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Disseminated Mycobacterium intracellulare Infection in an Immunocompetent Host
Kim, Won-Young,Jang, Sun-Joo,Ok, Tae-Jin,Kim, Gwang-Un,Park, Han-Seung,Leem, Jae-Chan,Kang, Bo-Hyoung,Park, Se-Jeong,Oh, Dong-Kyu,Kang, Byung-Ju,Lee, Bo-Young,Ji, Won-Jun,Shim, Tae-Sun The Korean Academy of Tuberculosis and Respiratory 2012 Tuberculosis and Respiratory Diseases Vol.72 No.5
Disseminated Mycobacterium avium complex (MAC) infection can occur in immunocompromised patients, and rarely in immunocompetent subjects. Due to the extensive distribution of the disease, clinical presentation of disseminated MAC may mimic malignancies, and thorough examinations are required in order to make accurate diagnosis. We report a case of disseminated Mycobacterium intracellulare disease in an immunocompetent patient, which involved the lung, lymph nodes, spleen, and multiple bones. F-18 fluorodeoxyglucose positron-emission tomography imaging showed multiple hypermetabolic lesions, which are suggestive of typical hematogenous metastasis. However, there was no evidence of malignancy in serial biopsies, and M. intracellulare was repeatedly cultured from respiratory specimens and bones. Herein, we should know that disseminated infection can occur in the immunocompetent subjects, and it can mimic malignancies.
Preliminary evaluation of new <sup>68</sup>Ga-labeled cyclic RGD peptides by PET imaging
Shin, Un Chol,Jung, Ki-Hye,Lee, Ji Woong,Lee, Kyo Chul,Lee, Yong Jin,Park, Ji-Ae,Kim, Jung Young,Kang, Joo Hyun,An, Gwang Il,Ryu, Young Hoon,Choi, Jae Yong,Kim, Kyeong Min Korean Society of Radiopharmaceuticals and Molecul 2016 Journal of radiopharmaceuticals and molecular prob Vol.2 No.2
Integrin ${\alpha}_v{\beta}_3$ plays an important role in the tumor metastases and angiogenesis. Arginine-glycine-aspartate (RGD) peptide motif binds to the integrin ${\alpha}_v{\beta}_3$. General $^{68}Ga$-labeled cyclic RGD peptides was rapidly eliminated from the circulatory system by renal excretion because of its hydrophilic property. The purpose of this study was to develop a novel $^{68}Ga$-labeled cyclic RGD peptides, which could acquire enhanced PET tumor images with improved pharmacokinetics by adopting biphenyl group between chelator and RGD peptides. $^{68}Ga$-DOTA-2P-c(RGDyK) was demonstrated a 12% higher lipophilicity level than $^{68}Ga$-DOTA-c(RGDyK) as a reference compound. In the animal PET, $^{68}Ga$-DOTA-2P-c(RGDyK) represented relatively lower blood-clearance, and an increased signal to noise ratio compared to $^{68}Ga$-DOTA-c(RGDyK). From these perspective, $^{68}Ga$-DOTA-2P-c(RGDyK) could be a good candidate for in integrin ${\alpha}_v{\beta}_3$-expressed tumor imaging.
소독방법에 따른 실내수영장 수질 특성 -브롬산염, 클로레이트, 염소이온을 중심으로-
조광운 ( Gwang Un Jo ),이세행 ( Se Haeng Lee ),위환 ( Whan Wi ),윤상훈 ( Sang Hoon Yoon ),김난희 ( Nan Hee Kim ),안상수 ( Sang Soo An ),정숙경 ( Suk Kyeong Jung ),김동수 ( Dong Su Kim ),조영관 ( Young Gwan Cho ) 한국환경분석학회 2015 환경분석과 독성보건 Vol.18 No.2
This study was carried out to investigate the characteristics of water quality parameters in the indoor swimming pool water according to the type of disinfection. The method of disinfection has a on-site oxidant generation, sodium hypochlorite and artificial seawater electrolysis that the salt was put in the pool directly. The on-site oxidant generation and sodium hypochlorite in the disinfectant contain high concentrations of bromate and chlorate. The bromate and chlorate containing the disinfectant is the cause of detection in a swimming pool. Maximum concentration of bromate in swimming pool waters was 1.365 mg/L at on-site oxidant generation and maximum concentration of chlorate was 36.00 mg/L at sodium hypochlorite. Therefore, to reduce the concentration of bromate and chlorate in swimming pool water, it is necessary to use the disinfectant containing the less quantity of bromate and chlorate and to exchange of swimming pool water frequently.
김광운 ( Gwang Un Kim ),예병덕 ( Byong Duk Ye ),변정식 ( Jeong Sik Byeon ),박환성 ( Hwan Sung Park ),옥태진 ( Tae Jin Ok ),양동훈 ( Dong Hoon Yang ),정기욱 ( Kee Wook Jung ),김경조 ( Kyung Jo Kim ),명승재 ( Seung Jae Myung ),양석 대한장연구학회 2011 Intestinal Research Vol.9 No.3
Background/Aims: With the growing volume of screening colonoscopies, the incidence of rectal carcinoids and the number of endoscopic resections for rectal carcinoids are also increasing. However, the prognosis including recurrence and metachronous lesions after endoscopic resection is unclear. Methods: The medical records of 255 patients who had undergone endoscopic resection for rectal carcinoids between October 1999 and April 2010 were retrospectively reviewed. Results: The number of males was 150 (58.8%), and the mean age was 54.1 years (range, 27-85 years). Mean tumor size was 6.9 mm. In total, 162 cases (63.5%) were treated with endoscopic mucosal resection and 93 (36.5%) were treated with endoscopic submucosal dissection. Although endoscopic complete resections were achieved in all cases, the histological examination showed 47 cases with a positive resection margin (18.4%) and three with lymphovascular invasion (1.2%). In the 54 patients with a free resection margin, who were followed for more than 12 months, abdominopelvic computed tomography and endoscopy did not show recurrence after a median of 30.5 and 36 months, respectively. Three patients with lymphovascular invasion did not show recurrence during follow-up period of 13, 30, and 37 months, respectively. Metachronous rectal carcinoids were detected in four patients at 23, 58, 61, and 89 months, respectively, after initial endoscopic resection, leading to a second endoscopic treatment. Conclusions: Small rectal carcinoids completely resected grossly and pathologically without lymphovascular invasion appear to have low probability of short-term recurrence. However, considering the slow growth rate of carcinoids, long-term follow-up for recurrence and metachronous carcinoids is required. (Intest Res 2011;9:217-224)
섬국수나무와 섬괴불나무의 삽목증식에 미치는 토양 및 PGRs 처리 효과
이수광 ( Su Gwang Lee ),이동준 ( Dong Jun Lee ),김효연 ( Hyo Yeon Kim ),구자정 ( Ja Jung Ku ),김현준 ( Hyeon Jun Kim ),정회석 ( Hea Seok Jeong ),신운섭 ( Un Seop Shin ),이기철 ( Ki Cheol Lee ),김현진 ( Hyun Jin Kim ),김성식 ( Sung 한국임학회 2014 산림과학 공동학술대회 논문집 Vol.2014 No.-
본 연구는 희귀식물 섬국수나무(Physocarpus insularis (Nakai) Nakai)와 섬괴불나무(Lonicera insularis Nakai)의 삽목증식에 미치는 토양 및 PGRs의 영향을 살펴보기 위해 수행되었다. 삽목토양은 녹소토와 펄라이트로 달리하였으며, PGRs는 IBA, NAA 100 ppm 한 시간 침지처리, 그리고 루톤분말 처리의 4가지를 달리하였다. 그 결과 섬국수나무는 녹소토 대조구와 루톤 처리구에서 29%의 가장 높은 발근율을 나타내었다. 또한 대조구에서 뿌리수(4.1개), 뿌리길이(5.8 cm) 및 지하생중량(33mg)이 가장 우수하게 나타나 섬국수나무의 삽목증식에는 PGRs처리가 부정적인 영향을 미치는 것으로 생각된다. 반면 섬괴불나무는 녹소토 조건에서 대조구(25%)에 비해 NAA 침지처리(82%)시 발근율이 유의적으로 향상된 결과를 나타내었다. 특히 NAA 100 ppm 침지처리시 뿌리수(7.3개), 뿌리길이(16.9 cm) 및 지하생중량(195 mg)이 가장 우수하게 나타나 녹소토 조건과 NAA 100 ppm 침지처리가 섬괴불나무 삽목증식에 적합한 처리조건인 것으로 판단된다. This study was conducted to investigate the propagation characteristics of Physocarpus insularis (Nakai) Nakai and Lonicera insularis Nakai. The treatment of rooting soil type(Kanumatsuchi, perlite) and PGRs(Rootone, 100 ppm of IBA or NAA). As a result, the highest rooting rate(29%) of P. insularis was obtained from the control and rootone in Kanumatsuchi. And best quality of cutting growth characteristics of P. insularis under control with number of root(4.1), root length(5.8 cm) and root weight(33 mg). Therefore, PGRs were negative effects on cutting of P. insularis. On the other hand, 100 ppm NAA treatment showed the highest rooting rate(82%) than control(25%) of L. insularis with cutting growth characteristics of the number of root(7.3), root length(16.9 cm) and root weight(195 mg) in Kanumatsuchi. A result indicated that treatment 100 ppm NAA and Kanumatsuchi were best treatment in increasing percentage of rooting and other cutting growth characteristics of L. insularis.
섬다래, 댕댕이나무 및 넌출월귤 종자의 기내발아에 미치는 GA3 처리 효과
이수광 ( Su Gwang Lee ),김효연 ( Hyo Yeon Kim ),구자정 ( Ja Jung Ku ),김현준 ( Hyeon Jun Kim ),정회석 ( Hea Seok Jeong ),신운섭 ( Un Seop Shin ),이기철 ( Ki Cheol Lee ),김현진 ( Hyun Jin Kim ),김성식 ( Sung Sik Kim ) 한국임학회 2014 산림과학 공동학술대회 논문집 Vol.2014 No.-
본 연구는 희귀식물 섬다래(Actinidia rufa (Siebold & Zucc.) Planch. ex Miq.), 댕댕이나무(Lonicera caerulea var. edulis Turcz. ex Herder) 및 넌출월귤(Vaccinium oxycoccus L.)의 기내발아에 미치는 GA3 처리 효과를 살펴보고자 수행되었다. WPM 기본배지로 하여 GA3 농도별로 대조구, 0.1, 0.5, 1.0 mg/L를 첨가하여 제조한 배지를 사용하여 기내발아 실험을 수행하였다. 그 결과 섬다래 종자는 GA3 첨가 농도가 높아질수록 뚜렷한 종자발아 효과를 나타내어 1.0 mg/L GA3 첨가구에서 92% 높은 발아율을 보였으나 대조구에서는 전혀 발아하지 않았다. 댕댕이나무의 기내발아는 6.6∼36.6%의 발아율을 나타내었으며, 1.0 mg/L GA3 첨가구에서 최고 발아율 36.6%로 나타났다. 넌출월귤은 1.0 mg/L GA3 첨가구에서 94%의 가장 높은 발아율을 보였고 대조구 0.1, 0.5 mg/L GA3 첨가구에서 각각 42%, 77% 및 92%의 발아율을 보였다. 이상의 결과를 통해 섬다래와 넌출월귤의 기내발아에는 각각 1.0과 0.5 mg/L GA3 첨가가 적절한 것으로 판단되며, 댕댕이나무는 최고 기내발아율이 36%로 나타나 발아율을 높이기 위한 추가연구가 필요한 것으로 생각된다. The effect of gibberellic acid concentration was studied on the in vitro seed germination of Actinidia rufa, Lonicera caerulea var. edulis, Vaccinium oxycoccus. The WPM basal medium supplemented with various concentrations of GA3 (0.1, 0.5, 1.0 mg/L) were used for in vitro seed germination. In 1.0 mg/L GA3, 92% seed germination of A. rufa. However, there was any seed germination in control. The range of germination of L. caerulea var. edulis was 6.6∼36.6%, optimal condition when 1.0 mg/L GA3 in WPM medium. And in vitro seed germination of V. oxycoccus increased to 42%, 77%, 92%, or 94% in control, 0.1, 0.5 or 1.0 mg/L GA3, respectively. Therefore, in vitro seed germination of A. rufa, L. caerulea var. edulis, V. oxycoccus were enhanced in GA3 supplemented in WPM medium.