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이만승,이광섭,이진영,김성돈,김준수 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.10
Solvent extraction experiments of Sm were performed from chloride solution with PC88A and saponified PC88A. Solvent extraction reaction of Sm with PC88A and the corresponding equilibrium constant were evaluated from the experimental and ionic equilibria data as follows Sm^(3+)_(aq)+ 1.5H₂A_(2,org)= SmA_(3,org)+ 3H^(+)_(aq) , K = 0.33. The predicted distribution coefficients of Sm agreed well with the experimental results. The distribution coefficients of Sm with saponified PC88A and the values of equilibrium pH depended on the initial extraction conditions. When the concentration of PC88A was in excess of that of Sm, saponification of PC88A greatly enhanced the extraction of Sm. (Received June 21, 2004)
비누화 PC88A에 의한 NdCl₃와 SmCl₃용매추출의 화학모델
이만승,이광섭,이진영,김성돈,김준수 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.10
A chemical model was developed to estimate equilibrium constant for the solvent extraction of Nd and Sm from chloride solution with saponified PC88A. The model could be employed to predict the distribution coefficient of metal from the initial extraction conditions. The model consisted of chemical equilibria, mass balance, charge balance and solvent extraction reaction. By applying the model to the experimental conditions and data, equilibrium constants for the solvent extraction of Nd and Sm were obtained. The effect of the saponification of PC88A on the extraction of Nd was explained in terms of the equilibrium constant obtained in this study and the change of equilibrium pH. The predicted distribution coefficients of Nd and Sm agreed well with those measured. (Received July 14, 2004)
염산용액에서 비누화 PC88A에 의한 용매추출로 Gd와 Sm의 분리
이만승,이광섭,이진영,김성돈,김준수 대한금속재료학회 2005 대한금속·재료학회지 Vol.43 No.5
Solvent extraction experiments have been performed to separate Gd and Sm from chloride solution with PC88A and saponified PC88A. The effects of extraction conditions on the distribution coefficients of Gd and Sm were investigated. The distribution coefficients of Gd were higher than those of Sm in the experimental ranges of experimental conditions of this study. A solvent extraction model was developed to predict the distribution coefficients of metals and separation factor between Gd and Sm from the initial extraction conditions. The measured distribution coefficients of Gd and Sm with PC88A and saponified PC88A showed good agreements with the predicted values. (Received March 3, 2005)
김병호,김효종,정인경,장린,이정일,동석호,장영운,김광국,황일섭,김윤화 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.1
Although intestinal bleeding is known to occur in amyloidosis, it is rare as a presenting symptom or sole manifestation of the disease. We experienced a case of intestinal hemor-rhage in a 64-year old female patient with primary amyloidosis, kappa type. Antral muco-sal erosions were discovered and one shallow healing ulcer at the angle. Colonoscopy revealed multiple purplish nodules in the sigmoid colon and descending colon, as well as a large shallow ulcer with blood clots in the sigmoid colon which was suspected to be the intestinal hemorrhage site. Endoscopic biopsy established amyloidosis. Polarizing microscopy after Congo red staining and immunohistochemical staining identified primary amyloid, kappa type. A case of intestinal hemorrhage in patients with primary amyloidosis is presented and the literature is reviewed.
Kim Byung-Wook,Park Jong-Jae,Moon Hee Seok,Lee Wan Sik,Shim Ki-Nam,Baik Gwang Ho,Lim Yun Jeong,Lee Hang Lak,Youn Young Hoon,Park Jun Chul,Sung In-Kyung,Chung Hyunsoo,Moon Jeong Seop,Kim Gwang Ha,Hong 거트앤리버 소화기연관학회협의회 2024 Gut and Liver Vol.18 No.2
Background/Aims: Tegoprazan is a novel potassium-competitive acid blocker that has beneficial effects on acid-related disorders such as gastroesophageal reflux and peptic ulcer diseases. This study aimed to validate the effect of tegoprazan on endoscopic submucosal dissection (ESD)-induced artificial ulcers. Methods: Patients from 16 centers in Korea who underwent ESD for gastric neoplasia were enrolled. After ESD, pantoprazole was administered intravenously for 48 hours. The patients were randomly allocated to either the tegoprazan or esomeprazole group. Tegoprazan 50 mg or esomeprazole 40 mg were administered for 4 weeks, after which gastroscopic evaluation was performed. If the artificial ulcer had not healed, the same dose of tegoprazan or esomeprazole was administered for an additional 4 weeks, and a gastroscopic evaluation was performed. Results: One hundred sixty patients were enrolled in this study. The healing rates of artificial ulcers at 4 weeks were 30.3% (23/76) and 22.1% (15/68) in the tegoprazan and esomeprazole groups, respectively (p=0.006). At 8 weeks after ESD, the cumulative ulcer healing rates were 73.7% (56/76) and 77.9% (53/68) in the tegoprazan and esomeprazole groups, respectively (p=0.210). Delayed bleeding occurred in two patients in the tegoprazan group (2.6%) and in one patient in the esomeprazole group (1.5%). Other adverse events were negligible in both groups. Conclusions: Tegoprazan showed similar effects on post-ESD artificial ulcer healing in comparison with esomeprazole.
Kim, Soyoun,Kim, Gwang Seob,Seo, Junyoung,Gowri Rangaswamy, Gunassekaran,So, In-Seop,Park, Rang-Woon,Lee, Byung-Heon,Kim, In-San American Chemical Society 2016 Biomacromolecules Vol.17 No.1
<P>Ferritin cage nanoparticles are promising platforms for targeted delivery of imaging and therapeutic agents. One of the main advantages of cage nanoparticles is the ability to display multiple functionalities through genetic modification so as to achieve desired therapeutic or diagnostic functions. Ferritin complexes formed from short ferritin (sFt) lacking the fifth helix can accommodate dual peptide and protein functionalities on N- and C-terminal sites in sFt monomers. The resulting double-chambered Nano Cage (DCNC) offers the potential of dual activities; these activities are augmented by the avidity of the ligands, which do not impede each other's function. Here we demonstrated proof-of-concept of DCNCs, loading the tumor-targeting proapoptotic peptide CGKRK(KLAKLAK)(2) onto the N-terminal chamber and green fluorescent protein (GFP) onto the C-terminal chamber. The resulting KLAK-sFt-GFP DCNCs were internalized into the human breast adenocarcinoma cell line MDA-MB-231 and induced apoptosis. These findings suggest that DCNCs containing various combinations of peptides and proteins could be applied as therapeutics in different diseases.</P>