양방향 고유압 말뚝재하시험(BDH PLT)의 개발 및 적용성에 관한 연구

이충숙,이민희,김상일,최용규 한국지반공학회 2007 한국지반공학회논문집 Vol.23 No.6

To overcome the limits of the static pile load test for large diameter drilled shafts, bi-directional low pressure pile load test (BDL PLT) has been used but this test method containes some problems that has not been solved basically. That is, BDL PLT has some problems: difficulty in jack (or cell) arrangement for large test capacity, void remain inside jack (or cell) due to the unrecovery of piston after test etc. In this study, bi-directional double-acting high pressure pile load test (BDH PLT w/DOJ) was developed and confirmed for a in-situ large diameter drilled shaft. At present, test specification of bi-directional pile load test (BDPLT) is being made, and severed main issues (such as, test kinds, test capacity, necessity of use of double-acting and attention of application to service pile) will be contained at the specification.

중금속 및 유류로 오염된 토질의 성토재료로서의 안정성에 관한 연구

이충숙,엄태규,최용규,이민희 한국지반환경공학회 2004 한국지반환경공학회논문집 Vol.5 No.2

In the site for apartment construction, the contaminated soils of the heavy metal and the oil were appeared. The representative soil samples were sampled at 7 sampling points. To confirm the geotechnical stability of the contaminated soils, the environmental checks for the heavy metal and the oil. The soils of 2 sampling points were contaminated heavily, so it was estimated that these soils must be disused. For 1 sampling point of the slightly contaminated soil, to confirm the re-applicability of fill material, the stability analysis was performed and it was concluded that this soil will be able to re-use 아파트 건설용 부지내에서 중금속 및 유류로 오염된 토사가 발견되었다. 7개 위치에서 대표적인 시료를 채취하였으며 이 오염된 토사의 지반공학적 안정성을 확인하기 위하여 중금속 및 유류에 대한 환경공학적 검토가 이루어졌다.2개 위치의 토사는 유류로 심하게 오염되어 있어 현장의 특정지역으로 반출하여 폐기해야 하는 것으로 판단하였다. 토양오염우려수준인 1개 위치의 토사에 대하여 성토재로서의 활용가능성을 확인하기 위하여 성토 안정성에 대한 해석을 수행하였으며 성토재로 사용할 수 있는 것으로 판단하였다.

한국인 정신분열병과 양극성 기분장애에서 Ciliary Neurotrophic Factor(CNTF)유전자 변이에 관하여

이충숙,신석철,지익성,왕성근,이영호 대한신경정신의학회 2000 신경정신의학 Vol.39 No.4

정신분열병과 양극성 기분장애 같은 주요 정신질환의 발병에서 유전적 요인이 중요하게 작용한다. 최 근 정신분열병과 양극성 기분장애의 원인을 신경병리학적 연구와 신경영상학적 연구를 통하여 신경발달 학인 면에서 이해하려고 시도하고 있다. Ciliary neurotrophic factor(CNTF)는 해마신경원와 내측 중 격신경원을 포함한 다양한 신경세포의 강력한 생명 유지인자로 작용하여 중추신경계의 발달과 유지와 관련이 있는 것으로 여겨지면서, 주요 정신질환의 원인적인 요인으로 제시되고 있지만 이에 대한 연구결 과는 일치되지 못한 상태이다. 이에 저자 등은 한국인 정신분열병 환자 112명과 양극성 기분장애 환자 81명 그리고 정상 대조군 125명을 대상을 CNTF 유전자 변이와 연관성을 알아보고자 본 연구를 시행하여 다음과 같은 결론을 얻었다. CNTF의 유전자형은 정신분열병 환자군에서 N/N 80(70.4%), N/M 32(28.6%), M/M 0(0.0%)이 었고, 양극성 기분장애 환자군에서 N/N 58(71.6%), N/M 23(28.4%), M/M 0(0.0%)이었으며, 정상 대조군에서는 N/N 94(75.2%), N/M 30(24.0%), M/M 1(0.8%)이었다. 대립유전자의 빈도는 정신분 열병 환자군에서 N 192(85.7%), M 32(14.3%)이었고, 양극성 기분장애 환자군에서는 N139(85.8%), M 23(14.2%)이었으며, 정상 대조군에서는 N 218(87.2%), M 32(12.8%)이었다. 3군간의 유전자형과 대립유전자에서 유의한 차이가 없었다. 이러한 연구결과 한국인 정신분열병과 양극성 기분장애에서 CNTF 유전자의 변이가 원인적 요인으 로 작용할 것이라고 볼 수 없었다. Genetic factors play an important role in the development of schizophrenia and bipolar disorder, and recently the neural maldevelopment hypothesis is suggested by neuropathological and neuroimaging studies. Neurotrophic factors, including ciliary neurotrophic factor(CNTF), play a central role in the regulation of neural development. This study was designed to investigate the association between the null mutation of CNTF gene and schizophrenia and bipolar disorder in a Korean population. The CNTF gene were typed with polymerase chain reaction in 112 patients with schizo-phrenia, 81 with bipolar disorders and in 125 healthy controls. The distributions of the CNTF genotype in schizophrenic patients with N/N, N/M, M/M were 80(71.4%), 32(28.6%), 0(0%), in bipolar disorders were 58(71.6%), 23(28.4%), 0(0%) and in the controls were 94(75.2%), 30(24.0%), 1(0.8%). The allele frequencies of the CNTF gene in schizophrenic patients with N and M were 192(85.7%), 32(14.3%), in bipolar disorders were 139(85.8%), 23(14.2%), and in the control were 218(87.2%), 32(12.8%). There were no differences in the genotype distributions and the allele frequencies of CNTF gene null mutation among the 3 groups. These results suggest CNTF gene null mutation is not causally related to the development of schizophrenia and bipolar disorder in Korea.

한국에 있어서 Mini-Mental State Examination(MMSE)의 표준화 연구

이충숙,신석철 大韓神經精神醫學會 1993 신경정신의학 Vol.32 No.6

The authors translated MMSE written by Folstein et al. into korean and performed standardization for the purpose of the application in Korea. The subjects were 53 organic mental disorder patients, 45 schizophrenia patients, 43 depression patients and 27 mania patients. For interrater reliability, two psychiatrists applied Korean version of MMSE to 53 organic mental disorder patients individually at the same time, and calculated Kappa of each item of MMSE. To fin out the difference among organic mental disorder, schizophrenia, depression and mania, t-test was done based on the score of the total and each item between organic mental disorder and each of the other group. Discriminant function analysis was done to differentiate organic mental disorder from each of the other group. Also, cut-off points and its diagnostic validities in organic mental disorder and functional mental disorder(schizophrenia, depression and mania) was calculated. The results were as follows : 1) As for the interrater reliability of Korean version of MMSE, the Kappa values of naming, expressive speech and registration were 0.65, 0.65 and 0.64, respectively, which suggest good reliability. And those of remaining 16 items of MMSE were ranging from 0.80 to 1.00, which suggest excellent reliability. Also Kappa value of total items was 0.86, which suggest excellent reliability. 2) There were statistically significant differences in the total scores of MMSE between organic mental disorder and schizophrenia, organic mental disorder and depression, organic mental disorder and mania patients(P<0.001). 3) Accuracy rates of discrimination between the group of organic mental disorder and each of the other group were as follows : It differentiated organic mental disorder from schizophrenia with 92.86% accuracy, from depression with 93.75% accuracy, and from mania with 93.75% accuracy. 4) We conclude that cut-off value of organic mental disorder and functional mental disorder(schizophrenia, depression and mania) in this study was 24/23 scores(sensitivity 88.6%, specificity 92.1%).

유분으로 오염된 흙의 성토재료로서의 안정성에 관한 연구

이충숙(Lee chung-sook),최용규(Choi yong-kyu),이민희(Lee min-hee) 한국지반환경공학회 2003 한국지반환경공학회 학술발표회논문집 Vol.2003 No.-

뇌경색후에 발생한 이차성 조증

신석철,이충숙,지익성,이선우 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

Mania is a rare complication of stoke. The clinical features and response to treatment are usually the same as mania without brain injury. Post-stroke mania strongly associated with both a right hemisphere lesion in a limbic-connected area and a second predisposing factor, such as genetic loading for a affective disorder, pre-existing subcortical atrophy or seizure disorder. It may be mediated through frontal lobe dysfunction. We report a case of secondary mania in 65-year old man who showed multiple lacunar infarction left thalamus and right periventricular area.

대구경 현장타설말뚝에 대한 현장수평재하시험에 관한 연구

최용규,이민희,이충숙 한국지반환경공학회 2004 한국지반환경공학회논문집 Vol.5 No.2

Most of pile foundations are a condition of fixed head on pile, but lateral loading test of pile have performed to free head on generally.This study performed field lateral loading test accompanying lateral displacement by depth of pile for two cases(fixed head and free head) and analyzed lateral behavior of large drilled shaft. Furthermore compared theoretical equation with result of lateral loading test. 대부분의 말뚝기초는 두부 고정상태이지만, 수평재하시험은 일반적으로 두부 자유상태에서 시행되었다. 이번 논문은 두가지 경우(두부고정, 두부자유)에 대한 말뚝깊이별 수평변위와 이론 방정식과 현장수평재하시험을 비교해가며 대구경현장타설말뚝의 수평거동을 분석한 말뚝현장수평재하시험을 수행하였다.

사례분석을 통한 말뚝재하시험 계획 및 설계 적용

서지원,김정환,이충숙,Seo, Ji-Won,Kim, Jeong-Hwan,Lee, Chung-Suk 한국지반공학회 2009 지반 : 한국지반공학회지 Vol.25 No.9

정상인에서 부분적 수면박탈이 수면구조에 미치는 영향

왕성근,이정규,이충숙,최하석,유남재,정인형,이선우 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

To identify the effects of partial sleep deprivation on the sleep structure, the authors performed polysomnographic study for 9 healthy young adults. The subjects were college students, ranging in age from 20 to 25 years, without personal past or present histories of medical, neurological, or psychiatric illness and suffering from current sleep disturbance or parasomomnias. Sleep records were analyzed according to the criteria of Rechtschaffen and Kales' manual and tried paired t-test. The results were summarized as follows. 1. As for sleep parameters, total sleep time(TST), REM latency and REM duration were not changed significantly during deprivation period and recovery period compared with baseline. Sleep efficiency increased significantly during deprivation period and recovery period compaired with baseline, and sleep latency and WASO were shortened significantly during deprivation period and recovery period compared with baseline. 2. As for sleep structure, 1) The absolute value(minutes) of stage 1 decreased significantly during deprivation period and first recovery night compared with baseline, and the relative value(percentage) of stage 1 decreased significantly during deprivation period and recovery period compared with baseline. 2) The absolute value(minutes) of stage 2 decreased significantly during deprivation period compared with baseline, and the relative value(percentage) of stage 2 decreased significantly during deprivation period and first recovery night compared with baseline. 3) The absolute value(minutes) of slow wave sleep were not changed significantly during deprivation period and recovery period compared with baseline, and the relative value(percentage) of slow wave sleep increased significantly during recovery period compared with baseline. 4) The absolute value(minutes) of REM sleep decreased significantly during deprivation period compared with baseline, and the relative value(percentage) of REM sleep decreased significantly in the first deprivation night but, were not changed significantly during recovery period compared with baseline.

살인을 범한 남자 정신분열병 환자와 5-HT2A 수용체 유전자 다형성(T102C)과의 관련 연구

지익성,왕성근,이선우,김정란,이영호,최상섭,이충숙 대한생물치료정신의학회 2007 생물치료정신의학 Vol.13 No.2

목 적:세로토닌체계의 변화가 정신분열병이나 폭력행동과 관련이 있다고 알려져 있다. 저자 등은 5-HT2A 수용체 유전자 다형성(T102C)이 살인을 범한 남성 정신분열병과 관련이 있는지 알아보기 위하여 본 연구를 시행하였다. 방 법:살인을 범한 정신분열병 환자 105명, 비폭력 정신분열병 환자 102명, 정상 대조군 104명을 대상으로 중합효소 연쇄반응을 이용하여 5-HT2A 수용체 유전자 다형성(T102C)의 유전자형과 대립유전자의 빈도를 비교하였다. 모든 대상은 한국인 남자였다. 결 과:살인을 범한 정신분열병군, 비폭력 정신분열병군, 정상대조군을 비교한 결과 세군간에 유전자형(χ2=8.090, df=4, p=0.088)이나 대립유전자(χ2=2.880, df=2, p=0.237)에서 통계적인 차이가 없었다. 또한 살인을 범한 정신분열병군과 비폭력 정신분열병군, 살인을 범한 정신분열병군과 정상 대조군, 그리고 비폭력 정신분열병군과 정상 대조군을 각각 비교하였을 때도 유전자형과 대립유전자에서 통계적인 차이가 없었다. 결 론:이러한 결과는 5-HT2A 수용체 유전자 다형성(T102C)이 남성 정신분열병환자의 살인행동과는 관련이 없음을 제시한다. 향후 살인을 범한 여성정신분열병환자와 살인을 범한 일반 범죄인을 포함한 연구가 필요할 것으로 사료된다. Objective : Alterations in the serotonergic system are related to schizophrenia and violent behavior. This study investigated whether T102C polymorphism of the 5-HT2A receptor gene is related to homicide in male schizophrenics. Methods : T102C polymorphism of the 5-HT2A gene was typed with PCR in 105 homicidal schizophrenics, 102 nonviolent schizophrenics, and 104 normal controls. All of the subjects were Korean males. Results : There were no differences in the genotypic distributions(χ2=8.090, df=4, p=0.088) or allele frequencies(χ2=2.880, df=2, p=0.237) of the T102C polymorphism of the 5-HT2A receptor in the three groups. In pairwise comparisons, no differences in the genotype distributions or allele frequencies were observed when homicidal schizophrenics and non-violent schizophrenics were compared, in the genotype distributions or allele frequencies of homicidal schizophrenics and normal controls, or in the genotype distributions and allele frequencies of nonviolent schizophrenics and normal controls. Conclusion : These results suggest that T102C polymorphism of the 5-HT2A receptor gene is not causally related to homicide in male schizophrenics. Further studies are required and should include homicidal female schizophrenics and non-psychotic subjects who have committed homicide.