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Study of Ge Surface Passivation using Radical Nitridation Technique for Ge Channel MOS Transistors
Kimihiko Kato,Hiroki Kondo,Mitsuo Sakashita,Wakana Takeuchi,Osamu Nakatsuka,Shigeaki Zaima 한국표면공학회 2010 한국표면공학회 학술발표회 초록집 Vol.2010 No.11
We have investigated the germanium (Ge) surface passivation using radical nitridation technique for future Ge channel metal-oxide-semiconductor field effect transistors (MOSFETs). Stoichiometric Ge-nitride (Ge₃N₄) is formed at a nitride temperature ranging from 50 to 510℃, and the thickness of Ge3N4 tend to saturate with the nitridation time. The minimum value of the leakage current density of Au/Ge₃N₄/Ge metal-insulator-semiconductor (MIS) capacitors is realized at a nitridation temperature of 300℃. In the Pr-oxide/Ge₃N₄/Ge MOS capacitor, the degradation of electrical properties with annealing is effectively suppressed by the introduction of the Ge₃N₄ passivation layer, and we can achieve the small interface state density as low as 4×10¹¹ eV?¹㎝?².
Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations
FUJIMAKI, TETSUO,KATO, KIMIHIKO,OGURI, MITSUTOSHI,YOHIDA, TETSURO,HORIBE, HIDEKI,YOKOI, KIYOSHI,WATANABE, SACHIRO,SATOH, KEI,AOYAGI, YUKITOSHI,TANAKA, MASASHI,YOSHIDA, HIROTO,SHINKAI, SHOJI,NOZAWA, YO Spandidos Publications 2011 Experimental and therapeutic medicine Vol.2 No.4
Yoshiki Yasukoch,Jun Sakuma,Ichiro Takeuchi,Kimihiko Kato,Mitsutoshi Oguri,Tetsuo Fujimaki,Hideki Horibe,Yoshiji Yamada 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Genome-wide association studies have identified various genetic variants associated with complex disorders. However, these studies have commonly been conducted in a cross-sectional manner. Therefore, we performed a longitudinal exome-wide association study (EWAS) in a Japanese cohort. We aimed to identify genetic variants that confer susceptibility to hypertension using ~ 244 000 single-nucleotide variants (SNVs) and physiological data from 6026 Japanese individuals who underwent annual health check-ups for several years. After quality control, the association of hypertension with SNVs was tested using a generalized estimating equation model. Finally, our longitudinal EWAS detected seven hypertension-related SNVs that passed strict criteria. Among these variants, six SNVs were densely located at 12q24.1, and an East Asian-specific motif (haplotype) ‘CAAAA’ comprising five derived alleles was identified. Statistical analyses showed that the prevalence of hypertension in individuals with the East Asian-specific haplotype was significantly lower than that in individuals with the common haplotype ‘TGGGT’. Furthermore, individuals with the East Asian haplotype may be less susceptible to the adverse effects of smoking on hypertension. The longitudinal EWAS for the recessive model showed that a novel SNV, rs11917356 of COL6A5, was significantly associated with systolic blood pressure, and the derived allele at the SNV may have spread throughout East Asia in recent evolutionary time.