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      • Characteristics of Consumers' Demand for "Kim Chee" in Hawaii

        Kim, Sung-Hoon 전남대학교 한국농어촌개발연구소 1972 농산어촌개발연구 Vol.6 No.-

        As mentioned earlier. there are five Kim Chee processing plants in the State; two are located on the big island and three on the island of Oahu as of 1968. Among the oldest firm in the industry is "Joe Kim’s" which has been in. busÎness for 25 years. The rest of the firms in the industry were established during the last eighteen years.

      • Characteristics of Consumers' Demand for "Kim Chee" in Hawaii

        Kim, Sung-Hoon 전남대학교 농어촌개발연구소 1972 농어촌개발연구 Vol.6 No.1

        As mentioned earlier. there are five Kim Chee processing plants in the State; two are located on the big island and three on the island of Oahu as of 1968. Among the oldest firm in the industry is "Joe Kim’s" which has been in. busÎness for 25 years. The rest of the firms in the industry were established during the last eighteen years.

      • Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

        ( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

        Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

      • SCOPUS
      • KCI등재후보

        Effect of Developmental Lead Exposure on the Expression of Hippocampal NMDA Receptor Subunit mRNA

        Kim, Tae-Wan,Chung, In-Sung,Bae, Jae-Hoon,Shin, Dong-Hoon,Lee, Mi-Young,Kim, Joon-Sik 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

        목적: in vivo 및 vitro에서 해마 신경세포의 발생단계별 NMDA 수용체 아단위 mRNA 발현에 대한 연 폭로 영향을 알아보고자 하였다. 방법: 흰쥐 해마 신경세포의 발생단계별 NMDA 수용체 NR2A, NR2B 아단위 mRNA 발현에 대한 연의 영향은 정상군과 연 폭로군의 출생 후 7일, 14일, 22일 흰쥐의 해마에서 in situ hybridization으로 mRNA 발현 정도를 densitometer로 측정하여 비교하였고, 연과 NMDA 의 세포독성은 해마 신경세포 일차배양 후 도립현미경을 이용한 형태학적인 관찰과 LDH 활성도를 이용하여 측정하였다. 결과: 연 과 NMDA 에 의한 세포독성에 대한 in vitro 실험에서 형태학적 소견과 LDH 활성도에서 해마 미성숙 신경세포와 성숙 신경세포사이의 차이가 있었으므로, 연과 NMDA 독성효과는 해마 신경세포의 발달 단계에 따라 차이가 있다. 정상군의 해마에서의 NR2A mRNA 발현은 출생 후 연령이 증가함에 따라 점진적으로 증가하였으나, NR2B mRNA 발현은 출생 후 연령이 증가함에 따라 점진적으로 증가하였으나 NR2B mRNA 발현은 연령의 증가에 따른 변화가 없었다. 연 폭로에 희한 NR2A mRNA 발현은 유의하게 감소하였으나(p<0.05), NR2B mRNA 발현은 변화가 나타나지 않았다. 만성적 연 폭로는 NR2A를 포함하는 NMDA 수용체를 감소시킬 수 있음을 알 수 있다. 결론: 연은 해마신경세포의 발생단계에서 NMDA 수용체 아단위 특히 NR2A mRNA 발현의 변화를 야기하여 시냅스 신호 전달에 영향을 나타냄을 알 수 있었다. Hippocampus

      • KCI등재

        Quantitative comparison of mRNA expression of glucosyltransferase(GTF) between xylitol-resistant(X^(R)) and xylitol-sensitive(X^(s)) mutans streptococci

        Kim, Chong-Chul,Lee, Mi-Na,Kim, Young-Jae,Lee, Sung-Hoon 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.1

        Since the long-term exposure of mutans streptococci to xylitol is known to select for xylitol-resistant(X^(R)) natural mutants, the occurrence and survival of such X^(R) strains were performed in batch culture methods. The aim of the study was to compare the differentiation and quantification of mRNA expression of the gtf genes of X^(R) and X^(S) mutans streptococci. Using a real-time reverse-transcription polymerase chain reaction, the expression of each gtf was determined. In X^(R) strains, the relative levels of transcription of gtfB and gtfC were decreased while that of gtfD was increased, suggesting the presence of independent promoters. It also suggested that mutation related to production of glucosyltransferase occurred under the exposure of xylitol could explain the caries-preventive mechanisms of xylitol. 자일리톨에 장기간 노출된 mutans streptococci는 자일리톨에 내성이 발현되어 자일리톨 내성균주가 생성된다고 알려져 있다. 본 연구의 목적은 mutans streptococci에서 자일리톨 내성균주와 감성균주의 gtf 유전자 발현량을 각각의 유전자별로 정량적으로 분석하고 비교하는 것이다. 실시간 역전사 중합효소연쇄반응법을 이용하여 각각의 gtf 발현을 조사한 결과 gtfD는 증가한 반면. gtfB와 gtfC는 감소하였는데 이는 각 유전자의 독립된 조절기전이 존재함을 보여주는 것이다. 또한 자일리톨에 노출된 mutans streptococci에서의 glucosyltransferase와 연관된 유전자변형이 자일리톨의 치아우식증 예방효과의 작용기전 중 하나임을 알 수 있었다.

      • SCIEKCI등재

        Disruption of rsmA Gene of Pectobacterium carotovorum subsp. carotovorum LY34 and Effect on Pathogenicity

        Kim, Min Keun,Kang, Tae Ho,Kim, Sung Kyum,Jeong, Yu Seok,Yun, Han Dae,Kim, Hoon The Korean Society for Applied Biological Chemistr 2012 Applied Biological Chemistry (Appl Biol Chem) Vol.55 No.6

        The rsmA gene was cloned from soft-rot bacterium Pectobacterium carotovorum subsp. carotovorum LY34 (Pcc LY34), and its role in pathogenicity was investigated by marker exchange mutagenesis. From a cosmid library of Pcc LY34 genomic DNA, a positive clone carrying the rsmA gene was selected, and the gene was cloned by polymerase chain reaction (PCR) amplification. The gene is 186 bp in size and encodes a protein of 62 amino acids with a predicted molecular mass of 6,839 Da. The calculated pI of the RsmA is 8.16. The phylogenetic tree showed that the RsmA of Pcc LY34 appeared genetically identical to the CsrA of Pectobacterium atrosepticum SCRI1043 (100% identity) and similar to the CsrA of Yersinia pestis KIM10+(98.3%). The gene was disrupted by the $Km^r$ gene, and the cells became mutated (i.e., $RsmA^-$ mutant). The pathogenicity test revealed that the disease rating of the $RsmA^-$ mutant only differed slightly from that of the wild type on a slice of potato tuber and a Chinese cabbage stalk. These results suggest that RsmA is not an essential factor for the pathogenicity of Pcc LY34 and that the rsmA gene of Pcc LY34 is not completely derepressed in the $RsmA^-$ mutant for virulence-related genes, contrary to the results of Erwinia carotovora subsp. carotovora $RsmA^-$ mutant, which proved hypervirulent for celery petioles. These results showed that the microenvironmental conditions of the host and/or strain of pathogen are important for the coordination of virulence gene expression.

      • KCI등재

        원문 : 야외운동기구를 이용한 운동프로그램이 노인들의 활동체력, 대사증후군 위험인자 및 염증인자에 미치는 영향

        양상훈 ( Sang Hoon Yang ),김종식 ( Jong Shik Kim ) 한국운동생리학회(구 한국운동과학회) 2014 운동과학 Vol.23 No.3

        양상훈, 김종식. 야외운동기구를 이용한 운동프로그램이 노인들의 활동체력, 대사증후군 위험인자 및 염증인자에 미치는 영향. 운동과학, 제23권 제3호, 229-240, 2014. 본 연구는 여성노인 65세 이상 16명을 대상으로 8주간의 야외운동기구를 이용한 운동프로그램 참여가 활동체력, 대사증후군 위험인자 및 염증인자에 미치는 영향을 규명하였다. 활동체력의 경우 악력은 유의한 차이가 없었으나 하지근력과 유연성은 운동 후 유의하게 증가한 것으로 나타났다. 대사증후군 위험인자의 경우 HDL-C는 운동 후 유의하게 증가하는 것으로 나타났으며, glucose는 유의하게 감소하는 것으로 나타났다. 허리둘레, 수축기 혈압, 이완기 혈압, TG는 유의한 차이가 없었다. 염증인자의 경우 CRP, TNF-α 모두 운동 후 감소하는 것으로 나타났으나 유의한 차이는 없었다. 결론적으로 야외운동기구 운동프로그램은 하지근력, 유연성 강화와 HDL-C 증가, glucose 감소의 연구결과를 보았을 때 더 다양한 야외운동기구를 이용한 운동프로그램을 개발하고 지속적으로 운동의 효율을 높여간다면 노화를 지연시킬 뿐만 아니라 각종 질병을 방지하고 건강을 유지시키는 효과를 기대할 수 있을 것으로 사료된다. Yang, Sang-Hoon, Kim, Jong-Shik. The Effects of Exercise Program Outdoor Exercise Equipment on Activity Fitness, Metabolic Syndrome Risk Factors and Inflammatory Factors in the Elderly. Exercise Science, 23(3): 229-240. 2014. This study is for observing the influence of exercising in outdoor exercise facilities for 8 weeks on activity fitness, risk factors of insulin resistance syndrome and inflammatory factors in 16 females who are aged 65 years or older. The major results on this analysis are as follows: In parameters for activity fitness, there was no significant difference in grasping power but a significant increase in strength of lower limb muscles and flexibility after exercise. For risk factors of insul in resistance syndrome, there was a significant increase in HDL-C after exercise with a significant decrease in gl ucose. There was no significant difference in waist l ine, systol ic bl ood pressure, diastol ic bl ood pressure and TG. For inflammatory factors, there was a decrease in CRP and TNF-α after exercise with no significance. In conclusion, the results showing positive effects on physical fitness of lower limb muscles and physiological markers including HDL-C and glucose indicates that elderly women exercising in outdoor exercise facilities may have benefits of antiaging effect, prevent various diseases and stay healthy if efficiency of exercise using outdoor exercise facilities is continually improved in a variety of training programs.

      • KCI등재

        신약 헬라어 본문 분석 방식의 새로운 연구

        김상훈(Sang Hoon Kim) 한국복음주의신약학회 2007 신약연구 Vol.6 No.1

        The New Testament Greek is often a compulsory pre-requisite course in theological seminary education. Although it becomes heavy burden to most students who take the course, spending much time to learn to read the NT in Greek, most of them fail to maintain their Greek after graduation. I think we need to advance some useful tool for Greek study, particularly from the pedagogical point of view, such as a syntactic-semantic arranged method contributed by Johannes Louw, Douglas Stuart, Walter Kaiser, Gordon Fee, William Mounce, and others. These sorts of methods differ from the traditional way of interpretation, the grammatical-historical method, in terms of how to approach the text. The texts arranged for the purpose of visualization, letting the reader to see the text with much clarity in terms of grammatical function of each phrase and their connections between them. The visualized arrangement itself is applied from the area of syntax and semantics in modern linguistics. There are various types of syntactic arrangements of the Greek text. Each pattern has its own principles and rules to be arranged in certain ways. I have compared, in this paper, those models of syntactic arrangements to my model, the Kim's diagram. For the purposes of this paper, I have posed several questions to my students in my classes, regarding their experiences on the syntactic-analytic arrangement of the Greek Bible (SAGB) and their practical uses of both the method and its materials, analyzing their questions in order to show up how much this type of study to be needed for the student

      • KCI등재

        Prediction of Retained Austenite Fraction in Quenching-and-Partitioning (Q&P) Steels Using the Gibbs Energy Balance Approach

        Seong Hoon Kim,Ji Hoon Kim,Jae Hoon Lee,Dong‑Woo Suh,Jae Sang Lee 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.9

        Prediction of retained austenite fraction is quite important in designing advanced high strength steels since retained austeniteis the source of transformation-induced plasticity. The present study investigates the phase constitution of a medium-carbonQ&P steel by comparing various approaches to the transformation stasis of bainitic ferrite and applying them to the partitioningprocess. Among them, the modified GEB approach gave the best agreement with the experimental observation, includingthe effects of heat-treatment condition and chemical composition on phase constitution. This indicates phase transformationduring partitioning can be effectively described by the physics of Gibbs energy balance approach.

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