Association Between Blood Pressure After Thrombolysis and Neurological Outcome in the Elderly Patients With Ischemic Stroke

Junsoo Seok,이종석,Ki Young Jeong,Han Sung Choi,홍훈표,고영관 대한노인병학회 2016 Annals of geriatric medicine and research Vol.20 No.4

Background: This study aimed to evaluate the relationship between systolic blood pressures (SBPs) within 10 hours after intravenous recombinant tissue plasminogen activator (rtPA) treatment and early neurological outcomes in geriatric and nongeriatric patients with acute ischemic stroke (AIS). Methods: This was a retrospective observational study of patients with AIS who received intravenous rtPA between January 2010 and May 2015. Clinical factors were compared between geriatric and nongeriatric patients. SBPs at the time of rtPA bolus and every hour thereafter were collected. The primary outcome was major neurological improvement (MNI) at 24 hours after thrombolysis. Results: Serial measures of SBP revealed different 10-hour courses between patients with and without MNI in the geriatric group. The difference in SBP tendency was statistically significant (p=0.049). In contrast, there was no significant difference in SBP change in the nongeriatric group (p=0.251). In univariate analysis, geriatric patients with MNI showed higher frequency of very early neurological improvement (VENI) at 1 hour after rtPA infusion (p=0.023) and lower level of SBP at 3 hours and 10 hours (p=0.037 and p=0.046, respectively). In multivariate analysis using a logistic regression model, VENI at 1 hour and SBP value after 10 hours were independently related to MNI. Conclusion: SBP level and its change during the first 10 hours after intravenous rtPA treatment are different between geriatric and nongeriatric patients. In the geriatric group, SBP decrease is predictive of neurological state at 24 hours after thrombolysis. In the nongeriatric group, SBP decrease is not associated with neurological outcome.

Comparison of traumatic femoral head osteonecrosis model in rats

Junsoo Kim,Seokwon Kwon,Yawon Hwang,Jinuk Park,Bibek Chandra Sutradha,Seok-Hwa Choi,Gonhyung Kim 한국실험동물학회 2008 한국실험동물학회 학술발표대회 논문집 Vol.2008 No.-

6-자유도 쿼드로터 모델링 및 시뮬레이션

이준수(Junsoo Lee),이석원(Seok-won Lee),이상현(Sanghyun Lee),김유단(Youdan Kim) 한국항공우주학회 2017 한국항공우주학회 학술발표회 논문집 Vol.2017 No.4

Effect of the wake on the heat transfer of a turbine blade endwall according to relative position of the cylindrical rod

Choi, Seok Min,Kim, Junsoo,Bang, Minho,Kim, JeongJu,Cho, Hyung Hee Elsevier 2018 International Communications in Heat and Mass Tran Vol.94 No.-

<P><B>Abstract</B></P> <P>In a turbine passage, the wake, which affects the heat transfer of a turbine blade, occurs periodically due to rotation of the blade. We analyzed the effect of wake on the endwall of the turbine blade according to the relative position of the turbine blade and the vane in a stationary condition. The naphthalene sublimation method was used to measure the heat transfer and detached eddy simulation (DES) was used to analyze flow characteristics. The wake from the vane was simulated by using a cylindrical rod upstream of the blade. The cylindrical rod was placed in four which positions that were aligned leading edge-to‑leading edge. The pressure and Q criterion distributions varied according to the position of the upstream wake. As the position of the upstream wake changed, the point at which the passage vortex and wake met varied. Wake and passage vortex met at <I>x</I>/<I>C</I> <SUB> <I>x</I> </SUB> = 0.2 in position 1 and at <I>x</I>/<I>C</I> <SUB> <I>x</I> </SUB> = 0.55 in position 2. After the wake and passage vortex had met, the secondary flow scattered. Therefore, the local and averaged heat transfer varied due to flow characteristics. Thus designers of film cooling holes on endwalls should consider these effects to ensure appropriate cooling performance.</P>

UV살균과 초고압살균에 의한 당근주스의 저장성 비교

오남석 ( Nam Seok Oh ),김민영 ( Min Young Kim ),장귀영 ( Gwi Young Jang ),백소윤 ( So Yune Baek ),정미연 ( Mi Yeun Joung ),강태수 ( Tae Su Kang ),이준수 ( Junsoo Lee ),정헌상 ( Heon Sang Jeong ) 한국식품영양학회 2017 韓國食品營養學會誌 Vol.30 No.5

The objective of this study was to investigate the non-thermal sterilization effect of methods such as high hydrostatic pressure (HHP) and UV-irradiation (specifically with regard to the storage stability and shelf-life of carrot juice. The microbial counts of the non-sterilized product increased from 5.51 to 7.34 log CFU/mL up to the fifth day, and then decreased to 5.46 log CFU/mL at six days. UV-irradiation was increased from 2.37 to 4.92 log CFU/mL. HHP was maintained under the 3 log CFU/mL. The pH of UV-irradiation and HHP was maintained withing the range of 6.29~6.30 and 6.20~6.22 during storage. However, the pH arising from non-sterilization decreased from 6.31 to 4.49. The color of non-sterilization changed significantly during storage, but UV-irradiation and HHP were similar during storage. The β- carotene content of non-sterilization was noted to have decreased from 269.45 to 65.19 μg/mL during storage. The UV- irradiation and HHP decreased from 263.46 and 268.35~281.16 μg/mL to 243.42 and 244.09~269.29 μg/mL, respectively. In conclusion, these findings suggest that HHP can be used for the pasteurization, or sterilization, of carrot juice and the optimal condition is two minutes.

포도씨추출물을 첨가한 포도씨유의 산화 안정성

장성호(Sungho Jang),이준수(Junsoo Lee),최원석(Won-Seok Choi) 한국식품영양과학회 2015 한국식품영양과학회지 Vol.44 No.12

본 연구에서는 높은 불포화지방산 함유율로 말미암아 항산화 성분을 함유하고 있음에도 불구하고 산패에 대한 위험성을 내포하고 있는 포도씨유에 다량의 항산화 성분을 함유한 것으로 알려진 포도씨추출물을 첨가하여 포도씨추출물 함유 포도씨유의 90일 동안의 저장 중 산화 안정성을 측정하였고, 갈색화, 비타민 E, 지방산 조성 및 폴리페놀 함량 변화를 조사해 보았다. 포도씨추출물을 첨가한 포도씨유의 경우 무첨가 포도씨유보다 저장기간 동안 과산화물가, 산가 및 공액이중결합가가 모두 낮아 포도씨추출물이 포도씨유의 산화 안정성에 기여하는 것으로 나타났다. 저장 중 흡광도 증가량 역시 포도씨추출물 첨가 포도씨유가 무첨가 포도씨유에서보다 적게 나타났고, 비타민 E 이성체의 감소량 또한 무첨가 포도씨유에서보다 포도씨추출물 첨가 포도씨유에서 적게 나타났으며, 지방산 조성 변화 역시 무첨가 포도씨유에서보다 포도씨추출물 첨가 포도씨유에서 적게 나타났다. 한편 저장 중 폴리페놀 함량 감소량은 포도씨추출물 함유 포도씨유에서 가장 크게 나타났다. 따라서 포도씨추출물은 저장중 포도씨유의 산화 안정성에 기여하는 것으로 확인되었으며, 다만 그 능력은 합성항산화제인 butylated hydroxytoluene보다는 낮은 것으로 조사되었다. Grape seed extract (GSE) was added to grape seed oil to improve the oxidative stability of the grape seed oil during storage. To measure the oxidative stability of grape seed oil, peroxide value, acid value, and conjugated diene value were measured, and changes in browning, vitamin E, fatty acid composition, and polyphenol content of oil were examined. In the case of grape seed oil with GSE, peroxide value, acid value, and conjugated diene value were lower than those of grape seed oil. The magnitude of increase in absorbance of grape seed oil with GSE was less than that of additive-free grape seed oil, whereas the magnitude of decrease in vitamin E isomers in grape seed oil with GSE was less than that of grape seed oil with no additive. Changes in fatty acid composition were also similar. However, polyphenol contents showed the greatest reduction in grape seed oil containing GSE. GSE contributes to the oxidation stability of grape seed oil, but the antioxidant capacity of GSE was lower than that of butylated hydroxytoluene.

큰눈벼와 일품벼의 발아에 의한 생리활성물질 함량 및 암세포 증식억제활성 변화

성지혜(Jeehye Sung),이준수(Junsoo Lee),오세관(Sea-Kwan Oh),이점식(Jeom-Sig Lee),최원석(Won-Seok Choi) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.7

본 연구에서는 현미의 발아를 통해 큰눈벼와 일품벼 두 품종에서의 GABA(γ-aminobutyric acid) 함량, 항산화성분 함량 및 암세포 증식억제 활성의 변화를 측정하고자 하였다. 연구 결과 두 품종의 현미는 발아 과정을 통해 GABA 함량이 증가하였으며, 특히 일품벼의 미강층에서 발아 후 가장 큰 증가율을 나타내었다. 항산화 성분의 경우, 큰눈벼에서는 발아 후 polyphenol 함량이 증가하였으나, flavonoid 함량의 경우 두 품종 모두 발아 후 감소하는 것으로 나타났다. 암세포 증식억제활성 측정 결과, 폐암 세포주의 경우 두 품종 모두 현미상태에서는 발아 후 암세포 증식 억제활성이 증가하였으며, 위암 세포주에서 발아 후에 암세포 증식 억제활성이 보다 증가하였다. 따라서 현미의 발아 시 항산화 성분이 용출되는 현상을 방지하는 조건이 확립된다면, 향후 발아현미는 건강기능식품 및 건강보조제 등을 위한 기능성 식품 소재로 이용될 수 있을 것으로 사료된다. The purpose of this work was to measure the changes in γ-aminobutyric acid (GABA) and polyphenolic content of two different rice varieties (Geunnun and Ilpum), as well as the antiproliferative activities of both germinated brown rice varieties in cancer cells. The contents of GABA in Geunnun and Ilpum, especially in the bran of Ilpum increased significantly after germination. The content of polyphenol in Geunnun also increased after germination, but the contents of flavonoid in both varieties decreased after germination. A significant increase in the antiproliferative activity of both varieties on human lung and gastric cancer cell line was observed after germination.

용매 변화에 따른 버섯추출물의 항충치활성

박은진(Eun-Jin Park),이준수(Junsoo Lee),최원석(Won-Seok Choi) 한국식품과학회 2011 한국식품과학회지 Vol.43 No.6

버섯류는 기호식품으로서의 성격과 기능성식품으로서의 성격을 동시에 갖는 매우 독특한 식품소재로서 본 연구에서는 국내에서 자생하는 8종류의 버섯에서 항충치 활성성분을 조사해 보았으며, 더불어 높은 항충치활성을 가진 추출물을 얻고자 다양한 용매를 이용, 최적의 용매조성을 탐색해 보았다. Chloroform, methanol, acetone, ethyl acetate 및 증류수를 용매로 사용하였으며, 이들 추출물의 S. mutans에 대한 항균 효과와 glucosyltransferase(GTase) 활성 억제효과를 살펴보았다. 표고버섯, 영지버섯 및 만가닥버섯 추출물이 상대적으로 높은 항충치활성을 나타내었으며, 추출용매에 의한 항균효과를 조사해본 결과, chloroform, methanol, ethyl acetate로 추출한 버섯 추출물에서 상대적으로 높은 항균효과를 보여주었다. 8종의 버섯 중 항균효과가 뛰어나고 GTase 활성 억제효과가 높은 만가닥(Lyopyllum ulmarium) 버섯으로부터 chloroform, methanol 및 ethyl acetate 추출물을 얻어 항충치활성을 조사하였다. S. mutans에 대한 만가닥 버섯의 최대 항균효과를 얻기 위해 심플렉스 중심 합성 계획법(simplex centroid design)을 이용하여 최적의 추출용매조성을 살펴본 결과, chloroform, methanol 및 ethyl acetate 3가지 용매를 모두 동일한 비율(1:1:1)로 혼합하여 추출한 추출물에서 가장 높은 항균효과가 나타났다. 만가닥버섯추출물은 항충치 소재로서 중요한 역할을 할 수 있을 것으로 기대되며, 버섯추출물의 항충치 효과는 추출용매에 의해 영향을 받으므로 버섯에서 항충치활성물질을 얻고자 할 때에는 추출용매선택이 매우 중요할 것으로 사료된다. Various mushroom extracts were examined for their anti-Streptococcus mutans and anti-glucosyltransferase (GTase) activities. Mushrooms were extracted with chloroform, methanol, acetone, ethyl acetate, and distilled water. The chloroform, methanol, and ethyl acetate extracts showed higher antimicrobial activity than that of the others. The inhibitory effects of the chloroform, methanol, and ethyl acetate extracts of Lyopyllum ulmarium, which have high anti-microbial and GTase activities, on the growth of S. mutans were examined and the optimal ratio of solvents was also evaluated to investigate the influence of solvents using a simplex centroid design. The anti-cariogenic effects of the L. ulmarium extract on S. mutans was influenced by the solvent, and the optimum anti-cariogenic activity of the extract was obtained with the ratio of chloroform:methanol:ethyl acetate=1:1:1 (v/v/v). These results suggest that solvent selection is an important factor to extract anti-cariogenic materials effectively from mushrooms.

만가닥버섯 추출물의 Streptococcus mutans 균에 의한 산생성 및 치아표면 glucan 점착 억제효과

박은진(Eun-Jin Park),이준수(Junsoo Lee),최원석(Won-Seok Choi) 한국식품과학회 2012 식품과학과 산업 Vol.45 No.4

Development of Antimicrobial Edible Film Incorporated with Green Tea Extract

Ki Myong Kim,Boo-Yong Lee,Young Teck Kim,Sung-Gil Choi,Junsoo Lee,Seung Yong Cho,Won-Seok Choi 한국식품과학회 2006 Food Science and Biotechnology Vol.15 No.3