples of carbon steel exposed to various atmospheres in Taiwan were analyzed to investigate the impacts of atmospheric factors on carbon steel corrosion. Carbon steel samples were collected from 87 experimental stations between 2009 and 2012. Statistical analysis was employed to investigate the correlations between the carbon steel corrosion situations and the atmospheric factors such as concentrations of sulfur dioxide or chloride, exposure time, rainfall, etc. The results indicate that for samples from industrial areas, the sulfur dioxide concentration and exposure time during fall and winter are significantly correlated to the condition of the carbon steel corrosion. However, for samples from coastal zones, the significant correlated factors are chloride concentration and wetting time during winter. The results of this study are useful for the development of carbon steel corrosion prediction models.

Degradation of dc characteristics of InAlN/GaN high electron mobility transistors by 5 MeV proton irradiation

Lo, C.-F.,Liu, L.,Kang, T.S.,Ren, F.,Schwarz, C.,Flitsiyan, E.,Chernyak, L.,Kim, H.-Y.,Kim, J.,Yun, S.P. American Vacuum Society 2012 Journal of vacuum science and technology. material Vol.30 No.3

Rate Bounds for MIMO Relay Channels

C. K. Lo,S. Vishwanath,R. W. Heath, Jr 한국통신학회 2008 Journal of communications and networks Vol.10 No.2

This paper considers the multi-input multi-output (MIMO) relay channel where multiple antennas are employed by each terminal. Compared to single-input single-output (SISO) relay channels, MIMO relay channels introduce additional degrees of freedom, making the design and analysis of optimal cooperative strategies more complex. In this paper, a partial cooperation strategy that combines transmit-side message splitting and block- Markov encoding is presented. Lower bounds on capacity that improve on a previously proposed non-cooperative lower bound are derived for Gaussian MIMO relay channels.

An Adaptive Fast Expansion, Loading Statistics with Dynamic Swapping Algorithm to Support Real Time Services over CATV Networks

C.-C. Lo,H.-C. Lai,W.-S. E. Chen 한국통신학회 2006 Journal of communications and networks Vol.8 No.4