개에서 발생한 폐수종의 치료 증례

김유수,심재현,김건우,김지용,이병희,송근호,이영원,김덕환 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

A 9 months intact male American bull dog with chief complaints of dry cough, dyspnea and fever was referred to the Veterinary Teaching Hospital, Chungnam National University. Based on the findings of physical examination, radiological examination, and blood and blood chemical examinations, the present patient was diagnosed into pulmonary edema secondary to primary bacterial and aspiration pneumonia. The patient was hospitalized and treated with buscopan, cephazolin and furosemide for 1 week. His activity and appetite was returned to normal and thoracic radiographs revealed that Jung was recovered to the normal condition after treatment for 7 days. The present patient was a case with pulmonary edema showed favorable therapeutic responses to proper medication.

HMG-CoA 환원효소 억제제에 의한 ICAM-1 유전자의 발현조절

김현진,정효균,홍우정,김군순,조영석,김도희,채수흥,구본정,송민호,노흥규,김영건 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Background : ICAM-1 act as one of major adhesion molecules in the atherosclerotic lesion. ICAM-1 expression is mainly regulated at the level of transcription and depend on IFN-γ signal transduction pathway in which the STAT1 transcrption factor is a critical intermediate. IFN-γreceptor not only initiates tyrosine 701 phosphorylation of STAT1 by Jak1 and Jak2, but also phosphorylates serine 727 through the activation of Raf-1/MAP kinases. HMG-CoA reductase inhibitors have anti-atherosclertic effects, beyond normalization of hypercholesterolemia, by directly acting on endothelial cells, macrophages and vascular smooth muscle cells. HMG-CoA reductase inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibition posttranslational farnesylation and geranyl-geranylation processing of small GTP-binding preoteins and inhibition of normal signaling activities. Method : We made several 5'-deletion constructs of rat ICAM-1 promoter and analyzed the promoter activities by measuring the luciferase activity after transfection into ECV304 cells and smooth muscle cells. We checked the level of total and phosphorylated STAT1 protein by immunoblot analysis using specific antibodies. Results : Lovastatin inhibits IFN-γ-induced ICAM-1 gene expression in the ECV304cell. The cells pretreated with PD98059, MEKK inhibitor showed significantly low ICAM-1 RNA induction with IFN-γ stimulatio. IFN-γ induced phosphorylation of tyrosine 701 was not significantly changed by the pretreatment of lovastatin. But lovastatin suppresses IFN-γ-induced phosphorylation of ERK1/ERK2 which are responsible for the seine 727 phosphorylation in STAT1. Conclusion : We showed that HMG-CoA reductase inhibitors, lovastatin, suppresses IFN-γ mediated ICAM-1 gene expression through the inhibition of transcription. HMG-CoA reductase inhibitor suppresses IFN-γ-induced phosphorylation of serine 727 in STAT1 through the modulation of MAP kinases.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

갑상선 세포에서 전사보조활성인자인 CBP와 CIITA의 인터페론-감마 활성 부위에 대한 조절 : CBP and CIITA on GAS(Interferon- γ Activated Site)-Mediated Transcription in Thyroid Cells

채수흥,홍우정,김군순,조영석,김도희,김현진,구본정,송민호,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Background : In the previous stuides, we identified that the interferon-r activated sequence (GAS) in the 5-flanking region of rat ICAM-1 gene is major element for interferon-r-inducible expression of the gene in rat thyroid cells, FRTL-5. We here, investigated the role of transcriptional coactivators, CBP(CREB binding protein) and CⅡTA (class Ⅱ transactivator) in the modulation of the activity of GAS which could interacts with signal transducers and activators of transcription-1 and 3 (STAT1 and STAT3). Methods : The expression of CBP RNA and protein were quantitated in FRTL-5 after stimulation with interferon-r (IFN-r), thyroid stimulating hormone (TSH), forskolin and methimazole. Direct association of CBP with STAT were analyzed by immunoprecipitation. The transcriptional roles of CBP and CⅡTA in the regulation of GAS were assessed by the cotransfection with their expression vectors with reporters; 5-deletion constructs of rat ICAM-1 promoter or 8xGAS-luc constructs, into FRTL-5 thyroid cells. Results : The level of CBP RNA and protein were not changed by the treatment with TSH, IFN-r, forskolin and methimazole in FRTL-5, FRT and BRL liver cells. The CBP could be directly associated with STAT1. Furthermore, the overexpression of CBP significantly increases the both promoter activities; rat ICAM-1 gene promoter which has GAS element and 8xGAS-luc cassette constructs. However, the cotransfection of CⅡTA decreased the constitutive and CBP-mediated transactivation of rat ICAM-1 promoter and 8xGAS-luc cassette constructs. Conclusion : We identified that the two tanscriptional coactivators; CBP and CⅡTA has differential roles in the regulation of transcriptional activity of GAS drived promoter. CBP increases the GAS activity through the direct binding with STAT1, but CⅡTA inhibited the CBP-mediated transactivation of GAS activity.

면역억제제를 사용치 않은 동소성 간이식 실험견의 조직병리소견

조원현,최순옥,김인호,임태진,김성수,박준희,김우석,김현철,최규택,김진모,권건영 大韓移植學會 1994 Korean Journal of Transplantation Vol.8 No.1

助用詞攷

金根洙 東國大學校 국어국문학부 1962 國語國文學 論文集 Vol.3 No.-

조용사는 조동사라고도 하는데, 이 조용사란 무언가? (1) 간다. 갑니다. 가오 (2) 가면, 가니 (3) 잡히오, 오시오 (4) 퉁퉁거린다, 시작한다, 정답다. 위의 (1)「ㄴ다, ㅂ니다, 오」, (2)「면, 니」, (3)「히, 시」, (4)「거리, 하, 답」을 조용사 또는 조동사라 하는 학자가 있는가 하면, 이와 반대로 이를 각각 (1)종지조사(끝씨), (2)접속조사 또는 어미, (3)보조어간 또는 (4)접미사라 하는 학자도 있는 것이다. 이와 같이, 국문법학에서 조용사는 그 정체가 알숭달숭한 존재로 되어 있는 것이다. 그렇다면, 조용사란 과연 무엇이며, 그것이 독립한 품사가 될 수 있는가? 있다면, 그것엔 무엇무엇이 있는가? 그 특질은 무엇인가? –이것이 본고에서 천명하려는 대상이다.

陸上競技選手와 他運動選手의 反應時間에 對한 比較實驗 硏究

金健洙,玉明哲 명지대학교 1982 明大論文集 Vol.13 No.-

This is a comparative research of the reaction between field and track events' players and other players, and it was tried out for an analysis of what kinf of results took place. Especially, in this research, 100V-bulb, 100W, 60W, 30W, 10W were used as buzzer and light, and measured simple Reaction time, whole body Reaction time, field and track crouching-start Reaction time in five groups separately. Persons in custody were mainly students of Myung Ji University and player's group, field and track events' players were Han Kook National College of physical Education. Results were analyzed by Random-sampling in all 70: field and track events' players, 10; general students, 17; Physical Education department's students, 21; football team, 12; basketball team, 10. As mentioned above results, conclusions are as follows: 1) The mean value of the reaction time to buzzer and light stimulus of each test group came to results as follows. A. In the Case of simple reaction, when buzzer stimulated, basketball team students were fastest; 0.150sec(high), 0.161sec (low), the second, field and track team students; 0.152sec(high), 0.180sec (low), football team students; 0.167sec (high), 0.184sec (low), P.E. department's students; 0.250sec (high), 0.226sec (low), the lowest-general students; 0.420sec (high), 0.284sec (low). As these results are measurement chronometry of using shoulder articulation mainly, I think that basketball team students who use hands frequently are in the leading position resolutely. B. In the case of whole body working time, small differences are shown and the fastest reactions are shown in field and track team; 0.230sec (high), 0.233sec (low). The second, football team; 0.233sec (high), 0.235 (low), P.E. department students; 0.257sec (high), 0.183sec (low), (In bass P.E. department students were the fastest in reaction time). Basketball team; 0.268sec (high), 0.264sec (low), general students; 0.322sec (high), 0.336sec (low). C. Reaction time of crouching-start as group-to-group comparison was fast also in the group of useing feet frequently. field and track team was the fastest; 0.161sec (high), 0.123sec (low), the second, football team; 0.175sec (high), 0.173sec (low), basketball team; 0.181sec (high), 0.176sec (low), P.E. department students; 0.243sec (high), 0.266sec (low), general students; 0.261sec (high), 0.262sec (low). 2) Reaction time of luminous intensity in each team was results that buzzer was more stimulant to reaction than light. 3) Reaction time of luminous intensity of each testing group was shown according with intension of stimulus to bright light, and the reverse phenomenons came out. 4) Reaction of the tone of buzzer to the buzzer in each group was shown that reaction time to a loud buzzer was fast in superior groups, and in other groups, in a bass.

병원표준화심사의 질 향상 관련 항목에 대한 평가와 개산방안

김창엽,이상일,이건세,신영수 한국의료QA학회 1995 한국의료질향상학회지 Vol.2 No.1

Background: Korean Hospital Standardization Program(KHSP), as a hospital accreditation program initiated and promoted by Korean Hospital Association since 1981, has played a key role in the hospital quality improvement in structural aspect particularly. Recently, however, KHSP has been critisized by hospitals and health personnels in that it is unpractical to be utilized as an initiative to improve hospital quality. In particular, the section of quality assurance in KHSP, strongly influenced by old version of Hospital accreditation of Joint Commission in U.S.A., has been required to be fundamentally sevised. For design of new criteria in quality assurance section, a survey for evaluation of existing program and collection of opinions for ideal one was conducted. Methods: For a month in 1994, structured questionnaires were administered by mailing to 470 hospital staffs from 200 hospitals, participated in the survey for the 1994 KHSP in each hospital. The total number of respondents was 116. Results: Less than half of the respondents(34.5%) value positively on the impact of current KHSP in general on the quality improvement of their hospitals. Moreover, most responses indicated that KHSP should be reorganized towards more practical and applicable one. Current KHSP criteria for quality activities in hospitals were regarded as a unpractical one which should be basically renewed. For new criteria and standards, most respondents emphasized the importance of applicability of those in real siuations. Conclusion: For the KHSP to be effective, new evaluation criteria for quality activities should be more practical and fully accommodated to hospital situations in reality.

건축공간에서 창에 의한 관념적 공간인지에 관한 연구

김정환,오건수 남서울대학교 2005 남서울대학교 논문집 Vol.11 No.2

Concept of space is one of endless discussion topics and research's targets until now a days from ancient time. Concept of space in architecture was well-known in late 19th century, and was used as a important principle. Many architects made architectural space from the basis of these concept of space, and made ideation space through window. This study is to interpret existence and possibility of such space called ideological cognitive space which is shown through window.

폴리설폰 중공사막에 대한 산소/질소 혼합물의 분리

김종수,송근호,이광래 江原大學校 附設 環境硏究所 1999 環境硏究 Vol.16 No.-

국내 K-그룹 연구소에서 제조한 폴리설폰 중공사막의 산소/질소 혼합물에 대한 압력, stage cut, 공급기체 혼합물의 조성에 따른 분리성능을 조사하였다. 본 실험의 압력범위와 온도 30℃에서의 이상분리인자(O₂/N₂)는 5.7이었으며, 유입기체 혼합물의 21 mole% 산소농도가 약 50 mole%로 농축되었다. 저압츠과 고압측의 압력비는 산소농축에 미치는 영향이 적었으며, 이상분리인자의 영향은 매우 컸다. 그러나, 이상분리인자가 증가함에 따라 이상분리인자의 영향은 둔화되었다. 따라서, 이상분리인자가 큰 신소재 개발과 더불어 공정변수의 최저화가 필요하다. 수학적 모델링에 의한 예측치와 실험치가 잘 맞았다. The performance of the polysulfone hollow-fiber membrane manufactured by K-group Research Institute in Korea was investigated for the separation of O₂/N₂mixture as a function of pressure, stage cut, and feed gas composition. The ideal separation factor(O₂/N₂) at temperature 30℃ was around 5.7 in the pressure ranges studied. Oxygen concentration of 21 mole% in feed stream was concentrated to about 50%. Although the pressure ratio between high and low pressure side showed little effect, ideal separation factor showed greater effect on the oxygen enrichment. However, the effect was declined with increase in the ideal separation factor. Therefroe, the optimization of process variable is necessary as well as development of new material with high ideal separation factor. It was fond that experimental data were well correlated with the prediction of mathematical model.