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Lu, Li-Rong,Liu, Jing,Xu, Zhen,Zhang, Geng-Lin,Li, De-Chang,Lin, Chao-Shuang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.10
We here document discovery of expression profile of myeloid derived suppressor cells (MDSCs) in chronic hepatitis B (CHB) patients and changes in the course of disease. The study population was composed of 75 outpatient HBV cases and 15 healthy control cases. Peripheral blood samples were collected for separation of mononuclear cells. Levels of MDSCs labeled with Lin-DR-CD11b+CD33+ obtained from peripheral blood mononuclear cells (PBMC), were revealed to have significant differences between the CHB and other groups. They were 0.414% for health control cases and 0.226% for CHB cases (Z=-2.356, p=0.0189). It also observed that the group of HBeAg positive cases had significant difference in MDSCs/PBMC median ($X^2=11.877$, p=0.003), compared with group of HBeAg negative cases and the healthy control group. It suggested considerable MDSCs might be involved in HBeAg immune tolerance. In addition, negative correlations between MDSCs/PBMC and parameters of ALT, AST and TBil, while positive correlation between MDSCs/PBMC and ALB parameter were found. Multiple comparisons between the four phases and health control phase again, there was a statistically sifnificant difference ($X^2=17.198$, p=0.002). Taken together, these findings may provide a new immunotherapy strategy for reduced the expression levels of MDSCs in CHB patients, through induction of an autoimmune response to virus removal.
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Enhancing Cross-Cultural Adaptation Skills of International Chinese Language Teachers
Zhang Lin(Lin Zhang),Sun Yi(Yi Sun) 아시아사회과학학회 2023 Jornal of Asia Social Science Vol.10 No.2
Since 2004, China National Office for Teaching Chinese as a Foreign Language began dispatching international Chinese language teachers to countries in need around the world, the teachers have made important contributions to international Chinese language education and cultural communication. International Chinese language teachers are bound to face various discomfort and difficulties when working and living in a cultural environment different from their own, which affects both their teaching and personal life. This paper attempts to analyze the internal and external factors that affect the teachers’ cross-cultural adaptability, as well as the deficiencies in pre-job training for international Chinese language teachers, to find the existing problems and make suggestions to solve them.
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Countryside Administration and Programming Management System
Lin, Xiao Quan,Zhang, Dong Hong,Zhang, Hai Ming,Liu, Yu Zeng 대한원격탐사학회 2000 International Symposium on Remote Sensing Vol.16 No.1
In accordance with the practical need to China countryside agricultural planting, land utilizing programming and countryside administrative information management, adopting MIS/GIS and large scaled map, the $quot;Countryside Administration and Programming Management System$quot; realizes the management functions to land resource, planting, land utilizing programming, household and population, family plan, administrative documents, developing programing, statistics analysis, lays goad ground work far using GIS and information Internet technology in countryside administration and producing management.
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Zhang Yingying,Liu Yingsen,Li Jiaolong,Xing Tong,Jiang Yun,Zhang Lin,Gao Feng 아세아·태평양축산학회 2020 Animal Bioscience Vol.33 No.12
Objective: This study was conducted to investigate the effects of dietary corn resistant starch (RS) on the intestinal morphology and barrier functions of broilers. Methods: A total of 320 one-day-old broilers were randomly allocated to 5 dietary treatments: one normal corn–soybean (NC) diet, one corn–soybean–based diet supplementation with 20% corn starch (CS), and 3 corn–soybean–based diets supplementation with 4%, 8%, and 12% corn resistant starch (RS) (identified as 4% RS, 8% RS, and 12% RS, respectively). Each group had eight replicates with eight broilers per replicate. After 21 days feeding, one bird with a body weight (BW) close to the average BW of their replicate was selected and slaughtered. The samples of duodenum, jejunum, ileum, caecum digesta, and blood were collected. Results: Birds fed 4% RS, 8% RS and 12% RS diets showed lower feed intake, BW gain, jejunal villus height (VH), duodenal crypt depth (CD), jejunal VH/CD ratio, duodenal goblet cell density as well as mucin1 mRNA expressions compared to the NC group, but showed higher concentrations of cecal acetic acid and butyric acid, percentage of jejunal proliferating cell nuclear antigen-positive cells and delta like canonical Notch ligand 4 (Dll4), and hes family bHLH transcription factor 1 mRNA expressions. However, there were no differences on the plasma diamine oxidase activity and D-lactic acid concentration among all groups. Conclusion: These findings suggested that RS could suppress intestinal morphology and barrier functions by activating Notch pathway and inhibiting the development of goblet cells, resulting in decreased mucins and tight junction mRNA expression.
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Lin, Mei-Gui,Liu, Li-Ping,Li, Chen-Yin,Zhang, Meng,Chen, Yuling,Qin, Jian,Gu, Yue-Yu,Li, Zhi,Wu, Xin-Lin,Mo, Sui-Lin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Background and Aims: Scutellaria is one of the most popular traditional Chinese herbal remedies against various human diseases, including cancer. In this study, we examined the active effects of Scutellaria extract and its main flavonoid constituents on the proportion of side population cells within human multiple myeloma cell line RPMI8226 in vitro and explored the potential molecular mechanisms involved. Materials and Methods: The contents of flavonoids in ethanolic extract of Scutellaria baicalensis Georgi were determined using high performance liquid chromatography. The antiproliferative effect of the ethanolic extract on RPMI-8226 was determined by CCK assay. Apoptosis was measured by annexin combining with propidium iodide in a flow cytometer. Cell cycle analysis was performed by propidium iodide staining in combination with flow cytometry analysis. Hoechst 33342 exclusion assay was used for the identification of side population within RPMI8226 cells. The expression of ABCG2 protein was assessed by Western blotting assay. Results: The content of major flavonoids constitutents of Scutellaria extract was baicalin (10.2%), wogonoside (2.50%), baicalein (2.29%), and wogonin (0.99%), respectively. The crude Scutellaria extract did not show significant anti-proliferative effect, apoptosis induction and cell cycle arrest in RPMI-8226 within the concentrations of $1-75{\mu}g/mL$. However, the ethanolic extract, baicalein, wogonin and baicalin reduced the side population cells in RPMI-8226, and data showed that baicalein and wogonin had stronger inhibitory effects. Correspondingly, they also exhibited significant effects on decreasing the expression level of ABCG2 protein in RPMI-8226 in vitro. Conclusions: Our results for the first time demonstrated a novel mechanism of action for Scutellaria extract and its main active flavonoids, namely targeting SP cells by modulating the expression of ABCG2 protein. This study provides an insight for new therapeutic strategies targeting cancer stem cells of multiple myeloma.
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Zhang Lin,Sun Jiazhao,Wu Xiaomeng,Xu Yu,Bi Shoudong,Zou Yunding 한국곤충학회 2021 Entomological Research Vol.51 No.12
The purpose of this study was to comprehensively evaluate the dominant natural enemies of Breuipalpus oboyats in autumn and winter tea gardens. The relationship between natural enemies and B.oboyats in time and space was studied by niche analysis and geostatistics combined with angular cosine coefficient method. According to the comparison of the sum of closeness index, it is found that the top three natural enemies (from large to small) that are most closely related to B.oboyats in the “Nongkangzao” tea garden are Plexippus paykulli, Clubiona japonicola,and Xysticus ephippiafus; “Pingyangtezao” tea garden are X.ephippiafus, Plexippus setipet,andOxyopes sertatus. In front of the two tea gardens, one of the three natural enemies is the same. The evaluation of the comprehensive closeness index of the two tea gardens shows that the top three natural enemies most closely related to B.oboyats are X.ephippiafus, P.paykulli, and O.sertatus. X.ephippiafus is the most important natural enemy of B.oboyats in tea gardens in autumn and winter; the dominant natural enemies of the same pests in different varieties of tea gardens in the same area are often different.
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Zhang Nan,Qian Guangjing,Zhang Lin,Song Xueyu,Zou Yunding,Bi Shoudong 한국곤충학회 2021 Entomological Research Vol.51 No.7
To improve the accuracy of forecasting the peak period of Dendrolimus punctatus, stationary time series, periodic distance method, stepwise regression model and the Bayes discriminant analysis were used. RSME value, kappa coefficient and accuracy were used as evaluation criteria to predict the peak period for the second generation egg of D. punctatus with over 33 years from 1983 to 2016 in Qianshan County, Anhui Province. The predictions of these models were verified in 2017 and 2018. The prediction of the stationary time model and Bayes discriminant analysis for 2017 was one level lower than the actual result and for 2018 was one level higher than the actual result, while the prediction of the periodic distance method was identical to the actual result for 2017 and greatly different from the actual result for 2018. The accuracy for stationary time series (RMSE = 0.92 kappa = 0.76) and periodic distance method (RMSE = 2.96, kappa = 0.81) from 1983 to 2018 were 87.88% and 85.71%, respectively. When taking into consideration the standard error was based on differential, the accuracy for the prediction of stepwise regression model (RMSE = 0.25, kappa = 1.00) from 1983 to 2018 was 100%. The accuracy of Bayes discriminant method (RMSE = 0.71, kappa = 0.96) was 97.14%. Comparatively speaking, the stepwise regression model and Bayes discriminant analysis method were better than the stationary time series and periodic distance method in RMSE value, kappa coefficient and accuracy. So they were relatively ideal forecast methods.
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The treatment effect of novel hGHRH homodimer to male infertility hamster
Zhang, Xu-Dong,Guo, Xiao-Yuan,Tang, Jing-Xuan,Yue, Lin-Na,Zhang, Juan-Hui,Liu, Tao,Dong, Yu-Xia,Tang, Song-Shan The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.6
Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important role in reproduction. To study the treatment effect of Grin (a novel hGHRH homodimer), the infertility models of 85 male Chinese hamsters were established by intraperitoneally injecting 20 mg/kg of cyclophosphamide once in a week for 5 weeks and the treatment with Grin or human menopausal gonadotropin (hMG) as positive control was evaluated by performing a 3-week mating experiment. 2-8 mg/kg of Grin and 200 U/kg of hMG showed similar effect and different pathological characteristics. Compared to the single cyclophosphamide group (0%), the pregnancy rates (H-, M-, L-Grin 26.7, 30.8, 31.3%, and hMG 31.3%) showed significant difference, but there was no difference between the hMG and Grin groups. The single cyclophosphamide group presented loose tubules with pathologic vacuoles and significant TUNEL positive cells. Grin induced less weight of body or testis, compactly aligned tubules with little intra-lumens, whereas hMG caused more weight of body or testis, enlarging tubules with annular clearance. Grin presented a dose-dependent manner or cell differentiation-dependentincrease in testicular GHRH receptor, and did not impact the levels of blood and testicular GH, testosterone. Grin promotes fertility by proliferating and differentiating primitive cells through up-regulating testicular GHRH receptor without triggering GH secretion, which might solve the etiology of oligoasthenozoospermia.
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Lin Cheng,Hongliang Lu,Yuming Zhang,Yimen Zhang 대한전자공학회 2022 Journal of semiconductor technology and science Vol.22 No.2
In this paper, a compact macromodeling method for characterizing the large-signal characteristics of heterojunction bipolar transistors (HBTs) is proposed and successfully applied to describe the DC and AC performance of InP and GaAs HBT devices. Using the Symbolically-defined Device (SDD) technology, an empirical macro circuit preserving the Spice Gummel-Poon (SGP) intrinsic network and a simplified thermal network is established. The empirical current and charge functions are embedded in the SDD macro circuit network module. Compared with other large-signal models, the proposed model description and the relevant parameter extraction are relatively simpler, and at the same time, this method can maintain high fitting accuracy. To assess the validity and the accuracy of the proposed model, the compact large-signal model is constructed for 1 µm InP HBT and 1 µm GaAs HBT. Based on the complete extraction of the model parameters, excellent consistency is obtained between the measured and modeled results.
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