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Investigation of the Bovine Leukemia Virus Proviral DNA in Human Leukemias and Lung cancers in Korea
Lim Chul Joo,Han Kyungja,Oh Jae Ho,Hwang Myung Sil,Yum Young Na,Kim Sheen Hee,Shin Dong Hwan,Yang Ki Hwa,Kim Yonggoo,Kang Chang Suk,Cho Dae Hyun,Lee Jehoon 대한의학회 2005 Journal of Korean medical science Vol.20 No.4
면역 결핍 환자에서 발생한 Fusarium oxysporum에 의한 범발성 피부 감염 1예
임숙희,이동원,이준영,임지향,한경자,조백기 대한의진균학회 2000 대한의진균학회지 Vol.5 No.1
With the wide and extensive use of immunosuppressive agents and broad-spectrum antibiotics, opportunistic fungal infections have been increased. Fusarium spp. are known to be significant emerging pathogens of opportunistic local infection. But very rarely it may cause fatal systemic infection. A 4-year-old boy with acute Iymphocytic leukemia developed asymptomatic disseminated purpura with high fever unresponsive to the antibiotics during chemotherapy. The skin lesions gradually increased in size and number, and progressed to forming central necrosis. Many septated hyphae and variable sized spore-like fungal elements are found in the epidermis, dermis and subcutis on histologic sections. The pathogenic fungus was identified as Fusarium oxysporum by culture and scanning electronic microscopic findings. [Kor J Med Mycol 5(1): 24-30]
Efficient Configuration of a Natural Gas Liquefaction Process for Energy Recovery
Lim, Wonsub,Lee, Inkyu,Tak, Kyungjae,Cho, Jae Hyun,Ko, Daeho,Moon, Il American Chemical Society 2014 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.53 No.5
<P>One of the most important challenges in a natural gas liquefaction plants is to improve the plant energy efficiency. In particular, if part of the natural gas is used as a fuel gas or the liquefaction ratio is taken into account as a design factor in an liquified natural gas (LNG) plant, process design focusing on cold energy recovery is an attractive option. In this study, various energy recovery-oriented process configurations and the potential improvements of energy savings in LNG plants were analyzed. Our primary focus for energy recovery in the LNG liquefaction process was centered on utilizing the flash gas stream from the phase separator. The applicability of the proposed configurations was validated by modeling and simulation of the single mixed refrigerant (SMR), propane precooled mixed refrigerant (C3MR), and single nitrogen (N2) expander processes. The simulation results for all cases exhibited considerable reductions of refrigerant flow rates, seawater cooling duties, and the specific work. For example, when the liquefaction ratio was fixed at 0.90, the amount of refrigerant was reduced by 4–5% by employing configuration 1, which recovers cold energy from the flash gas in LNG heat exchangers. This also led to 4–5% reductions of the specific work and seawater duty. Any energy recovery configuration will result in a considerable energy consumption reduction as the natural gas liquefaction process consumes a large amount of energy. Therefore, the optimization of energy recovery configurations in the natural gas liquefaction process is highly recommended with the objective of maximized energy savings considering capital costs.</P>
Chae, Hyojin,Lim, Jihyang,Kim, Myungshin,Park, Joonhong,Kim, Yonggoo,Han, Kyungja,Lee, Seok,Min, Woo Sung Springer International 2012 Annals of hematology Vol.91 No.2
<P>SET-NUP214 rearrangement is a recently recognized recurrent chromosomal translocation mostly observed in T-ALL. In order to characterize this rare entity, we performed phenotypic and genetic characterization of SET-NUP214 rearrangement through an investigation of a series of 40 consecutive samples of adult T-ALL that was selected among 229 adult ALL cases during 4?years in a single institution. Four cases (10%) of SET-NUP214 translocation were identified in our study. In all cases, diagnosis of T-ALL was established according to the World Health Organization (WHO) classification, and clonal TCR rearrangements were found. The immunophenotypic markers were indicative of the precursor nature of T lymphoblasts, and they expressed one or both of the myeloid-associated antigens (CD13, CD33). Conventional cytogenetic analysis revealed complex chromosomal aberrations in all four SET-NUP214 rearranged cases and del(12)(p13)/ETV6 was frequently involved. Array-CGH demonstrated additional genomic imbalances in addition to deletion 9q34. The genomic breakpoint sequencing identified breakpoints at SET intron 7 and NUP214 intron 17, and random nucleotide addition was found in two cases at the site of rearrangement. Our independently derived data set from a single institution confirms previous findings of SET-NUP214 rearrangement, indicates the relatively high incidence of SET-NUP214 rearrangement in adult T-ALLs, and also demonstrates comprehensive clinical, phenotypic, and genetic characteristics of this entity. Also, our report on genomic breakpoints demonstrates the homogeneity in the localization of the genomic breakpoints at 9q34. Concurrent chromosomal aberrations identified in this study should provide further areas of interest in investigation of SET-NUP214-mediated leukemogenesis.</P>
Is Laughter Therapy Useful in a Health CRISIS?: Meta-Analysis of Laughter Therapy
Wonsook Bak,Kyungja Kim,Yimsun Lee,Hyeyoung Lee,Jeongin Park,Rosa Yoon,Kyuri Lim,Sanghee Kim,임견주,강지숙 J-INSTITUTE 2021 International Journal of Crisis & Safety Vol.6 No.1
Purpose: This study was to identify the trends of laughter therapy and to analyze the effect size of laughter therapy Method: KISS, KMDB, KERIS and the National Assembly Library was searched for relevant journals by using the following key words ‘laughter treatment’, ‘laughter intervention’ and ‘laughter therapy’. 48 journals were included in this study. Data were analyzed using CMA ver. 2.0 and effect size was calculated by ‘the standardized mean difference Results: The major findings of this study were as follows. 1)The overall effect size of laughter therapy was 0.668. 2)The sub-group effect size were social(0.863), psycho-somatic(0.836), emotional(0.775), psychologi-cal(0.679), physiological(0.464), physical(0.653) by each. 3)As the laughter therapy program, the effect size of only laughing therapy was larger than parallel therapy and the effect size of 4 step program was larger than 3 step program. More program in a week was larger effect size of laughter therapy. Conclusion: It might be useful for this study to review systematic research on laughter therapy in Korean journals. Laughter therapy was also effective therapy for people and develop program based on knowledge from laughter therapy research.