정신분열병에 대한 Risperidone의 효과 및 안전성에 관하여

신석철,왕성근,지익성,이선우,이규광,이봉희,이진영,황선희,신용재,배경도,김정란 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

In order to evaluate the efficacy and safety of risperidone, 10 patients with chronic schizophrenia were examined for 8 weeks in a silgle-open study. After the wash-out period of 1 week, risperidone was administered. Efficacy was evaluated by means of Positive and Negative syndrome Scale for Schizophernia(PANSS) and Clinical Global Impression(CGI). Safety assessment included the Extrapyramidal Symptom Rating Scale(ESRS), vital signs, body weight, ECG, and laboratory tests. The results were as follows 1) On the PANSS total score, there was significant improvement of total score after 1 week (P<.05) of administratiom. 2) On the PANSS positive and negative subscal, there were significant improvement of posotive and negative scores after 2 weeks (P<.05) of administration. 3) On the PANSS general psychopatholgy subscals, there were significant improvement of general psychopathologyscores after 1 week (P<.05) of administratiom. 4) On the CGI, there was significant decreasement of clinical impression of severity of schizophrenia score after 2 week (P<.05) of administration. 5) A statistically significant increase in body weight (P<.05) was observed after 8 weeks of administration. 6) EPS reached the peak at the end of the 1st week of administration of risperidone (11.8± 24.25) but they were easily relieved by addition of benztropine and clonazepam. There was not significant change in laboratory tests, vital sign, ECG after 8 weeks of administration. These results suggest that Risperidone is an effective antipsychotics and clinically safe except for increased body weight in chronic schizophrenia.

수면무호흡증 환자의 수면양상

왕성근,이선우,윤미숙 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

To confirm the clinical characteristics of sleep apnea syndrome in korean, author analyzed 28 cases of polysomnographic findings statistically, diagnosed as sleep apnea syndrome during January, 1996 to August, 1997. The results were summarized as follows. 1. The mean age of subjects was 41.3 years, the distribution of age was 19 to 64 years, and male to female sex ratio was about 5:1. 2. As for mean values of sleep parameters, total bed time was 423.6 minutes, waking after sleep onset was 95.1 minutes, total sleep time was 328.5 minutes and sleep efficiency was 77.5. 3. The proportions of sleep stage 1, stage 2, slow wave sleep, REM sleep, and movement time to total sleep time were 20.9%, 54.2% 6.1%, 15.6%, and 3.2% respectively.

정상인에서 부분적 수면박탈이 수면구조에 미치는 영향

왕성근,이정규,이충숙,최하석,유남재,정인형,이선우 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

To identify the effects of partial sleep deprivation on the sleep structure, the authors performed polysomnographic study for 9 healthy young adults. The subjects were college students, ranging in age from 20 to 25 years, without personal past or present histories of medical, neurological, or psychiatric illness and suffering from current sleep disturbance or parasomomnias. Sleep records were analyzed according to the criteria of Rechtschaffen and Kales' manual and tried paired t-test. The results were summarized as follows. 1. As for sleep parameters, total sleep time(TST), REM latency and REM duration were not changed significantly during deprivation period and recovery period compared with baseline. Sleep efficiency increased significantly during deprivation period and recovery period compaired with baseline, and sleep latency and WASO were shortened significantly during deprivation period and recovery period compared with baseline. 2. As for sleep structure, 1) The absolute value(minutes) of stage 1 decreased significantly during deprivation period and first recovery night compared with baseline, and the relative value(percentage) of stage 1 decreased significantly during deprivation period and recovery period compared with baseline. 2) The absolute value(minutes) of stage 2 decreased significantly during deprivation period compared with baseline, and the relative value(percentage) of stage 2 decreased significantly during deprivation period and first recovery night compared with baseline. 3) The absolute value(minutes) of slow wave sleep were not changed significantly during deprivation period and recovery period compared with baseline, and the relative value(percentage) of slow wave sleep increased significantly during recovery period compared with baseline. 4) The absolute value(minutes) of REM sleep decreased significantly during deprivation period compared with baseline, and the relative value(percentage) of REM sleep decreased significantly in the first deprivation night but, were not changed significantly during recovery period compared with baseline.

수면무호흡증의 다원수면기록 소견 : 폐색성 수면무호흡증을 중심으로

이선우,왕성근 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

To identify the clinical characteristics and sleep parameter of sleep apnea syndrome, author performed for statistical analysis of polysomnographic findings of 31 cases, were diagnosed as sleep apnea syndrome from December, 1993 to June, 1995. The results were summarized as follows. 1) Male were predominantly more (M:F=14.5:1) and subject's mean age 41.0±10.7 years. All subjects were obstructive type sleep apnea syndrome, and diastolic blood pressure have met the criteria for hypertension, and that many subjects had ECG abnormality finding. 2) Significant correlations were found among various polysomnographic variables. Respiration disturbance index (RDI) correlated significantly with sleep period during oxygen saturation below 85%, episodes of waking, duration of waking, episodes of obstructive apnea, and episodes of obstructive apnea with heart rate drop & oxygen saturation drop. Same results showed when comparison of two groups were divided by median value of RDI. Sleep period during oxygen saturation below 85% was especially important to select in more severe apnea patients. Also the more episode was apnea, the more episode was waking and time of waking. 3) Sleep apnea episodes during REM sleep were as sleep apnea episodes during NREM sleep, but apnea episodes during REM sleep were more longer time apnea episodes during NREM sleep. This result explain that sleep apnea episode of REM sleep was more adverse effect to cardiovascular system. 4) Subjects with obstructive sleep apnea syndrome had central and mixed type apneas too, and hypopneas with oxygen saturation drop were relatively more that central and mixed type apnea, therefore author thought, when diagnoses of sleep apnea syndrome, hypopnea episode should be considered for more specific diagnoses.

304L 오스테나이트 스테인레스강 분말의 소결성에 미치는 Mo의 첨가 영향

최국선,이동희,최왕규 연세대학교 산업기술연구소 1989 논문집 Vol.21 No.2

An investigation of Mo addition effect on the sinterability of 304L austenitic stainless steel powders was carried out by using the compacts of three different Mo contents(0.2 and 5 wt%) and using diffusion couple of same stainless steel and Mo powders. The compacts of pure stainless steel powder showed conventional sintering process. And also. we found the diffusion (alloying) layer, 60㎛, and porosity formation toward stainless steel compact in the vicinity of coupled zone by means of SEM and EDS analysis. The porosity of compacts to which Mo was added, was high compared with no Mo added compacts except early stage of sintering. But in compacts sintered at 1200℃ for 45 min, the abnormal increase of porosity could be understood by "bridging" effect of alloying layer formed during sintering process.

흰쥐 시상하부에서 NMDA에 의한 c-fos의 발현

이영기,최기열,이원돈,유영복,이왕재,황덕호,조사선,장가용 대한해부학회 1994 Anatomy & Cell Biology Vol.27 No.3

정신분열증에서 공존하는 신체질환에 대하여

지익성,왕성근,신석철,이선우,황선희,신용재,김정란,배경도 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

In order to determine the frequency of physical illness in schizophrenia, 107 schizophrenics were assessed with physical exam and routine laboratoy test. The results were as follows 1) Among the total number of 107 schizophrenics, 31 had the physical illness(29%), and among the schizophrenics with physical illness, female outnumbered male at the rate of 17:14. 2) There was no difference between schizophrenics with physical illness and schizophrenics without physical illness in demographic characteristics. 3) Classification of physical illness were disease of skin 7 (22.6%), musculoskeletal system 5(16. 1%), ENT(ear nose throat) 3(9.7%), endocrine system 3(9.7%), circulatory system 2(6.5%), respiratory system 2(6.5%), digestive system 1(3.2%), genitourinary system 1(3.2%), infection 1(3. 2%), eye 1(3.2%) respectively Authors suggest that physical exam and routine laboratory test should be done for all hospitalized psychiatric patients

수면무호흡증의 다원수면기록 소견

김용조,이선우,왕성근 대한생물치료정신의학회 1996 생물치료정신의학 Vol.2 No.2

To identify the clinical characteristics of sleep apnea syndrome in Korean, author analyzed 24 cases of polysomnographic findings statistically, diagnosed as sleep apnea syndrome during May, 1995 to July,1996. The results were summarized as follows: 1. The mean age of subjects was 35.7 years, the distribution of age was 12 to 64 years, and male to female sex ratio was 5:1. 2. As for mean values of sleep parameters, total bed time was 429.8 minutes, waking after sleep onset was 93.4 minutes, total sleep time was 336.1 minutes and sleep efficiency was 77.7%. 3. The proportions of sleep stage 1, stage2,slow wave sleep, REM sleep, and movement time to total sleep time were 13.1%, 39.4%, 24.4%, 20.8%, and 2.2% respectively. 4. Mean AI(apnea index) was 28.7 and RD(respiration disturbance index ) was 34.3. 5. Waking after sleep onset correlated with total sleep time and sleep efficiency negatively, and with sleep stage 1 positively. Sleep efficiency correlated with sleep stage 1 negatively, and sleep stage 1 correlated with slow wave sleep negatively.

Clozapine으로 인한 야뇨증에서 Oxybutynin Hydrochloride 사용 3례

지익성,박철범,이선우,왕성근,신석철 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

Clozapine은 치료 저항성 정신분열병의 치료에 있어서의 우수한 효과에도 불구하고, 야뇨증과 같은 환자를 곤란하게 하는 부작용을 유발한다. 야뇨증은 발견 즉시 처리되야 할 부작용 중의 하나이다. 저자들은 oxybutynin hydrochloride가 일일 용량 5∼10mg의 소량으로, 별다른 부작용 없이 빠르게 항 야뇨증 효과가 나타남을 알 수 있었고, clozapine으로 인한 야뇨증 치료의 대안으로 만족할 만한 것이었다. 중심단어:Oxybutinin hydrochloride·Clozapine·야뇨증·정신분열병증. Nocturnal enuresis has been recognized as an adverse effect of clozapine treatment. We re-ported 3 chronic schizophrenic patients who had showed nocturnal enuresis following clozapine treatment. Oxybutynin hydrochloride on clozapine-induced enuresis was very effective in 3 patients. The dose in our patients was 5 to 10mg/day. This medication was well tolerated. It is suggested that oxybutynin hydrochloride is a effective therapeutic option in clozapine-induced nocturnal enuresis. KEY WORDS:Oxbutynin hydrochloride ·Clozapine·Nocturnal enuresis·Schizophrenia.

양극성 기분장애에서 세로토닌 수용체 유전자의 다형성(102T/C)에 관하여

지익성,신석철,왕성근,이선우,신용재,김충수,김상국,최하석,오승용,류택근,이영호 대한생물치료정신의학회 1999 생물치료정신의학 Vol.5 No.2