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Park, Ka Hyun,Lee, Kang Mun,Go, Min Jeong,Choi, Sung Ho,Park, Hyoung-Ryun,Kim, Youngjo,Lee, Junseong American Chemical Society 2014 Inorganic Chemistry Vol.53 No.16
<P>We report formation of a new metallascorpionate ligand, [Fe<I><B>L</B></I><SUB>3</SUB>]<SUP>3–</SUP> (IPtz), containing a Fe core and three 5-(2-hydroxyphenyl)-1<I>H</I>-tetrazole (<I><B>L</B></I>H<SUB>2</SUB>) ligands. It features two different binding sites, oxygen and nitrogen triangles, which consist of three oxygen or nitrogen donors from tetrazole. The binding affinities of the complex for three alkali metal ions were studied using UV spectrophotometry titrations. All three alkali metal ions show high affinities and binding constants (>3 × 10<SUP>6</SUP> M<SUP>–1</SUP>), based on the 1:1 binding isotherms to IPtz. The coordination modes of the alkali metals and IPtz in the solid were studied using X-ray crystallography; two different electron-donor sites show different coordination numbers for Li<SUP>+</SUP>, Na<SUP>+</SUP>, and K<SUP>+</SUP> ions. The oxygen triangles have the κ<SUP>2</SUP> coordination mode with Li<SUP>+</SUP> and κ<SUP>3</SUP> coordination mode with Na<SUP>+</SUP> and K<SUP>+</SUP> ions, whereas the nitrogen triangles show κ<SUP>3</SUP> coordination with K<SUP>+</SUP> only. The different binding affinities of IPtz in the solid were manipulated using multiple metal precursors. A Fe–K–Zn trimetallic complex was constructed by assembly of an IPtz ligand, K, and Zn precursors and characterized using X-ray crystallography. Oxygen donors are coordinated with the K ion via the κ<SUP>3</SUP> coordination mode, and nitrogen donors are coordinated with Zn metal by κ<SUP>3</SUP> coordination. The solid-state structure was confirmed to be a honeycomb coordination polymer with a one-dimensional infinite metallic array, i.e., −(K–K–Fe–Zn–Fe–K)<SUB><I>n</I></SUB>–.</P><P>A metallascorpionate complex featuring two different binding sites was prepared, and its different coordination modes with alkali metals in solution were studied. A honeycomb-coordinated structure with a one-dimensional infinite metallic array of −(K−K−Fe−Zn−Fe−K)<SUB><I>n</I></SUB>− was constructed by assembly of tetrazole and Fe, K, and Zn precursors.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/inocaj/2014/inocaj.2014.53.issue-16/ic5002336/production/images/medium/ic-2014-002336_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ic5002336'>ACS Electronic Supporting Info</A></P>
Jeon, Young Joo,Choi, Joon Seok,Lee, Jung Yun,Yu, Kyung Ryun,Kim, Sangman Michael,Ka, Seung Hyeun,Oh, Kyu Hee,Il Kim, Keun,Zhang, Dong‐,Er,Bang, Ok Sun,Ha Chung, Chin EMBO 2009 EMBO reports Vol.10 No.4
<P>Interferon (IFN)-induced signalling pathways have essential functions in innate immune responses. In response to type I IFNs, filamin B tethers RAC1 and a Jun N-terminal kinase (JNK)-specific mitogen-activated protein kinase (MAPK) module--MEKK1, MKK4 and JNK--and thereby promotes the activation of JNK and JNK-mediated apoptosis. Here, we show that type I IFNs induce the conjugation of filamin B by interferon-stimulated gene 15 (ISG15). ISGylation of filamin B led to the release of RAC1, MEKK1 and MKK4 from the scaffold protein and thus to the prevention of sequential activation of the JNK cascade. By contrast, blockade of filamin B ISGylation by substitution of Lys 2467 with arginine or by knockdown of ubiquitin-activating enzyme E1-like (UBEL1) prevented the release of the signalling molecules from filamin B, resulting in persistent promotion of JNK activation and JNK-mediated apoptosis. These results indicate that filamin B ISGylation acts as a negative feedback regulatory gate for the desensitization of type I IFN-induced JNK signalling.</P>