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Modified automotive organic friction materials through infiltration of liquid carbon precursors
Kuo‑Jung Lee,Ting‑Yu Wu,Hsun‑Yu Lin,Huy‑Zu Cheng,Chih‑Feng Wang 한국탄소학회 2019 Carbon Letters Vol.29 No.4
This research combines the liquid carbon precursor infiltration process for carbon/carbon composites with the fabrication procedure for organic, carbon-matrix friction materials in automotive. In the densification process, different liquid carbon precursors and numbers of densification cycle are adopted to investigate the influence on physical and mechanical properties, microstructure and tribological behavior. Experimental results indicate that the infiltration of liquid carbon precursors could improve the physical, mechanical properties and tribological performances of organic friction materials. The open porosity decreases with the number of densification cycle. Both bulk density and hardness increase with the number of densification cycle. The resin-based specimens show higher hardness and lower open porosity than those of the pitch-based specimens after each densification cycle. The tribological measurement of specimens with different carbon precursors shows that the pitch-based specimen shows lower and more stable friction coefficients and exhibits lower weight losses in comparison with other carbon precursors. Morphological observations show that a large area of smooth lubricative film was easily presented on the worn surfaces of the pitch-based specimens, whereas it was seldom observed on the worn surfaces of the preform specimen and resin-based specimens.
Individual and common inhibitors of coronavirus and picornavirus main proteases
Kuo, Chih-Jung,Liu, Hun-Ge,Lo, Yueh-Kuei,Seong, Churl-Min,Lee, Kee-In,Jung, Young-Sik,Liang, Po-Huang Elsevier 2009 FEBS letters Vol.583 No.3
<P><B>Abstract</B></P><P>Picornaviruses (PV) and coronaviruses (CoV) are positive-stranded RNA viruses which infect millions of people worldwide each year, resulting in a wide range of clinical outcomes. As reported in this study, using high throughput screening against ∼6800 small molecules, we have identified several novel inhibitors of SARS-CoV 3CL<SUP>pro</SUP> with IC<SUB>50</SUB> of low μM. Interestingly, one of them equally inhibited both 3C<SUP>pro</SUP> and 3CL<SUP>pro</SUP> from PV and CoV, respectively. Using computer modeling, the structural features of these compounds as individual and common protease inhibitors were elucidated to enhance our knowledge for developing anti-viral agents against PV and CoV.</P>
Impact of Adjuvant Chemotherapy in Elderly Breast Patients in Taiwan, A Hospital-Based Study
Lee, Hsiu Chuan,Chen, Wei Yu,Huang, Wen Tsung,Cheng, Kuo Chen,Tian, Yu Feng,Ho, Chung Han,Tsao, Chao Jung,Feng, Yin Hsun Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.10
Purpose: Decisions as to whether to provide adjuvant treatment in older breast cancer patients remains challenging. Side effects of chemotherapy have to be weighed against life expectancy, comorbidities, functional status, and frailty. To aid decision-making, we retrospectively analyzed 110 women with breast cancer treated with a curative intention from 2006 to 2012. Survival data with clinical and pathological parameters were evaluated to address the role of adjuvant chemotherapy in this study population. Method: A total of 110 elderly (>70 years) patients that received mastectomy at two hospitals in Taiwan were observed retrospectively for a medium of 51 months. After mastectomy, patients received conservative treatment or adjuvant chemotherapy, or hormone therapy following clinical guidelines or physician's preference. Data were collected from the cancer registry system. Results: Median age at diagnosis was 75.7 years. Thirty-five percent of patients received adjuvant chemotherapy, these having a significantly younger age ($mean=74.0{\pm}5.3$ vs $77.5{\pm}5.3$, p<0.001) and higher tumor staging (p=0.003) compared with their non-chemotherapy counterparts.Five-year overall survival was non-significantly higher in patients who received adjuvant chemotherapy (with chemotherapy 64.2% vs without chemotherapy 62.6%, p=0.635), while five-year recurrence free survival was non-significantly lower (with chemotherapy 64.1% vs without chemotherapy 90.5%, p=0.80). Conclusions: In this analysis, adjuvant chemotherapy tended to be given to patients with a younger age and higher tumor staging at our institute. It was not associated with any statistically significant improvement in survival and recurrence rate. Until age specific recommendations are available, physicians must use their clinical judgment and assess the tumor biology with the patient's comorbidities to make the best choice. Clinical trials focusing on this critical issue are warranted.
Provable Secure Brand-new Multi-auction Mechanism with Dynamic Identity
Lee, Jung-San,Wei, Kuo-Jui,Chen, Ying-Chin,Sun, Yun-Hsiang Korean Society for Internet Information 2016 KSII Transactions on Internet and Information Syst Vol.10 No.12
Different from traditional auctions, electronic auctions provide a platform to allow bidders and auctioneers merchandise to each other over network anytime and anywhere. Auctioneers can publish information of goods, and bidders can choose the interested targets through this bidding platform. To ensure the fairness and security of electronic auctions, Li et al. have proposed a practical electronic auction scheme which can confirm the requirement of strong anonymity, bidding privacy, and secret bidding price. However, we have found out that Li et al.'s scheme may lurk the risk of the denial-of-service attack during the bidding phase in a sealed-bid auction. Thus, we propose a brand-new sealed-bid auction mechanism, in which the essentials of e-auction can be firmly preserved. In particular, each bidder only needs to register at the center once and then can join to multiple plays launched by different auctioneers. Moreover, the correctness of mutual authentication is confirmed according to the BAN logic model.
Provable Secure Brand-new Multi-auction Mechanism with Dynamic Identity
( Jung-san Lee ),( Kuo-jui Wei ),( Ying-chin Chen ),( Yun-hsiang Sun ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.12
Different from traditional auctions, electronic auctions provide a platform to allow bidders and auctioneers merchandise to each other over network anytime and anywhere. Auctioneers can publish information of goods, and bidders can choose the interested targets through this bidding platform. To ensure the fairness and security of electronic auctions, Li et al. have proposed a practical electronic auction scheme which can confirm the requirement of strong anonymity, bidding privacy, and secret bidding price. However, we have found out that Li et al.`s scheme may lurk the risk of the denial-of-service attack during the bidding phase in a sealed-bid auction. Thus, we propose a brand-new sealed-bid auction mechanism, in which the essentials of e-auction can be firmly preserved. In particular, each bidder only needs to register at the center once and then can join to multiple plays launched by different auc-tioneers. Moreover, the correctness of mutual authentication is confirmed according to the BAN logic model.
Aerosol Effects on Instability, Circulations, Clouds, and Precipitation
Lee, Seoung-Soo,Tao, Wei-Kuo,Jung, Chang-Hoon Hindawi Limited 2014 Advances in meteorology Vol.2014 No.-
<P>It is well known that increasing aerosol and associated changes in aerosol-cloud interactions and precipitation since industrialization have been playing an important role in climate change, but this role has not been well understood. This prevents us from predicting future climate with a good confidence. This review paper presents recent studies on the changes in the aerosol-cloud interactions and precipitation particularly in deep convective clouds. In addition, this review paper discusses how to improve our understanding of these changes by considering feedbacks among aerosol, cloud dynamics, cloud and its embedded circulations, and microphysics. Environmental instability basically determines the dynamic intensity of clouds and thus acts as one of the most important controls on these feedbacks. As a first step to the improvement of the understanding, this paper specifically elaborates on how to link the instability to the feedbacks.</P>
Enhancing the Security of Credit Card Transaction based on Visual DSC
( Kuo-jui Wei ),( Jung-san Lee ),( Shin-jen Chen ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.3
People have transferred their business model from traditional commerce to e-commerce in recent decades. Both shopping and payment can be completed through the Internet and bring convenience to consumers and business opportunities to industry. These trade techniques are mostly set up based on the Secure Sockets Layer (SSL). SSL provides the security for transaction information and is easy to set up, which makes it is widely accepted by individuals. Although attackers cannot obtain the real content even when the transferred information is intercepted, still there is risk for online trade. For example, it is impossible to prevent credit card information from being stolen by virtual merchant. Therefore, we propose a new mechanism to solve such security problem. We make use of the disposable dynamic security code (DSC) to replace traditional card security code. So even attackers get DSC for that round of transaction, they cannot use it for the next time. Besides, we apply visual secret sharing techniques to transfer the DSC, so that interceptors cannot retrieve the real DSC even for one round of trade. This way, we can improve security of credit card transaction and reliability of online business. The experiments results validate the applicability and efficiency of the proposed mechanism.
Chia-Lun Kuo,Pei-Chen Lee,Li-Jung Elizabeth Ku,Yu Sun,Tsung-Hsueh Lu,Muhammad Atoillah Isfandiari,Chung-Yi Li 한국역학회 2023 Epidemiology and Health Vol.45 No.-
OBJECTIVES: Information regarding the underlying causes of death (UCODs) and standardized mortality ratio (SMR) of dementia is instrumental in formulating medical strategies to prolong life in persons with dementia (PWD). We examined the leading UCODs among PWD and estimated the overall and cause-specific SMRs in relation to dementia in Taiwan. METHODS: Data were retrieved from 2 national datasets: the Taiwan Death Registry and the medical claim datasets of the National Health Insurance program. The observed person-years for each study participant were counted from the date of cohort enrollment to either the date of death or the final day of 2016. Sex-specific and age-specific SMRs were then calculated. RESULTS: The leading UCOD was circulatory disease, accounting for 26.0% of total deaths (n=3,505), followed by respiratory disease at 21.3% (n=2,875). PWD were at significantly increased risk of all-cause mortality (SMR, 2.01), with SMR decreasing with advancing age. A cause-specific analysis revealed that the highest SMRs were associated with nervous system diseases (SMR, 7.58) and mental, behavioral, and neurodevelopmental disorders (SMR, 4.80). Age appeared to modify SMR, suggesting that younger age at cohort enrollment was linked to higher SMRs for nearly all causes of mortality. CONCLUSIONS: Circulatory and respiratory diseases were the leading UCODs among PWD. The particularly elevated mortality due to nervous system diseases and mental disorders suggests that allocating more resources to neurological and psychiatric services is warranted. The elevated SMRs of various UCODs among younger PWD underscore the need for clinicians to pay particular attention to the medical care provided to these patients.