Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

급성 일산화 탄소 중독이 흰쥐 심장의 Cytochrome oxidae활성에 미치는 영향

배기원,김영선 최신의학사 1980 最新醫學 Vol.23 No.1

승모판대치술후 도플러 심초음피를 이용한 인공 판막의 종류에 따른 최대혈류속도와 평균혈류속도에 관한 연구

박선우,김권배,김윤년,김기식 啓明大學校 醫科大學 1988 계명의대학술지 Vol.7 No.2

The conventional non-invasive and invasive technique have limitations in evaluating cardiac prosthetic valves and artificial valves. We have used continuous wave Doppler echocardiography to evaluate 48 patients with tissue and mechanical mitral valves implanted within 4 months prior to examination. The results are as follows. 1) Of these patients, male are 28. The mean ages of male are 35.60 (yr) and female are 41.82. 2) The differences of peak and mean velocities of prosthetic acardiac valves between male and female are not significant, but the differences of valvular size between male and female are significant(male:31.00±1.30(mm), female:29.36±2.11, p<0.01). 3) The difference of size and flow velocities between mechanical (Edwards-Duromedics) and tissue(Ionescue-Shiley) valves are not significant, but the ages of patients with mechanical valves are significantly lower than tissue valves(mechanical valve; 34.05±11.28, tissue valve; 43.62±11.26, p<0.01). 4) The differences of flow velocities between mechanical and tissue valves, sizes of which are 31mm, are significant statistically (peak velocity; 130.15±24.59 vs 110.00±19.41, mean velocity; 74.49±23.14 vs 51.38±12.71, p<0.01). 5) The sizes of valves are larger, the peak and mean velocities are lower, but it is not significant statistically. The results indicated that Doppler echocardiography is a useful method for evaluating function of prosthetic valves.

N₂분위기에서 Solder 접합부의 젖음성 및 결함특성에 관한 연구

최명기,황선효,이창배,정재필,서창제 大田産業大學校 2001 한밭대학교 논문집 Vol.18 No.-

본 실험을 통하여 대기와 N_2분위기에서의 젖음력과 솔더 접합부의 결함특성에 대하여 연구 검토하였다. 모든 시편 조건에서 질소분위기에서의 젖음성이 대기 중에서 젖음성 보다 좋아졌다. 또한 N_2유량이 증가함으로서 젖음 시간은 짧아지고, 젖음력은 증가하였다. N_2분위기에서 브리지(Bridge)발생률이 25∼76%정도로 현저히 감소하였다. N_2분위기에서는 젖음력의 향상으로 솔더 접합부가 안정되었으며 결함 발생률도 현저하게 감소되는 것을 확인할 수 있었다. This study was prepared to find out wettability and properties of defects on solder joints in N_2 conditions. The wettability of solder joints in N_2 condition was better than that in atmosphere condition, and when the flow rate of N_2 was increased, it is found that the wetting time got a little bit short and the wetting force got stronger as time passed. Also the rate of bridge defects was specially decreased in N_2 conditions, showing the decreasing ratio of 25∼76%. The solder joints were stabilized and the rate of defects was decreased by cause to increasement of wetting force in N_2 conditions.

8.3% Carbamide Peroxide 함유 펜 형 자가미백제인 BIancTis Forte의 색조개선 및 안전성에 관한 임상연구

이진경,민선홍,홍성태,오소람,정신혜,황영혜,유성엽,배광식,백승호,이우철,손원준,금기연 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.2

This clinical study evaluated the whitening effect and safety of polymer based-pen type BlancTis Forte(NIBEC) containing 8.3% carbamide peroxide. Twenty volunteers used the BlancTis Forte whitening agent for 2 hours twice a day for 4 weeks As a control. Whitening Effect Pen (LG) containing 3% hydrogen peroxide was used by 20 volunteers using the same protocol. The change in shade (ΔE^(*) color difference) was measured using Shadepilot™ (DeguDent) before, during and after bleaching (2 weeks, 4 weeks and postbleaching 4 weeks). A clinical examination for any side effects (tooth hypersensitivity or soft tissue complications) was also performed at each check-up. The following results were obtained. 1 Both the experimental and control groups displayed a noticeable change in shade (ΔE) of over 2 No significant differences were found between the two group (p>0.05) implying that the two agents have a similar whitening effect. 2 The whitening effect was mainly due to changes in a and b values rather than in L value (brightness). The experimental group showed a significantly higher change in b value thus yellow shade than the control(p < 0.05) 3 None of the participants complained of tooth hypersensitivity or soft tissue complications confirming the safety of both whitening agents 8.3%의 carbamide peroxide를 함유한 펜형 코팅용 미백제인 BlancTis Forte (NIBEC, Seosul & JinCheon)를 실험군으로, 3% hydrogen peroxide를 함유한글 Whitening Effect Pen (LG. Seoul) 제재를 대조군으로 각각 피험자 20명에게 2시간씩 1일 2회 제조사의 지시대로 치아표면에 4주간 적용하도록 지시하고 색조개선 효능과 안전성을 평가하였다. 미백 효과는 미백 전 및 미백 2주, 4주 및 미백 종료 4주 후에 Shadopilot™을 이용하여 색 변화를 측정하였고, 매 내원시기마다 모든 환자는 치수생활력 검사와 치주 및 치태 검사를 통해 부작용 여부 (치아과민증 및 구감 내 연조직의 부작용)를 기록한 후 다음과 같은 결과를 얻었다. 1.실험군 및 대조군의 색 변화량 (ΔE)은 2이상으로 인지할 수 있는 색 변화를 보였으며, 두 제품 간에는 통계적으로 유의한 차이를 보이지 않아 (p > 0.05) 유사한 미백효능을 나타냄을 알 수 있었다. 2,미백효과는 명도의 개선보다는 주로 a. b값의 변화에 의한 것으로 특히 실험군에서 b값의 변화, 즉 황색조의 개선효과가 대조군에 비해 유의성 있게 높은 것으로 나타났다 (p <0.05). 3.치아나 치은의 과민증이나 이상증상을 호소하는 피험자는 없어 두 제품 모두 안전성을 확인할 수 있었다.

초경 시작 시기가 여성 정신분열병 환자의 병의 경과에 미치는 영향

김진훈,윤선욱,배명지,임선진,정은기,장동원 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.5

Objectives : The protective effects of estrogen against the development of schizophrenia have been investigated in various perspectives, Previous studies showed patients with earlier age of menarche had later onset of schizophrenia and less frequent admissions. This study was performed to evaluate the effect of the age of menarche on subsequent courses including hospitalizations, suicidal attempts, Physical harm to others, and psychotic symptoms in women with schizophrenia. Methods : Self-report menarche age, onset of psychotic symptoms, and clinical status were collected in a sample of 108 Premenopausal women with the diagnosis of schizophrenia. Results : There was significant correlation between the age of menarche and the frequency of admissions (r=.321, p=.006). Also, Patients with history of physical harms to others showed later age of menarche than those without (t=2.025, df=106, p=.045). Conclusion : In women with schizophrenia, the age of onset of menarche affects subsequent courses indicated by frequency of admissions and violent behaviors. It is suggested that identifying the age of menarche might be helpful to predict the courses in women with schizophrenia. Further investigations regarding the relationship between estrogen and the courses of Schizophrenia in women are needed.

Pharmacokinetics and tissue distribution of ginsenoside Rh2 and Rg3 epimers after oral administration of BST204, a purified ginseng dry extract, in rats

Bae, Soo Hyeon,Park, Jung Bae,Zheng, Yu Fen,Jang, Min Jung,Kim, Sun Ok,Kim, Jeom Yong,Yoo, Young Hyo,Yoon, Kee Dong,Oh, Euichaul,Bae, Soo Kyung Taylor & Francis 2014 Xenobiotica Vol.44 No.12

<P><OL><LI><P>BST204, a purified ginseng dry extract containing a high concentration of racemic Rh2 and Rg3 mixtures, is being developed for supportive care use in cancer patients in Korea. This study investigates the pharmacokinetics and tissue distribution of BST204 in rats.</P></LI><LI><P>After oral administration of BST204, only the <I>S</I> epimers, S-Rh2 and S-Rg3, could be determined in rat plasma. The poor absorption of the <I>R</I>-epimers, R-Rh2 and R-Rg3, may be attributed to lower membrane permeability and extensive intestinal oxygenation and/or deglycosylation into metabolites. The AUC and <I>C</I><SUB>max</SUB> values of both S-Rh2 and S-Rg3 after BST204 oral administration were proportional to the administered BST204 doses ranged from 400 mg/kg to 2000 mg/kg, which suggested linear pharmacokinetic properties.</P></LI><LI><P>There were no statistically significant differences in the pharmacokinetics of S-Rh2 and S-Rg3 after oral administration of pure S-Rh2 (31.5 mg/kg) and S-Rg3 (68 mg/kg) compared with oral administration of BST204, 1000 mg/kg. These indicated that the presence of other components of BST204 extract did not influence the pharmacokinetic behavior of S-Rh2 and S-Rg3.</P></LI><LI><P>After oral dosing of BST204, S-Rh2 and S-Rg3 were distributed mainly to the liver and gastrointestinal tract in rats.</P></LI><LI><P>Our finding may help to understand pharmacokinetic characteristics of S-Rh2, R-Rh2, S-Rg3, and R-Rg3, comprehensively, and provide useful information in clinical application of BST204.</P></LI></OL></P>

화엄사 홍매화

배개선(Kee Sun Bae) 한국콘크리트학회 2021 콘크리트학회지 Vol.33 No.3

스페인 몬세라트 수도원(Montserrat Monastery)

배기선(Kee Sun Bae) 한국콘크리트학회 2020 콘크리트학회지 Vol.32 No.1

형형색색 가을 단풍

배기선(Kee Sun Bae) 한국콘크리트학회 2018 콘크리트학회지 Vol.30 No.6