Presence and predominance of histological grade 3 define cT1HG bladder cancer prognostic groups

Leonardo Oliveira Reis,Luciana S. B. Dal Col,Diego M. Capibaribe,Gustavo B. de Mendonça,Fernandes Denardi,Athanase Billis 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.1

Purpose: Current World Health Organization/International Society of Urological Pathology (2004 WHO/ISUP) grading of bladder urothelial carcinoma relies on the highest pathologic grade of the specimen and does not reflect the inherent qualitative and quantitative heterogeneity of disease. Materials and Methods: We retrospectively studied consecutive urothelial high-grade cT1 (cT1HG) carcinomas submitted to adjuvant bacille Calmette–Guérin between 2008 and 2015 to evaluate the prognostic potential of grade 3 (presence or predominance) according to the 1973 WHO system concerning disease progression and cancer-specific death. Results: Among 253 patients, grading distribution was 34.4% 1+2, 7.5% 2+1, 20.2% 2+2, 19.0% 2+3, 5.1% 3+2, and 13.8% 3+3. Recurrence was diagnosed in 115 (45.5%), progression in 83 (32.8%), and cancer-specific death in 50 patients (19.8%). Mean time to recurrence, progression, and death from disease were 35.9±31.7, 47.6±44.5, and 51.2±50.4 months, respectively. Grade 3 presence (2+3, 3+2, or 3+3) occurred in 96 (37.9%) and independently predicted time to progression (p<0.001; hazard ratio [HR], 3.11; 95% confidence interval [CI], 1.88–5.14). Grade 3 predominance (3+2 or 3+3) occurred in 48 (18.9%) and independently predicted time to disease-specific death. Conclusions: Grade 3 presence and predominance are independent predictors of progression and disease-specific death and occur in about 40% and 20% of cT1HG, respectively. Describing qualitative and quantitative heterogeneity in urothelial carcinoma grading might improve the stratification of patients. This gives three prognostic high-grade groups based on WHO/ISUP 1973: prognostic grade group I (grade 3 absence), prognostic grade group II (grade 3 presence), and prognostic grade group III (grade 3 predominance).

The influence of nanofillers on the properties of ethanol-solvated and non-solvated dental adhesives

Leonardo Bairrada Tavares da Cruz,Marcelo Tavares Oliveira,Adriano Fonseca Lima 대한치과보존학회 2019 Restorative Dentistry & Endodontics Vol.44 No.3

Objectives: The aim of this study was to evaluate the influence of different concentrations of nanofillers on the chemical and physical properties of ethanol-solvated and non-solvated dental adhesives. Materials and Methods: Eight experimental adhesives were prepared with different nanofiller concentrations (0, 1, 2, and 4 wt%) and 2 solvent concentrations (0% and 10% ethanol). Several properties of the experimental adhesives were evaluated, such as water sorption and solubility (n = 5, 20 seconds light activation), real-time degree of conversion (DC; n = 3, 20 and 40 seconds light activation), and stability of cohesive strength at 6 months (CS; n = 20, 20 seconds light activation) using the microtensile test. A light-emitting diode (Bluephase 20i, Ivoclar Vivadent) with an average light emittance of 1,200 mW/cm2 was used. Results: The presence of solvent reduced the DC after 20 seconds of curing, but increased the final DC, water sorption, and solubility of the adhesives. Storage in water reduced the strength of the adhesives. The addition of 1 wt% and 2 wt% nanofillers increased the polymerization rate of the adhesives. Conclusions: The presence of nanofillers and ethanol improved the final DC, although the DC of the solvated adhesives at 20 seconds was lower than that of the non-solvated adhesives. The presence of ethanol reduced the strength of the adhesives and increased their water sorption and solubility. However, nanofillers did not affect the water sorption and strength of the tested adhesives.

Comparison of Climacteric Symptoms, Quality of Life, and Self-Care Attitudes before and during the COVID-19 Pandemic

( Camila Oliveira Serra ),( Paula Mara Gomes Leite ),( Andráa Beatriz Bezerra ),( Laura Freitas ),( Lucas Veras ),( Marcela Deda Costa ),( Leila Luiza Conceição Gonçalves ),( Leonardo Yung Dos Santos 대한폐경학회 2022 대한폐경학회지 Vol.28 No.1

Objectives: This study aimed to compare the climacteric symptoms, quality of life indices, and self-care attitudes in women before and during the coronavirus disease 2019 (COVID-19) pandemic. Methods: This cross-sectional study was conducted between January 2020 and September 2021. The sample consisted of 342 climacteric women who were divided into two groups: before the pandemic (BP group; n = 62) and during the pandemic (DP group; n = 280). The Menopause Rating Scale and Women’s Health Questionnaire were used to measure the health-related quality of life and degree of climacteric symptoms reported by women. Results: During the COVID-19 pandemic, women were able to decrease their somatic symptoms derived from the climacteric period (BP group: 7.84 ± 4.46, DP group: 5.94 ± 9.20; P = 0.003). Conclusions: There was no worsening in the self-reported symptoms, quality of life, and self-care attitudes of climacteric women because of the COVID-19 pandemic. Moreover, only somatic symptoms decreased during the pandemic.

Influence of tooth position within the field of view on the intensity of cone-beam computed tomographic imaging artifacts when assessing teeth restored with various intracanal materials

de Oliveira Pinto, Martina Gerlane,Melo, Saulo Leonardo Sousa,Cavalcanti, Yuri Wanderley,de Lima, Elisa Diniz,Bento, Patricia Meira,de Melo, Daniela Pita Korean Academy of Oral and Maxillofacial Radiology 2020 Imaging Science in Dentistry Vol.50 No.2

Purpose: This study aimed to quantify the influence of tooth position within the field-of-view (FOV) on cone-beam computed tomography (CBCT) imaging artifacts' intensity when assessing teeth restored with various intracanal materials. Materials and Methods: Seventy single-rooted teeth were divided into 7 groups (10 teeth per group): NiCr post (NC), AgPd post (AP), metal core fiberglass post (MCFG), fiberglass post (FG), anatomical fiberglass post (AFG), fiberglass post cemented with core build-up cement (FGCo), and anatomical fiberglass post cemented with core build-up cement (AFGCo). All posts were cemented using a regular dual-curing resin cement (Allcem), except FGCo and AFGCo which were cemented with a core build-up dual-curing resin cement (AllcemCore). Each tooth was scanned on a CS9000 in 5 positions within the FOV: a central position, anterior horizontal peripheral, peripheral superior, peripheral inferior, and posterior horizontal peripheral position. Hyperdense, hypodense, remaining teeth areas and ROI areas were quantitatively analyzed using ImageJ software. Results: Posterior horizontal peripheral position increased the intensity of artifacts on FGCo and AFGCo post groups (P<0.05), and specifically the hypodense artifact intensity on FG and AFG post groups (P<0.05). NC and AP groups presented greater intensity of artifacts than any other post groups(P<0.05). Conclusion: Artifact intensity increases in the presence of high atomic number materials and when the object is not centered within the FOV. The impact of positioning within the FOV on artifact was greater for fiberglass posts cemented with core build-up dual-curing cement than for metal posts and fiberglass posts cemented with regular dual-curing cement.

The influence of nanofillers on the properties of ethanol-solvated and non-solvated dental adhesives

da Cruz, Leonardo Bairrada Tavares,Oliveira, Marcelo Tavares,Saraceni, Cintia Helena Coury,Lima, Adriano Fonseca The Korean Academy of Conservative Dentistry 2019 Restorative Dentistry & Endodontics Vol.44 No.3

Objectives: The aim of this study was to evaluate the influence of different concentrations of nanofillers on the chemical and physical properties of ethanol-solvated and non-solvated dental adhesives. Materials and Methods: Eight experimental adhesives were prepared with different nanofiller concentrations (0, 1, 2, and 4 wt%) and 2 solvent concentrations (0% and 10% ethanol). Several properties of the experimental adhesives were evaluated, such as water sorption and solubility (n = 5, 20 seconds light activation), real-time degree of conversion (DC; n = 3, 20 and 40 seconds light activation), and stability of cohesive strength at 6 months (CS; n = 20, 20 seconds light activation) using the microtensile test. A light-emitting diode (Bluephase 20i, Ivoclar Vivadent) with an average light emittance of $1,200mW/cm^2$ was used. Results: The presence of solvent reduced the DC after 20 seconds of curing, but increased the final DC, water sorption, and solubility of the adhesives. Storage in water reduced the strength of the adhesives. The addition of 1 wt% and 2 wt% nanofillers increased the polymerization rate of the adhesives. Conclusions: The presence of nanofillers and ethanol improved the final DC, although the DC of the solvated adhesives at 20 seconds was lower than that of the non-solvated adhesives. The presence of ethanol reduced the strength of the adhesives and increased their water sorption and solubility. However, nanofillers did not affect the water sorption and strength of the tested adhesives.

Experimental Evaluation of the Load Carrying Capacity of SFRC Flat Slabs Varying the Rectangularity Index of Columns

Vinicius Alves,Leonardo Oliveira,Antonio Santos,Leandro Trautwein 대한토목학회 2021 KSCE Journal of Civil Engineering Vol.25 No.2

This work aims to evaluate the punching shear carrying capacity of flat slabs of reinforced concrete added with different amounts of steel fibers and varying the rectangularity index of columns under symmetrical loading. The addition of steel fiber provide higher load-carrying capacity. However, the column rectangularity index tends to lower that load-carrying capacity for magnitudes beyond 1.5 for the tested slabs. Nine models were tested with dimensions of 1,800 × 1,800 mm and 130 mm height varying the amount of added fiber (0, 50 and 60 kg/m) and the index of rectangularity (1.0, 1.5 e 2.0). From the results, the load carrying capacity, the vertical displacement, and the crack patterns were obtained. In addition, the results were compared with other similar studies and analytical models for steel fiber. The addition of steel fibers showed to be effective in increasing the punching shear load carrying capacity, it leads to a higher number of cracks and higher vertical displacements. Regarding the rectangularity index, for those tested slabs which was below 1.5, the load carrying capacity of punching shear of the slabs increases. However, for slabs above 1.5, it was observed that the punching shear load carrying capacity decreases.

Recursive Approach of Sub-Optimal Excitation Signal Generation and Optimal Parameter Estimation

Marina B. A. Souza,Leonardo de Melo Honório,Edimar José de Oliveira,António Paulo G. M. Moreira 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.8

Optimal Input Design (OID) methodologies are developed to find a signal that could best estimate a set of parameters of a given model. Their application in constrained nonlinear systems, especially when the search space limits or the initial conditions are unknown, may present several difficulties due to the numerical instability related to the optimization processes. A good choice over the parameters possible ranges is a trade-off among numerical stability, search space size, and effectiveness, and it is hardly found. To deal with this problem, this paper proposes a series of changes in the Sub-Optimal Excitation Signal Generation and Optimal Parameter Estimation (SOESGOPE) methodology. First, the limits over the parameters are tightly adjusted according to their confidence. A recursive approach runs the optimization methodology, analyzes the solution’s feasibility and marginal costs given by the Lagrange Multipliers, and selects a direction that could improve the system’s response. This approach improves the convergence and the assertiveness of the estimation process. To validate this approach, some cases, including a parameters estimation of a mobile robot nonlinear system, are tested.

Innovative Analysis for Parameter Estimation Quality

Marina B. A. Souza,Leonardo de Mello Honório,Edimar José de Oliveira 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.1

This paper performs an analysis of the solution space influence of a nonlinear dynamic system on theparameter estimation quality. For parameters estimation, the proposed approach uses an Optimal Input Design(OID) as the Suboptimal Excitation Signal Generation and Optimal Parameter Estimation (SOESGOPE). Basedon the studies of a small mobile robot that is represented by a parametric mathematical model indicate that themodel reliability level maximizes using the shortest set of parameters. Applications, qualities, and limitations of themethod are analyzed considering the solution space. Through an in-depth analysis of the identification process ofa differential mobile robot, the paper becomes a reference for a review of a nonlinear dynamic system, aiming toselect the most suitable model for the identification process.

Influence of tooth position within the field of view on the intensity of cone-beam computed tomographic imaging artifacts when assessing teeth restored with various intracanal materials

Martina Gerlane de Oliveira Pinto,Saulo Leonardo Sousa Melo,Yuri Wanderley Cavalcanti,Elisa Diniz de Lima,Patrícia Meira Bento,Daniela Pita de Melo 대한영상치의학회 2020 Imaging Science in Dentistry Vol.50 No.2

Purpose: This study aimed to quantify the influence of tooth position within the field-of-view (FOV) on cone-beam computed tomography (CBCT) imaging artifacts’ intensity when assessing teeth restored with various intracanal materials. Materials and Methods: Seventy single-rooted teeth were divided into 7 groups (10 teeth per group): NiCr post (NC), AgPd post (AP), metal core fiberglass post (MCFG), fiberglass post (FG), anatomical fiberglass post (AFG), fiberglass post cemented with core build-up cement (FGCo), and anatomical fiberglass post cemented with core build-up cement (AFGCo). All posts were cemented using a regular dual-curing resin cement (Allcem), except FGCo and AFGCo which were cemented with a core build-up dual-curing resin cement (AllcemCore). Each tooth was scanned on a CS9000 in 5 positions within the FOV: a central position, anterior horizontal peripheral, peripheral superior, peripheral inferior, and posterior horizontal peripheral position. Hyperdense, hypodense, remaining teeth areas and ROI areas were quantitatively analyzed using ImageJ software. Results: Posterior horizontal peripheral position increased the intensity of artifacts on FGCo and AFGCo post groups (P<0.05), and specifically the hypodense artifact intensity on FG and AFG post groups (P<0.05). NC and AP groups presented greater intensity of artifacts than any other post groups (P<0.05). Conclusion: Artifact intensity increases in the presence of high atomic number materials and when the object is not centered within the FOV. The impact of positioning within the FOV on artifact was greater for fiberglass posts cemented with core build-up dual-curing cement than for metal posts and fiberglass posts cemented with regular dual-curing cement.

Improvement of 2,2′-Azobis(2-Methylpropionamidine) Dihydrochloride-Induced Hepatic Redox Imbalance in Swiss Mice and HepG2 Cells by Rutin

Paula Alexandre de Freitas,Keciany Alves de Oliveira,Laryssa Alves Magalha˜es,Regina de Jesus das Neves,Carla Soraya Costa Maia,Leonardo Reis Silveira,Tanes Tamamura de Lima,Renata Prado Vasconcelos,L 한국식품영양과학회 2022 Journal of medicinal food Vol.25 No.6

Redox imbalance can lead to irreversible damages to biological functions. In this context, rutin stands out for its antioxidant potential. The objective of this study was to evaluate the acute and chronic effect of rutin on the hepatic redox imbalance. The study was performed according to three different protocols. First, healthy male Swiss mice were divided into two groups: control and rutin, the second of which received chronic oral supplementation of rutin (10 mg/kg). The second involved evaluation of the generation of reactive oxygen species (ROS) by HepG2 cells, incubated or not with rutin (20 and 40 μg/mL) for 3 h. The final protocol involved assessment of the acute effect of rutin (10 mg/kg) in mice with oxidative stress induced by 2,2′-azobis(2-methylpropionamidine) dihydrochloride (ABAP). After the in vivo treatments, the livers were collected to analyze the oxidative damage by thiol, and the antioxidant defense by catalase, superoxide dismutase, and glutathione peroxidase. In the HepG2 cells, the following probes were employed to assess the ROS production: dichlorofluorescein, MitoSOX, dihydroethidium, and Amplex Red. Rutin administered chronically improved the antioxidant defense in healthy animals, and when administered acutely both inhibited the increased production of ROS in HepG2 cells and improved the redox imbalance parameters in mice with induced oxidative stress. This study suggests rutin as a protective agent for restoration of hepatic redox homeostasis in redox injury induced by ABAP in Swiss mice and HelpG2 cells.