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Real-space Imaging of Ferroelectric and Structural Antiphase Domains in Hexagonal YMnO<sub>3</sub>
Keisuke Kobayashi,Hideki Kamo,Kosuke Kurushima,Yoichi Horibe,정상욱,Yoshihiko Togawa,Shigeo Mori 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.7
A high-angle annular-dark-field (HAADF) imaging technique was applied to the investigation of domain wall structures in the ferroelectric phase of hexagonal manganites, YMnO<sub>3</sub>, on an atomic scale. The displacements of the Y<sup>3+</sup> ions along the [001] direction can be clearly visualized. The ferroelectric dipole moments are revealed to be caused by the opposite and unequal displacements of Y<sup>3+</sup> ions. Two types of domain walls should be identified in the ferroelectric domain structures. One is charged longitudinal domain walls with head-to-head or tail-to-tail configurations and the other is non-charged transverse domain walls with head-to-tail configurations. In addition, the ferroelectric and the structural antiphase domains in YMnO<sub>3</sub> change into fragmentary domains because of substitution of Ti<sup>4+</sup> for Mn<sup>3+</sup>, and ferroelectric nanodomains with sizes of 10 - 20 nm are found in the x = 0.30 compound.
Yoshiki Yasukoch,Jun Sakuma,Ichiro Takeuchi,Kimihiko Kato,Mitsutoshi Oguri,Tetsuo Fujimaki,Hideki Horibe,Yoshiji Yamada 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Genome-wide association studies have identified various genetic variants associated with complex disorders. However, these studies have commonly been conducted in a cross-sectional manner. Therefore, we performed a longitudinal exome-wide association study (EWAS) in a Japanese cohort. We aimed to identify genetic variants that confer susceptibility to hypertension using ~ 244 000 single-nucleotide variants (SNVs) and physiological data from 6026 Japanese individuals who underwent annual health check-ups for several years. After quality control, the association of hypertension with SNVs was tested using a generalized estimating equation model. Finally, our longitudinal EWAS detected seven hypertension-related SNVs that passed strict criteria. Among these variants, six SNVs were densely located at 12q24.1, and an East Asian-specific motif (haplotype) ‘CAAAA’ comprising five derived alleles was identified. Statistical analyses showed that the prevalence of hypertension in individuals with the East Asian-specific haplotype was significantly lower than that in individuals with the common haplotype ‘TGGGT’. Furthermore, individuals with the East Asian haplotype may be less susceptible to the adverse effects of smoking on hypertension. The longitudinal EWAS for the recessive model showed that a novel SNV, rs11917356 of COL6A5, was significantly associated with systolic blood pressure, and the derived allele at the SNV may have spread throughout East Asia in recent evolutionary time.
Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations
FUJIMAKI, TETSUO,KATO, KIMIHIKO,OGURI, MITSUTOSHI,YOHIDA, TETSURO,HORIBE, HIDEKI,YOKOI, KIYOSHI,WATANABE, SACHIRO,SATOH, KEI,AOYAGI, YUKITOSHI,TANAKA, MASASHI,YOSHIDA, HIROTO,SHINKAI, SHOJI,NOZAWA, YO Spandidos Publications 2011 Experimental and therapeutic medicine Vol.2 No.4