軟口蓋에 發生한 混合腫瘍의 1例

高敬煥 대한이비인후과학회 1970 대한이비인후과학회지 두경부외과학 Vol.13 No.4

活性슬럿지法에 의한 炭化水素 함유 廢水의 淨化

고정삼,김재하,강경수,고영환 濟州大學校工科大學附屬産業技術硏究所 1991 尖端技術硏究所論文集 Vol.2 No.-

Activated sludge process which has been widely applied to the treatment of waste-water was slightly modified to remove hydrocarbons from wastewater. The process of wastewater treatment consisted of two consecutive reactors. Cells of Acinetobacter calcoaceticus were first cultivated in synthetic wastewater containing 3%(W/V) of hydrocarbons. The resulting culture was then exposed to acclimatized active sludge. Hydrocarbon concentrations of the effluent from the process were 0.19-0.21%(W/V). The contents of suspended solid were reduced to 17-53 ㎎/l. The data imply that A.calcoaceticus can be used for the treatment of wastewater containing hydrocarbons.

활성슬럿지법에 의한 탄화수소 함유 폐수의 정화

고영환,강경수,김재하,고정삼 濟州大學校 工科大學 産業技術硏究所 1991 産業技術硏究報告 Vol.2 No.-

Activated sludge process which has been widely applied t o the treatment of waste-water was slightly modified to remove hydrocarbons from wastewater. The process of wastewater treatment consisted of two consecutive reactors. Cells of Acinetobacter calcoaceticus were first cultivated in synthetic wastewater containing 3% (W/V) of hydrocarbons. The resulting culture was then exposed to acclimatized active sludge. Hydrocarbon concentrations of the effluent from the process were 0.19-0.21% (W/V). The contents of suspended solid were reduced to 17-53 ㎎/l. The data imply that A. calcoaceticus can be used for the treatment of wastewater containing hydrocarbons.

Nephron Heterogeneity of Renin Release in Rat Kidney Slices: Effects of L-Isoproterenol, Angiotensin II and TMB-8

Seul. Kyung-Hwan,Kim. Suhn-Hee,Koh. Gou-Young,Cho. Kyung-Woo 대한생리학회 1991 대한생리학회지 Vol.25 No.1

In order to determine possible relationships between the renin-angiotensin system and nephron heterogeneity, we compared the response of renin release and the angiotensin-converting enzyme (ACE) activity from different areas of the rat kidney. We used the renal cortical slices from the capsular surface to the juxtamedullary junction. Slices from outer one-third of the cortex were designated as outer cortical slices (OC), middle one-third as midcortical slices (MC), and inner one-third as inner cortical slices (IC). The renal renin content markedly decreased from OC and MC to IC. The basal lenin release was higher in OC than in MC or IC. On the contrary the percent change of renin release in response to L-isoproterenol was significantly higher in MC than in OC or IC. By TMB-8, the renin release in MC by 231±21% was higher than OC by 171±19% or IC by 162±19. Angiotensin II suppressed renin release in OC and MC by 68±2, 71±4% respectively, but only 40±7% in IC. The ACE activity was higher in IC than in OC, MC, medulla and papilla. The present data indicate that renin content and basal lenin release gradulally decreased from outer (OC) to inner (IC) cortex. The renin release in response to beta-adrenergic agonist, L-isoproterenol and intracellular calcium antagonist, TMB-8 were higher in MC than in OC and IC, but angiotensin II suppressed renin release less in IC than in OC and MC. It is suggested that juxtaglomerular cells of outer, mid-and inner cortices show a difference in renin release response to the stimuli.

문법과 담화

고경환(Koh, Kyung-Hwan) 미래영어영문학회 2007 영어영문학 Vol.12 No.1

SINGLE INJECTION OF PENTOBARBITAL INDUCES LONG-LASTING EFFECTS ON ANP SYNTHESIS AND GENE EXPRESSION IN THE RAT ATRIA

Seul, Kyung Hwan,Cho, Kyung woo,Kim, Suhn Hee,Hwang, Yun Ha,Park, Chung Ung,Koh, Gou Young 全北大學校 基礎科學硏究所 1994 基礎科學 Vol.16 No.-

To define the long-term effects of pentobarbital sodium on the plasma and atrial atrial natriuretic peptide (ANP) system, experiments were performed in female Sprague-Dawley rats. The plasma levels of immunoreactive (ir) ANP showed chronic as well as acute response to pentobarbital sodium administration. A single dose (30mg/kg, i.p.) of pentobarbital sodium resulted in s suppression in the plasma levels of irANP up to 1 week of administration. The suppressive effect on plasma irANP concentrations was dose-dependent. Right but not left atrial contents of irANP increased by an administration of pentobarbital sodium up to 4 weeks. ANP mRNA contents of the atria exposed to pentobarbital sodium began to increase after 2 days, reached to the peak after 2 weeks, and began to return to control values after 6 weeks. Surgical stress accentuated these patterns of plasma and atrial ANP responses to pentobarbital sodium treatment. The present data, therefore, suggest that even a single anesthetic dose of pentobarbital could elicit long-lasting profound changes in ANP system, i.e., changes in gene expression, synthesis and the secretion of ANP.

진행성 바터팽대부 선암종에서 카페시타빈과 옥살리플라틴 병합요법의 효과

이정환 ( Jung Hwan Lee ),김경희 ( Kyung Hee Kim ),우상명 ( Sang Myung Woo ),박상재 ( Sang-jae Park ),한성식 ( Sung-sik Han ),홍은경 ( Eun Kyung Hong ),고영환 ( Young Hwan Koh ),이주희 ( Ju Hee Lee ),이우진 ( Woo Jin Lee ) 대한췌담도학회 2017 대한췌담도학회지 Vol.22 No.3

배경/목적: 바터팽대부에서 발생하는 선암종은 드문 질환으로 항암화학요법에 대한 연구가 부족하다. 본 연구에서 진행성 바터팽대부 선암종 환자에서 XELOX 병합요법의 효능 및 안전성을 분석하고자 한다. 방법: 2006년 10월부터 2014년 1월까지 국립암센터에서 XELOX 병합요법으로 치료한 바터팽대부 선암종 환자 28명을 대상으로 후향적으로 분석하였다. 모든 환자는 진단 당시 전이성 또는 재발한 바터팽대부 선암종 환자이었다. XELOX 병합요법은 외래에서 3주마다 다음과 같은 프로토콜에 따라 투여되었다. 치료 시작 1-14일에 하루 2회 카페시타빈 750mg/m²를 경구 투여하고, 1일에 옥살리플라틴 130 mg/m²을 정맥 주사하였다. 결과: 24.6개월(범위 4.8-78개월)의 중앙 추적관찰 기간에서 중앙 무진행 생존 기간은 4.8개월(범위 0.7-18.0개월)이었고, 중앙 생존 기간은 11.9개월(범위 2.0-26.1개월)이었다. 1명의 환자(4%)가 완전 관해를 얻었고, 5명의 환자(18%)는 부분 관해를 보였다. 무진행 생존 기간와 전체 생존 기간에서 항암화학요법 반응 여부에 따른 차이는 없었다. 환자에서 가장 흔한 3등급의 이상 반응은 메스꺼움과 구토였다(10.7%). 치료와 관련된 사망은 관찰되지 않았다. 결론: XELOX 요법은 전이 혹은 재발 바터팽대부 선암종에서 비교적 낮은 독성의 발현과 중등도 효과를 보이는 치료법이다. Background/Aim: Adenocarcinoma arising from the ampulla of Vater is a rare disease and has limited data regarding outcome of palliative chemotherapy. We investigated the efficacy and safety of capecitabine plus oxaliplatin (XELOX) in patients with advanced ampullary adenocarcinoma. Methods: From October 2006 to January 2014, we retrospectively analyzed 28 patients with advanced ampullary adenocarcinoma treated by XELOX regimen at single institution. All the patients had histologically confirmed stage IV or recurrent ampullary adenocarcinoma. XELOX was administered in outpatient clinic every 3 weeks according to the following protocol: oral administration of capecitabine 750 mg/m² twice a day on days 1-14 and intravenous injection of oxaliplatin 130 mg/m² on day 1. Results: With follow-up of median 24.6 months (range 4.0-78.0 months), median progression-free survival (PFS) was 4.8 months (range 0.7-26.1 months), and median overall survival (OS) was 11.9 months (range 2.0-36.0 months). One patient (4%) achieved complete response and 5 patients (18%) showed partial response. There were no significant differences for PFS and OS according to response by chemotherapy. The most common grade 3 adverse events in patients were nausea and vomiting (10.7%). There was no treatment-related mortality. Conclusions: XELOX regimen is well tolerated and show moderate activity against advanced ampullary adenocarcinoma.

Furosemide 투여후 Aldosterone 분비율의 변동

고주환,유용운,성호경 대한핵의학회 1976 핵의학 분자영상 Vol.10 No.1

정상 혈압을 유지하고 있는 건강한 청년을 대상으로 furosemide 이뇨기간중과 이뇨후 1일간의 aldosterone 분비율, 배설율 및 혈중농도를 측정하여 아래와 같은 성적을 얻었다. 1) Furosemide 투여후 2시간 동안의 aldosterone 배설량은 투여를 받지 않은 사람에 비하여 현저히 증가하였다. 2) Furosemide 투여후 뇨중으로의 Na 및 K 배설량은 모두 현저히 증가하였다. 3) Furosemide 이뇨기간중의 뇨증 배설 증가량은 심히 증가되었으나 aldosterone 분비율은 훨씬 미급하였다. 4) Furosemide 이뇨후 1일간의 aldosterone 배설은 별다른 변동을 보이지 않았고 분비율 변동도 크지는 않았지만 1일동안의 총분비량 증가분은 이뇨로 잃은양을 보충할만한 분량이었다. 5) 이상 성적으로 보아 aldosterone 분비를 증가하는데 양적 한계가 있는 것으로 보였으나 이를 해명하기 위하여는 대사성 제거율 측정이 있어야 할 것으로 고찰되었다. Marked augmentation of urinary aldosterone excretion following furosemide adnainistration was observed in previous experiment. In this study, author measured the changes of aldosterone secretion after furosemide administration in normotensive young volunteers with high sodium intake. After intraveeous injection of 1.2-3H-aldosterone, urine samples were collected in course of time until 24 hours after the injection. Furosemide administration was done at 30 minutes prior to aldosterone injection. Specific activities of 3H-aldosterone during and after diuresis were measured and aldosterone secretion rates were calculated dividing the doses by specific activities. Results were as followed. 1) Furosemide resulted in a marked increase in urinary aldosterone excretion. 2) Furosemide lead to an increase in both sodium and potassium excretion. 3) Aldosterone secretion rate was also inc rease d during furosemide diuresis, but the rate was smaller than that of urinary excretion. 4) Continuous modest increase in aldosterone secretion rate was shown after diuresis and tota1 excess amount of aldosterone secretion for 24 hrs was equivalent to the amount of aldosterone excretion produced by diruesis. 5) Abrupt marked loss of circulating aldosterone produced by diuresis was supplemented by long lasting increase in secretion for over twenty four hours.

The value of prophylactic cranial irradiation in limited-stage small cell lung cancer: should it always be recommended?

Koh, Minji,Song, Si Yeol,Jo, Ji Hwan,Park, Geumju,Park, Jae Won,Kim, Su Ssan,Choi, Eun Kyung The Korean Society for Radiation Oncology 2019 Radiation Oncology Journal Vol.37 No.3

Purpose: Prophylactic cranial irradiation (PCI) is a standard treatment for limited-stage small cell lung cancer (LS-SCLC) showing a response to initial treatment, but many patients do not receive PCI due to comorbidities or refusal. This study aims to define the patient group for whom PCI can be omitted with minimal risk. Materials and Methods: Patients with LS-SCLC who underwent radiotherapy with curative aim at our institution between January 2004 and December 2015 were retrospectively reviewed. Patients who did not receive PCI were evaluated for brain metastasis-free survival (BMFS), progression-free survival (PFS), overall survival (OS), and prognostic factors for survival, and treatment outcomes were compared with a patient cohort who received PCI. Results: A total of 350 patients achieved a response following thoracic radiotherapy, and 190 of these patients did not receive PCI. Stage I-II and a complete response (CR) to initial therapy were good prognostic factors for BMFS and OS on univariate analysis. Patients with both stage I-II and a CR who declined PCI showed comparable 2-year BMFS to those who received PCI (92% vs. 89%). In patients who achieved CR, PCI did not significantly improve OS or PFS. Conclusion: There should be less concern about omitting PCI in patients with comorbidities if they have stage I-II or a CR, with brain metastasis control being comparable to those patients who receive PCI.

Single injection of pentobarbital induces long-lasting effect on ANP synthesis and gene expression in the rat artia

(Kyung Woo Cho),(Suhn Hee Kim),(Yun Ha Hwang),(Kyung Hwan Seul),(Chung Ung Park),(Gou Young Koh) 전북대학교 의과학연구소 1994 全北醫大論文集 Vol.18 No.1