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Expression of Cyclooxygenase (COX)-2 as a Prognostic Factor in Nasopharyngeal Cancer
Kyubo Kim,Hong-Gyun Wu,Suk Won Park,Chong Jai Kim,Charn Il Park 대한암학회 2004 Cancer Research and Treatment Vol.36 No.3
PURPOSE: To evaluate the relationship between treatment failure and COX-2 expression in nasopharyngeal cancer patients treated with chemotherapy and radiotherapy. MATERIALS AND METHODS: The subjects of this study were 22 nasopharyngeal cancer patients. The patients were treated with neoadjuvant chemotherapy, followed by radiotherapy, or with radiotherapy alone. The formalin- fixed, paraffin- embedded tissues of 11 patients who developed a locoregional recurrence (n=7) or distant metastasis (n=4) were compared with those of 11 disease free patients. Prognostic factors, including histological type, stage, radiation dose and chemotherapy, were well balanced between the two groups. The COX-2 expression was determined immunohistochemically. RESULTS: COX-2 expression was stronger in the patients with a locoregional recurrence or distant metastasis than in those free of disease. The COX-2 distribution scores of the control group were as follows: 0 in 7, 1 in 2 and 2 in 2 patients. In the recurrence group, the scores were as follows; 0 in 3, 1 in 1, 2 in 2 and 3 in 5 patients. COX-2 expression was shown to have a statistically significant influence on the treatment failure by the Mann-Whitney U test (p=0.024) and Mantel-Haenszel Chi-Square test (p=0.018). It also significantly influenced the treatment failure when an analysis was performed within patients with a undifferentiated histology (p=0.039 by the Mann- Whitney U test, p=0.037 by the Mantel-Haenszel Chi- Square test). CONCLUSION: COX-2 expression is believed to be one of the important factors associated with a locoregional recurrence or distant metastasis.(Cancer Res Treat. 2004;36:187-191)
Treatment Outcome of Metastatic Carcinoma of Cervical Lymph Node from an Unknown Primary
Kyubo Kim(김규보),Eui Kyu Chie(지의규),Hong-Gyun Wu(우홍균),Kwang Hyun Kim(김광현),Myung-Whun Sung(성명훈),Dae Seog Heo(허대석),Charn Il Park(박찬일) 대한방사선종양학회 2005 Radiation Oncology Journal Vol.23 No.3
목 적: 원발병소 불명의 경부림프절 전이의 치료는 각 기관들의 치료원칙에 따라 경부림프절청소술, 림프절 절제술, 방사선치료 및 항암화학치료 등 다양한 조합의 치료가 적용되고 있다. 저자들은 서울대학교병원에 서 원발병소 불명의 경부림프절 전이의 치료성적을 분석하고자 하였다. 대상 및 방법: 1981년 7월부터 1999년 6월까지 서울대학교병원 방사선종양학과에서 근치적 또는 수술 후 방사선치료를 받은 39명의 환자들을 대상으로 후향적으로 분석하였다. 방사선치료가 12명에서, 선행항암화학요법 및 방사선치료가 8명에서, 수술 및 수술 후 방사선치료가 18명에서 시행되었고, 1명은 선행항암화학요법, 경부림프절청소청술 및 수술 후 방사선치료를 받았다. 성별은 남자가 31명, 여자가 8명이었고, 연령의 중앙값은 55세였다.결 과: 전체 환자의 5년 생존율은 55%였다. 치료방법에 따라 분석해보았을 때, 수술+방사선치료가 방사선치료 단독 혹은 항암화학요법+방사선치료에 비해 우월한 5년 무병생존율을 보고하였다 (75% vs. 48% vs.19%). 그 외에 원발병소 발현여부가 무병생존율에 유의한 영향을 주는 것으로 나타났다.결 론: 원발병소 불명의 경부림프절 전이의 치료에 있어서 수술적 절제술 및 방사선치료의 병용요법이 방사선치료±항암화학요법에 비해 우월한 무병생존율을 보여주었다. 항암화학요법의 효과에 대해서는 추가 연구가 요망된다. Purpose: To analyze the outcome of radiation therapy for patients with a metastatic carcinoma of cervical lymph nodes from an unknown primary (MUO), and identify the prognostic factors for these patients. Materials and Methods: Between July 1981 and June 1999, 39 patients with MUO underwent radiation therapy with curative intent. Twelve patients were treated with radiation therapy alone (Group 1), 8 with neoadjuvant chemotherapy followed by radiation therapy (Group 2), and 19 with either an excision or neck dissection and postoperative radiation therapy (Group 3). There were 31 males and 8 females, with a median age of 55 years, ranging from 25 to 77 ears. The median duration of follow-up was 38 months, ranging from 3 to 249 months. Results: The 5-year overall survival rate was 55%. According to the treatment modality, the 5-year disease-free survival rates of Groups 1, 2 and 3 were 48, 19 and 75%, respectively (p=0.0324). In addition to the treatment modality, the appearance of the primary site was a significant prognostic factor for disease-free survival (p=0.0085). Conclusion: Surgical resection and radiation therapy achieves a superior disease-free survival compared to radiation therapy alone, either with or without chemotherapy. Further investigation is needed to evaluate the role of chemotherapy in the treatment of MUO.
CD24 expression predicts distant metastasis in extrahepatic bile duct cancer.
Kim, Kyubo,Min, Hye Sook,Chie, Eui Kyu,Jang, Jin-Young,Kim, Sun Whe,Han, Sae-Won,Oh, Do-Youn,Im, Seock-Ah,Kim, Tae-You,Bang, Yung-Jue,Jang, Ja-June,Ha, Sung W WJG Press 2013 World journal of gastroenterology Vol.19 No.9
<P>To evaluate the prognostic significance of CD24 expression in patients undergoing adjuvant chemoradiotherapy for extrahepatic bile duct (EHBD) cancer.</P>
Kim, Kyubo,Chie, Eui Kyu,Jang, Jin-Young,Kim, Sun Whe,Han, Sae-Won,Oh, Do-Youn,Im, Seock-Ah,Kim, Tae-You,Bang, Yung-Jue,Ha, Sung W Doyma 2012 Clinical & translational oncology Vol.14 No.5
<P>To analyse the outcome of adjuvant chemoradiotherapy for periampullary adenocarcinoma and the impact of tumour location as a prognosticator.</P>
메탄올 개질 연료를 이용한 과도 및 소음·진동 특성 연구
김규보(Kyubo Kim),최승환(Seunghwan Choi),김태환(Taehan Kim),장영준(Youngjune Chang),진충환( Changhwan Jeon) 한국자동차공학회 2002 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2002 No.5_1
As environmental and energy concerns are forcing emission standards to tighten, it is necessary to develop low emission vehicles, for example by modifying combustion processes, adding exhaust aftertreatments and changing fuel composition. In this experimental study, the effect of methanol-reformulated fuel by changing fuel composition on engine performance and exhaust emission characteristics for transient phase which is acceleration and deceleration and noise and vibration by using methanol reformulated fuel in a four-stroke DOHC 1.8L S.I. engine were studied. The results show thaI methanol reformulated fuel is better emission reduction than that of net gasoline especially in HC CO and NOx emissions at transient phase, and engine performance, noise and vibration arc similar to both fuel.<br/>