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Lee, Hae Won,Lim, Mi-sun,Seong, Sook Jin,Lee, Joomi,Park, Jeonghyeon,Seo, Jeong Ju,Yun, Hwi-yeol,Baek, In-hwan,Kwon, Kwang-il,Yoon, Young-Ran Informa UK, Ltd. 2011 Expert opinion on drug metabolism & toxicology Vol.7 No.12
<P><B><I>Objectives:</I></B> An enteric-coated formulation of triflusal (triflusal EC), an antiplatelet agent, was developed to reduce the high incidence of gastrointestinal adverse events (AEs). The aim of this study is to compare the pharmacokinetics, pharmacodynamics and safety of triflusal EC with triflusal in healthy Korean male subjects to determine bioequivalence and non-inferiority for the purposes of marketing approval.</P><P><B><I>Methods:</I></B> A randomized, open-label, two-period, crossover study was conducted in 38 subjects. Either triflusal EC or triflusal was administered orally as a single 900 mg loading dose (day 1) followed by eight 600 mg/day maintenance doses on days 2 - 9, with a 13-day washout period. The plasma concentrations of 2-hydroxy-4-trifluoromethyl benzoic acid (HTB), the predominant active metabolite of triflusal, were assessed after administration of the loading dose, using HPLC/MS/MS. The platelet aggregation response to arachidonic acid was determined using turbidimetric aggregometry. </P><P><B><I>Results:</I></B> The 90% CIs, for the geometric mean ratios of the log-transformed AUC<SUB>τ</SUB> and C<SUB>max</SUB> of HTB were seen to be within the predetermined range of 0.8 - 1.25. Triflusal EC was also shown to be non-inferior in its anti-aggregatory effect. No serious AEs were reported during this study.</P><P><B><I>Conclusions:</I></B> The pharmacokinetic and pharmacodynamic profiles of the two triflusal formulations met the requirements for bioequivalence and non-inferiority, respectively. Both formulations were well tolerated.</P>
Lee, Sang-Min,Wang, Joong-San,Park, Sung-Kyu,Kim, Hong-Rae,Ko, Jin-Hee,Oh, Yu-Jung,Yoon, Hae-Ran,Kim, Ji-Sung International Academy of Physical Therapy Research 2012 Journal of International Academy of Physical Ther Vol.3 No.1
The aim of this study was to investigate the correlation among bone mineral density(BMD), body composition and body circumference on 20's college women in Hwaseong. A total of 86 subjects were measured with BMD and body composition and body circumference. To evaluate the correlation between BMD and body composition, bone density and body weight, body mass index(BMI), lean body mass, muscle mass, fat mass and body fat mass were compared. The results of this study, weight was considered the strong correlation with BMD than the height and BMI seems to be greater significance rather than the lumbar spine and femur BMD. In addition, the relationship between body composition and BMD, lean body mass, muscle mass, body fat mass were the most relevant factors and BMD. The relationship between BMD and body circumference that have been difficult because of not enough previous studies but somewhat the study showed that association.
Hae June Lee,Joong Sun Kim,Changjong Moon,Jong Choon Kim,Chun Sik Bae,Sung Soo Kang,Uhee Jung,Hae Ran Park,Sung Kee Jo,Sung Ho Kim 한국실험동물학회 2009 Laboratory Animal Research Vol.25 No.1
The morphological changes of small intestine and protective properties of an herbal preparation (HemoHIM) in intestinal damages were examined by evaluating its effects on jejunal crypt survival, apoptosis and other histological assessment in 5-fluorouracil (5-FU)-treated mice. The female ICR mice were treated with 5-FU for the examination of jejunal crypt survival and any morphological changes (200 ㎎/㎏ of body weight, i.p.), and for the detection of apoptosis (40 ㎎/㎏ of body weight, i.p.). HemoHIM was administered intraperitoneally at a dosage of 50 ㎎/㎏ of body weight at 36 and 12 hours preirradiation and 30 minutes post-irradiation, or orally at a dosage of 250 ㎎/㎏ of body weight/day for 7 or 11 days before autopsy. Compared to normal controls, 5-FU increased the incidence of apoptosis by 20-fold. 5-FU decreased villus height in the jejunum (44.6%) with crypt depths increased by 18.6% in this gut region. In comparison with normal controls, the values of basal lamina length of 10 enterocytes in the jejunum were significantly higher in 5-FU treated mice (55.5%). These effects were less profound in HemoHIM treated mice in which apoptosis was decreased 11.4% (p.o.) and 27.4% (i.p.), with villus height increased by 37% (p.o.) and 28% (i.p.), crypt depth by 13.4% (p.o.) and 19.0% (i.p.) and accompanied by decreases in basal lamina length of 23.5% (p.o.) and 31.9% (i.p.), compared to 5-FU control group. These results suggested that HemoHIM may be therapeutically useful to reduce intestinal injury following 5-FU treatment.
Cariogenic Activity in Saliva of Korean Head and Neck Cancer Patients
Hae-Soon Lim,Kyung-Yi Chung,Ae-Ok Kim,Mi-Ran Kim,Youn-Shin Kim,Mi-Sun Kang,Jeong-Won Hong,Ji-Yeon Jung,Ji-Il Park,Guem-Sug Lee KOREAN ACADAMY OF ORAL BIOLOGY 2014 International Journal of Oral Biology Vol.39 No.2
The purpose of this study is to evaluate salivary flow rate,salivary pH, and cariogenic activity using unstimulatedsaliva of the head and neck cancer patients. Twenty threecancer patients (19 males, 4 females) who had undergonechemotherapy and radiation therapy and twenty four healthyvolunteers (14 males, 10 females) as a control were included. Salivary flow rate, salivary pH, and cariogenic activity usingunstimulated saliva were examined. Compared to saliva ofthe control group, salivary flow rate (p<0.001) and salivarypH (p<0.001) were significantly lower in head and neckcancer patients. The colony counts of Lactobacilli was higherin head and neck cancer patients (p<0.05) than in controlgroup. These salivary factors and cariogenic activity canincrease the prevalence of dental caries in head and neckcancer patients.
Lee, Jung Hyun,Lee, Ho Seok,Park, Mi Ran,Lee, Sang Woon,Kim, Eun Hye,Cho, Joong Bum,Kim, Jihyun,Han, Youngshin,Jung, Kweon,Cheong, Hae Kwan,Lee, Sang Il,Ahn, Kangmo The Korean Academy of Asthma, Allergy and Clinical 2014 Allergy, Asthma & Immunology Research Vol.6 No.6
<P><B>Purpose</B></P><P>This study was aimed to investigate the relationship between indoor air pollutant levels and residential environment in children with atopic dermatitis (AD) living in Seoul.</P><P><B>Methods</B></P><P>A total of 150 children with AD were included. Residential environment was assessed by questionnaires which were completed by their parents. To evaluate the level of exposure to the indoor air pollutants, concentrations of the indoor air pollutants including particulate matter with diameter less than 10 µm (PM<SUB>10</SUB>), formaldehyde, carbon dioxide (CO<SUB>2</SUB>), carbon monoxide (CO), nitrogen dioxide (NO<SUB>2</SUB>), Total Volatile Organic Compound (TVOC), benzene, toluene, ethyl-benzene, xylene, styrene, bacterial aerosols, and airborne fungi were measured.</P><P><B>Results</B></P><P>A significant difference was exhibited in the levels of PM<SUB>10</SUB> in case of visible fungus on the walls (<I>P</I>=0.047). There was relationship between the construction year of the house, moving to a newly constructed building within 1 year and formaldehyde level. With the use of artificial air freshener, the differences were found in the concentrations of TVOC (<I>P</I>=0.003), benzene (<I>P</I>=0.015), toluene (<I>P</I>=0.012) and ethyl-benzene (<I>P</I>=0.027). The concentration of xylene was significantly high when oil was used as heating fuel (<I>P</I>=0.015). Styrene exhibited differences depending on building type and its concentrations were significantly high in a residential and commercial complex building (<I>P</I>=0.005). The indoor concentration of bacterial aerosols was significantly low with the use of air cleaner (<I>P</I>=0.045). High NO<SUB>2</SUB>, benzene concentrations were present in case of almost no ventilation (<I>P</I>=0.028 and <I>P</I>=0.028, respectively).</P><P><B>Conclusions</B></P><P>Individual residential environments are closely related with the levels of the indoor air pollutants. To alleviate AD symptoms, simple questions about residential environments such as visible fungus on the walls and the use of artificial air freshener are helpful to assess the possibility of increased indoor air pollutant levels when direct measurement is not available.</P>