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김영숙,김애정,김선여,김순경 순천향대학교 기초과학연구소 1999 순천향자연과학연구 논문집 Vol.5 No.1
This study was conducted to investigate the effect of mulberry leaves on lipid metabolism in adult females. The subjects(n=13) intake 1.8g mulberry leaves powdered per day with the common diet. To conduct this study, anthropometric measurements, daily nutrients intake, and serum lipids(total-cholesterol, HDL-cholesterol, triglycerides, LDL-cholesterol) were measured 3 times(before, after 2week and 4week during the experimental periods). The results are as follows: Serum LDL-cholesterol contents were significantly(P<0.05) decreased with treatment of mulberry leaves powder. And serum total-cholesterol and triglycerides were decreased, but did not show significant differences.
한방 다이어트 식품 HBM(Healthy Body Maker)의 체중감소 및 혈청 콜레스테롤 저하 효과
박재상,김애정,김선여 동아시아식생활학회 2001 동아시아식생활학회지 Vol.11 No.4
This study was performed to investigate the effects of HBM(Healthy Body Maker) on the weight loss and serum cholesterol level of rats. Twenty male Sprague-Dawley rats weighing 200±5g were grouped into 2. Rats were raised for 6 weeks with diet containing 0% and 5% of HBM. 1. There were no clinical signs for all the experimental period(6 weeks) in 0% and 5% groups. 2. At 3 and 6 weeks, body weight of 5% HBM group was significantly lower than that of control group. respectively (p<0.05, p<0.01). 3. At 4 weeks, the level of MCHC of 5% HBM group was significantly higher than that of control group(p<0.01). And at 6 weeks the level of RBC and Hct of 5% HBM group were significantly higher than those of control group(p<0.05). 4. At 6 weeks, the level of serum cholesterol of 5% HBM group was significantly lower than that of control group. 5. Absolute liver weight of 5% HBM group was significantly lower than that of control group(p<0.05). 6. Minor subaceous sickness of liver cell in the control group appeared but no symptom of liver cell in 5% HBM group, It is concluded that HBM was a safe and effective diet food which aided in inducing weight loss in rat without any observed harmful clinical side effects.
황금(黃芩)의 4-VO로 유발한 흰쥐뇌허혈에 대한 신경방어효과
李秉哲,林康鉉,金榮玉,金善礪,安德均,朴虎君,金護哲 대한본초학회 1999 大韓本草學會誌 Vol.14 No.2
Scutellariae Radix(SR), the root of Scutellaria baicalensis G_EORGI, whose property, flavour and channel tropism is bitter in flavour, cold in property(寒), acting on the lung, gallbladder, stomach and large intestine channels(歸?,?,?,大??), has the effects of clearing away heat and dampness(淸熱??), purging fire, detoxicating(?火解?), stopping bleeding(止血) and preventing miscarriage(安?). This drug is one of the popular drugs in traditional Korean medicine, which has been used to antipyretic, antibacterial, antitoxic and antihypersensitive effects. So this study was planned to check the neuroprotective effect of SR on the global ischemia induced by 4-vessel occlusion in Wister rats. and SR extract was lyophilized after extraction with 70% methanol. We induced 4-vessel occlusion for 10 minutes and reperfused again. The number of CA1 pyramidal neurons were counted after 7 days of reperfusion under the cresyl violet staining. The result obtained that in 4-VO ischemia, SR showed significantly neuroprotective effects(1,000 and 500 ㎎/㎏ of SR extracts, p<0.05) compared with control group. Each neuroprotective ratio was about 27.4 %, 23.2 % respectively. Consequently, Scutellariae Radix has neuroprotective effects on the global ischemia induced by 4-vessel occlusion in Wistar rats.
Phenolic Glycosides from the Twigs of <i>Salix glandulosa</i>
Kim, Chung Sub,Kwon, Oh Wook,Kim, Sun Yeou,Choi, Sang Un,Kim, Jae Yoon,Han, Ji Young,Choi, Soo Im,Choi, Jong Gil,Kim, Ki Hyun,Lee, Kang Ro American Chemical Society and American Society of 2014 Journal of natural products Vol.77 No.8
<P>As a part of an ongoing search for bioactive constituents from Korean medicinal plants, the phytochemical investigations of the twigs of <I>Salix glandulosa</I> afforded 12 new phenolic glycosides (<B>1</B>–<B>12</B>) and a known analogue (<B>13</B>). The structures of <B>1</B>–<B>13</B> were characterized by a combination of NMR methods (<SUP>1</SUP>H and <SUP>13</SUP>C NMR, <SUP>1</SUP>H–<SUP>1</SUP>H COSY, HMQC, and HMBC), chemical hydrolysis, and GC/MS. The absolute configuration of <B>13</B> [(1<I>R</I>,2<I>S</I>)-2-hydroxycyclohexyl-2′-<I>O</I>-<I>trans</I>-<I>p</I>-coumaroyl-β-<SMALL>d</SMALL>-glucopyranoside] was determined for the first time. Compounds <B>1</B>–<B>3</B>, <B>6</B>, and <B>7</B> exhibited inhibitory effects on nitric oxide production in lipopolysaccharide-activated murine microglial cells (IC<SUB>50</SUB> values in the range 6.6–20.5 μM).</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2014/jnprdf.2014.77.issue-8/np500488v/production/images/medium/np-2014-00488v_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np500488v'>ACS Electronic Supporting Info</A></P>
석창포 (石菖蒲) 의 4 - VO 로 유발한 흰쥐뇌허혈의 신경방어효과
金榮玉,金瑩洙,林康鉉,石庚浩,金善礪,朴珠暎,安德均,金頀哲 대한본초학회 2000 大韓本草學會誌 Vol.15 No.2
Acori Graminei Rhizoma(AR, 右??), the rhizome of Acorus gramineus Soland, whose property, flavour and channel tropism is pungent in flavour(辛), warm in property(溫), acting on the heart and stomach channels(歸心??), has the effects of inducing resuscitation, tranquilizing the mind(開?安神), resolving dampness, and regulating the functions of the stomach(化?和?). This drug is one of the popular drugs in traditional Korean medicine, which has been used to treat loss of consciousness and confusion of the mind(神志?亂) due to mental disturbance by pathogenic dampness in the course of febrile diseases, and palpitation(心?), insomina(失眼), amnesia(?忘) and tinnitus(耳?) due to isufficiency of the herat-qi. So, this study was planned to check the neuroprotective effect of AR on the global ischemia induced by 4-vessel occlusion in Wistar rats. AR extract was lyophilized after extraction with 70% methanol. We induced 4-vessel occlusion for 10 minutes and reperfused again. The number of CA1 pyramidal neurons were counted after 7 days of reperfusion under the cresyl violet staining. The results obtained that in 4-VO ischemia, AR showed significantly neuroprotective effects(1,000 and 500 ㎎/㎏ of AR extracts, p<0.05) compared with control group. Each neuroprotective ratio was about 16.8%, 13.8% respectively. Consequently, Acori Graminei Rhizoma has neuroprotective effects on the global ischemia induced by 4-vessel occlusion in Wistar rats.
Antioxidative flavonoids from the Leaves of Morus alba
Kim, Sun-Yeou,Gao, Jian Jun,Lee, Won-Chu,Ryu, Kang-Sun,Lee, Kang-Ro,Kim, Young-Choong The Pharmaceutical Society of Korea 1999 Archives of Pharmacal Research Vol.22 No.1
Nine flavonoids (1-9) were isolated from the leaves of Morus alba (Moraceae). The structures of compounds were determined to be kaempferol-3-O-$\beta$-glucopyranoisde (astragalin, 1) kaempferol-3-O-(6"-O-acetyl)-$\beta$-D-glucopyranoside (2), quercetin-3-O-(6"-O-acetyl)-$\beta$-D-glucopyranoside (3), quercetin-3-O-$\beta$-D-glucopyranoside (4), kaempferol-3-O-$\alpha$-L-rhamnopyranosyl-(1 6)-$\beta$-D-glucopyranoside (5), quercetin-3-O-$\alpha$-L-rhamnopyranosyl-(1 6)-$\beta$-D-glucopyranoside (rutin, 6), quercetin-3-O-$\beta$-D-glucopyranosyl-(1 6)-$\beta$-D-glucopyranoside (7), quercetin-3,7-di-O-$\beta$-D-glucopyranoside (8) and quercetin (9) on th basis of spectroscopic and chemical studies. Compounds 7 and 9 exhibited significant radical scavenging effect on 1,1-diphenyl-2-picryl-hydrazyl radical.
Antineuroinflammatory constituents from the root extract of <i>Paris verticillata</i>
Kim, Ki Hyun,Lee, Kyu Ha,Kim, Ho Kyung,Moon, Eunjung,Kim, Sung-Hoon,Kim, Sun Yeou,Kim, Kyung Ran,Lee, Kang Ro Canadian Science Publishing 2011 Canadian journal of chemistry Vol.89 No.4
<P> Two new cyclopropanoic fatty acid glycosides, named parisveroside A (1) and parisveroside B (2), were isolated from a MeOH extract of the roots of Paris verticillata (Liliaceae) together with three other known compounds, salicin (3), 3-(β-d-glucopyranosyloxymethyl)-2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-(2R,3S)-dihydrobenzofuran (4), and allantoin (5). Their structures were elucidated on the basis of spectroscopic data, including 1D and 2D NMR, HR-FAB-MS, and chemical evidence. To investigate the antineuroinflammatory effects of the isolated compounds (1-5), nitric oxide (NO) production was evaluated in the lipopolysaccharide-activated microglia cell line, BV-2. Compounds 2 and 4 significantly inhibited NO production with IC50 values of 74.8 and 60.5 µmol/L, respectively. </P>