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Hyeon, Ji-Yeon,Hwang, Seoyeon,Kim, Hyejin,Song, Jaehyoung,Ahn, Jeongbae,Kang, Byunghak,Kim, Kisoon,Choi, Wooyoung,Chung, Jae Keun,Kim, Cheon-Hyun,Cho, Kyungsoon,Jee, Youngmee,Kim, Jonghyun,Kim, Kisang Centers for Disease Control and Prevention 2013 Emerging infectious diseases Vol.19 No.8
<P>The epidemiology of enteroviral infection in South Korea during 1999–2011 chronicles nationwide outbreaks and changing detection and subtyping methods used over the 13-year period. Of 14,657 patients whose samples were tested, 4,762 (32.5%) samples were positive for human enterovirus (human EV); as diagnostic methods improved, the rate of positive results increased. A seasonal trend of outbreaks was documented. Genotypes enterovirus 71, echovirus 30, coxsackievirus B5, enterovirus 6, and coxsackievirus B2 were the most common genotypes identified. Accurate test results correlated clinical syndromes to enterovirus genotypes: aseptic meningitis to echovirus 30, enterovirus 6, and coxsackievirus B5; hand, foot and mouth disease to coxsackievirus A16; and hand, foot and mouth disease with neurologic complications to enterovirus 71. There are currently no treatments specific to human EV infections; surveillance of enterovirus infections such as this study provides may assist with evaluating the need to research and develop treatments for infections caused by virulent human EV genotypes.</P>
김기순(Kisoon Kim),신지철(Jicheol Shin),이기학(Ki Hak Lee),배소영(Soyeong Pae) 한국언어청각임상학회 2007 Communication Sciences and Disorders Vol.12 No.1
본 연구에서는 학령전기 아동의 이야기 회상 산출 능력을 살펴보았다. 방법: 이 연구에서는 4~6세 일반 아동 60명을 대상으로 이야기 회상 산출 능력을 양적으로 분석하였다. 검사 도구는 ‘그네 이야기’와 ‘공 이야기’를 사용하였으며, 분석은 이야기문법 총점, 낱말로 본 평균절길이(MLC-w), 형태소로 본 평균절길이(MLC-m)를 산출하여 연령간 평균의 차이가 있는지를 알아보았다. 결과 및 결론: 이야기문법 총점, 낱말로 본 평균절길이(MLC-w), 형태소로 본 평균절길이(MLC-m) 모두 연령에 따라 유의미하게 증가하는 것으로 나타났다. 이를 통해 이야기문법과 평균절길이(MLC)로 학령전기 아동의 이야기 회상 능력이 양적으로 증가하는 것을 알 수 있었다. 또한 이야기 평가시 이야기문법과 평균절길이(MLC)로 분석하는 것이 이야기 발달을 보는데 적절하고 효율적임을 확인할 수 있었다. The purpose of the study was to evaluate story retelling abilities of preschool children. Methods: The participants comprised 60 preschoolers aged 4 to 6 years. Two Korean stories written by Soyeong Pae, “The Swing Story” and “The Ball Story” were used. We showed the story cards to the children, told a story corresponding to the cards, and asked the children to retell the story after removing the cards. The total scores of story grammar, MLC-w(Mean Length of C-units by words), and MLC-m(Mean Length of C-units by morphemes) were compared to determine differences in story retelling performance according to age. Results & Conclusion: The total scores for story grammar, MLC-w, and MLC-m significantly increased with age. The use of story grammar and MLC are considered effective measure of children’s story intelligibility. Implications for future study were discussed.
Enhanced Polynomial Selection Method for GNFS
Suhri Kim(김수리),Jihoon Kwon(권지훈),Sungmin Cho(조성민),Nam Su Chang(장남수),Kisoon Yoon(윤기순),Chang Han Kim(김창한),Young-Ho Park(박영호),Seokhie Hong(홍석희) 한국정보보호학회 2016 정보보호학회논문지 Vol.26 No.5
RSA 암호 시스템은 가장 널리 사용되는 공개키 암호 알고리즘 중 하나이며, RSA 암호 시스템의 안전성은 큰 수의 인수분해의 어려움에 기반을 둔다. 따라서 RSA 암호 시스템의 합성수 을 인수분해하려는 시도는 계속 진행 중에 있다. General Number Field Sieve는 현재까지 알려진 가장 빠른 인수분해 방법이고, RSA-704를 인수분해 하는데 사용된 소프트웨어인 CADO-NFS도 GNFS를 기반으로 설계되어 있다. 그러나 CADO-NFS는 다항식 선택 과정에서 입력된 변수로부터 항상 최적의 다항식을 선택하지 못하는 문제점이 있다. 본 논문에서는 CADO-NFS의 다항식 선택 단계를 분석하고 중국인의 나머지 정리와 유클리드 거리를 사용하여 다항식을 선택하는 방법을 제안한다. 제안된 방법을 이용하면 기존의 방법보다 좋은 다항식이 매번 선택되며, RSA-1024를 인수분해 하는데 적용할 수 있을 것으로 기대한다. RSA cryptosystem is one of the most widely used public key cryptosystem. The security of RSA cryptosystem is based on hardness of factoring large number and hence there are ongoing attempt to factor RSA modulus. General Number Field Sieve (GNFS) is currently the fastest known method for factoring large numbers so that CADO-NFS – publicly well-known software that was used to factor RSA-704 – is also based on GNFS. However, one disadvantage is that CADO-NFS could not always select the optimal polynomial for given parameters. In this paper, we analyze CADO-NFS’s polynomial selection stage. We propose modified polynomial selection using Chinese Remainder Theorem and Euclidean Distance. In this way, we can always select polynomial better than original version of CADO-NFS and expected to use for factoring RSA-1024.
Efficient Optimization Method for Polynomial Selection
Suhri Kim(김수리),Heetaek Kwon(권희택),Yongseong Lee(이용성),Nam Su Chang(장남수),Kisoon Yoon(윤기순),Chang Han Kim(김창한),Young-Ho Park(박영호),Seokhie Hong(홍석희) 한국정보보호학회 2016 정보보호학회논문지 Vol.26 No.3
현재까지 알려진 가장 효율적인 인수분해 방법은 General Number Field Sieve (GNFS)를 이용하는 방법이다. CADO-NFS는 GNFS를 기반으로 구현된 공개된 소프트웨어로 RSA-704의 인수분해에 사용된 도구이다. CADO-NFS에서 다항식 선택은 크게 다항식을 생성하는 과정과 이를 최적화하는 과정으로 나누어져 있다. 그러나 CADO-NFS에서 다항식의 최적화 과정은 전체 다항식 선택 소요 시간 중 약 90%를 차지할 정도로 큰 부하를 주고 있다. 본 논문에서는 사전 연산 테이블을 이용하여 다항식 최적화 과정의 부하를 줄이는 방안을 제안한다. 제안하는 방법은 기존 CADO-NFS의 다항식과 같은 다항식을 선택하지만, 다항식 선택에 걸리는 시간은 약 40% 감소한다. Currently, General Number Field Sieve(GNFS) is known as the most efficient way for factoring large numbers. CADO-NFS is an open software based on GNFS, that was used to factor RSA-704. Polynomial selection in CADO-NFS can be divided into two stages – polynomial selection, and optimization of selected polynomial. However, optimization of selected polynomial in CADO-NFS is an immense procedure which takes 90% of time in total polynomial selection. In this paper, we introduce modification of optimization stage in CADO-NFS. We implemented precomputation table and modified optimization algorithm to reduce redundant calculation for faster optimization. As a result, we select same polynomial as CADO-NFS, with approximately 40% decrease in time.
( Chi-kyeong Kim ),( Eun-ji Choi ),( Heui Man Kim ),( Jin Moo Lee ),( Hyuk Chu ),( Kisoon Kim ),( Joo-yeon Lee ) 대한인수공통전염병학회 2016 창립총회 및 학술대회 초록집 Vol.2016 No.1
Introduction: Since the first detection of the highly pathogenic avian influenza (HPAI) H5N8 virus in 2014 in South Korea, it has been spread into many countries. Although there are no reports on human infection to H5N8 virus, it is not still excluded the potential possibility. There have been studies on the genetic characterization and pathogenesis of H5N8 virus. However, only limited studies have focused on airborne transmission of this virus. To assess the possibility of human infection, we studied the pathogenesis and transmission in ferrets of representative H5N8 viruses isolated in Korea. Methods: Six-month-old female ferrets (donor) were infected by intranasal or intratracheal inoculation with 10<sup>7</sup>TCID<sub>50</sub>/mL of H5N8 viruses (Buan2 or Gochang1). After one day, two serologically naive ferrets were cohoused with the infected ferret for the assessment of virus transmission in direct contact. Also to investigate the transmission via droplets, two naive ferrets were housed in a separate cage designed to allow airflow from the donor to the recipient ferret. Clinical symptoms of the ferrets were monitored each day for period of 14 days. Nasal washes were harvested every other day for two weeks. The viral titer was determined by inoculating the sample to embryonated chicken eggs. Results: We compared the virulence and transmission of Buan2 or Gochang1 virus in ferrets by infection route. While the body weight of the ferret (donor) infected with Buan2 or Gochang1 virus via the nasal cavity decreased slightly, those of the ferrets in direct contact and droplet transmission increased. Ferrets with Buan2 virus via tracheal inoculation showed that body temperature increased over baseline during first 6 days post-infection (dpi) and 18% weight loss. Additionally, clinical symptoms such as snivel and lethargy were observed by 7 dpi. However, the ferrets in direct contact and exposed to respiratory droplets of both viruses infected ferret with no distinct clinical symptoms. Virus was detected in nasal washes of donor ferrets by nasal inoculation but not detected in direct contact or exposed to the respiratory droplets. Conclusions: In this study, we found that HPAI H5N8 viruses were not transmitted via direct contact and airborne route and low pathogenicity in ferrets by intranasal inoculation. These results suggest that H5N8 virus is hardly likely to transmit to mammalian species under natural conditions. However, there still remains a possibility of the emergence of a new virus due to genetic mutation that can pose threat to public health, therefore further studies on virus transmission in ferrets is essential. This study was supported by intramural research fund (2014-NI43002-00 and 4834-303-210) from the Korea Centers for Disease Control and Prevention.