간질환자의 항경련제 혈중농도와 정신증상에 관한 연구

연규월 梨花女子大學校 韓國生活科學硏究院 1991 韓國生活科學硏究院 論叢 Vol.48 No.-

Recently with increasing recognition of some of the chronic and neuropathological effects of anticonvulsant therapy and the development of technique for measuring serum anticonvulsant levels, more serious attentin is being derected at the possible role of such therapy in the precipitation of mental symptoms. The author studied 61 epileptic patients attending the neuropsychiatric clinic of Ewha Womans University Hospital to confirm the serum anticonvulsant levels in relation to the clinical symptoms of mental state, seizure control and the sign of toxicity from Jan.1, 1990 to May 31, 1991. For each category of mental state(psychomotor slowing, intellectual deterioration, psychiatric illness or personality change), the subjects with evidence of impairment had higher concentration of both DPH and PB, CBZ, VPA than those without such impairment. Those subjects with well controlled seizures had higher concentrations than those with poorly controlled seizures. The sign of toxicity(ataxia and dysarthria) was in the range of therapeutic blood level and 3 of those subject with the sign of toxicity had history of brain damage and abnormal findings of computerized axial tomography of brain. So, the anticonvulsant medication may have an adverse effect on the mental processes of epileptic patients quite apart from an inderectly beneficial effects from controlling seizures in the range of therapeutic blood level.

정동장애에서의 생물학적 이론에 대한 최근 동향 : 신경화학과 신경내분비 조절 이상 Neurochemical and Neuroendocrine Dysregulation

연구월,이근후 中央醫學社 1987 中央醫學 Vol.52 No.11

Neuroendocrine function has been reported by several workers to be abnormal in affec-tive disorder and it has been shown that neurotransmitters are involved in the regulation of neuroendocrine function. Depressed patients demonstrated deregulation in multiple neurochemical and neuro-endocrine systems, many of which are involved stress mediated reactions. Thus it is very intriguing that neuroendocrine & neurochemical abnormalities in depres-sion that we have reviewed involve imbalance of neurotransmitters and deregulation of neuroendocrine that directly or indirectly mediate stress-responsivity in humans. But it is necessary to define how this deregulation becomes translated into the clinical phenomenon of depression as the further research method.

포르피린증 환자에서 보인 가역적 자기공명영상소견 1례

강석윤,마효일,곽규환,이상암 대한신경과학회 1998 대한신경과학회지 Vol.16 No.2

신사구체 경변증을 나타내는 FGS/NgaKist mice 간장에서 사이토크롬 P4501A1/2 단백질 발현

정규식,현병화,이철호,박상준,최양규,류시윤,이차수,민병길 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.2

닭에 있어서의 Catecholamine의 代謝作用

尹圭玉 全南大醫大 1965 전남의대학술지 Vol.2 No.1

零細的 農業經營의 矛盾과 이의 克服의 方向論考

延圭執 淸州大學校 1963 論文集 Vol.4 No.1

생활사건스트레스, 우울증심도와 면역기능

연규월 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.3

저자는 우울증 환자를 대상으로 생활사건 스트레스와 우울증의 심도에 따른 면역기능의 변화를 조사하였다. 이화여대부속 동대문병원 정신과에 입원한 우울증 환자 30명과 정상대조군 24명을 대상으로 rate Nephelo-metry 방법에 의해 혈청 면역글로부린과 보체농도를 정량분석하여 비교하였고, 임상적 평가는 Hamilton 우울증 척도와 사회재적응 평가척도를 사용하였다. 결과는 다음과 같았다. 1) 우울증 환자군의 혈청 Ig G, Ig A, Ig M 과 C3, C4 농도는 대부분이 정상범위내에 있었고 정상대조군의 농도와 비교시 차이가 없었다. 2) 우울증 환자군의 혈청 Ig M평균 농도는 대조군의 평균 농도보다 더 높았고 두 군간 유의한 차이가 있었다. 3) 우울증 환자군의 혈청 C3,C4평균 농도는 대조군의 평균 농도보다 높았으나 두 군간 유의한 차이는 없었다. 4) 우울증 환자군에서 연령, 우울증 심도, 스트레스 심도와 혈청 Ig G, Ig A, Ig M 과 C3, C4 농도 사이에는 상관 관계가 없었다. 이상의 결과로 볼 때, 우울증 환자군에서 보이는 Ig M, C3, C4 농도의 증가는 급성기 혈장 단백질 반응을 시사하기는 하나, 이들의 농도가 대부분 정상범위에 속하고 스트레스 심도에 따른 혈청 Ig G, Ig A, Ig M과 C3, C4농도사이에 직접적인 상관관계가 없는 것으로 보아 혈청 Ig와 C3,C4농도의 변화가 우울증의 특이적 소견이라고 보기는 어렵다. 따라서 생활사건 스트레스에 의한 체액성 면역계의 변화는 동질의 환자군을 대상으로 Ig, C3, C4이외의 다른 면역 가능의 지표가 사용되어야 할 것으로 생각된다. Objective : Stress and depression have been known to be associated with impairment in immune function. This study was designed to elucidate the abnormalities of humoral immune function in patients with depressive illness. Method : The author compared serum immunoglobulin Ig G, Ig A, Ig M and complements C3, C4, checked with rate Nephelometry, between hospitalized depressed patients and healthy normal controls. The depressive symptoms were rated with the Hamilton Depression Rating Scale and the current life events were evaluated with the Social Readjustment Rating Scale. Results : 1) Serum levels of immunoglobulin and complements of depressed patients as well as those of normal controls were generally within normal range. 2) The levels of the immunoglobulin Ig M were found to be significantly increased in depressed patients compared to healthy normal controls. 3) The levels of complement C3, C4k tended to be slightly increased in depressed patients compared to healthy normal controls, but with no statistical significance. 4) Serum immunoglobulin and complement levels were not significnatly correlated with age, severity of depression and life events in depressed patients. Conclusion : These findings expand previously reported evidence of immune abnormalities in depressive illness and provide a partial explanation for some of these findings and suggest that depressive illness is associated with an acute phase immune response. However, the serum immunoglobulin and complement levels were not correlated with the severity of depression and life events in depressive illness. So, it is difficult to consider the serum immunoglobulin and complement levels as specific markers of depressive illness. Further research on the interaction between hormones and immunity in depression is warranted.

성적갈등과 결혼만족도에 관한 연구

연규월,이근후 梨花女子大學校 醫科大學 醫科學硏究所 1988 EMJ (Ewha medical journal) Vol.11 No.3

Autor has been interested in the factors which influence the sexual conflict of marital relation and researched the latent sexual conflict of mairital relation by way of social field survey through questionnaire method from June 20th, 1984 to Aug. 10th, 1984(The subjects:653 couples of middle class people in Seoul). This study is researched and analyzed under the following hypothesis; If the latent sexual conflict of marital relation comes into existence, the unsatisfaction of wives will be shown in higher degree than that of husbands. The results are as followings; 1) As to the satisfaction of marital relation, the attitude about the importance of sexual life, and the anticipation about the sex before marriage which are the factors operating on the sexual life of marital relation, the unsatisfaction of wives is shown in higher degree than that of husbands. 2) The reason for the unsatisfaction of wives is interpreted under the followings. Psychoanalytically, woman has complicated process of dissolution of Oedipus complex and the unconscious drive wish to have an achievement about the passive attitude. Psychosocially, woman has much more role conflict and disadventages of sexuality under the double concepts of social value system.

Fosfomycin의 항균효과 및 capillary electrophoresis에 의한 측정법에 관한 연구

윤효인,박승춘,이규승,권진욱,조준형,신광순,김무열,허강준,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-

Fosfomycin, a low molecular antibiotic, is to be easily synthesized, therefore to be possibly used in veterinary sectors due to econimic reasons. In this study, we determined the antibacterial activities of fosfomycin against some domestic animal-origin pathogens, and its combined effects with some important antibacterials available. We also compared detection methods of fosfomycin from various measuring instruments. The results obtained through this experiment were as follows: 1. Antibacterial activities of fosfomycin against the pathogens used in this experiment were appeared fairly low. We found the antobacterial activities depanded on the kinds of media and the addition of some material thereins, which suggests the importance of appropriate medium so as to judge the antibacterial activity of fosfomycin. 2. Fosfomycin showed varying antibacterial effects in combination with other antibacterials, which should be taken into consideration when combining other antobacterials especially in the clinical settings. Of the combined antivacterials, fosfomycin had synergistic effects in combination with amoxicillin but antagonistic effects with oxytetracyline. 3. Conventional detection methods using HPLC, GC and spectrophotometer were not appropriate to measure fosfomycin. Capillary electrophoresis by the way of the indirect ultraviolet detection method was good enough to detect fosfomycin in the range of expected concentration in tissues, with the limit of quantitation (LOQ) of 1.25 ㎍/㎖. We recommend the eletrophoresis method could be used to detect fosfomycin, thereby being able to set the optimal dosage for animals and providing the measures in relation with the residual concentration in the meat.

가족환경이 정신분열증 환자 재발에 미치는 영향

연규월 梨花女子大學校 韓國生活科學硏究院 1992 韓國生活科學硏究院 論叢 Vol.49 No.-

Objective : The aim of this work was to study the relationship between intrafamilial expressed emotion(EE) and other prognostic indicators on the schizophrenic relapse. Method : Subjects were 43 schizophrenic patients who were admitted to the department of neuropsychiatry at Ewha Womans university hospital. During hospital admission, their key relatives were interviewed with the Camberwell Family Interview(CFI) and levels of emotional expression were assessed. After discharge from hospital with clinical improvement, all patients were followed-up for a period of nine months and their psychiatric state was assessed to provide information about relapse. Results : The majority of patients were female and unmarried and living with parents. The greater proportion of the key relatives was mother. Remitted patients from high-expressed emotion households relapsed at a significantly higher rate than did those from low expressed emotion households. The best clinical outcome was observed in those patients who redided in low-EE home environments and regularly adhered to antipsychotic medication regimens. Conclusions : There was a significant association between high levels of expressed emotion and relapse for remitted schizophrenic patients and the regular use of medication was a protective factor to the schizophrenic relapse particularly for the patients in high-EE environments.