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캡슐내시경과 단일풍선 소장내시경으로 진단된 공장의 간질종양 1예
송도경,심기남,태정현,김경진,송명은,송하응,윤혜원,정가영,정정화 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2
Gastrointestinal stromal tumors (GISTs) are common mesenchymal tumors that arise in the wall of the gastrointestinal tract. We report a case of obscure gastrointestinal bleeding due to a GIST of the jejunum successfully documented by videocapsule endoscopy (VCE) and single-balloon enteroscopy (SBE). A 36-year-old man with hematochezia was referred for further evaluation of no evidence of bleeding focus on esophagogastroduodenoscopy and colonoscopy. A VCE showed a suspicious ulcerative hyperemic mass that located in about 1 hour apart from duodenal second portion. SBE revealed a nonbleeding 4×2 cm mass with an ulcer at the proximal jejunum. The patient underwent laparoscopic resection without complication. Histological examination revealed a well circumscribed, dumbbell-shaped firm mass comprised of spindle cells. Immunohistochemical staining for CD 117 was diffusely positive, whereas staining for S-100, CD 34 and MIB-1 was all negative. It was confirmed to be a low-grade GIST at the proximal jejunum.
윤혜원,심기남,나선경,송도경,정정화,정가영 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2
Double primary cancers are two independently developed cancers in an individual. There have been some reports on double primary cancer since Billroth reported it for the first time in 1879. Double primary cancer of the stomach and esophagus has been revealed a very low incidence worldwide. The incidence of an esophageal cancer with another primary cancer is reported to be 9.5∼27%, but double primary cancers in the esophagus and stomach have been rarely reported to our knowledge. In this study, we present here a case of double primary esophageal and stomach cancer in a 66-year-old man because of progressive dysphagia.
Noh, Ka‐,Won,Lee, Mi‐,Sook,Lee, Seung Eun,Song, Ji‐,Young,Shin, Hyun‐,Tae,Kim, Yu Jin,Oh, Doo Yi,Jung, Kyungsoo,Sung, Minjung,Kim, Mingi,An, Sungbin,Han, Joungho,Shim, Young Mo Longman 2017 The Journal of pathology Vol.243 No.3
<P><B>Abstract</B></P><P>Most anaplastic lymphoma kinase (<I>ALK</I>)‐rearranged non‐small cell lung cancers (NSCLCs) show good clinical response to ALK inhibitors. However, some <I>ALK</I>‐rearranged NSCLC patients show various primary responses with unknown reasons. Previous studies focused on the clinical aspects of <I>ALK</I> fusions in small cohorts, or were conducted <I>in vitro</I> and/or <I>in vivo</I> to investigate the function of ALK. One of the suggested theories describes how echinoderm microtubule‐associated protein‐like 4 (<I>EML4</I>)<I>–ALK</I> variants play a role towards different sensitivities in ALK inhibitors. Until now, there has been no integrated comprehensive study that dissects <I>ALK</I> at the molecular level in a large scale. Here, we report the largest extensive molecular analysis of 158 <I>ALK</I>‐rearranged NSCLCs and have investigated these findings in a cell line construct experiment. We discovered that NSCLCs with <I>EML4–ALK</I> short forms (variant 3/others) had more advanced stage and frequent metastases than cases with the long forms (variant 1/others) (<I>p</I> = 0.057, <I>p</I> < 0.05). <I>In vitro</I> experiments revealed that <I>EML4–ALK</I> short forms show lower sensitivity to ALK inhibitors than do long forms. Clinical analysis also showed a trend for the short forms showing worse PFS. Interestingly, we found that breakpoints of <I>ALK</I> are evenly distributed mainly in intron 19 and almost all of them undergo a non‐homologous end‐joining repair to generate <I>ALK</I> fusions. We also discovered four novel somatic <I>ALK</I> mutations in NSCLC (T1151R, R1192P, A1280V, and L1535Q) that confer primary resistance; all of them showed strong resistance to ALK inhibitors, as G1202R does. Through targeted deep sequencing, we discovered three novel <I>ALK</I> fusion partners (<I>GCC2</I>, <I>LMO7</I>, and <I>PHACTR1</I>), and different <I>ALK</I> fusion partners showed different intracellular localization. With our findings that the <I>EML4–ALK</I> variants, new <I>ALK</I> somatic mutations, and novel <I>ALK</I>‐fusion partners may affect sensitivity to ALK inhibitors, we stress the importance of targeted therapy to take the <I>ALK</I> molecular profiling into consideration. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</P>
Kim, Ka Young,Park, Sunhong,Jung, Sung Ho,Lee, Shim Sung,Park, Ki-Min,Shinkai, Seiji,Jung, Jong Hwa American Chemical Society 2014 Inorganic Chemistry Vol.53 No.6
<P>A coordination polymer gel that is self-assembled to form a network structure between a thiacalix[4]arene derivative (<B>L</B>) and Co<SUP>2+</SUP> has been prepared. This gel is capable of selectively changing color in the presence of gases that yield hydrogen chloride upon hydrolysis. The UV–vis absorption spectrum of a coordination polymer gel derived from Co(NO<SUB>3</SUB>)<SUB>2</SUB> exhibits an absorption band at 527 nm and is colored red, indicating the formation of an octahedral Co<SUP>2+</SUP> complex. Treatment with a small amount of volatile gases containing a chlorine atom (VGCl) causes a red shift of ∼150 nm, resulting in a new strong band with a maximum at 670 nm and a color change to blue. In addition, the red color of the filter paper coated with a Co(NO<SUB>3</SUB>)<SUB>2</SUB> coordination polymer gel changed to blue upon exposure to VGCl, reflecting a change in the coordination geometry. Red and blue colors of single crystals of Co<SUP>2+</SUP> complexes were obtained from a basic solution. From X-ray crystallographic analysis, the red Co<SUP>2+</SUP> complex corresponds to an octahedral structure, while the blue Co<SUP>2+</SUP> complex reflects the presence of a tetrahedral structure. Thus, the induced color change of Co<SUP>2+</SUP> gel from red to blue upon exposure to VGCl is due to the coordination geometry. The quantitative concentration of VGCl was calculated by employing the RGB histogram available in a smartphone application.</P><P>We prepared a coordination polymer gel that is self-assembled to form a network structure between a thiacalix[4]arene derivative and Co<SUP>2+</SUP>. This gel is capable of selectively changing color in the presence of phosgene. We found that this rapid and dramatic color change under ambient conditions originated from a change from an octahedral to a tetrahedral structure. Furthermore, the quantitative concentration of phosgene can be easily calculated by employing the RGB histogram available in a smartphone application.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/inocaj/2014/inocaj.2014.53.issue-6/ic402804p/production/images/medium/ic-2013-02804p_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ic402804p'>ACS Electronic Supporting Info</A></P>
Jung, Sung Ho,Kim, Ka Young,Ahn, Ahreum,Lee, Shim Sung,Choi, Myong Yong,Jaworski, Justyn,Jung, Jong Hwa The Royal Society of Chemistry 2016 NEW JOURNAL OF CHEMISTRY Vol.40 No.9
<P>Enantiomeric excess of chiral compounds is a key parameter that can influence their activity or therapeutic action. Current approaches to the rapid measurement of enantiomeric excess using H-1 NMR is based on the formation of diastereomeric complexes between chiral analytes and a chiral host, leading to two species with no symmetry relationship. Here, we demonstrate that a gelator host system can provide a means to elicit distinct chemical shifts in the H-1 nuclear magnetic resonance (NMR) of a mixture of diamines or monoamines depending on the corresponding enantiomeric excess of the guest mixture of chiral amines. These gelator hosts provide a unique example of NMR based assessment of the chirality and enantiopurity of guest amines.</P>
Chiral Supramolecular Gels with Lanthanide Ions: Correlation between Luminescence and Helical Pitch
Kim, Chaelin,Kim, Ka Young,Lee, Ji Ha,Ahn, Junho,Sakurai, Kazuo,Lee, Shim Sung,Jung, Jong Hwa American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.4
<P>We report the correlation between the fluorescence intensity and the helical pitch of supramolecular hydrogels with Tb(III) and Eu(III) as well as their inkjet printing patterning as an application. The luminescent gels, which exhibited three different emissions of red, green, and blue, could be prepared without and with Eu(III) and Tb(III). The luminescence intensity of supramolecular gels (gel-Tb and gel-Eu) composed of Tb(III) and Eu(III) was ca. 3-fold larger than that of the sol (1+Tb(III) or 1+Eu(III)), which was attributed to large tilting angles between molecules. By AFM observations, these gels showed well-defined right-handed helical nanofibers formed by coordination bonds in which the helical pitch lengths were strongly dependent on the concentrations of lanthanide ions. In particular, the large luminescence intensity of gel-Tb exhibited a smaller helical pitch length than that of gel-1 due to relatively weak pi-pi stacking with large tilting angles between molecules. The luminescence intensities were enhanced linearly with increasing concentrations of lanthanide ions. This is the first example of the correlation between the helical pitch length and the luminescence intensity of supramolecular materials. The coordination bonding in supramolecular hydrogels had a strong influence on rheological properties. We also developed a water-compatible inkjet printing system to generate luminescent supramolecular gels on A4-sized paper. The images of a logo and the text were composed of three different emissions and were well-printed on A4-sized paper coated with gel-1.</P>
Jung, Sung Ho,Kim, Ka Young,Lee, Ji Ha,Moon, Cheol Joo,Han, Noh Soo,Park, Su-Jin,Kang, Dongmin,Song, Jae Kyu,Lee, Shim Sung,Choi, Myong Yong,Jaworski, Justyn,Jung, Jong Hwa American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.1
<P>To more accurately assess the pathways of biological systems, a probe is needed that may respond selectively to adenosine triphosphate (ATP) for both in vitro and in vivo detection modes. We have developed a luminescence probe that can provide real-time information on the extent of ATP, ADP, and AMP by virtue of the luminescence and luminescence lifetime observed from a supramolecular polymer based on a C-3 symmetrical terpyridine complex with Tb3+ (S1-Tb). The probe shows remarkable selective luminescence enhancement in the presence of ATP compared to other phosphate-displaying nucleotides including adenosine diphosphate (ADP), adenosine monophosphate (AMP), guanosine triphosphate (GTP), thymidine triphosphate (TTP), H2PO4- (Pi), and pyrophosphate (PPi). In addition, the time-resolved luminescence lifetime and luminescence spectrum of S1-Tb could facilitate the quantitative measurement of the exact amount of ATP and similarly ADP and AMP within living cells. The time-resolved luminescence lifetime of S1-Tb could also be used to quantitatively monitor the amount of ATP, ADP, and AMP in vitro following the enzymatic hydrolysis of ATP. The long luminescence lifetime, which was observed into the millisecond range, makes this S1-Tb-based probe particularly attractive for monitoring biological ATP levels in vivo, because any short lifetime background fluorescence arising from the complex molecular environment may be easily eliminated.</P>
Lee, Ji Ha,Kim, Ka Young,Jin, Hanyong,Baek, Yeong Eun,Choi, Yeonweon,Jung, Sung Ho,Lee, Shim Sung,Bae, Jeehyeon,Jung, Jong Hwa American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.4
<P>The development of specifically targeted nano particles for subcellular organelles modified with a low molecular-weight organic compound as drug nanocarriers can bring about wide applications in cancer therapy. However, their utility has been hampered by low selectivity, poor biodistribution, and limited efficiency. Herein, we report the aggregation behavior of a triphenylphosphonium-appended coumarin probe (TPP-C) in an aqueous solution and its applications as a mitochondria-targeting probe, and drug delivery carrier, which is a rare example for a low molecular-weight organic compound. The TPP-C formed homogeneous nanoparticles with small diameters in water as well as in mixtures of organic solvents and water. In pure water, the homogeneous nanopartides induced J-aggregation, whereas in mixed solvents, the homogeneous nanoparticles induced H-aggregation. The luminescence intensities of nanoparticles originated from the aggregation-induced emission (ATE) effect in pure water and also in mixtures of organic solvents and water. These findings indicate that the AIE effect of TPP-C was dependent on the solvent. More interestingly, the TPP-C nanoparticles selectively accumulated in mitochondria. The TPP-C nanoparticles alone exhibited noncytotoxicity toward cancer cells. However, with the encapsulation of the anticancer drug doxorubicin (DOX) into the TPP-C nanoparticles, the DOX was efficiently delivered to the mitochondria. These results indicated that the proposed system demonstrates promise as a platform for future clinical medication, particularly for specific suborganelle-targeted drug delivery systems for cancer therapy.</P>