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A new miroestrol glycoside from the roots of Pueraria mirifica
Bang, Myun-Ho,Lee, Do-Gyeong,Baek, Yoon-Su,Cho, Jin-Gyeong,Han, Min-woo,Choi, Kyoung-Sook,Chung, Dae-Kyun,Ko, Sung-kwon,Oh, Chang-Hwan,Cho, Soo-Yeul,Chai, Kap-Yong,Kim, Jin-Ho,Baek, Nam-In Springer-Verlag 2013 Chemistry of natural compounds Vol.49 No.3
서면,오성훈,김영수,고용,오석전,김남규,정환영,김광명 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.3
The author has studied 60 patients of degenerative spondylolisthesis diagnosed and operatively treated at Hanyang University Hospital from January 1987 to June 1992, and analized the outcome. The results were summarized as followings : 1) Male to female ratio was 1 : 4, showing female predominance. Average peak ages were 5th and 6th decades. 2) "Pedicle-Facet Angle" and the degree of slipping had directly proportional relationship(Y=0.58X+110). The wider the angle is, the more slipping develops. 3) The significant symptom and sign were neurogenic intermittant claudication and negative straight-leg-raising test. 4) The degenerative spondylolisthesis developed most frequently at L4-5 level(74%), L5-S1(15%), L3-4(8%), 57 cases(95%) fell into Grade by Meyerding classification. 5) Complete or incomplete block on myelogram was present in 59%, and pseudodisc and lumbar spinal stenosis were noticed on CT. 6) Laminectomy with P.L.I.F. were done in 50 cases(83%) and total laminectomy and medical facetectomy and foraminotomy were done in only 4cases(7%). In the comparison on the slipping degree before & after operation, in 55 cases(92%), slipping degrees showed no great change less than 2㎜, but the almost showed excellent & good results. So we considered decompression & fusion without excessive reduction was sufficient. 7) Threaded fusion cage(T.F.C) had the several benifits that 1) stability was good, 2) osteosynthesis through threaded was possible and 3) postoperative ambulation was possible earlier. Therefore recently, P.L.I.F, using T.F.C in the treatment of degenerative spondylolisthesis were used in many cases and further evaluation for T.F.C. should be considered.
kMIT를 이용한 비유창성 실어증 환자 음성 언어의 치료효과 연구
이주희,고명환,김현기,홍기환,Lee Ju Hee,Ko Myun Hwan,Kim Hyun Gi,Hong Ki Hwan 대한후두음성언어의학회 2005 대한후두음성언어의학회지 Vol.16 No.2
Melody intonation therepy (MIT) is to improve the linguistic aspects of the verbal utterance for aphasic patients utilizing the intact right brain. It is applied to the aphasic patients with good comprehension, poor fluency, and little available speech are thought to be ideal candidates. The purpose of the study was to investigate the effects of Korean Melody intonation therapy (kMIT) in patients with non-fluent aphasia. Five male non-fluent aphasic patients were participated in this study. Average ages were 49.9 years old. Each therapy took 45-50minutes once a week for six months. Aphasic Screen lest (RISS) was used to assess language parameter such as Auditory comprehension, oral expression, reading, writing and calculation ability before and after kMIT. Mean of Length Utterance, verbal intelligibility and articulation disorder were assessed also. Computerized Speech Lab was used to assess the acoustic characteristics of aphasic patients before and after kMIT. The results are as follows : 1) Auditory comprehension, oral expression, reading, writing and calculation ability of the subjects increased after UH'. However, only oral expression showed significant difference (p<0.05). 2) Mean of Length Utterance of five patients generally increased after Un. 3) After kMIT, verbal intelligibility increased and showed significant difference (p<0.05). 4) Misarticulation rate generally decreased after m. 5) Voice Onset Time of the alveolar lenis /t/ and velar lenis /k/ gradually decreased after kMIT. 6) However, intonation pattern were increased gradually in yes'no question after kMIT.
태국칡(Pueraria mirifica)으로부터 norsesquiterpene의 분리 및 동정
권정화 ( Jung Hwa Kwon ),조진경 ( Jin Gyeong Cho ),박희정 ( Hee Jung Park ),허규원 ( Gyu Won Huh ),방면호 ( Myun Ho Bang ),한민우 ( Min Woo Han ),오창환 ( Chang Hwan Oh ),고성권 ( Sung Kwon Ko ),조수열 ( Soo Yeul Cho ),최갑용 ( Ka 한국응용생명화학회(구 한국농화학회) 2014 Journal of Applied Biological Chemistry (J. Appl. Vol.57 No.4
Pueraria mirifica 뿌리를 실온에서 70% EtOH 수용액으로 추출하고 이 추출물을 EtOAc 분획, n-BuOH 분획, H2O 분획으로 나누었다. EtOAc 분획에 대하여 silica gel, octadecyl silica, 및 Sephadex LH-20 c.c.를 반복 실시하여 4종의 화합물을 분리, 정제하였다. Nuclear magnetic resonance, infrare, 및 mass spectrometry의 spectroscopic data를 해석하여, 화합물 1-4를 각각 megastigm-5-en-3,9-diol, linarionoside B, 3,5,6,9-tetrahydroxymegastigm-7-ene 및 3,4,9-trihydroxymegastigma-5,7-diene으로 구조를 결정하였다. 화합물 1-4 모두 P. mirifica에서는 이번에 처음으로 분리된 화합물이다. The roots of Pueraria mirifica were extracted with 70% aqueous ethyl alcohol and partitioned into ethyl acetate (EtOAc), n-butyl alcohol (BuOH), and H2O fractions, successively. From the EtOAc fraction, four norsesquiterpenes were isolated through the repeated silica gel, octadecyl silica gel and Sephadex LH-20 column chromatographies. On the basis of physicochemical and spectroscopic data including nuclear magnetic resonance (NMR), mass spectrometry, and infrared spectroscopy, the chemical structures were identified as megastigm-5-en-3,9-diol (1), linarionoside B (2), 3,5,6,9-tetrahydroxymegastigm-7-ene (3) and 3,4,9-trihydroxymegastigma-5,7-diene (4). Especially, the configuration of the anomer hydroxyl group was determined as a from the coupling constants of the anomer proton (J =8.0 Hz) in the 1H-NMR spectrum. These compounds were isolated for the first time from the roots of P. mirifica in this study.
Flavonoids from Pueraria mirifica roots and quantitative analysis using HPLC
Cho, Jin-Gyeong,Park, Hee-Jung,Huh, Gyu-Won,Lee, Seung Su,Bang, Myun-Ho,Choi, Kyoung-Sook,Oh, Chang-Hwan,Ko, Sung-Kwon,Cho, Soo-Yeul,Chai, Kap-Yong,Kim, Jin-Ho,Baek, Nam-In Springer-Verlag 2014 Food Science and Biotechnology Vol.23 No.6