Preparation and characterization of electrospun poly(ε-caprolactone)-poly(l-lactic acid) nanofiber tubes

Khatri, Zeeshan,Nakashima, Ryu,Mayakrishnan, Gopiraman,Lee, Ki-Hoon,Park, Young-Hwan,Wei, Kai,Kim, Ick-Soo Springer-Verlag 2013 JOURNAL OF MATERIALS SCIENCE - Vol.48 No.10

Pressure-settlement behavior of square and rectangular skirted footings resting on sand

Khatri, Vishwas Nandkishor,Debbarma, S.P.,Dutta, Rakesh Kumar,Mohanty, Bijayananda Techno-Press 2017 Geomechanics & engineering Vol.12 No.4

The present study deals with the Pressure-settlement behavior of square and rectangular skirted footing resting on sand and subjected to a vertical load through a laboratory experimental study. A series of load tests were conducted in the model test tank to evaluate the improvement in pressure-settlement behavior and bearing capacity of square and rectangular model footings with and without structural skirt. The footing of width 5 cm and 6 cm and length/width ratio of 1 and 2 was used. The relative density of sand was maintained at 30%, 50%, 70%, and 87% respectively. The depth of skirt was varied from 0.25 B to 1.0 B. All the tests were carried out using a strain controlled loading frame of 50 kN capacity. The strain rate for all test was kept 0.24 mm/min. The results of present study reveal that, the use of structural skirt improves the bearing capacity of footing significantly. The improvement in bearing capacity was observed almost linearly proportional to the depth of skirt. The improvement in bearing capacity of skirted footings over footing without skirt was observed in the range of 33.3% to 68.5%, 68.9% to 127% and 146.7% to 262% for a skirt depth of 0.25 B, 0.50 B and 1.0 B respectively. The skirted footings were found more effective for sand at relative density of 30% and 50% than at relative density of 70% and 87%. The bearing capacity was found to increase linearly with footing width for footings with and without skirts. This observation was found to be consistent for footings with different skirt depths and for relative density of sand i.e., 30%, 50%, 70%, and 87%. The obtained results from the study for footing with and without skirts were comparable with available solutions from literature.

One Pot Synthesis of Novel Cyanopyridones as an Intermediate of Bioactive Pyrido[2,3-d]Pyrimidines

Khatri, Taslimahemad T.,Shah, Viresh H. Korean Chemical Society 2014 대한화학회지 Vol.58 No.4

Synthesis, structural characterization, and biological activity studies of novel pyrido[2,3-d]pyrimidines (10a-h, 11a-h) are described. Cyclization of cynoacetamides (4, 5) with malonitrile (7) and aldehyde (6a-h) via Hantzsch pyridine synthesis afforded cyanopyridones (8a-h, 9a-h), which on cyclization with formic acid under microwave conditions led to the final product. All the reactions are significantly faster and the isolated yields are remarkably higher in microwave conditions compared to the conventionally heated reactions. The compounds were tested in vitro for their antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtillus, Staphylococcus aureus, and Micrococcus luteus and antifungal activity against Trichphyton longifusus, Candida albicans, Microsporum canis, Fusarium solani. Compounds 10b, 10e, 11b and 11e exhibited good antibacterial and antifungal activities compared with standards.

ON A CLASS OF GENERALIZED RECURRENT (k, 𝜇)-CONTACT METRIC MANIFOLDS

Khatri, Mohan,Singh, Jay Prakash Korean Mathematical Society 2020 대한수학회논문집 Vol.35 No.4

The goal of this paper is the introduction of hyper generalized 𝜙-recurrent (k, 𝜇)-contact metric manifolds and of quasi generalized 𝜙-recurrent (k, 𝜇)-contact metric manifolds, and the investigation of their properties. Their existence is guaranteed by examples.

Multi-biomarkers-Base Alzheimer's Disease Classification

Khatri, Uttam,Kwon, Goo-Rak Korea Multimedia Society 2021 The journal of multimedia information system Vol.8 No.4

Various anatomical MRI imaging biomarkers for Alzheimer's Disease (AD) identification have been recognized so far. Cortical and subcortical volume, hippocampal, amygdala volume, and genetics patterns have been utilized successfully to diagnose AD patients from healthy. These fundamental sMRI bio-measures have been utilized frequently and independently. The entire possibility of anatomical MRI imaging measures for AD diagnosis might thus still to analyze fully. Thus, in this paper, we merge different structural MRI imaging biomarkers to intensify diagnostic classification and analysis of Alzheimer's. For 54 clinically pronounce Alzheimer's patients, 58 cognitively healthy controls, and 99 Mild Cognitive Impairment (MCI); we calculated 1. Cortical and subcortical features, 2. The hippocampal subfield, amygdala nuclei volume using Freesurfer (6.0.0) and 3. Genetics (APoE ε4) biomarkers were obtained from the ADNI database. These three measures were first applied separately and then combined to predict the AD. After feature combination, we utilize the sequential feature selection [SFS (wrapper)] method to select the top-ranked features vectors and feed them into the Multi-Kernel SVM for classification. This diagnostic classification algorithm yields 94.33% of accuracy, 95.40% of sensitivity, 96.50% of specificity with 94.30% of AUC for AD/HC; for AD/MCI propose method obtained 85.58% of accuracy, 95.73% of sensitivity, and 87.30% of specificity along with 91.48% of AUC. Similarly, for HC/MCI, we obtained 89.77% of accuracy, 96.15% of sensitivity, and 87.35% of specificity with 92.55% of AUC. We also presented the performance comparison of the proposed method with KNN classifiers.

Bearing capacity factor N_γ for a rough conical footing

Khatri, Vishwas N.,Kumar, Jyant Techno-Press 2009 Geomechanics & engineering Vol.1 No.3

The bearing capacity factor $N_{\gamma}$ is computed for a rough conical footing placed over horizontal ground surface. The axisymmetric lower bound limit analysis formulation, in combination with finite elements and linear programming, proposed recently by the authors is used in this study. The variation of $N_{\gamma}$ with cone apex angle (${\beta}$), in a range of $30^{\circ}-180^{\circ}$, is obtained for different values of ${\phi}$; where ${\phi}$ is soil friction angle. For ${\phi}<30^{\circ}$, the magnitude of $N_{\gamma}$ is found to decrease continuously with an increase in ${\beta}$ from $30^{\circ}$ to $180^{\circ}$. On the other hand, for ${\phi}>30^{\circ}$, the minimum magnitude of $N_{\gamma}$ is found to occur generally between ${\beta}=120^{\circ}$ and ${\beta}=150^{\circ}$. In all the cases, it is noticed that the magnitude of $N_{\gamma}$ becomes maximum for ${\beta}=30^{\circ}$. For a given diameter of the cone, the area of the plastic zone reduces generally with an increase in ${\beta}$. The obtained values of $N_{\gamma}$ are found to compare quite well with those available in literature.

Impact of parthenium weed invasion on plants and their soil seedbank in a subtropical grassland, central Nepal

Khatri-Chettri Jyoti,Rokaya Maan Bahadur,Shrestha Bharat Babu 한국생태학회 2022 Journal of Ecology and Environment Vol.46 No.1

Background: Parthenium hysterophorus L. (Asteraceae; hereafter Parthenium) is an invasive alien species of global significance because of its’ negative ecological and socioeconomic impacts. This species is spreading rapidly from lowland Tarai to Middle Mountain regions in Nepal. In the present study, we analyzed the impacts of Parthenium on plant community composition including their soil seedbank in subtropical grasslands located in central Nepal. Data was collected in a 10 m long transects passing through areas of high (> 90% cover), medium (40%–60%) and low (< 10%) levels of Parthenium cover using a plot of 1 m2. Altogether, we sampled 90 plots in 30 transects. Seedling emergence method was used to estimate soil seedbank density in the soil samples (0–10 cm depth) collected from the plots with high Parthenium cover. Results: There was no significant difference in the plant species richness at different levels of Parthenium invasion whereas there was a significant change in the species composition of above ground flora due to Parthenium invasion. There was also a significant difference in species composition between soil seedbank and aboveground flora in the highly invaded plots. Parthenium was the most dominant in soil seedbank, contributing 65% to the total soil seedbank. Conclusions: Our study suggests that Parthenium has considerable negative impact on the native grassland flora, and the dominance of Parthenium in the soil seedbank means there is a challenge for its management. It also suggests the need of monitoring the soil seedbank dynamics while managing Parthenium weed.

Classification of Alzheimer Disease by Combining Hippocampus Volume and Cortical Thickness from sMRI, Plus APoE ε4 and CSF Biomarkers

Uttam Khatri,Goo-Rak Kwon 대한전자공학회 2021 IEIE Transactions on Smart Processing & Computing Vol.10 No.1

sMRI measurement is important for characterizing the pathology of Alzheimer’s disease (AD), mild cognitive impairment (MCI), and healthy control (HC). To date, several imaging and non-imaging bio-markers for AD and MCI have been identified. Cortical thickness, hippocampal atrophy, apolipoprotein E gene ε4 (APoE ε4), and cerebrospinal fluid (CSF) biomarkers are believed to be the major indicators for AD and MCI. In this paper, these features have been utilized successfully to identify AD patients from controls. These biomarkers have mostly been used separately, so far. The full possibilities of combining sMRI, cortical thickness, hippocampal volume, APoE ε4, and CSF biomarkers for AD diagnosis might thus yet lead to optimal analysis. Therefore, we combined hippocampal volume, cortical thickness, APoE ε4, and CSF markers to enhance diagnostic classification of AD. For 53 clinically diagnosed AD patients, 103 patients with mild cognitive impairment, and 61 cognitively healthy controls, we obtained cortical thickness, hippocampal volume, APoE ε4, and CSF biomarkers. These four measures were first applied separately and were then combined to predict AD in support vector machine–recursive feature elimination (SVM-RFE) to select the optimal features. They were fed into different classifiers (naïve Bayes, k-nearest neighbors, and SVM), and experimental results show that the combination of the different biomarkers performs well, as compared to using separate features individually.

Neglected Thoraco Lumbar Traumatic Spine Injuries

Kavin Khatri,Kamran Farooque,Vijay Sharma,Babita Gupta,Shivanand Gamanagatti 대한척추외과학회 2016 Asian Spine Journal Vol.10 No.4

Study Design: Retrospective study. Purpose: To outline the etiology, complications and management difficulties encountered in the management of neglected thoracolumbar spine injuries. Overview of Literature: The English literature describes overlooked diagnosis as the most common cause of neglected spine injuries. However, the reasons differ in developing or under-developed nations. Moreover, there is scarcity of literature about the neglected spinal injuries. Methods: Patients presenting with thoracolumbar traumatic injuries who had not received any form of treatment for more than three weeks were included in the study. The demographic details, operative procedure performed and complications encountered, along with American Spinal Injury Association grade and spinal cord independence measure score recorded on the history sheets were noted. The data were analyzed. Results: Forty patients were included in the study. Inadequate treatment at the first contact hospital (45%) followed by late presentation (38%) and missed injury (17%) were the major etiological factors for the neglected traumatic injuries in the thoracolumbar spine. The most common complications seen in the management of these cases were pressure sores (58%), back pain (57%), urinary tract infection (42%) and residual kyphotic deformity (42%). Conclusions: Management of neglected thoracolumbar injuries is challenging. The delay in presentation should not prevent spine surgeon in proceeding with operative intervention as good results can be expected.

On a class of generalized recurrent $(k,\mu)$-contact metric manifolds

Mohan Khatri,Jay Prakash Singh 대한수학회 2020 대한수학회논문집 Vol.35 No.4

The goal of this paper is the introduction of hyper generalized $\phi$-recurrent $(k,\mu)$-contact metric manifolds and of quasi generalized $\phi$-recurrent $(k,\mu)$-contact metric manifolds, and the investigation of their properties. Their existence is guaranteed by examples.