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( Lei Shen ),( Soon Lee ),( Jong Cheon Joo ),( Eunmi Hong ),( Zhen Yang Cui ),( Eunbi Jo ),( Soo Jung Park ),( Hyun-jin Jang ) 한국미생물생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.4
Forkhead transcription factor 3a (Foxo3a) is believed to be a tumor suppressor as its inactivation leads to cell transformation and tumor development. However, further investigation is required regarding the involvement of the activating transcription factor 3 (ATF3)-mediated Tat-interactive protein 60 (Tip60)/Foxo3a pathway in cancer cell apoptosis. This study demonstrated that Chelidonium majus upregulated the expression of ATF3 and Tip60 and promoted Foxo3a nuclear translocation, ultimately increasing the level of Bcl-2-associated X protein (Bax) protein. ATF3 overexpression stimulated Tip60 expression, while ATF3 inhibition by siRNA repressed Tip60 expression. Furthermore, siRNA-mediated Tip60 inhibition significantly promoted Foxo3a phosphorylation, leading to blockade of Foxo3a translocation into the nucleus. Thus, we were able to deduce that ATF3 mediates the regulation of Foxo3a by Tip60. Moreover, siRNA-mediated Foxo3a inhibition suppressed the expression of Bax and subsequent apoptosis. Taken together, our data demonstrate that Chelidonium majus induces SKOV-3 cell death by increasing ATF3 levels and its downstream proteins Tip60 and Foxo3a. This suggests a potential therapeutic role of Chelidonium majus against ovarian cancer.
Shen, Lei,Lee, Jong Ha,Joo, Jong Cheon,Park, Soo Jung,Song, Yung Sun KOREAN PHARMACOPUNCTURE INSTITUTE 2020 Journal of pharmacopuncture Vol.23 No.2
Objectives: Our review aimed to summarize and evaluate evidence on the effectiveness of bee venom acupuncture (BVA) in the treatment of shoulder pain. Methods: Randomized controlled trials (RCTs) evaluating the effectiveness of BVA on shoulder pain were searched up to October 2019 in 11 electronic databases (Medline, Embase, CENTRAL, CiNii, CNKI, VIP, Wanfang, Kmbase, NDSL, RISS, OASIS). The methodological quality of the included RCTs were evaluated using Cochrane Risk of Bias tool and a meta-analysis was performed. Results: Seven studies were included in the review, and four studies were included in the meta-analysis. Comparing BVA plus conventional therapy (CT) with saline injection plus CT, it showed an effect in favor of BVA plus CT in visual analog scale (VAS) and pain rating scale (PRS) (p = 0.02, p = 0.009, respectively). Comparing BVA plus physiotherapy (PT) with saline injection plus PT, it showed that there was no significant difference in VAS and verbal rating scale (VRS) between the two groups. Conclusion: This systematic review and meta-analysis suggest that BVA could be beneficial as an adjuvant treatment for shoulder pain.
Lei Shen,Jong Ha Lee,Jong Cheon Joo,Soo Jung Park,Yung Sun Song 대한약침학회 2020 Journal of pharmacopuncture Vol.23 No.2
Objectives: Our review aimed to summarize and evaluate evidence on the effectiveness of bee venom acupuncture (BVA) in the treatment of shoulder pain. Methods: Randomized controlled trials (RCTs) evaluating the effectiveness of BVA on shoulder pain were searched up to October 2019 in 11 electronic databases (Medline, Embase, CENTRAL, CiNii, CNKI, VIP, Wanfang, Kmbase, NDSL, RISS, OASIS). The methodological quality of the included RCTs were evaluated using Cochrane Risk of Bias tool and a meta-analysis was performed. Results: Seven studies were included in the review, and four studies were included in the meta-analysis. Comparing BVA plus conventional therapy (CT) with saline injection plus CT, it showed an effect in favor of BVA plus CT in visual analog scale (VAS) and pain rating scale (PRS) (p = 0.02, p = 0.009, respectively). Comparing BVA plus physiotherapy (PT) with saline injection plus PT, it showed that there was no significant difference in VAS and verbal rating scale (VRS) between the two groups. Conclusion: This systematic review and meta-analysis suggest that BVA could be beneficial as an adjuvant treatment for shoulder pain.
Shen, Lei,Gwak, Si Ra,Joo, Jong Cheon,Park, Soo Jung Korean Association of Traditional Oncology 2020 大韓癌韓醫學會誌 Vol.25 No.1
Objectives : Lung cancer is one of the most common cancer and the leading cause of cancer deaths worldwide. This study aimed to evaluate the role of acupuncture as an adjunctive therapy for lung cancer. Methods : We conducted a systematic review and meta-analysis on the role of acupuncture therapy in lung cancer treatment by electronic and manual searching in ninedatabases, including PubMed, Cochrane library, Embase, Korean databases, and Chinese medical databases. Results : A total of 21 trials were included in the meta-analysis. The study results showed that acupuncture therapy had significant efficacy in immuneregulation, including CD3 andCD4. Further analysis revealed that acupuncture therapy significant improvements in quality of life, including Karnofsky performance status(KPS)score, functional assessment of cancer therapy-lung cancer subscale (FACT-L) and European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). In addition, the pooled studies also showed that acupuncture therapy reduced cancer pain and chemotherapy-induced nausea and vomiting. Conclusions : Our study provides moderate evidence of the efficacy of the acupuncture therapy in the treatment of lung cancer.
Application on Web Page Filtering Technology
Bo Shen,Lei Li,Ning-wei Wang 보안공학연구지원센터 2014 International Journal of Multimedia and Ubiquitous Vol.9 No.12
Web page filtering technology intends to filter out the large number of the repeated and theme-unrelated noise information and obtain useful information. Some web filtering methods cannot make full use of the layout and visual features. In view of the new mainstream “DIV+CSS” designing style of modern commercial web sites, this paper summarizes that elements laying in the same div blocks have common semantic features and proposed a DIV_FOREST model to represent the web pages. And in combination with the Vision-based Page Segmentation Algorithm, a DVPS Algorithm which considers both layout features and visual features was proposed to improve web page filtering efficiency.
Liu-Lei Shen,Zhi-Bin Shen,Hai-Yang Li,Ze-Yuan Zhang 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.11
The mechanical properties of Composite solid propellant (CSP) are the critical material parameters to analyze the structural integrity of propellant grains, and have a significant influence on the life and reliability of solid rocket motors. A Voronoi cell finite element method using an adaptive algorithm in the time domain is proposed for investigating the linear viscoelasticity of CSP in the present paper. A process is brought forward to produce a Representative volume element (RVE) model, which reflects the microstructural features of CSP. Numerical viscoelastic examples are used for varying the accuracy of this method. In addition, finite element simulations are conducted to understand the effect of microstructural morphology and material properties of inclusion on the effective mechanical properties of CSP using the new method. When this method is applied to the design process of CSP, it can reduce the design cost and shorten the design cycle effectively. The current microscopic numerical analysis method can be used to provide guidance for designing and analyzing the mechanical properties of composite viscoelastic materials.
( Lei Jiang ),( Jing Feng ),( Ye Shen ),( Xinli Xiong ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.7
An emerging satellite technology, Operationally Responsive Space (ORS) is expected to provide a fast and flexible solution for emergency response, such as target tracking, dense earth observation, communicate relaying and so on. To realize large distance transmission, we propose the use of available relay satellites as relay nodes. Accordingly, we apply software defined network (SDN) technology to ORS networks. We additionally propose a satellite network architecture refered to as the SDN-based ORS-Satellite (Sat) networking scheme (SDOS). To overcome the issures of node failures and dynamic topology changes of satellite networks, we combine centralized and distributed routing mechanisms and propose a fast recovery routing algorithm (FRA) for SDOS. In this routing method, we use centralized routing as the base mode.The distributed opportunistic routing starts when node failures or congestion occur. The performance of the proposed routing method was validated through extensive computer simulations.The results demonstrate that the method is effective in terms of resoving low end-to-end delay, jitter and packet drops.
Lei, Y.,Wang, H.F.,Shen, W.A. Techno-Press 2012 Smart Structures and Systems, An International Jou Vol.10 No.4
In this paper, the structural health monitoring (SHM) benchmark problem of the Canton tower is studied. Based on the field monitoring data from the 20 accelerometers deployed on the tower, some modal frequencies and mode shapes at measured degrees of freedom of the tower are identified. Then, these identified incomplete modal data are used to update the reduced finite element (FE) model of the tower by a novel algorithm. The proposed algorithm avoids the problem of subjective selection of updated parameters and directly updates model stiffness matrix without model reduction or modal expansion approach. Only the eigenvalues and eigenvectors of the normal finite element models corresponding to the measured modes are needed in the computation procedures. The updated model not only possesses the measured modal frequencies and mode shapes but also preserves the modal frequencies and modes shapes in their normal values for the unobserved modes. Updating results including the natural frequencies and mode shapes are compared with the experimental ones to evaluate the proposed algorithm. Also, dynamic responses estimated from the updated FE model using remote senor locations are compared with the measurement ones to validate the convergence of the updated model.