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Park, Chan H.,Kimler, Bruce F.,Yi, Seong Yoon,Park, Se Hoon,Kim, Kihyun,Jung, Chul Won,Kim, Sun Hee,Lee, Eun Ryung,Rha, Miyong,Kim, Seonwoo,Park, Mary H.,Lee, Sook J.,Park, Hye K.,Lee, Mark H.,Yoon, S Blackwell Publishing Ltd 2009 European journal of haematology Vol.83 No.2
<P>Abstract</P><P>Purpose: </P><P><SMALL>L</SMALL>-ascorbic acid (LAA) modifies the <I>in vitro</I> growth of leukemic cells from ∼50% of patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). To test the hypothesis that depletion of LAA, alternating with supplementation to prevent scurvy, would provide therapeutic benefit, a single-arm pilot trial was conducted (ClinicalTrials.gov identifier: NCT00329498).</P><P>Experimental results: </P><P>During depletion phase, patients with refractory AML or MDS were placed on a diet deficient in LAA; during supplementation phase, patients received daily intravenous administration of LAA. An <I>in vitro</I> assay was performed pretherapy for LAA sensitivity of leukemic cells from individual patients.</P><P>Results: </P><P>Of 18 patients enrolled, eight of 16 evaluable patients demonstrated a clinical response. Responses were obtained during depletion (four patients) as well as during supplementation (five patients) but at a pharmacologic plasma level achievable only with intravenous administration. Of nine patients for whom the <I>in vitro</I> assay indicated their leukemic cells were sensitive to LAA, seven exhibited a clinical response; compared with none of six patients who were insensitive to LAA.</P><P>Conclusions: </P><P>The clinical benefit, along with a conspicuous absence of significant adverse events, suggests that further testing of LAA depletion alternating with pharmacologic dose intravenous supplementation in patients with these and other malignancies is warranted.</P>
Keon Woo Park,Young-Hyuc kIm,이지연,Eungho Kim,Hyuk Lee,Bong Geun Song,Joon Oh Park,Kihyun Kim,정철원,Young Suk Park,Won Ki Kang,Mark H. Lee,Keunchil Park 대한암학회 2003 Cancer Research and Treatment Vol.35 No.5
uncommon and typically occurs in patients with disseminated diseases. This may cause difficulty in differentiating it from primary gastric carcinoma. The correct diagnosis of the primary source is important, since the treatment and prognosis of metastatic breast cancer is quite different from those of metastatic gastric cancer. Immunohistochemical staining with GCDFP-15 (gross cystic disease fluid protein-15) can be used to differentiate primary gastric carcinoma and gastric metastasis from breast cancer. We report two cases of gastric metastasis of breast cancer by describing their clinical course, illustrating the histologic findings, and showing the results of immunohistochemical staining with GCDFP-15. (Cancer Res Treat. 2003;35:460-464)
Facilitated Protein-DNA Binding: Theory and Monte Carlo Simulation
Kihyun Park,김효준 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.3
The facilitated diffusion effect on protein-DNA binding is studied. A rigorous theoretical approach is presented to deal with the coupling between one-dimensional and three-dimensional diffusive motions. For a simplified model, the present approach can provide numerically exact results, which are confirmed by the lattice-based Monte Carlo simulations.
Kihyun Park,Byung-Il Min,Sora Kim,Jiyoon Kim,Kyung-Suk Suh 한국방사성폐기물학회 2020 방사성폐기물학회지 Vol.18 No.2(E)
북한은 2017년 9월 3일 풍계리 핵실험장에서 6차 지하 핵실험을 단행하였다. 이전에 수행했던 핵실험들과 달리 풍계리 핵 실험장 주변에서 몇 차례의 유발지진이 발생하였고 이로 인해 지하에 갇혀 있던 방사성제논이 대기 중으로 방출되는데 영향을 끼쳤을 것으로 예상된다. 본 연구에서는 북한의 6차 핵실험 이후에 발생한 유발지진을 고려하여 핵실험으로 발생한 방사성제논의 몇 가지 방출 시나리오에 따른 대기확산 모의실험을 본 연구진이 개발한 LADAS (Lagrangian Atmospheric Dose Assessment System) 모델에 기상청의 수치예보자료를 적용하여 수행하였다. 방사성제논의 가능한 검출 위치와 시간을 찾기 위해, 1일 간격 및 1주일 간격의 지연방출뿐만 아니라 유발지진으로 유출된 지연방출 시나리오도 설정하였다. 포괄 적핵실험금지조약기구(Comprehensive Nuclear-Test-Ban Treaty Organization)에서 운영중인 전세계관측망(International Monitoring System)과 원자력안전위원회의 133Xe 탐지 결과는 유발지진으로 유출된 방사성제논의 방출 시나리오에 따른 모의실험의 결과와 대체로 부합되었다. North Korea conducted the sixth underground nuclear test on September 3, 2017 at the Punggye-ri Nuclear Test Site (NTS). In contrast to the previous five nuclear tests, several induced earthquakes occurred around the NTS after the sixth nuclear test and this may have caused radioxenon leakages at the site. Considering these reported earthquakes, we performed atmospheric dispersion simulations on some radioxenon emission scenarios for this event using our Lagrangian Atmospheric Dose Assessment System (LADAS) model by employing the Unified Model (UM) based numerical weather prediction data produced by the Korea Meteorological Administration (KMA). To find out possible detection locations and times, we combined not only daily and weekly based delayed releases but also leakages after the reported earthquakes around the NTS to create emission scenarios. Our simulation results were generally in good agreement with the measured data of the Nuclear Safety and Security Commission and International Monitoring System (IMS) stations operated by the Comprehensive nuclear Test-Ban-Treaty Organization (CTBTO).