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Theoretical models of ferromagnetic III-V emiconductors
T.Jungwirth,JairoSinova,J.Kucera,A.H.MacDonald 한국물리학회 2003 Current Applied Physics Vol.3 No.5
Recent materials research has advanced the maximum ferromagnetic transition temperature in semiconductors containingmagnetic elements toward room temperature. Reaching this goal would make information technology applications of these ma-terials likely. In this article we briey review the status of work over the past ve years which has attempted to achieve a theoreticalunderstanding of these complex magnetic systems. The basic microscopic origins of ferromagnetism in the (III,Mn)V compoundsthat have the highest transition temperatures appear to be well understood, and ecient computation methods have been developed. 2003 Published by Elsevier B.V.
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Photo-Induced Cytotoxicity of Prodigiosin Analogues
Park, Gyung-Se,Tomlinson, John T.,Misenheimer, Jacob A.,Kucera, Gregory L.,Manderville, Richard A. Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.1
Prodigiosin (1) is the parent member of a class of polypyrrole natural products that exhibit promising anticancer activities. They can facilitate copper-promoted oxidative DNA damage by binding to copper ions, and this activity is thought to represent their mechanism of cytotoxicity in the dark. They also possess photoinduced cytotoxicity, although 1 is too toxic in the dark to be used effectively for the treatment of cancer by photodynamic therapies. To circumvent dark toxicity by prodigiosins, the semi-synthetic analogue 2, in which the N-pyrrolic atoms of 1 are methylated to block copper coordination, and the synthetic phenyl analogues 3 and 4, which lack the copper-coordinating A-pyrrole ring of 1, were tested for their ability to inhibit colony formation of HL-60 cancer cells in the absence and presence of visible light (λ > 495 nm). Our results show that 2-4 lack cytotoxicity in the dark, but are able to inhibit colony formation of HL-60 cells following irradiation for 30 min. The synthetic derivative 4 exhibits photo-induced cytotoxicity similar to that of the natural product 1, demonstrating the potential use of prodigiosin-based compounds for treatment of cancers following irradiation with visible light.
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Photo-Induced Cytotoxicity of Prodigiosin Analogues
Gyungse Park*,John T. Tomlinson,Jacob A. Misenheimer,Gregory L. Kucera,Richard A. Manderville* 대한화학회 2007 Bulletin of the Korean Chemical Society Vol.28 No.1
Prodigiosin (1) is the parent member of a class of polypyrrole natural products that exhibit promising anticancer activities. They can facilitate copper-promoted oxidative DNA damage by binding to copper ions, and this activity is thought to represent their mechanism of cytotoxicity in the dark. They also possess photoinduced cytotoxicity, although 1 is too toxic in the dark to be used effectively for the treatment of cancer by photodynamic therapies. To circumvent dark toxicity by prodigiosins, the semi-synthetic analogue 2, in which the N-pyrrolic atoms of 1 are methylated to block copper coordination, and the synthetic phenyl analogues 3 and 4, which lack the copper-coordinating A-pyrrole ring of 1, were tested for their ability to inhibit colony formation of HL-60 cancer cells in the absence and presence of visible light (l > 495 nm). Our results show that 2-4 lack cytotoxicity in the dark, but are able to inhibit colony formation of HL-60 cells following irradiation for 30 min. The synthetic derivative 4 exhibits photo-induced cytotoxicity similar to that of the natural product 1, demonstrating the potential use of prodigiosin-based compounds for treatment of cancers following irradiation with visible light.
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Acute Toxicity and Cytotoxicity of Pereskia aculeata, a Highly Nutritious Cactaceae Plant
Debora O. Silva,Mauricio Seifert,Fabiana R. Nora,Vera L. Bobrowski,Rogerio A. Freitag,Heidi R. Kucera,Leonardo Nora,Nilesh W. Gaikwad 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.4
Pereskia aculeata is a Cactaceae plant with valuable nutritional properties, including terrific amounts of protein, minerals, vitamins, and fiber. However, P. aculeata is reported to contain antinutrients and alkaloids in its leaves. In addition, in a study on growth and development, Wistar rats fed with P. aculeata and casein as protein source grew less than the control group (fed with casein only). Therefore, in this study, we evaluated, for the first time, the oral acute toxicity of P. aculeata in rats and also the cytotoxicity behavior of the plant on lettuce seeds. The acute toxicity research was carried out using dried P. aculeata ethanolic extract, in three different doses, administered by gavage to 24 female Wistar rats. The rats were then examined for signs of toxicity, food intake, body weight, and fecal excretion fluctuations, as well as histopathological alterations, using eight different body tissues. The acute toxicity study did not show any difference among the groups in either clinical evaluation or histopathological analyses. For the cytotoxicity study, dried P. aculeata ethanolic extract was applied on lettuce seeds in five different concentrations. These seeds were evaluated for germination, root and shoot length, and mitotic index. The results show that P. aculeata extract affects lettuce root and shoot growth, but not germination or mitotic index. In conclusion, the acute toxicity on rats and the cytogenotoxicity on lettuce of P. aculeata are neglectable, validating the potential of this plant to be used as a functional food.
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