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권호영,임종호,강세선 한국비파괴검사학회 2000 한국비파괴검사학회지 Vol.20 No.5
표준시험편이란 재질, 형상, 치수 및 성능이 권위 있는 기관에 위해 검정된 국제적인 시험편을 말하며 이것은 탐상기의 특성시험 또는 감도조정, 시간축의 측정범위 조정에 사용된다. 그런데 이 표준시험편은 초음파탐상 결과에 아주 크게 영향을 미치는 하나의 변수로 ASTM 이나 JIS에서는 이들 표준시험편의 규격, 재질 및 성분 등을 엄격하게 규격화하고 있다. 그 이유는 이들 성질들이 감도와 분해능 및 재현성에 아주 큰 영향을 미치기 때문이다. 따라서 결함의 크기 및 치수를 정량화하고 재현성 있는 결과를 얻기 위해서는 엄격한 품질의 표준시험편이 요구되고 있다. 그러나 ASTM 또는 JIS등의 규격품들은 상당히 고가이며 시중에는 품질이 검증되지 않은 표준시험편들이 일부 사용되고 있는 실정에 있고 이들 시험편의 품질 및 사용 적합성을 재고하기 위하여 각종 규격에 비추어 보고, 규격품들과 비규격품의 각종 성질들을 비교하여 그 사용 안정성을 고찰하고자 하였다. 그 결과 비규격품들은 치수 및 성분에서 많은 문제점을 안고있으며 비규격품들을 검증없이 사용할 경우 피검물내의 결함의 위치나 크기 측정에 오차를 유발할 가능성을 확인하였다. Standard Test Block(STB) for UT(Ultrasonic Testing) is a block approved by authoritative for material, shape and quality. STB is used for characteristic tests, sensitivity calibration and control of the time base range of UT inspection devices. The material, size and chemical components of STB should be strictly controlled to meet the related standards such as ASTM and JIS because it has an effect upon sensitivity, resolution and reproductivity of UT. The STBs which are not approved are sometimes used because the qualified STBs are very expensive. So, the purpose of this study is to survey the characteristics, quality and usability of Non-Standardized Test Blocks. Non-Standardized Test Blacks did not meet the standard requirements in size or chemical components, and ultrasonic characteristics. Therefore if the Non-Standardized Test Blocks are used without being tested, it's likely to cause errors in detecting the location and measuring the size of the defects.
Son, Ho Young,Kang, Joon Ki,Bahk, Yong Whee,Kwon, Hyoung Chul,Yoon, Sei Chul,Oh, Yoon Kyeong,Song, Jin Un CATHOLIC MEDICAL CENTER 1985 Bulletin of the Clinical Research Institute Vol.13 No.1
Twenty-four cases of pituitary adenoma, 13 males and 11 females with the age ranging from 11 to 65 years, received radiation therapy (RT) on the pituitary area with a 6 MV linear accelerator during past 25 months at the Division of Radiation Therapy, Kang-Nam St. Mary's Hospital, Catholic Medical College. Of 24 cases of RT, 20 were postoperative and 4 primary. To evaluate the effect of RT, we analyzed the alteration of the endocrinologic tests (prolactin, growth homme), neurologic abnormalities, major clinical symptoms, endocrinologic changes and improvement in visual problems after RT.
Kang, Myung-Ji,Kwon, Eun-Bin,Yuk, Heung Joo,Ryu, Hyung Won,Kim, Soo-Yeon,Lee, Mi-Kyeong,Moon, Dong-Oh,Lee, Su Ui,Oh, Sei-Ryang,Lee, Hyun-Sun,Kim, Mun-Ock Informa UK (TaylorFrancis) 2017 Bioscience, Biotechnology, and Biochemistry Vol.81 No.12
<P>In the course of screening to find a plant material decreasing the activity of triacylglycerol and cholesterol, we identified Tripterygium regelii (TR). The methanol extract of TR leaves (TR-LM) was shown to reduce the intracellular lipid contents consisting of triacylglycerol (TG) and cholesterol in HepG2 cells. TR-LM also downregulated the mRNA and protein expression of the lipogenic genes such as SREBP-1 and its target enzymes. Consequently, TR-LM reduced the TG biosynthesis in HepG2 cells. In addition, TR-LM decreased SREBP2 and its target enzyme HMG-CoA reductase, which is involved in cholesterol synthesis. In this study, we evaluated that TR-LM attenuated cellular lipid contents through the suppression of de novo TG and cholesterol biosynthesis in HepG2 cells. All these taken together, TR-LM could be beneficial in regulating lipid metabolism and useful preventing the hyper-lipidemia and its complications, in that liver is a crucial tissue for the secretion of serum lipids.</P>
Chronic intermittent hypoxia augments lipopolysaccharide induced acute lung injury
( Sei Won Kim ),( In Kyoung Kim ),( Hee Young Kwon ),( Sung Bae Cho ),( Jong Min Lee ),( Jick Hwan Ha ),( Hyeon Hui Kang ),( Seok Chan Kim ),( Sang Haak Lee ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Obstructive sleep apnea (OSA) is characterized by repetitive upper airway collapse during sleep, causing chronic intermittent hypoxia (CIH). OSA affects 2-5% of the middle-aged population and is associated with significant morbidity and mortality. In intensive care unit, considerable numbers of patients with acute lung injury (ALI) have underlying OSA. However, little is known regarding the effects of OSA on the clinical course of ALI. This study is aimed to evaluate the impact of CIH on inflammation, fibrosis and related pathway in a murine model of ALI. Seven-to-eight week-old male, C57BL/6J mice were used. The mice were divided into two groups and exposed to room air (RA) or CIH. During 4 weeks, the CIH group was exposed to a 30 s RA/hypoxia (approximately fractional inspired O2 7±0.5%) cycle for 8 hours a day. After 4 weeks, each group was divided into two additional groups with intratracheal lipopolysaccharide (LPS, 0.5 mg/kg) or saline exposure. In CIH group with LPS exposure, lung wet/dry ratio and lung injury score were higher than other three groups. Level of hyproxyproline, TGF-beta, VEGF and collagen deposition were also higher in CIH group with LPS exposure compared to other groups. From the cell differentiation of bronchoalveolar lavage, CIH group with LPS exposure showed significantly higher number of total cell and neutrophil compared with other groups, especially compared with RA group with LPS exposure (p<0.001, respectively). These results suggest that CIH may aggravate inflammation and fibrosis in LPS induced ALI, resulting more damage.
( Sei Won Kim ),( Chin Kook Rhee ),( Hea Yon Lee ),( Hwa Young Lee ),( Ji Young Kang ),( Sook Young Lee ),( Young Kyoon Kim ),( Soon Suk Kwon ),( Hyoung Kyu Yoon ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Asthma is characterized by airway inflammation and remodeling. Roflumilast is a selective phosphodiesterase-4 (PDE4) inhibitor that has anti-inflammatory effect in chronic obstructive pulmonary disease (COPD). However, little is known regarding the effect of roflumilast in chronic asthma. This study is aimed to evaluate the effects of roflumilast on airway inflammation and remodelling in a murine model of chronic asthma. Methods: Female BALB/c mice, 6 weeks of age, were used. We developed a mouse model of airway remodeling in which ovalbumin (OVA)-sensitized mice were repeatedly exposed to intranasal OVA administration twice a week for 3 months. Roflumilast was administered orally starting on the 38th and 5 days a week thereafter for 3 months during the intranasal OVA challenge. A lung fibroblast cell line was used in the proliferation assay. Results: Compared with control mice, mice chronically exposed to OVA developed sustained eosinophilic airway inflammation, airway hyperresponsiveness (AHR), and exhibited features of airway remodeling. Administration of roflumilast significantly inhibited eosinophilic inflammation and AHR. The levels of interleukin (IL)-4, IL-5, and IL-13 in the bronchoalveolar lavage (BAL) fluids were significantly lower in the roflumilast group. The level of hydroxyproline was also significantly lower in the roflumilast group. In vitro, roflumilast significantly inhibited stem cell factor (SCF) induced cell proliferation of fibroblasts. Conclusions: These results suggest that roflumilast administration modulates the airway inflammation, AHR, and airway remodeling associated with chronic allergen challenge.
Kwon, Eun-Bin,Kang, Myung-Ji,Kim, Soo-Yeon,Lee, Yong-Moon,Lee, Mi-Kyeong,Yuk, Heung Joo,Ryu, Hyung Won,Lee, Su Ui,Oh, Sei-Ryang,Moon, Dong-Oh,Lee, Hyun-Sun,Kim, Mun-Ock Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P><I>Zanthoxylum ailanthoides</I> (ZA) has been used as folk medicines in East Asian and recently reported to have several bioactivity; however, the studies of ZA on the regulation of triacylglycerol (TG) biosynthesis have not been elucidated yet. In this study, we examined whether the methanol extract of ZA (ZA-M) could reduce oleic acid- (OA-) induced intracellular lipid accumulation and confirmed its mode of action in HepG2 cells. ZA-M was shown to promote the phosphorylation of AMPK and its upstream LKB1, followed by reduction of lipogenic gene expressions. As a result, treatment of ZA-M blocked de novo TG biosynthesis and subsequently mitigated intracellular neutral lipid accumulation in HepG2 cells. ZA-M also inhibited OA-induced production of reactive oxygen species (ROS) and TNF-<I>α</I>, suggesting that ZA-M possess the anti-inflammatory feature in fatty acid over accumulated condition. Taken together, these results suggest that ZA-M attenuates OA-induced lipid accumulation and inflammation through the activation of LKB1/AMPK signaling pathway in HepG2 cells.</P>
Markov Chain 模型을 利用한 農作物의 植付面積 豫測
康廷赫,朴世權 한국경영과학회 1989 한국경영과학회 학술대회논문집 Vol.- No.1
The conventional and Bayesian procedures which make use of aggregate time series data have been revieved for estimating transition probability and applied to forecast the planted area of agricultural crops. Also, the predictive performance of various estimators is examined with respect to the mean squared error(MSE) and the chi square value through the x^2 goodness of fit test. The results are consistent with the hypothesis that data are generated from Markov process, which indicate that estimation procedures yield reasonable results.
( Sei Won Kim ),( Chin Kook Rhee ),( Hea Yon Lee ),( Hwa Young Lee ),( Ji Young Kang ),( Sook Young Lee ),( Young Kyoon Kim ),( Soon Suk Kwon ),( Hyoung Kyu Yoon ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Asthma is characterized by airway in ammation and remodeling. Ro umilast is a selective phosphodiesterase-4 (PDE4) inhibitor that has anti-in ammatory effect in chronic obstructive pulmonary disease (COPD). However, little is known regarding the effect of ro umilast in chronic asthma. This study is aimed to evaluate the effects of ro umilast on airway in ammation and remodelling in a murine model of chronic asthma. Methods: Female BALB/c mice, 6 weeks of age, were used. We developed a mouse model of airway remodeling in which ovalbumin (OVA)-sensitized mice were repeatedly exposed to intranasal OVA administration twice a week for 3 months. Ro umilast was administered orally starting on the 38th and 5 days a week thereafter for 3 months during the intranasal OVA challenge. A lung fi broblast cell line was used in the proliferation assay. Results: Compared with control mice, mice chronically exposed to OVA developed sustained eosinophilic airway in ammation, airway hyperresponsiveness (AHR), and exhibited features of airway remodeling. Administration of ro umilast signifi cantly inhibited eosinophilic in ammation and AHR. The levels of interleukin (IL)-4, IL-5, and IL-13 in the bronchoalveolar lavage (BAL) uids were signifi cantly lower in the ro umilast group. The level of hydroxyproline was also signifi cantly lower in the ro umilast group. In vitro, ro umilast signifi cantly inhibited stem cell factor (SCF) induced cell proliferation of fi broblasts. Conclusions: These results suggest that ro umilast administration modulates the airway in ammation, AHR, and airway remodeling associated with chronic allergen challenge.