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Nanobubbles from Gas-Generating Polymeric Nanoparticles: Ultrasound Imaging of Living Subjects
Kang, Eunah,Min, Hyun Su,Lee, Jaeyoung,Han, Moon Hee,Ahn, Hyung Jun,Yoon, In-Chan,Choi, Kuiwon,Kim, Kwangmeyoung,Park, Kinam,Kwon, Ick Chan WILEY-VCH Verlag 2010 Angewandte Chemie Vol.122 No.3
<B>Graphic Abstract</B> <P>Durch die Koaleszenz und Fusion von Kohlendioxidnanobläschen in einem Tumor entstehen Mikrobläschen, die mit Ultraschall sichtbar gemacht werden können (siehe Bild). Die Bläschen stammen von Gas freisetzenden polymeren Nanopartikeln mit einem Überzug aus hydrophobisiertem Chitosan. Die Hydrolyse des Polymers Poly(BL-PO) mit einem bioabbaubaren Rückgrat und einer Carbonatseitenkette setzt Kohlendioxid frei. <img src='wiley_img/00448249-2010-122-3-ANGE200903841-content.gif' alt='wiley_img/00448249-2010-122-3-ANGE200903841-content'> </P>
Kang, Eunah,Lee, Da Hyun,Jung, You Jung,Shin, Soon Young,Koh, Dongsoo,Lee, Young Han The Korean Society for Applied Biological Chemistr 2016 Applied Biological Chemistry (Appl Biol Chem) Vol.59 No.4
2,6,6-Trimethylbicyclo[3.1.1]hept-2-ene (${\alpha}$-Pinene) is an organic compound of the terpene class found in the essential oil of many plants. In this study, the inhibitory effect of ${\alpha}$-pinene on tumor invasion in highly metastatic MDA-MB-231 human breast cancer cells was evaluated. ${\alpha}$-Pinene inhibited tumor necrosis factor (TNF)-${\alpha}$-induced invasiveness of MDA-MB-231 cells as revealed by three-dimensional spheroid invasion assay. Further analysis showed that ${\alpha}$-pinene reduced $TNF{\alpha}$-induced matrix metalloproteinase-9 gene promoter activation and mRNA expression in a dose-dependent manner. In addition, ${\alpha}$-pinene treatment attenuated $TNF{\alpha}$-induced nuclear factor ${\kappa}B$ (NF-${\kappa}B$) activation and NF-${\kappa}B$-dependent transcriptional activity. These results suggest that ${\alpha}$-pinene has a significant effect on the inhibition of tumor invasion and may potentially be developed into an anti-metastatic drug.
Pericyte-targeting drug delivery and tissue engineering
Kang, Eunah,Shin, Jong Wook Dove Medical Press 2016 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.11 No.-
<P>Pericytes are contractile mural cells that wrap around the endothelial cells of capillaries and venules. Depending on the triggers by cellular signals, pericytes have specific functionality in tumor microenvironments, properties of potent stem cells, and plasticity in cellular pathology. These features of pericytes can be activated for the promotion or reduction of angiogenesis. Frontier studies have exploited pericyte-targeting drug delivery, using pericyte-specific peptides, small molecules, and DNA in tumor therapy. Moreover, the communication between pericytes and endothelial cells has been applied to the induction of vessel neoformation in tissue engineering. Pericytes may prove to be a novel target for tumor therapy and tissue engineering. The present paper specifically reviews pericyte-specific drug delivery and tissue engineering, allowing insight into the emerging research targeting pericytes.</P>