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Kim, Myung-Sunny,Kim, Soon-Hee,Park, Su-Jin,Sung, Mi Jung,Park, Jaeho,Hwang, Jin-Taek,Yang, Hye Jeong,Kim, Sunmi,Seo, Daebang,Shin, Song Seok,Hur, Haeng Jeon Elsevier 2017 Journal of Functional Foods Vol.35 No.-
<P><B>Abstract</B></P> <P>This study investigated the effect and the underlying mechanism of ginseng berry (GB) in a mouse model of type 2 diabetes, supplied with 0.05% or 0.1% dietary GB for 12weeks. GB significantly improved hyperglycemia and insulin resistance, as demonstrated by the blood glucose and insulin levels, HOMA-IR, and GTT. Moreover, the expression of gluconeogenic genes such as PEPCK and G6Pase and the hepatic metabolites involved in the pathway of gluconeogenesis, such as glucose-6-phosphate and dihydroxyacetone phosphate, were significantly reduced by GB. Hepatic steatosis was also significantly ameliorated; TG content and expression of lipogenic enzymes and transcriptional factors such as FAS, ACC, and SREBP1 were reduced by GB. Simultaneously, AMPK phosphorylation was increased both in fatty liver and in lipid-accumulated HepG2 cells by GB. In conclusion, GB improved hyperglycemia by downregulating hepatic glucose production and hepatic steatosis, and AMPK appeared to be an important regulator of these effects.</P> <P><B>Highlights</B></P> <P> <UL> <LI> GB significantly improves obesity-induced hyperglycemia and insulin resistance. </LI> <LI> Anti-diabetic effects of ginseng berry is mediated by downregulating hepatic glucose production and hepatic steatosis. </LI> <LI> AMPK may be an important contributing regulator in the GB-mediated suppression of hepatic glucose production. </LI> </UL> </P>
Effects of Kimchi on human health : A protocol of systematic review of controlled clinical trials
Kim, Myung-Sunny,Yang, Hye Jeong,Kim, Soon-Hee,Lee, Hye Won,Lee, Myeong Soo Williams & Wilkins Co 2018 Medicine Vol.97 No.13
<P><B>Abstract</B></P><P><B>Background:</B></P><P>Kimchi, a traditional, fermented Korean food that is consumed daily, has been recognized as a health food due to its beneficial effects on human health. The aim of this overview is to critically evaluate all clinical trials of the use of Kimchi in the treatment of any condition or symptom.</P><P><B>Methods and analysis:</B></P><P>Eight databases will be searched from inception until March 2018. We will include all prospective trials, including randomized controlled trials (RCTs), non-RCTs, and uncontrolled trials. The methodological quality of the trials will be assessed using Cochrane risk of bias (ROB) assessment tool and ROB in nonrandomized studies-I for RCTs and non-RCTs, respectively.</P><P><B>Ethics and dissemination:</B></P><P>Ethical approval will not be required, given that this protocol is for a systematic review. The full systematic review will be published in a peer-reviewed journal. The review will also be disseminated electronically and in print. Updates of the review will be conducted to inform and guide health care practice and policy.</P><P><B>Trial registration number:</B></P><P>PROSPERO 2018 CRD42018087375</P>
Protective effects of Korean herbal remedy against oxidative stress in cardiomyocytes
Kim, Myung-Sunny,Kwon, Dae Young,Cho, Hye-Jin,Lee, Myeong Soo John Wiley Sons, Ltd. 2006 Phytotherapy research Vol.20 No.3
<P>Ondamtanggagambang (ODG) has been used as a prescription for psychological anxiety and depression in Korean medicine. In this study, we found that ODG have protective effects against oxidative stress in cardiomyocytes. Pretreatment with ODG extract prevented H<SUB>2</SUB>O<SUB>2</SUB> and ZnCl<SUB>2</SUB>-induced cell damage in H9c2 cardiomyocytes, whereas simultaneous treatment of ODG extract did not. The protective effect of ODG extract on oxidative stress-induced damage was suppressed significantly by heme oxygenase (HO) inhibitors, zinc protoporphyrin-IX (ZnPP-IX, p < 0.01) and tin protoporphyrin-IX (SnPP-IX, p < 0.01) in H9c2 cells. ODG stimulation of cells strongly induced the expression of HO-1 protein. Taken together, it is suggested that ODG-induced expression of HO-1 may have a beneficial role in cardiomyocytes under oxidative stress. Copyright © 2006 John Wiley & Sons, Ltd.</P>
Kim, Do-Sung,Kwon, Dae-Young,Kim, Myung-Sunny,Kim, Hye Kyung,Lee, Yong Chul,Park, Seong Ju,Yoo, Wan Hee,Chae, Soo-Wan,Chung, Myoung-Ja,Kim, Hyung-Ryong,Chae, Han-Jung Pharmaceutical Society of Great Britain 2010 Journal of pharmacy and pharmacology Vol.62 No.2
<P>Objectives We have investigated whether endoplasmic reticulum stress and Bcl-2 proteins were linked to the protective effect exerted by flavonoids on ischaemia/reperfusion-induced cardiac damage. Methods Cell viability and immunoblotting were performed. Key findings H9c2 cardiac muscle cells were exposed to flavonoids such as biochanin A, daidzein, genistein, luteolin, quercetin and rutin, followed by ischaemia 12 h/reperfusion 4 h. The flavonoids protected against cell death induced by ischaemia/reperfusion. Flavonoid treatment significantly increased the expression level of the anti-apoptotic protein, Bcl-2, but decreased that of the proapoptotic protein, Bax. The flavonoids down-regulated the expression levels of endoplasmic reticulum stress proteins, glucose-regulated protein-78, activating transcription factor 6alpha, X-box binding protein 1, inositol-requiring protein-1, phosphor-eukaryotic initiation factor 2alpha, and C/EBP-homologous protein. Conclusions This study suggested that the protective mechanisms of flavonoids included regulation of Bcl-2/Bax proteins as well as the endoplasmic reticulum stress proteins.</P>
Ginseng for managing menopause symptoms: a systematic review of randomized clinical trials
Kim, Myung-Sunny,Lim, Hyun-Ja,Yang, Hye Jeong,Lee, Myeong Soo,Shin, Byung-Cheul,Ernst, Edzard The Korean Society of Ginseng 2013 Journal of Ginseng Research Vol.37 No.1
The aim of this review was to assess the effectiveness of ginseng as a treatment option for managing menopause symptoms. We searched the literature using ll databases from their inception to 26 September 2012 and included all randomised clinical trials (RCTs) that compared any type of ginseng to a placebo controls in postmenopausal women. The methodological quality of all studies was assessed using a Cochrane risk of bias tool. Four RCTs met our inclusion criteria. Most RCTs had high risk of bias. One RCT showed that Korean red ginseng (KRG) significantly improved sexual arousal and global health compared with placebo. Another RCT reported the superiority of KRG over placebo for treating menopause symptoms on Kupperman's index and menopausal rating score. The third RCT failed to show a significant effect of KRG on hot flash frequency compared to placebo. The fourth RCT found beneficial effects of ginseng compared to placebo on depression and well-being. In conclusion, the evidence on ginseng as an effective treatment for managing menopause symptoms is limited. Most of the RCTs are burdened with a high risk of bias. Thus firm conclusions cannot be drawn. Rigorous studies seem warranted.
Kim, Do-Sung,Ha, Ki-Chan,Kwon, Dae-Young,Kim, Myung-Sunny,Kim, Hyung-Ryong,Chae, Soo-Wan,Chae, Han-Jung Marcel Dekker 2008 IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY Vol.30 No.2
<P>This study examined whether or not the ER stress and Bcl-2 proteins are linked to the protective effect of kaempferol, a phytoestrogen, on ischemia-reperfusion (I/R)-induced cardiac damage. In order to determine if kaempferol modifies the I/R-induced response in H9c2 cardiac muscle cells, the cells were exposed to kaempferol followed by ischemia 12h/reperfusion 4h. kaempferol had a protective effect on the apoptosis induced by I/R in the cardiac muscle cells. The Kaempferol treatment significantly increased the expression level of the anti-apoptotic protein, Bcl-2, but decreased the level of the pro-apoptotic protein, bax. Kaempferol down-regulated the expressions of the endoplasmic reticulum (ER) stress proteins, GRP78, ATF-6alpha, XBP-2, IRE1-alpha, phosphor-eIF-2alpha and CHOP. In ex vivo-Langendorff experiment, the kaempferol treatment regulated the expression of ER stress proteins-CHOP and GRP78. The kaempferol also improved the post-ischemic LVEDP and LVDP significantly after 20, 30, 40 and 50 min of reperfusion compared with the untreated control hearts, which shows that kaempferol offers protection against I/R-associated cardiac dysfunction.</P>
Kim, Sung Hee,Hur, Haeng Jeon,Yang, Hye Jeong,Kim, Hyun Jin,Kim, Min Jung,Park, Jae Ho,Sung, Mi Jeong,Kim, Myung Sunny,Kwon, Dae Young,Hwang, Jin-Taek Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>The antidiabetic effect of the <I>Citrus junos</I> Tanaka (also known as yuja or yuzu) was examined. Ethanol extract of yuja peel (YPEE) significantly stimulated 2-[<I>N</I>-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG) uptake in C2C12 myotubes. However, ethanol extract of yuja pulp (YpEE) and water extract of yuja peel (YPWE) or pulp (YpWE) did not stimulate glucose uptake. In addition, peroxisome proliferator-activated receptor gamma (PPAR-<I>γ</I>) and AMP-activated protein kinase (AMPK) activities were increased by YPEE in a dose-dependent manner. Pretreatment of AMPK inhibitor decreased the glucose uptake stimulated by YPEE in C2C12 myotubes. We confirmed the anti-diabetic effect of YPEE in mice fed a high fat-diet (HFD). Compared with control mice on a normal diet (ND), these mice showed increased body weight, liver fat, insulin resistance, triacylglycerol (TG), and total cholesterol content. Addition of 5% YPEE significantly reduced the weight gain and rise in liver fat content, serum triacylglycerol (TG), total cholesterol, and insulin resistance found in mice fed a high-fat diet (HFD). Moreover, YPEE reduced the secretion of HFD-induced adipocytokines such as leptin and resistin. YPEE also resulted in increased phosphorylation of AMPK in muscle tissues. These results suggest that ethanol extract of yuja peel exerts anti-diabetic effects via AMPK and PPAR-<I>γ</I> in both cell culture and mouse models.</P>