A Multi-Stage TSK Fuzzy Modeling Method by Genetic Programming

Li, Bo,Cho, Kyu-Kab 한국경영과학회 2002 한국경영과학회 학술대회논문집 Vol.- No.1(2)

This paper deals with a multi-stage TSK fuzzy modeling method by using Genetic Programming (GP). Based on the time sequence of sampling data, the best structural change points of complex systems are determined by using GP, and also the moving window is simultaneously introduced to overcome the excessive amount of calculation during the generating procedure of GP tree. There fire, a multi-stage TSK fuzzy model that attempts to represent a complex problem by decomposing it into multi-stage sub-problems is addressed and its learning algorithm is proposed based on the Radial Basis Function (RBF) network. This approach allows us to determine the model structure and parameters by stages so that the problems can be simplified.

Maximizing the Lifetime of Wireless Sensor Networks Using Multiple Sets of Rendezvous

Li, Bo,Park, Sungkwon Hindawi Limited 2015 Mobile information systems Vol.2015 No.-

<P>In wireless sensor networks (WSNs), there is a “crowded center effect” where the energy of nodes located near a data sink drains much faster than other nodes resulting in a short network lifetime. To mitigate the “crowded center effect,” rendezvous points (RPs) are used to gather data from other nodes. In order to prolong the lifetime of WSN further, we propose using multiple sets of RPs in turn to average the energy consumption of the RPs. The problem is how to select the multiple sets of RPs and how long to use each set of RPs. An optimal algorithm and a heuristic algorithm are proposed to address this problem. The optimal algorithm is highly complex and only suitable for small scale WSN. The performance of the proposed algorithms is evaluated through simulations. The simulation results indicate that the heuristic algorithm approaches the optimal one and that using multiple RP sets can significantly prolong network lifetime.</P>

Highly Organized Two- and Three-Dimensional Single-Walled Carbon Nanotube–Polymer Hybrid Architectures

Li, Bo,Hahm, Myung Gwan,Kim, Young Lae,Jung, Hyun Young,Kar, Swastik,Jung, Yung Joon American Chemical Society 2011 ACS NANO Vol.5 No.6

<P>Single-walled carbon nanotube (SWCNT) network architectures combined with flexible mediums (especially polymers) are strong candidates for functional flexible devices and composite structures requiring the combination of unique electronic, optical, and/or mechanical properties of SWCNTs and polymer materials. However, to build functional flexible devices with SWCNTs, it is required to have abilities to assemble and incorporate SWCNTs in desired locations, orientations, and dimensions on/inside polymer substrates. Here, we present unique two- and three-dimensional SWCNT network–polymer hybrid architectures by combining unprecedented control over growth, assembly, and transfer processes of SWCNTs. Several SWCNT architectures have been built on polymer materials ranging from two-dimensional suspended SWCNT microlines on PDMS microchannels to three-dimensional “PDMS-vertically aligned SWCNTs-PDMS” sandwich structures. Also a combined lateral SWCNT microline and vertically aligned SWCNT flexible device was demonstrated with good electrical conductivity and low junction resistance. The results reported here open the pathway for the development of SWCNT-based functional systems in various flexible device applications.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2011/ancac3.2011.5.issue-6/nn2008782/production/images/medium/nn-2011-008782_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn2008782'>ACS Electronic Supporting Info</A></P>

Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2 cells

LI, BO,KIM, DO SUNG,YADAV, RAJ KUMAR,KIM, HYUNG RYONG,CHAE, HAN JUNG UNKNOWN 2015 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.36 No.1

<P>Sulforaphane, a natural isothiocyanate compound found in cruciferous vegetables, has been shown to exert cardioprotective effects during ischemic heart injury. However, the effects of sulforaphane on cardiotoxicity induced by doxorubicin are unknown. Thus, in the present study, H9c2 rat myoblasts were pre-treated with sulforaphane and its effects on cardiotoxicity were then examined. The results revealed that the pre-treatment of H9c2 rat myoblasts with sulforaphane decreased the apoptotic cell number (as shown by trypan blue exclusion assay) and the expression of pro-apoptotic proteins (Bax, caspase-3 and cytochrome <I>c</I>; as shown by western blot analysis and immunostaining), as well as the doxorubicin-induced increase in mitochondrial membrane potential (measured by JC-1 assay). Furthermore, sulforaphane increased the mRNA and protein expression of heme oxygenase-1 (HO-1, measured by RT-qPCR), which consequently reduced the levels of reactive oxygen species (ROS, measured using MitoSOX Red reagent) in the mitochondria which were induced by doxorubicin. The cardioprotective effects of sulforaphane were found to be mediated by the activation of the Kelch-like ECH-associated protein 1 (Keap1)/NF-E2-related factor-2 (Nrf2)/antioxidant-responsive element (ARE) pathway, which in turn mediates the induction of HO-1. Taken together, the findings of this study demonstrate that sulforaphane prevents doxorubicin-induced oxidative stress and cell death in H9c2 cells through the induction of HO-1 expression.</P>

Design of supplemental viscous dampers in inelastic SDOF system based on improved capacity spectrum method

Li, Bo,Liang, Xing-Wen Techno-Press 2007 Structural Engineering and Mechanics, An Int'l Jou Vol.27 No.5

A simplified yet effective design procedure for viscous dampers was presented based on improved capacity spectrum method in the context of performance-based seismic design. The amount of added viscous damping required to meet a given performance objective was evaluated from the difference between the total demand for effective damping and inherent damping plus equivalent damping resulting from hysteretic deformation of system. Application of the method is illustrated by means of two examples, using Chinese design response spectrum and mean response spectrum. Nonlinear dynamic analysis results indicate that the maximum displacements of structures installed with supplemental dampers designed in accordance with the proposed method agree well with the given target displacements. The advantage of the presented procedure over the conventional iterative design method is also highlighted.

A New Strategy for Economic Virtual Power Plant Utilization in Electricity Market Considering Energy Storage Effects and Ancillary Services

Li Bo,Ghiasi Mohammad 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.6

A group of distributed generators (DGs) systems including wind, solar, diesel, energy storage (ES), etc., that are under a central management and control is often considered as virtual power plant (VPP) concept. One of the components of a VPP is ES, whose presence and participation in the electricity market can create business opportunities. In this paper, a new mathematical-based strategy for identifying diff erent types of trading situations considering VPPs eff ects is proposed in the electricity market to obtain maximum benefi t. Also VPP trading between energy and ancillary services is considered and analysed. The presented model considers all limitations of the VPP including network constrains and the structure of VPPs. The optimal management of distributed energy units determines the state of charge (SoC) or discharge of ES resources and the amount of intermittent load for the day ahead electricity market. By implementing the proposed model on the microgrid (MG), two diff erent modes of trading for VPPs are examined and the changes of effi ciency related to energy storages are analysed. In order to solve the issue of optimal operation strategy, an intelligent approach based on diff erential evolution (DE) algorithm is used. The obtained simulation results of both modes are compared with those VPP without energy storage. The results show notable profi ts in both modes.

Associations Between Mammography and Ultrasound Imaging Features and Molecular Characteristics of Triple-negative Breast Cancer

Li, Bo,Zhao, Xin,Dai, Shao-Chun,Cheng, Wen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

Background: The triple-negative breast cancer (TNBC) is an aggressive cancer characterized by the absence of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). Preoperative mammography and ultrasound features of TNBC may potentially suggest characteristics of the disease and assist in treatment decisions. Materials and Methods: The study covered 153 patients with TNBC from May 2011 to May 2012 who were confirmed by postoperative pathology results in our hospital. We compared the radiological findings among the patients and sought to determine the significant iconographic features. The biomarkers p53 and Ki-67 are regarded as significant factors in TNBC. They were therefore used to divide the TNBC into four groups for assessment of relationships with TNBC imaging features. Results: On mammography, most TNBCs exhibit obscure (44.3%) masses. On ultrasound, the majority of masses (95.4%) were predominantly indistinct (50.7%), irregular (76.0%) or featuring posterior echo enhancement/shadowing. Color Doppler flow imaging (CDFI) emphasized hypervascular (32.9%) masses. Differences in CDFI by ultrasound among the four groups were statistically significant (p=0.009). There were obvious differences in the percentages of spiculated margin (p=0.049) and intensive posterior echo (p=0.006) with spotty flow imaging by ultrasound between the Ki-67 (+) p53 (+) and other groups. Conclusions: A combination of mammography and ultrasound revealed the imaging characteristics of TNBC included an obscure mass with less attenuated posterior echoes and some vascularity. A worse prognosis was associated with spiculated margin and intensive posterior echoes with spotty flow imaging.

Effect of soil flexibility on bridges subjected to spatially varying excitations

Li, Bo,Chouw, Nawawi Techno-Press 2014 Coupled systems mechanics Vol.3 No.2

Pounding is a major cause of bridge damage during earthquakes. In an extreme situation, it can even contribute to the unseating of bridge girders. Long-span bridges will inevitably experience spatially varying ground motions. Soil-structure interaction (SSI) may play a significant role in the structural response of these structures. The objective of this research is to experimentally investigate the effect of spatially varying ground motions on the response of a three-segment bridge considering SSI and pounding. To incorporate SSI, the model was placed on sand contained in sandboxes. The sandboxes were fabricated using soft rubber in order to minimise the rigid wall effect. The spatially varying ground motion inputs were simulated based on the New Zealand design spectra for soft soil, shallow soil and strong rock conditions, using an empirical coherency loss function. The results show that with pounding, SSI can amplify the pier bending moments and the relative opening displacements.

Ultrathin SWNT Films with Tunable, Anisotropic Transport Properties

Li, Bo,Jung, Hyun Young,Wang, Hailong,Kim, Young Lae,Kim, Taehoon,Hahm, Myung Gwan,Busnaina, Ahmed,Upmanyu, Moneesh,Jung, Yung Joon WILEY‐VCH Verlag 2011 Advanced functional materials Vol.21 No.10

<P><B>Abstract</B></P><P>Directional transport properties at the nanoscale remain a challenge, primarily due to issues pertaining to control over the underlying anisotropy and scalability to macroscopic scales. Here, we develop a facile approach based on template‐guided fluidic assembly of high mobility building blocks – single walled carbon nanotubes (SWNTs) – to fabricate ultrathin and anisotropic SWNTs films. A major advancement is the complete control over the anisotropy in the assembled nanostructure, realized by three‐dimensional engineering of the dip‐coated SWNTs ultrathin film into alternating hydrophilic and hydrophobic microline patterns with prescribed intra/inter‐line widths and line thicknesses. Variations in the contact line profile results in an evaporation‐controlled assembly mechanism that leads to alternating, and more importantly, contiguous SWNTs networks. Evidently, the nanoscopic thickness modulations are direct reflections of the substrate geometry and chemistry. The nanostructured film exhibits significant anisotropy in electrical and thermal transport properties as well as an optically transparent nature, as revealed by characterization studies. The direct interplay between the anisotropy and the 3D microline patterns of the substrate combined with the wafer‐level scalability of the fluidic assembly allows us to tune the transport properties for a host of nanoelectronic applications.</P>

Qianhu (Peucedanum praeruptorum Dunn) Improves exercise capacity in mice by regulating Nrf2/HO-1 oxidative stress signaling pathway

Li Bo,Wang Yeni,Yang Xiaoguang 한국응용생명화학회 2023 Applied Biological Chemistry (Appl Biol Chem) Vol.66 No.-

This study assessed the effect of Qianhu (Peucedanum praeruptorum Dunn) on the recovery of movement in mice with D-galactose-induced dyskinesia. The evaluation of the ability of mice to exercise revealed that Qianhu increased the running and swimming time to exhaustion in mice with dyskinesia. In addition, measurement of biochemical indices in mice showed that Qianhu altered the serum levels of blood urea nitrogen (BUN), blood lactic acid (BLA), malonaldehyde (MDA), liver glycogen (HG), muscle glycogen (MG), while the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) remained normal. Additionally, Qianhu regulated the mRNA expression of copper/zinc-superoxide dismutase (Cu/Zn-SOD), manganese-superoxide dismutase (Mn-SOD), catalase (CAT), heme oxygenase 1(HO-1), nuclear factor erythroid2-related factor (Nrf2) and syncytin-1 in mice and also protected mice against D-galactose-induced oxidative stress. The analysis of the chemical composition of Qianhu revealed that it mainly contains isochlorogenic acid B, myricetin, baicalin, luteolin, and kaempferol, which are known excellent antioxidants that protect against tissue damage due to oxidative stress and have anti-aging properties. Thus, these compounds may be the active components in Qianhu that improve the ability of mice to exercise, and may also represent the key compounds for its use as natural medicine or health food.