주의력결핍 과잉행동장애 아동에 있어서 연속수행검사의 진단적 유용성

구본훈,박형배,이희정,송창진,김진성,이광헌 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

서 론: 본 연구는 주의력결핍 과잉행동장애(이하 ADHD) 아동과 정상대조군의 연속수행검사(이하CPT) 결과 양상을 비교하여 CPT의 진단적 유용성을 알아보고자 하였다. 그리고, ADHD 아동의 연령과 성별, 지능, 그리고, 장애의 유형 등과 같은 변수에 따른 CPT의 결과양상을 비교하여, CPT가 ADHD의 어떤 특성을 잘 반영해주는가를 알아보고자 하였다. 대상 및 방법: DSM-Ⅳ의 진단기준에 의하여 진단이 내려진 ADHD 실험군 68명과 정상대조군 30명을 선정하였으며, 두 군간의 연령과 성별을 통제하였다. 실험군과 정상대조군 모두 환아의 부모가 ADHD 평가척도(ADDES-HV)를 작성하였으며, 환아에게 직접 CPT를 실시하였고 지적 능력을 평가하기 위해 K-ABC를 시행하였다. 결 과: 실험군과 정상대조군에서의 CPT 결과 양상을 비교하였을 때, 실험군과 정상대조군 사이에 민감도가 유의한 차이를 나타내었고, 반응 기준도 유의한 차이를 나타내었다(p<0.05). ADHD 아동을 대상으로 연령과 지능의 변화에 따른 CPT의 결과 양상을 비교하였을 때, 연령과 지능이 증가함에 따라 CPT각각의 결과들도 대체로 수행력이 호전되는 경향을 나타내었다. 주의력결핍 과잉행동 장애의 유형을 과잉행동을 동반한 군과 과잉행동을 동반하지 않은 군으로 나누어 비교분석을 한 결과, CPT 각각의 결과에서 유의한 차이는 나타나지 않았다. CPT 결과 양상에 있어서 남녀간 차이점을 비교하였을 때, 오경보오류와 정반응시간의 표준편차, 표준편차의 다양성, 그리고, 민감도가 유의한 차이를 나타내었다(p<0.05). CPT 각각의 8가지 결과 변수들에 대해 판별분석을 실시한 결과, 각각의 결과 변수들에 있어서 진단에 대한 전체 판별력이 모두 50%이상을 나타내었다. 그 중, 정반응시간의 표준편차와 표준편차의 다양성, 그리고, 민감도는 진단에 대한 전체 판별력이 모두 60%이상을 나타내었다. 결론 및 고찰: 이러한 결과들은 CPT가 ADHD의 진단에 있어서 어느 정도의 유용성을 가지고 있다는 점을 보여준다 하겠다. 즉, ADHD에 있어서 CPT는 비교적 선별검사와 같은 목적으로는 유용할 것으로 생각되며, 이는 또한 CPT가 장애의 진단에 있어서 보조적인 검사도구임을 나타낸다 하겠다. Objectives: The purpose of this study was to examine to diagnostic availability of CPT in children with ADHD, and what factors are affected to CPT results in the diagnosis of ADHD. Method: CPT, ADHD scales(ADDES-HV), K-ABC were administered to 68 ADHD patients and 30 normal elementary school students as the control group. Also, ages and sex are controlled between two groups. Results: In the differences of the results of CPT between ADHD patients and normal subjects, attentiveness and risk taking are significantly different(p<0.05). In the differences of the results of CPT between ages in ADHD patients, usually as more aged children are better performances in CPT. Also, in the differences of the results of CPT between intelligence in ADHD patients, usually as higher intelligent children are better performances in CPT. There are no differences of the results of CPT between types of ADHD in ADHD patients. In the differences of the results of CPT between sex in ADHD patients, commission error, hit reaction time standard error, variability of standard error, and attentiveness are significantly different between male and female patients(p<0.05). The correlations between ADHD scales and the results of CPT show that inattention subscale is significantly related to hit, omission error, hit reaction time standard error, and variability of standard error. In the discriminant ability between ADHD patients and normal children by the results of CPT, accuracy rates are more than 50% in all results of CPT. Especially, the accuracy rate of hit reaction time standard error, and the accuracy rate of variability of standard error, and also, the accuracy rate attentiveness are more than 60%. Conclusion: In this point of view, this study suggest that CPT is relatively valuable method in the diagnosis of ADHD. For instances, CPT is more likely to screen the ADHD from normal children, or to use as assisted method of diagnosis of ADHD in clinical settings.

Group Contribution법에 의한 고압기-액평형

구본식,배효광 嶺南大學校 工業技術硏究所 1986 연구보고 Vol.14 No.2

The mixing rule derived from excess Gibbs free energy at infinite pressure is newly introduced in the SRK equation of state. The Gibbs free energy is predicted by the method of analytical solution of groups(ASOG). The group pair parameters for CH₂, CH₃, CH₄and CO₂groups are well correlated to the temperature. The vapar-liquid equilibria predicted from using the parameters for the binary systems of n-paraffins and carbon dioxide are compared with the results using the optimum interaction parameter(??). The average deviations of vapor mole fraction and pressure in this work are comparative to them by the optimum ??.

반복적 스트레스가 흰쥐의 Opioid성 신경전달에 미치는 영향

사공정규,이광헌,김진성,구본훈,이종범,하정희 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.3

연구목적: 반복적인 스트레스에 노출된 실험동물에서 opioid성 신경전달의 변화양상을 검색하고 내인성 opioid peptide의 변화양상을 알아보기 위하여 본 연구를 시행하였다. 방 법: 본 연구에서는 웅성 흰쥐에게 하루 2시간, 2주간의 반복적인 부동화 스트레스를 가한 후 뇌의 각 부위에서 opioid 수용체의 mu-, delta- 및 kappa- 아형의 최대결합력 및 친화력의 변화 양상을 관찰하였다. 결 과: 반복적 부동화 스트레스 노출군에서는 대조군에 비하여 delta-아형 수용체의 수가 시상하부(hypo-thalamus) 및 선조체(striatum)에서 증가하였다. 본 연구결과 관찰된 선조체에서의 delta-아형 수용체의 상향조절과 관련지어 delta-아형 수용체의 내인성 효현제인 enkephalin의 뇌조직 내에서의 활성도를 검색하였을 때, 반복적 스트레스 노출군에서는 대조군에 비하여 그 함량이 감소하였다. 이러한 뇌조직내 enkephalin 활성도 감소 현상은 수용체 변화와 상응하게 시상하부 및 선조체에서 관찰되었으며, 이러한 수용체의 조절 현상은 내인성 수용체 효현제인 enkephalin의 활성도의 감소에 따른 생체의 적응 현상으로 해석되었다. 결 론: 이상의 결과로부터 반복적인 스트레스는 opioid 수용체 delta-아형을 상향조절하였으며, opioid 수용체 delta-아형의 내인성 효현제의 활성도를 감소시킴을 관찰하였다. Objectives : Research into emotional or behavioral stress typically focuses upon the hypothalamic-pituitary-adrenal axis. It is well established that the hypothalamic-pituitary-adrenocortical axis is subject to inhibitory control by opioids in a variety of animal species including pigs. Exposure to acute stress induces the upregulation of opioid receptors and the release of endogenous peptides which mediate the stress-induced analgesia. There is some literature substantiating that repeated stress can lead to changes in opioidergic neurotransmission. However, the changes are highly variable. This study was designed to observe the modulatory effect of repeated immobilization stress on opioidergic neurotransmission. Methods : Male Sprague-Dawley rats weighing 150-200g were forced to suffer immobilization stress for 2 hours on each of 14 successive days. Then we examined the maximum binding capacity and affinity of each opioid subtypes(mu, delta, kappa). Results : Repeated immobilization stress increased the binding of [³H]DPDPE on the delta-subtype opioid receptor in the striatum and hypothalamus. Saturation experiments followed by scatchard analyses of the results showed an increase in the density of delta-subtype opioid receptors, but the affinity of the delta-subtype opioid receptor remained unchanged. Repeated immobilization stress reduced enkephalin activity of striatum and hypothalamus. Conclusions : From these results, it could be concluded that repeated immobilization stress up-regulated the delta-subtype opioid receptors and reduced the activity of enkephalin, an endogenous ligand for the delta-subtype opioid receptor.

Pyrantel Pamoate (Combantrin)에 依한 蛔蟲 및 鉤蟲感染의 集團治療

徐丙卨,朴定圭,趙昇烈,姜信榮,魚光本,康世喆,李源宰,李正雨,黃邱一 中央醫學社 1972 中央醫學 Vol.23 No.6

The mass treatment trial of pyrantel pamoate on Ascaris lumbricoides and Ancylostoma duodenale infections was carried out to school-children and inhabitants in rural areas in the central part of Korea. Pyrantel pamoate ("Combantrin") tablet (123 mg base) was administered as a single dose of 10. 0 mg per kg. body weight to a total of 4,198 Ascaris infected cases selected out of 4,436 (41. 6%) positives, who were screened from the total 10,660 collected stool specimens. Of these, only 3,169. cases were followed up after treatment to provide an analysis in this study. Incidentally 161 cases with concomittently infected hookworm were also subjected to assess the efficacy of pyrantel pamoate against A. duodenale. The egg negative conversion rate on A. lumbricoides was 95.3%, and on A. duodenale, 97.5% four weeks following treatment. In failed cases, the egg reduction rates on both of the infections were 97.6% and 97.3% respectively. No side effects and no problem in drug administration were demonstrated. It is concluded that this study confirms the high efficacy of pyrantel pamoate in the treatment of Ascaris lumbricoides and Ancylostoma duodenale infections and also proves the acceptability and safety of this drug in the mass treatment of ascariasis in a population with relatively high worm burden.

Characterization, Cloning and Expression of the Ferritin Gene from the Korean Polychaete, Periserrula leucophryna

Kwang Bon Koo,Hyung Suk Baik,Han-Seung Joo,Chung-Soon Chang,Byeong Ryong Jeong,Jang Won Choi 한국생명과학회 2006 한국생명과학회 심포지움 Vol.46 No.-

Protective Effect of Cyclo(His-Pro) on Streptozotocin-Induced Cytotoxicity and Apoptosis In Vitro

Kwang Bon Koo,Hyung Joo Suh,Kyung Soo Ra,Jang Won Choi 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.2

Cyclo(His-Pro) (CHP) is a naturally occurring, cyclic dipeptide structurally related to thyrotropin-releasing hormone (TRH). CHP was efficiently obtained from soybean meal by hydrolysis with flavourzyme and alcalase. In this study, the effects of CHP on streptozotocin (STZ)-induced β-cell dysfunction and apoptosis were investigated in rat insulinoma cells (RINm5F) secreting insulin. When the RINm5F cells were treated with 2mM STZ, insulin secretion decreased to approximately 54% that of control cells. However, CHP treatment restored the insulin-secreting activity of RINm5F cells to approximately 71% that of the untreated control cells. Moreover, CHP significantly protected the cells from STZ-mediated cytotoxicity via reduction of nitric oxide (NO) production (2.3-fold) and lipid peroxidation (1.9-fold), which were induced by STZ. Moreover, CHP treatment also attenuated STZ-induced apoptotic events, such as activation of caspase-3, poly(ADP-ribose) polymerase (PARP) cleavage, and DNA fragmentation in RINm5F cells, indicating that CHP could protect the cells from apoptotic cell death induced by oxidative stress of STZ by increasing the expression of an anti-apoptotic protein, Bcl-2. These results suggest that CHP could be a candidate material for a protective and therapeutic agent against STZ-mediated cytotoxicity and apoptosis.

Antioxidant Activities of Culture Broth of Tremella fuciformis

Kwang Bon KOO,Dong Ju SHIN,Kyung Soo RA,Jang Won CHOI 한국생물공학회 2010 한국생물공학회 학술대회 Vol.2010 No.4

Biochemistry : Fibrinolytic Activity of a Novel Serine Protease from the Hemolymph of a Polychaeta, Periserrula Leucophryna

Kwang Bon Koo,Hyung Joo Suh,Kyung Soo Ra,Yeon Hyang Kim,Han Seung Joo,Jang Won Choi 한국응용생명화학회 2010 Journal of Applied Biological Chemistry (J. Appl. Vol.53 No.2

Morphological Changes by Culture Conditions of Cordyceps sinensis and Immunological Properties of Hot Water Extract of Mycelium

Kwang Bon KOO,Dong Ju SHIN,Hyung Joo SUH,Jang Won CHOI 한국생물공학회 2010 한국생물공학회 학술대회 Vol.2010 No.4

Protective Effect of Cyclo-His-Pro on Streptozotocin-Induced Apoptosis of Pancreatic β-Cells

Kwang Bon KOO,Jang Won CHOI 한국생물공학회 2010 한국생물공학회 학술대회 Vol.2010 No.10