백혈병환자에서 Liposomal Amphotericin B로 치료된 파종성 Fusarium 감염 1예

이지연,김성범,박대원,신성희,김용현,윤소영,엄중식,최철원,정희진,김우주,김준석,김장수,이갑노 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

Fusarium spp.는 사람에서 드물게 각막염, 조갑진균증, 상처나 화상부위감염 등을 유발하는 것으로 알려져 있으나 최근에는 면역저하자에서 기회감염의 원인균으로 증가하고 있는 추세이다. 면역저하자에서 파종성 감염이 있는 경우에 예후는 치명적이나, 증례가 많지 않고 진단방법이 제한되어 있어 조기 진단과 신속한 치료가 쉽지 않다. 그러나 특징적으로 피부병변의 동반이 흔하여 면역저하자에서는 피부 병변의 면밀한 관찰과 함께 Fusarium 감염을 조기에 의심하여 피부생검이나 배양을 하는 것이 진단에 도움이 되리라 생각된다. 파종성 Fusarium 감염의 치료로는 감염 부위의 국소적 외과적 절제와 전신적 항진균제의 사용이 필요하고 현재까지는 amphotericin B가 비교적 효율적인 항진균제로 알려져 있으나 면역저하자에서 이에 반응을 하지 않는 경우가 많다. 저자들은 급성골수성백혈병 환자에서 관해유도화학요법 시행 후 호중구감소상태에서 피부병변과 폐침윤이 발견되었고 피부의 중심부 궤양을 동반한 구진성 병변에서 배양검사를 통해 파종성 Fusarium 감염을 진단하였으며 liposomal amphotericin B (AmBisome )를 사용하여 성공적으로 치료한 예를 경험하여 보고하는 바이다. Fusarium spp., basically a superficial pathogen, is a newly emerging fungal pathogen of opportunistic infections in immunocompromised patients. At present, although Fusarium spp. are relatively resistant to amphotericin B, the combination of amphotericin B and surgical debridement appear to be optimal treatment for disseminated infection. Recently we experienced a 32-year-old neutropenic patient after induction chemotherapy for acute myelocytic leukemia presented with skin lesions and infiltrations in both lungs. We diagnosed with disseminated fusariosis by skin culture and successfully treated the patient with liposomal amphotericin B. We emphasize a high index of suspicion for skin lesions especially in immunocopromised patients.

통행시간절약가치 추정을 위한 QR 모형에 관한 연구 : 자가 운전자의 선호의식을 고려하여

김갑수,권대우 영남대학교 환경문제연구소 2000 環境硏究 Vol.20 No.1

통행시간절약가치는 교통계획, 교통정책 및 교통투자사업의 사업타당성 검토시 필수요소이다. 시간절약이란 것이 실제 거래되지 않는 것이므로, 행동데이타와 의식데이타를 이용하여 시간의 행동가치를 측정하기 위한 간접적인 다양한 계측방법이 사용되어 왔다. 그러나 대개 실용적 이유로 비집계 로짓형 모형을 많이 사용하여 왔으나, 선택지들이 상호 독립적이라는 모형의 가정은 종종 한정적인 경우가 많다. 본 연구는 실험적인 연구로서, 자가용승용차 이용자의 유료도로 동행에 대한 선호의식을 이용하여, 그들의 통행시간절약가치를 추정하기 위해 로짓모형을 포함한 3가지 QR 모형을 구축하였으며, 그 결과물을 이용하여 최적 모형을 구하기 위해 모형간을 비교 분석 하였다. 분석 결과 세 모형 모두가 양호한 적합도를 보였으며, 통행시간절약가치는 약 2,400원/시간/대로 나타났다. 또한 통행단축시간보다 통행요금에 대한 탄력성이 큰 것으로 나타났다. 모형간의 비교분석결과는 적중률을 제외한 잔차제곱합, 추정확출잔차제곱합, 로그우도함수 값 등에 있어서 로짓 모형이 다소 우위를 차지하는 것으로 나타났으나, 전체적으로 차이가 있다고 보기는 어려운 것으로 나타났다. The purpose of this study is to establish three QR (Qualitative Response) models for evaluating vague of travel time saving and to find out best model by comparing these models using outcomes of model formulation. The results of this study is as follows. First, value of travel time saving is about 2,400 won/hour in all three models. Second, the three models show that the goodness-of-fit is satisfactory. Third, the results of comparing models show that logit model is best in SSR (Sum of Squared Residuals), SSR weighted by estimated probabilities and value of log likelihood function without hit ratio, but the difference between each models is very small.

K형 강관접합부의 편심접합에 관한 실험적 연구

김갑순,신의균,김우범,정수영 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.1

A finite element analysis and experimental study were performed to investigate the behavior and strength of a connection of tubular steel member considering slenderness ratio and eccentricity. Primary interest here are ultimate strength of connections having eccentricity. In comparison with the current design standard according to which the gravity axes of the main and branch pipes coincide with each other, the inner eccentric joint where the gravity axes of the branch pipes are shifted to the gusset plate side can reduce the gusset plate size. However, in the eccentric joint where the gravity axes do not coincide, the bending moment that acts on the main pipe due to eccentricity causes a problem. As a result, in cases where the slenderness ratio is 40 or less, the buckling strength of the inner eccentric joint was similar to that of a joint without eccentricity. Therefore the possibility of use of inner eccentricity connection to reduce the gusset plate size has been verified.

K형 강관접합부의 보강효과에 관한 실험적 연구

김갑순,한병찬,성수용,김우범,정수영 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.2

In current design, the strength formula for a Gusset-Tube connections stiffened with rib-plate is proposed only in the limited case because of its complexity of the behavior. So in this study, experimental study and finite element analysis were performed to investigate the behavior and strength of a Gusset-Tube connections stiffened with rib-plate. Because of limitations in loading capacity, the specimens were fabricated with 1/3 scale of full size. Tensile coupon tests and stub column tests were also carried out. Of primary interest here are the stiffened effect of Gusset-Tube connections considering lateral force ratio, gusset plate length, eccentricity, stiffened length. Consequently, we intend to obtain accumulated database to propose practical strength equation and suggest rational reinforcing method of Gusset-tube connection.

일반화시간을 이용한 대중교통 서비스 평가에 관한 연구

김갑수,권대우 영남대학교 공업기술연구소 2000 工業技術硏究所論文集 Vol.28 No.2

This paper suggested generalized time model and method for service evaluation of public transportation using it. Generalized time model was established using equivalent time coefficient and VOT. The results of this study are as follows: 1) In scoring of service, generally bus satisfactory degree is lower than subway's. In case of bus, satisfactory degree of access time is the biggest and travel time, wait time, fare in order. In case of subway, satisfactory degree of travel time is the biggest and fare, access time in order. 2) In order to know a burden of each travel mode, equivalent time coefficient was estimated as following. Single transfer 16.19, walk 2.61, wait 1.87, parking 1.75, subway 0.76, car 0.66. Therefore it is found that single transfer is 16 times than bus and subway and car are lower than bus. It was appeared that these have theoretical and practical propriety in view of each personal characteristics. But, it is need to consider parking and car equivalent time coefficient of under 19 age. 3) It was appeared that estimated value of time is reasonable and the result is 17.27(\/min). Generally there was a large deviation according to personal characteristics, specially driver licence and car being or not. 4) Evaluation of current service, desired service, satisfactory service and dissatisfactory service in case study district is done using generalized time model which was established using equivalent time coefficient and value of time. Availability of generalized time model would be shown to compare and evaluate service between different modes, bus routes or areas with different service, service after improvement and before improvement. Also in the future, generalized time may be used to establish another service evaluation model of public transportation. It is needed to study wait time for subway and to consider trip purpose in establishing equivalent time coefficient and value of time.

옥수수(Zea mays L.)根毛細胞의 電子顯微鏡的 硏究

金宇甲,金恩洙 순천향대학교 1982 논문집 Vol.5 No.2

옥수수 근모세포를 전자 현미경으로 관찰하여 아래와 같은 결과를 얻었다. 1. 핵은 세포의 기부에 존재하고 인이 매우 발달하였다. 2. 세포질에는 미토콘드리아, 활면소포체, 조면 소포체, 리보소옴, microbody들이 주로 나타났으며 색소체와 dictyosome은 관찰하지 못하였다. 3. 액포는 많이 관찰되었는데 이는 원형질막이 세포질안으로 부분 함입이 일어나서 다소포상구조를 이루는 plasmalemmasome과 세포질의 막계인 소포에서 유래되어지는 것으로 보이는 다층막성구조인 lomasome등에 의하여 형성된다고 믿어진다. 4. acid phosphatase 활성은 나타나지 않았으나 ruthenium red처리에 있어서는 세포벽에 활성이 나타났다. 특히 세포벽 외연부에 그 활성이 강한 바 이는 mucilage의 존재를 암시한다. Corn root hairs were examined by electron microscopy. Quite frequently cytoplasmic structures such as a mitochondrion, endoplasmic reticulum and ribosomes have been observed in these cells. Mitochondria having cristae were oval or oblong in forms. Ribosomes were present freely, but most of them forming polysomes. R-ER were relatively abundant in the central region of the cells and same of them formed pear shaped feature. Microbodies bounded by limiting membrane were about 1.5∼6.5m in diameter. Various vacuoles and vesicles were also founded in these cells. 1t is considered that invaginations of the plasma membrane may continue to increase in size and typically expanded into the central region, ultimately forming a large vacuole. During the vacuolation, it seemed that multivesicular or multilamellar structures gradually differentiated and fused with each other. Although acid phosphatase activity didn't occur in these cells, the reaction of ruthenium red appeared on the outer surface of the cell wall, suggesting that mucilage exist in that region.

野生鳥獸의 分布와 捿息密度 및 食性에 關한 硏究 -第2報-

金甲德,禹漢貞,金泰旭 서울大學校 農科大學 1980 서울대농학연구지 Vol.5 No.1

1. Birds and Mammals census by line transect (Roadside census) and food plants for birds (plants birds like the most) was made at Mt. Baek Woon, No.4 No.5 No.6 and at Mt. Chi Ak, during 18 April 1978 to 11 February 1979. 2. The number per hour and percent dominance (for the total of all species) were calculated as indices for relative abundance of each species, (Table: 4,5,6,7). 3. Distance (per Km), width (per ha.), time (per hour) and relative abundance for each species in four census areas were observed. 4. 49 species of bird recorded, Great Tit, Parus major, Brandt's Jay, Garrulus glandarius, Crow Tit, Paradoxornis webbiana, Meadow Bunting, Emberiza cioides(resident) and Naumann's Thrush, Turdus naumanni, Brambling, Fringilla montifringilla, Rustic Bunting, Emberiza rustica(winter bird) were recorded as dominant species Mt.Baek Woon. Great Tit, Parus major, Blue Magpie, Cyanopica cyane, and Crow Tit, Paradoxornis webbiana were recorded as dominant species at Mt. ChiAK. 5. Blue Magpie, Cyanopica cyane is breeding at Mt. ChiAK but at Mt. Baek Woon it was not yet observed. 6. Korean Magpie, Pica pica is no distributed four census areas. 7. Mammalian fauna in four census area is relatively low and Korean Red Fox, Vulpes vulpes Chinese Wolf, Canis lupus and Siberian Leopard, Panthera pardus had exterminated since Korean War Table: 3) 8. A few number of Korean Flying Squirrel, Petaurista leucogenys hintoni is breeding at Mt. ChiAK.

選好多樣性을 考慮한 버스 서비스 評價模型에 關한 硏究

김갑수,권대우,김상황 嶺南大學校 工業技術硏究所 2004 工業技術硏究所論文集 Vol.32 No.2

In order to overcome the weakness of previous studies an the average-based customer satisfaction, bus service evaluation technique was proposed in this study. A perceived service(i.e. perception of service quality, mobility, transfer and economy) and stated preference survey were conducted to investigate passenger’ consciousness toward bus service. The analysis results from study are as follows; The likelihood ratio of evaluation model for bus service established in mixed multinomial logit model is 0.259 and the hit ratio is 62.1 %. It was found that the ratio is far better than the model established by multinomial logit model. Standard deviations of some variables like accessing time, travel time, comfort of driving, information sign, 1ow floor bus and standing-bus have significant level of 5 %, which indicates the reflection of user' heterogeneity.

Paraquat 중독환자의 초기검사로서 sodium dithionite를 이용한 소변내 paraquat검출의 임상적 의의

윤갑준,임경수,이진웅,김영식,이부수,박덕우,김선만,이강현,황성오,안무업 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

Background : Mortality from paraquat intoxication depends upon plasma paraquat concentration. To know the severity of paraquat intoxication is important for directing therapeutic modality and predicting prognosis. Sodium dithionite test for urinary paraquat provides an easy and simple method to determine the severity of paraquat intoxication in emergency department. purpose : To determine whether the result urinary paraquat test by sodium dithionite can predict outcome in patients with paraquat intoxication in emergency department. Subjects : 48 patients(male 31, female 17, mean age 37 years) who had exposure to paraquat and presented within 24 hours after exposure. Result : Thirty five patients were positive in paraquat urine test and thirteen patients were negative. Clinical manifestations were more severe in positive patients than in negatives. Complication was much more in positives than in negatives. 28 of 35 patients(80%) in positives and 2 of 13 patients(15%) in negatives died. Conclusion : Positive test for urinary paraquat is associated with high mortality and morbidity from paraquat intoxication, and qualitative test for urinary paraquat by sodium dithionite is an useful method to determine the severity of paraquat intoxication in emergency department.

아파트 團地內 騷音特性과 住民意識

李澤九,金甲洙,成相雨 嶺南大學校 環境問題硏究所 1994 環境硏究 Vol.13 No.2

幹線 道路邊 住宅團地 內에 道路交通騷音의 水平傳播 特性은 道路邊 1列棟과 2列棟 사이에 9dB(A) 程度의 騷音 減衰가 있으며 鉛直傳播 特性은 一般的으로 1層에 1dB(A) 程度의 騷音增加 現象이 있으므로 아파트 團地 建設時 騷音이 問題化될 所持가 있는 團地에 있어서는 아파트 棟의 配置를 考慮해야 한다. 그리고 騷音과 住民意識 關係에서 心理的, 精神的, 身體的 影響은 各 要因別로 10∼40% 程度를 나타내고 있으며, 騷音의 被害程度는 電話걸 때, TV 聽取時, 讀書, 思索, 睡眠 등의 影響은 住民의 20∼50% 程度가 被害意識을 나타내고 있으며 騷音의 影響은 定住意識이나 住居年數에도 큰 關係가 있음을 알 수가 있었다. 따라서 아파트 團地 內의 騷音問題는 深刻함을 알 수 있고 그의 對策 마련이 時急한 實情이다. This stucy is to grasp the noise condition of Apartment development, to analyze the characteristics about horizontal and vertical propagation of noise, and to grip dweller's sense about noise. The major results of this paper may be summarized as follows; 1) Reduction in 7dB at roadside and first row, 16dB at second row and 20dB at third row was appeared in the noise's horizontal propagation in Apartment development. 2) The propagation's characteristics of noise by the number of floors in same Apartment dong was increased about 1dB(A) by each floor. 3) In the relation between noise and dweller's conscious, an intention of settlement is a factor of noise also, the degree of noise is apparently appeared by the number of floors and the influence of dwelling history is appeared very much. 4) Constructing Apartment development, the arrangement of Apartment dong obtaining sound insulation is considered in Apartment development which is going into question of noise.