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- 저자 : Lei-Ching Huang (검색결과 3 건)
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Magnetic field effects on the electric modulus properties of nematic mixture E7
Lei-Ching Huang,Chao-Ming Fu,An-Cheng Sun,Chia-Wei Lee 한국물리학회 2014 Current Applied Physics Vol.14 No.1
The molecular dynamics of the homogeneously aligned nematic liquid crystal mixture E7 subject to a magnetic field has been studied. The dielectric spectra study has revealed a low bias magnetic field effect on the evolution of dielectric relaxation spectra occurred at lower (wkHz) (d-relaxation) and higher (wMHz) (a-relaxation) frequency regions. The complex electric modulus, which converted from experimental dielectric spectra, has been analyzed with theoretical model of Debye relaxation. The obtained fitting parameters of relaxation time and strength of dielectric components are shown to vary systematically with the strength of applied magnetic field. A microscopic molecular dynamic model has been proposed to describe the two-step variation of E7 molecular under the bias magnetic field. The results provide implication for magneto-modulation of liquid crystal molecular dynamics under the bias magnetic field.
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Ching-Ying Wang,Chen-Sheng Lin,Chun-Hung Hua,Yu-Jen Jou,Chi-Ren Liao,Yuan-Shiun Chang,Lei Wan,Su-Hua Huang,Mann-Jen Hour,Cheng-Wen Lin 한국응용약물학회 2019 Biomolecules & Therapeutics(구 응용약물학회지) Vol.27 No.1
Cis-3-O-p-hydroxycinnamoyl ursolic acid (HCUA), a triterpenoid compound, was purified from Elaeagnus oldhamii Maxim. This traditional medicinal plant has been used for treating rheumatoid arthritis and lung disorders as well as for its anti-inflammation and anticancer activities. This study aimed to investigate the anti-proliferative and apoptotic-inducing activities of HCUA in oral cancer cells. HCUA exhibited anti-proliferative activity in oral cancer cell lines (Ca9-22 and SAS cells), but not in normal oral fibroblasts. The inhibitory concentration of HCUA that resulted in 50% viability was 24.0 μM and 17.8 μM for Ca9-22 and SAS cells, respectively. Moreover, HCUA increased the number of cells in the sub-G1 arrest phase and apoptosis in a concentrationdependent manner in both oral cancer cell lines, but not in normal oral fibroblasts. Importantly, HCUA induced p53-mediated transcriptional regulation of pro-apoptotic proteins (Bax, Bak, Bim, Noxa, and PUMA), which are associated with mitochondrial apoptosis in oral cancer cells via the loss of mitochondrial membrane potential. HCUA triggered the production of intracellular reactive oxygen species (ROS) that was ascertained to be involved in HCUA-induced apoptosis by the ROS inhibitors YCG063 and N-acetyl-L-cysteine. As a result, HCUA had potential antitumor activity to oral cancer cells through eliciting ROS-dependent and p53-mediated mitochondrial apoptosis. Overall, HCUA could be applicable for the development of anticancer agents against human oral cancer.
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Strategy for Fabricating Wafer-Scale Platinum Disulfide
Xu, Hongjun,Huang, Hsin-Pan,Fei, HaiFeng,Feng, Jiafeng,Fuh, Huei-Ru,Cho, Jiung,Choi, Miri,Chen, Yanhui,Zhang, Lei,Chen, Dengyun,Zhang, Duan,Coileá,in, Cormac Ó,Han, Xiufeng,Chang, Ching-Ra American Chemical Society 2019 ACS APPLIED MATERIALS & INTERFACES Vol.11 No.8
<P>PtS<SUB>2</SUB> is a newly developed group 10 2D layered material with high carrier mobility, wide band gap tunability, strongly bound excitons, symmetrical metallic and magnetic edge states, and ambient stability, making it attractive in nanoelectronic, optoelectronic, and spintronic fields. To the aim of application, a large-scale synthesis is necessary. For transition-metal dichalcogenide (TMD) compounds, a thermally assisted conversion method has been widely used to fabricate wafer-scale thin films. However, PtS<SUB>2</SUB> cannot be easily synthesized using the method, as the tetragonal PtS phase is more stable. Here, we use a specified quartz part to locally increase the vapor pressure of sulfur in a chemical vapor deposition furnace and successfully extend this method for the synthesis of PtS<SUB>2</SUB> thin films in a scalable and controllable manner. Moreover, the PtS and PtS<SUB>2</SUB> phases can be interchangeably converted through a proposed strategy. Field-effect transistor characterization and photocurrent measurements suggest that PtS<SUB>2</SUB> is an ambipolar semiconductor with a narrow band gap. Moreover, PtS<SUB>2</SUB> also shows excellent gas-sensing performance with a detection limit of ∼0.4 ppb for NO<SUB>2</SUB>. Our work presents a relatively simple way of synthesizing PtS<SUB>2</SUB> thin films and demonstrates their promise for high-performance ultrasensitive gas sensing, broadband optoelectronics, and nanoelectronics in a scalable manner. Furthermore, the proposed strategy is applicable for making other PtX<SUB>2</SUB> compounds and TMDs which are compatible with modern silicon technologies.</P> [FIG OMISSION]</BR>
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