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      • KCI등재

        Reflection on the Use of Blended Learning at a Korean University

        ( Katie Mae Klemsen ),( Myeong Hee Seong ) 범태평양응용언어학회 2012 범태평양응용언어학회지 Vol.16 No.2

        The purpose of this study was to examine students`` satisfaction and investigate the potential of improved learning outcomes in smart and blended learning environments. This paper reflects on the experience of the delivery of a program at H University in Seoul, Korea using smart and blended learning. The goal was to apply the findings to current blended learning models in order to explore possible modifications that may enhance learning environments for Korean university students. The participants were 19 students enrolled in an English Language major course, Speaking 2: Presentation, which aimed to teach students to deliver oral presentations in English. Data was collected from student questionnaires, the smart/blended learning platform English 360, and an instructor reflection journal in order to address the following research questions: 1) What are the students`` perceptions of smart/blended learning environments?; 2) What are the benefits of smart/blended learning environments?; and 3) What are the drawbacks of smart/blended learning environments? The analysis of the data indicated that the overall student perception of smart and blended learning environments is positive. In addition, students`` perception of the course content influenced their interest in smart and blended learning environments. One of the primary findings was the importance of clear and transparent communication and organization of a smart and blended learning environment. Students indicated that they would be interested in additional courses that utilized smart/blended environments.

      • KCI등재

        Application of Supercharge End-to-Side (SETS) Obturator to Femoral Nerve Transfer in Electrical Injury-Induced Neuropathy to Improve Knee Extension

        Katie Pei-Hsuan Wu,Li-Ching Lin,Johnny Chuieng-Yi Lu 대한성형외과학회 2022 Archives of Plastic Surgery Vol.49 No.6

        Femoral nerve injuries are devastating injuries that lead to paralysis of the quadriceps muscles, weakening knee extension to prohibit ambulation. We report a devastating case of electrical injury-induced femoral neuropathy, where no apparent site of nerve disruption can be identified, thus inhibiting the traditional choices of nerve reconstruction such as nerve repair, grafting, or transfer. Concomitant spinal cord injury resulted in spastic myopathy of the antagonist muscles that further restricted knee extension. Our strategy was to perform (1) supercharge end-to-side technique (SETS) to augment the function of target muscles and (2) fractional tendon lengthening to release the spastic muscles. Dramatic postoperative improvement in passive and active range of motion highlights the effectiveness of this strategy to manage partial femoral nerve injuries.

      • SCIESCOPUS

        Vibration analysis of a Timoshenko beam carrying 3D tip mass by using differential transform method

        Kati, Hilal Doganay,Gokdag, Hakan Techno-Press 2018 Structural Engineering and Mechanics, An Int'l Jou Vol.65 No.4

        Dynamic behaviour of beam carrying masses has attracted attention of many researchers and engineers. Many studies on the analytical solution of beam with concentric tip mass have been published. However, there are limited works on vibration analysis of beam with an eccentric three dimensional object. In this case, bending and torsional deformations of beam are coupled due to the boundary conditions. Analytical solution of equations of motion of the system is complicated and lengthy. Therefore, in this study, Differential Transform Method (DTM) is applied to solve the relevant equations. First, the Timoshenko beam with 3D tip attachment whose centre of gravity is not coincident with beam end point is considered. The beam is assumed to undergo bending in two orthogonal planes and torsional deformation about beam axis. Using Hamilton's principle the equations of motion of the system along with the possible boundary conditions are derived. Later DTM is applied to obtain natural frequencies and mode shapes of the system. According to the relevant literature DTM has not been applied to such a system so far. Moreover, the problem is modelled by Ansys, the well-known finite element method, and impact test is applied to extract experimental modal data. Comparing DTM results with finite element and experimental results it is concluded that the proposed approach produces accurate results.

      • KCI등재
      • KCI등재

        Dysregulation of the EphrinB2−EphB4 ratio in pediatric cerebral arteriovenous malformations is associated with endothelial cell in vitro and functions as a novel noninvasive biomarker in patients

        Katie Pricola Fehnel,David L. Penn,Micah Duggins-Warf,Maxwell Gruber,Steven Pineda,Julie Sesen,Alexander Moses-Gardner,Nishali Shah,Jessica Driscoll,David Zurakowski,Darren B. Orbach,Edward R. Smith 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-

        We investigated (1) EphrinB2 and EphB4 receptor expression in cerebral AVMs, (2) the impact of an altered EphrinB2: EphB4 ratio on brain endothelial cell function and (3) potential translational applications of these data. The following parameters were compared between AVM endothelial cells (AVMECs) and human brain microvascular endothelial cells (HBMVECs): quantified EphrinB2 and EphB4 expression, angiogenic potential, and responses to manipulation of the EphrinB2:EphB4 ratio via pharmacologic stimulation/inhibition. To investigate the clinical relevance of these in vitro data, Ephrin expression was assessed in AVM tissue (by immunohistochemistry) and urine (by ELISA) from pediatric patients with AVM (n=30), other cerebrovascular disease (n=14) and control patients (n=29), and the data were subjected to univariate and multivariate statistical analyses. Compared to HBMVECs, AVMECs demonstrated increased invasion (p=0.04) and migration (p=0.08), impaired tube formation (p=0.06) and increased EphrinB2:EphB4 ratios. Altering the EphrinB2:EphB4 ratio (by increasing EphrinB2 or blocking EphB4) in HBMVECs increased invasion (p=0.03 and p<0.05, respectively). EphrinB2 expression was increased in AVM tissue, which correlated with increased urinary EphrinB2 levels in AVM patients. Using the optimal urinary cutoff value (EphrinB2>25.7pg/μg), AVMs were detected with high accuracy (80% vs. controls) and were distinguished from other cerebrovascular disease (75% accuracy). Posttreatment urinary EphrinB2 levels normalized in an index patient. In summary, AVMECs have an EphrinB2:EphB4 ratio that is increased compared to that of normal HBMVECs. Changing this ratio in HBMVECs induces AVMEC-like behavior. EphrinB2 is clinically relevant, and its levels are increased in AVM tissue and patient urine. This work suggests that dysregulation of the EphrinB2:EphB4 signaling cascade and increases in EphrinB2 may play a role in AVM development, with potential utility as a diagnostic and therapeutic target.

      • KCI등재

        Effects of Reactive Air Brazing Parameters on the Interfacial Microstructure and Shear Strength of GDC–LSM/Crofer 22 APU Joints

        Kati Raju,Seyoung Kim,Young-Hoon Seong,Dang-Hyok Yoon 한국세라믹학회 2019 한국세라믹학회지 Vol.56 No.4

        In this paper, the joining characteristics of GDC–LSM ceramics with Crofer 22 APU metal alloys was investigated at different brazing temperatures and holding times by reactive air brazing. Brazing was performed using Ag–10 wt% CuO filler, at three different temperatures (1000, 1050, and 1100°C for 30 minutes) as well as for three different holding times (10, 30, and 60 minutes at 1050°C). The interfacial microstructures were examined by scanning electron microscopy and the joining strengths were assessed by measuring shear strengths at room temperature. The results show that with increasing brazing temperature and holding time, joint microstructure changed obviously and shear strength was decreased. Shear strength varied from a maximum of 100±6 MPa to a minimum of 18±5 MPa, depending on the brazing conditions. These changes were attributed to an increase in the thickness of the oxide layer at the filler/metal alloy interface.

      • SCIESCOPUSKCI등재

        A Highly Pathogenic Strain of Bacillus thuringiensis serovar kurstaki in Lepidopteran Pests

        Kati, Hatice,Sezen, Kazim,Nalcacioglu, Remziye,Demirbag, Zihni The Microbiological Society of Korea 2007 The journal of microbiology Vol.45 No.6

        In order to detect and identify the most toxic Bacillus thuringiensis strains against pests, we isolated a B. thuringiensis strain (Bn1) from Balaninus nucum (Coleoptera: Curculionidae), the most damaging hazelnut pest. Bn1 was characterized via morphological, biochemical, and molecular techniques. The isolate was serotyped, and the results showed that Bn1 was the B. thuringiensis serovar, kurstaki (H3abc). The scanning electron microscopy indicated that Bn1 has crystals with cubic and bipyramidal shapes. The Polymerase Chain Reactions (PCRs) revealed the presence of the cry1 and cry2 genes. The presence of Cry1 and Cry2 proteins in the Bn1 isolate was confirmed via SDS-PAGE, at approximately 130 kDa and 65 kDa, respectively. The bioassays conducted to determine the insecticidal activity of the Bn1 isolate were conducted with four distinct insects, using spore-crystal mixtures. We noted that Bn1 has higher toxicity as compared with the standard B. thuringiensis subsp. kurstaki (HD-1). The highest observed mortality was 90% against Malacosoma neustria and Lymantria dispar larvae. Our results show that the B. thuringiensis isolate (Bn1) may prove valuable as a significant microbial control agent against lepidopteran pests.

      • KCI등재

        The Changing Anatomy of Regional Trade Agreements in East Asia

        Kati Suominen 동아시아연구원 2009 Journal of East Asian Studies Vol.9 No.1

        The recent proliferation of regional trade agreements in the East Asian region can be seen as the most notable development in the region's trading panorama in recent years. Yet, very little is as yet understood about the anatomy of these agreements and, consequently, their full implications to the regional economy. This article strives to fill this gap by analyzing the structure of four dozen RTAs by their various key component parts, including tariff liberalization schedules, rules of origin, and competition policy, customs, investment, and services provisions. The results reveal that intra-Asian RTAs are generally quite rapidly liberalizing, with the exception of agriculture, but they are also quite thin in trade-related disciplines when compared with the more legalistic US trans-Pacific RTAs and those of Mexico and Chile. The proposed Free Trade Area of the Asia-Pacific would inherently be a construct of the political economy interests of these various constituent RTAs.

      • KCI등재

        Pregnancy After Breast Cancer – Prognostic Safety and Pregnancy Outcomes According to Oestrogen Receptor Status: A Systematic Review

        Katie Nolan,Michael R. Boland,Arnold D.K. Hill 한국유방암학회 2022 Journal of breast cancer Vol.25 No.6

        Purpose: Breast cancer is the primary cause of cancer-related death in women. Women diagnosed with estrogen receptor (ER)-positive breast cancer have prolonged treatment durations. Owing to the paucity of research and lack of consensus regarding conception planning and pregnancy for patients with ER-positive breast cancer, we aimed to assess pregnancy and survival outcomes in women with ER-positive breast cancer during and after treatment. Methods: We conducted a systematic review of the available studies on pregnancy after ERpositive breast cancer. The assessed outcomes included overall survival (OS), disease-free survival (DFS), hormonal therapy duration, and pregnancy outcomes. Results: Ultimately, 2,669 patients from five studies were included in this study. When all breast cancer receptor subtypes were included in the analysis, pregnancy after breast cancer was associated with a time-dependent protective effect on both DFS and OS. This protective effect was not evident when examining ER-positive patients with subsequent pregnancies, and no significant differences in DFS were observed. ER-positive patients who became pregnant received significantly lower rates of hormonal therapy. Hormonal treatment at the time of pregnancy was correlated with increased rates of termination owing to concerns about teratogenic effects. Conclusions: Pregnancy after breast cancer did not significantly affect DFS in ER-positive patients over a follow-up period of 5–10 years from diagnosis, although did significantly affect hormonal treatment duration in the reviewed studies. Further analysis and in-depth studies are required to assess the effects of altered hormonal treatment times, as well as patient management related to pregnancy planning after breast cancer.

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