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José Luis Muñoz-Carrillo,José Luis Muñoz-López,José Jesús Muñoz-Escobedo,Claudia Maldonado-Tapia,Oscar Gutiérrez-Coronado,Juan Francisco Contreras-Cordero,María Alejandra Moreno-García 대한기생충학ㆍ열대의학회 2017 The Korean Journal of Parasitology Vol.55 No.6
The immune response against Trichinella spiralis at the intestinal level depends on the CD4+ T cells, which can both suppress or promote the inflammatory response through the synthesis of diverse cytokines. During the intestinal phase, the immune response is mixed (Th1/Th2) with the initial predominance of the Th1 response and the subsequent domination of Th2 response, which favor the development of intestinal pathology. In this context, the glucocorticoids (GC) are the pharmacotherapy for the intestinal inflammatory response in trichinellosis. However, its therapeutic use is limited, since studies have shown that treatment with GC suppresses the host immune system, favoring T. spiralis infection. In the search for novel pharmacological strategies that inhibit the Th1 immune response (proinflammatory) and assist the host against T. spiralis infection, recent studies showed that resiniferatoxin (RTX) had anti-inflammatory activity, which decreased the serum levels of IL-12, INF-γ, IL-1β, TNF-α, NO, and PGE2, as well the number of eosinophils in the blood, associated with decreased intestinal pathology and muscle parasite burden. These researches demonstrate that RTX is capable to inhibit the production of Th1 cytokines, contributing to the defense against T. spiralis infection, which places it as a new potential drug modulator of the immune response.
Grouped Approach for the Design of H.264/AVC Motion Estimation Architectures
Sebastián López,Gustavo M. Callicó,Félix Tobajas,Valentín de Armas,José F. López,Roberto Sarmiento 한국전자통신연구원 2008 ETRI Journal Vol.30 No.6
This letter presents a novel approach for organizing computational resources into groups within H.264/AVC motion estimation architectures, leading to reductions of up to 75% in the equivalent gate count with respect to state-of-the-art designs
Humberto Cortes-López,Javier Castro-Rosas,Rodolfo García-Contreras,José Salud Rodríguez-Zavala,Bertha González-Pedrajo,Miguel Díaz-Guerrero,Javier Hernández-Morales,Naybi Muñoz-Cazares,Marcos Soto-Her 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.9
Hibiscus sabdariffa L. (Hs) calyxes, rich in organic acids, are included in diets in different countries. In recent years, some phytochemicals have been shown to reduce bacterial virulence at sublethal concentrations by interfering with quorum sensing (QS) systems. Therefore, in this study the antivirulence properties of Hs calyxes and two γ-lactones (hibiscus acid [HA] and its methyl ester) in Pseudomonas aeruginosa were analyzed. Acetone and methanol extracts of Hs showed anti-QS activity by inhibiting violacein production (60% to 80% with 250 μg/mL). In molecular docking analysis, the γ-lactones registered a good binding score, which suggests strong interaction with the active site of LasR protein. To verify their effect in vitro, they were isolated from Hs and evaluated in six QS-regulated phenotypes, as well as in ExoU toxin that is released by the type III secretion system (T3SS). At 500 μg/mL they reduced alkaline protease (29–52%) and elastase (15–37%) activity, biofilm formation (∼75%), and swarming (50%), but there was no effect on pyocyanin production, hemolytic activity, or type III secretion. In a mouse abscess/necrosis model, HA at sublethal concentrations (15 and 31.2 μg/mL) affected infection establishment and prevented damage and systemic spread. In conclusion, HA is the first molecule identified with antivirulence properties in Hs with the potential to prevent infections caused by P. aeruginosa.
Nayelli Ortega López,Digna Pachuca González,José Alfonso Rumoroso García,Juan Carlos García Reyna,Luis Felipe Alva López 대한핵의학회 2013 핵의학 분자영상 Vol.47 No.1
The acquisition of an 18F-FDG PET-CT scan in patients with suspected paraneoplastic cerebellar syndrome can be helpful in determining the origin of a neoplasm because of its high sensitivity and also helps guide the neurological development course depending on the degree of incorporation of 18F-FDG to the cerebellar parenchyma when compared with the rest of the brain.
Lidia Elena Ayón-Reyna,José Ángel López-Valenzuela,Francisco Delgado-Vargas,Martha Edith López-López,Francisco Javier Molina-Corral,Armando Carrillo-López,Misael Odín Vega-García 한국식물병리학회 2017 Plant Pathology Journal Vol.33 No.6
Anthracnose of papaya fruit caused by the fungus Colletotrichum gloeosporioides is one of the most economically important postharvest diseases. Hot water immersion (HW) and calcium chloride (Ca) treatments have been used to control papaya postharvest diseases; however, the effect of the combination HW-Ca on the pathogen growth and the development of the disease in infected papaya fruit has been scarcely studied. The aim of this study was to evaluate the effect of the HWCa treatment on the in vitro growth of C. gloesporioides conidia and the quality of infected papaya. In vitro, the HW-Ca treated conidia showed reduced mycelial growth and germination. In vivo, the HW-Ca treatment of infected papaya delayed for 5 days the onset of the anthracnose symptoms and improved the papaya postharvest quality. The combined treatment HW-Ca was better than any of the individual treatments to inhibit the in vitro development of C. gloeosporioides and to reduce the negative effects of papaya anthracnose.
Juan M. Lujano-Rojas,Ghassan Zubi,Rodolfo Dufo-López,José L. Bernal-Agustín,José L. Atencio-Guerra,João P. S. Catalão 한국CDE학회 2020 Journal of computational design and engineering Vol.7 No.2
This paper presents a methodology for the optimal placement and sizing of reactive power compensation devices in a distribution system (DS) with distributed generation. Quasi-static time series is embedded in an optimization method based on a genetic algorithm to adequately represent the uncertainty introduced by solar photovoltaic generation and electricity demand and its effect on DS operation. From the analysis of a typical DS, the reactive power compensation rating power results in an increment of 24.9% when compared to the classical genetic algorithm model. However, the incorporation of quasi-static time series analysis entails an increase of 26.8% on the computational time required.
José Arnold González-Garrido,José Rubén García-Sánchez,Carlos Javier López-Victorio,Adelma Escobar-Ramírez,Ivonne María Olivares-Corichi 한국영양학회 2023 Nutrition Research and Practice Vol.17 No.2
BACKGROUND/OBJECTIVES: Cocoa consumption is associated with health benefits due to its high content of polyphenols. However, the effects of short-term cocoa consumption remain unclear. We aimed to determine the effects generated by cocoa consumption (for 7 days) in young adults in normoweight and class II obesity. SUBJECTS/METHODS: Before-and-after study was carried out in normoweight (NW) (n = 15) and class II obesity (CIIO) (n = 15) young adults. The NW and CIIO participants consumed 25 and 39 g of cocoa, respectively, per day for 7 days. The effect of cocoa consumption was evaluated on the lipid profile, insulin resistance (IR), and inflammation. Oxidative damage was also examined by assessing the biomarkers of oxidative damage in plasma. In addition, recombinant human insulin was incubated with blood obtained from the participants, and the molecular damage to the hormone was analyzed. RESULTS: Cocoa consumption resulted in decreased low-density lipoprotein-cholesterol in both groups (P = 0.04), while the total cholesterol, high-density lipoprotein cholesterol, and triglycerides were maintained at the recommended levels. Initially, IR was detected in the CIIO group (homeostasis model assessment [HOMA] = 4.78 ± 0.4), which is associated with molecular damage to insulin. Interestingly, intervention with cocoa resulted in improved IR (HOMA = 3.14 ± 0.31) (P = 0.0018) as well as molecular damage to insulin. Finally, cocoa consumption significant decreased the arginase activity (P = 0.0249) in the CIIO group; this is a critical enzymatic activity in the inflammatory process associated with obesity. CONCLUSIONS: The short-term consumption of cocoa improves the lipid profile, exerts antiinflammatory effects, and protects against oxidative damage. Results of this study indicate that cocoa consumption can potentially improve IR and restore a healthy redox status.
José Daniel Barquero-Cabrero,Arnulfo Luévanos-Rojas,Sandra López-Chavarría,Manuel Medina-Elizondo,Francisco Velázquez-Santillán,Ricardo Sandoval-Rivas 국제구조공학회 2018 Smart Structures and Systems, An International Jou Vol.22 No.6
This paper presents a model of the elastic curve for rectangular beams with straight haunches under uniformly distributed load and moments in the ends considering the bending and shear deformations (Timoshenko Theory) to obtain the deflections and rotations on the beam, which is the main part of this research. The traditional model of the elastic curve for rectangular beams under uniformly distributed load considers only the bending deformations (Euler-Bernoulli Theory). Also, a comparison is made between the proposed and traditional model of simply supported beams with respect to the rotations in two supports and the maximum deflection of the beam. Also, another comparison is made for beams fixed at both ends with respect to the moments and reactions in the support A, and the maximum deflection of the beam. Results show that the proposed model is greater for simply supported beams in the maximum deflection and the traditional model is greater for beams fixed at both ends in the maximum deflection. Then, the proposed model is more appropriate and safe with respect the traditional model for structural analysis, because the shear forces and bending moments are present in any type of structure and the bending and shear deformations appear.
José María Paredes,Tomás Ripollés,Ángela Algarra,Rafael Diaz,Nadia Moreno,Patricia Latorre,María Jesús Martínez,Pilar Llopis,Antonio López,Eduardo Moreno-Osset 대한장연구학회 2022 Intestinal Research Vol.20 No.3
Background/Aims: Tight control of inflammation and adjustment of treatment if activity persists is the current strategy for the management of Crohn’s disease (CD). The usefulness of fecal calprotectin (FC) in isolated involvement of the small intestine in CD is controversial. To assess the usefulness of FC to determine the inflammatory activity detected by intestinal ultrasonography (IUS) in ileal CD. Methods: Patients with exclusively ileal involvement CD who underwent IUS and an FC were prospectively included. Simple ultrasound index was used to determine inflammatory activity. The usual statistical tests for comparison of diagnostic techniques were used. Results: One hundred and five patients were included, IUS showed inflammatory activity in 59% of patients and complications in 18.1%. FC showed a significant correlation with IUS in the weak range (Spearman coefficient <i>r</i>=0.502; <i>P</i><0.001); the area under the receiver operating characteristic curve was 0.79 (95% confidence interval, 0.70–0.88; <i>P</i><0.001). The FC value that best reflected the activity in IUS was 100 μg/g with sensitivity, specificity, and positive and negative predictive values of 73.0%, 71.4%, 79.3% and 63.8%, respectively. There were no differences in FC concentration between patients with or without transmural complications. The addition of serum C-reactive protein to FC did not improve the ability to assess IUS activity.Conclusions: FC has a significant correlation with IUS to monitor ileal CD activity. This correlation is weak and it does not allow assessing the presence of CD complications. Both tests should be used in conjunction for tight control of ileal CD. More studies on noninvasive tests in this location are needed.