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Shinsuke NISHIMURA,Kisa MATSUSHIMA,Kazuhiro NAKAHASHI 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-
The compact scheme with a new method to detect the transition point is applied to low-Reynolds number (Re = 3.43 x 10?, 2.51 x 10?) over the NACA9324 airfoil. RANS simulations have difficultly to predict the stalling characteristics because the large separation and transition occur in flow at low-Reynolds number region, NACA9324 shows peculiar aerodynamic characteristics. Its stall type change from leading-edge stall to trailing-edge stall when the Reynolds number increase over 3.43 x 10?. In preliminary study, fully laminar computations using conventional 3<SUP>rd</SUP>-order TVD and 2<SUP>nd</SUP>-order central differencing could not predict stalling characteristics of the NACA9324. Because that computations couldn’t resolve a laminar bubble and a transition from laminar to turbulent flow. Thus, compact high-order scheme with the new transition method is applied to the flow around the NACA9324 airfoil. As a current result, the compact scheme succeeds in predicting the trailing-edge stalling aerodynamic characteristics. The new transition method is being examined.
Mutsuo Yamaya,Kazuhiro Nomura,Kazuya Arakawa,Mitsuru Sugawara,Xue Deng,Nadine Lusamba Kalonji,Hidekazu Nishimura,Mitsuhiro Yamada,Ryoichi Nagatomi,Tetsuaki Kawase 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.5
Rhinoviral infection is associated with anincreased risk of asthma attacks. The macrolide clarithromycindecreases cytokine production in nasopharyngealaspirates from patients with wheezing, but the effectsof macrolides on cytokine production in nasal epithelialcells obtained from asthmatic subjects remain unclear. Here, human nasal epithelial cells were infected with type-14 rhinovirus (RV14), a major RV group. Titers and RNAof RV14 and cytokine concentrations, including IL-1b andIL-6, were higher in the supernatants of the cells obtainedfrom subjects with bronchial asthma (asthmatic group) thanin those from the non-asthmatic group. Pretreatment withclarithromycin decreased RV14 titers, viral RNA andcytokine concentrations, and susceptibility to RV14infection. Pretreatment with clarithromycin also decreasedIL-33 production, which was detected after infection. Pretreatment with clarithromycin decreased the expressionof intercellular adhesion molecule-1, the receptor forRV14, after infection, the number and fluorescence intensityof the acidic endosomes through which RV RNAenters the cytoplasm, and the activation of nuclear factorkappa-B proteins in nuclear extracts. These findings suggestedthat RV replication and cytokine production may beenhanced in nasal epithelial cells obtained from subjectswith bronchial asthma and may be modulated byclarithromycin.
稻森悠平,小沼和博,水落元之,西村修 제주대학교 환경연구소 1996 환경연구논문집 : 제주대 Vol.4 No.-
Treatment of domestic and industrial wastewater and purification of polluted groundwater and lake water are very important for conservation of sound water environment. Biological treatment processes are widely used for wastewater treatment and natural water body purification, because most of the pollutants contained in wastewaters are degraded or assimilated by microorganisms. Nowadays, the technologies of mass cultivation of effective microorganisms and their introduction to waste water treatment system have been developed. The present report concerns the current situation and developing tendency of these biotechnologies. The importance of the application of effective microorganisms is also described.
Yuki Ichinose,Takafumi Nishimura,Minori Harada,Ryota Kashiwagi,Mikihiro Yamamoto,Yoshiteru Noutoshi,Kazuhiro Toyoda,Fumiko Taguchi,Daigo Takemoto,Hidenori Matsui 한국식물병리학회 2020 Plant Pathology Journal Vol.36 No.2
Pseudomonas syringae pv. tabaci 6605 has two mul- tidrug resistance (MDR) efflux pump transporters, MexAB-OprM and MexEF-OprN. To understand the role of these MDR efflux pumps in virulence, we generated deletion mutants, ∆mexB, ∆mexF, and ∆mexB∆mexF, and investigated their sensitivity to plant-derived antimicrobial compounds, antibiotics, and virulence. Growth inhibition assays with KB soft agar plate showed that growth of the wild-type (WT) was inhibited by 5 μl of 1 M catechol and 1 M coumarin but not by other plant-derived potential antimicrobial compounds tested including phytoalexins. The sensitiv- ity to these compounds tended to increase in ∆mexB and ∆mexB∆mexF mutants. The ∆mexB∆mexF mutant was also sensitive to 2 M acetovanillone. The mexAB- oprM was constitutively expressed, and activated in the ∆mexF and ∆mexB∆mexF mutant strains. The swarming and swimming motilities were impaired in ∆mexF and ∆mexB∆mexF mutants. The flood inocula- tion test indicated that bacterial populations in all mu- tant strains were significantly lower than that of WT, although all mutants and WT caused similar disease symptoms. These results indicate that MexAB-OprM extrudes plant-derived catechol, acetovanillone, or cou- marin, and contributes to bacterial virulence. Further- more, MexAB-OprM and MexEF-OprN complemented each other’s functions to some extent.
Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity
Motohiro Nishida,Tomohiro Tanaka,Supachoke Mangmool,Kazuhiro Nishiyama,Akiyuki Nishimura 한국지질동맥경화학회 2020 지질·동맥경화학회지 Vol.9 No.1
Vascular smooth muscle cells (VSMCs) play a pivotal role in the stability and tonic regulation of vascular homeostasis. VSMCs can switch back and forth between highly proliferative (synthetic) and fully differentiated (contractile) phenotypes in response to changes in the vessel environment. Abnormal phenotypic switching of VSMCs is a distinctive characteristic of vascular disorders, including atherosclerosis, pulmonary hypertension, stroke, and peripheral artery disease; however, how the control of VSMC phenotypic switching is dysregulated under pathological conditions remains obscure. Canonical transient receptor potential (TRPC) channels have attracted attention as a key regulator of pathological phenotype switching in VSMCs. Several TRPC subfamily member proteins—especially TRPC1 and TRPC6—are upregulated in pathological VSMCs, and pharmacological inhibition of TRPC channel activity has been reported to improve hypertensive vascular remodeling in rodents. This review summarizes the current understanding of the role of TRPC channels in cardiovascular plasticity, including our recent finding that TRPC6 participates in aberrant VSMC phenotype switching under ischemic conditions, and discusses the therapeutic potential of TRPC channels.