Effect of Oriental & Western Anti-Stress Agents on the Changes of the Salivary Gland of Rats under Restraint Stress

Hong, Jung-Pyo 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Jung-Pyo Hong. Department of Oral Diagnosis and Oral Medicine, College of Dentistry, Kyung Hee University, Seoul, Korea. Effect of Oriental & Western Anti-Stress Agents on the Changes of the Salivary Gland of Rats under Restraint Stress. Proceedings of International Symposium on East-West Medicine, Seoul. 162-171, 1999.-Stress caused the changes in the neural, vascular and immune system of the body. If stress is mild so as not to exceed the adaptability of the body to it, the homeostasis of the body is maintained. Otherwise psychological and physical disturbances of the body may occur, ample evidence suggests that stress causes apoptosis of the cells, inducing morphological and functional changes of the tissue as the result of tissue destruction. These disorders are also frequently observed in the orofacial region(dentistry), including not only such paychological oral lesions as Iichen planus and geographic tongue but stress-related diseases like temporomandibular disorder and xerostomia. It is, Therefore, possible that anti-stress medicines and stress-reliving activities may prevent and treat the psychosomatic disorders. In the study, we intended to check whether anti-depressant and anti-stress drugs such as Fluoxetine, Bunsimkium and Bohyulanshintang(oriental herbal medicine) can prevent pathologic changes of the salivary gland under the restraint condition. Seven-week old sprague-Dawley rats were divided into 5 groups.: Group Ⅰ, normal control;GroupⅡ,rats were under the restraint stress placed in the stress cages; GroupⅢ, rats were administrated Fluoxetine (5mg/kg/day), p.o., under the restraint stress; GroupⅣ,rats were administrated Bunsimkium, p.o., for 10 days before applying the restraint stress also.; Group Ⅴ,rats were administrated Bohyulanshintang, p.o., for 10 days before they were placed under the restraint stress. The rats were sacrificed at day 0,1,3,5,7 of the experiment. The submandibular glands of the rats were sampled immediately. The levels of clusterin protein and mRNA in the tissues were measured by immunohistochemistry and Northen blot analysis respectively. Our results were as follows. 1. Restraint stress induced apoptosis of the submandibular gland. 2. Restraint stress induced the expression of clusterin. The expression of clusterin reached the maximum level when the cellular apoptosis apparent and decreased after then. 3. Apoptosis was occurred on the acinar cells earlier than ductal cells by restraint stress. 4. In the Northern blot and immunohistochemistry, noremarkable difference of clusterin was found in between the normal control group and the Fluoxetine administrated-restraint stress group. 5. In Bunsimkium administrated-restraint stress group, apoposis was delayed. 6. In the Bohyulanshintang administered-restraint stress group, expression of clusterin increased with time and reached the maximum level at day 5 of the experiment and decreased after then. But apoptosis did not occurthrough all days of the experiment. The overall results suggenst that stress can induce pathologic changes in the salivary glands. By an early response to stress, clusterin is expressed in the glands to protect the glandular cells form the stress. But if stress is so strong and prolonged as to exceed the stress adaptability of the cells, then the cells may undergo apoptosis instead of producing clusterin. Administration of stress-relieving drugs such as Fluoxeting, BunsimKium and Bohyulanshintang may be useful in preventing and treating stress-related salivary glands diseases. Our results are thought to be useful to identify the mechanism of stress-related salivary gland diseases such as xerostomia. Hereafter, among the anti-stress medicines such as western medicine and traditional herb medicine, Bohyulanshintang with minimal side effect could be applied to effectively prevent and treat psychosomatic disease.

차세대 이동 위성서비스의 특성 분석

홍정식,안재경,김지표 한국정보사회진흥원 2005 정보화정책 Vol.12 No.4

1990대에 본격적으로 시작된 위성에 대한 연구를 바탕으로 국내에서는 무궁화 위성이 3호까지 성공적으로 운용되고 있으며, 곧 무궁화위성 5호도 발사될 예정에 있다. 현재 이러한 위성들은 통신, 방송용으로 지상망을 보완하는 역할을 수행하고 있으나, 차후 위성은 언제 어디서나 개인이 원하는 형태로 이용할 수 있는 초고속 멀티미디어 서비스를 제공할 예정이다. 본 연구에서는 미래 이동위성통신시스템의 원활한 개발을 위하여 필수적으로 수반되어야 하는 차세대 유망 위성서비스에 대한 다양한 분류작업과 지상망 대비 경쟁력 검토를 하였으며, 이를 바탕으로 양방향 HDTV, 양방향 DMB, LBS와POS, PPDR, DCD, Glass Vision, 실시간 여행/운전 안내, 자동 정보 업데이트, 산간/오지의 인터넷 등 9개의 유망 위성서비스를 도출하고 그 특성을 분석하였다. 또한 이들 서비스를 심층 분석한 결과 재난정보 서비스, 디지털 콘텐츠 분배서비스, 그리고 산간/오지 인터넷 서비스가 보다 경쟁력 있는 서비스로 드러났다.

리비아 대수로공사 지역의 지반특성

홍원표,남정만,김시현,이재호 중앙대학교 기술과학연구소 1996 기술과학연구소 논문집 Vol.26 No.-

리비아 사막지역의 지반특성을 연구하기 위하여 리비아 1단계 대수로공사가 실시된 지역의 지반특성을 검토하였다. 본 연구에서는 Sarir 취수원에서 Ajdabiya 저수조를 경유하여 Sirt 저수조까지의 대수로 공사지역을 따라 실시된 실내시험과 현장시험결과를 포함하고 있다. 이 지역은 내륙지역(Sarir 취수원에서 Ajdabiya 저수조까지)과 해안지역(Ajdabiya 저수조에서 Sirt 저수조까지)으로 구분하여 연구된다. 본 연구결과, 지표면 부근에 있는 모암(Cap rock)은 주로 Caliche나 석회사암(Calcarenite) 성분을 많이 띠고 있고, 이들의 깊이에 따른 강도변화는 발견할 수 없었다. 또한 모래에 대한 Ncl도 깊이에 대한 변화를 발견할 수 없었으나 이들을 종류별로 분류하였을 경우, N치가 약간 증가하는 추세를 보였다. 끝으로 해안지역의 점토에서는 지표면부근에서 조금 과압밀된 경향을 볼 수 있었으며, 내륙지역의 점토에서는 대단히 높은 팽윤포텐셜이 관찰되었다. To study geotechnical properties on Sahara desert of Libya, geotechnical characteristics in the region of the Great Man-made River Project were reviewed. A series of field and laboratory tests were carried out along the route of the conveyance lines from Sarir well field to Sirt end reservoir through Ajdabiya holding reservoir. In the view of geotechnical aspect, the research subject area can be divided into two areas ; one is the inland area(from Ajdabiya holding reservoir to Sirt reservoir). The results of this study showed that the cap rocks nearby ground surface were generally composed of caliche or calcarenite and variation of its strength according to depth could not find. Also, N value in sand did not show a trend of variation with depth however, the N value in the classified soil reveals tendency to increased. The clay of ground surface in the coastal area was slightly overconsolidated due to the desiccation of the surface soils. The clay in the inland area had high swelling potential.

두개하악장애증환자의 컴퓨터체열측정법을 이용한 임상진단기준에 관한 연구

홍정표,전양현,류호경 대한 두개하악 장애학회 1996 대한두개하악장애학회지 Vol.8 No.2

AbstractRecently, Thermography was widely performed to diagnose the orofacial pain. The purpose of this study was to control the various condition which have an effect on the thermographic image, to observe the secondary effects of the symptoms and to properly evaluate the thermographic image. For this study, 66 patients with craniomandibular disorders and 5 healthy volunteers were examined and analyzed with the thermographic image. The results were as followed 1. Craniomandibular disorders were most frequently occurred in 20-year-old female group. 2. 58 cases(87.9% ) of 66 patients with craniomandibular pain showed the thermal differen- ces with a clinical significance 3. Craniomandibular symptoms were composed of the joint pain(31 cases ; 47.0%), the joint-muscle pain(27 cases '? 40.9%) and the muscle pain only(8 cases :12.1%). 4. Clinically, Most patients with the joint pain or with the muscle pain showed thermal changes on the only pain site of temporomandibular joint area. But, patients with the joint-muscle pain showed no thermal changes on the both of joint and masseter areas. 5. By masticatory movements, the surface temperature of the working side was increased, and gradually decreased in the course of time. And then the normal temperature was observed after 40 minutes Recently, Thermography was widely performed to diagnose the orofacial pain. The purpose of this study was to control the various condition which have an effect on the thermographic image, to observe the secondary effects of the symptoms and to properly evaluate the thermographic image. For this study, 66 patients with craniomandibular disorders and 5 healthy volunteers were examined and analyzed with the thermographic image. The results were as followed 1. Craniomandibular disorders were most frequently occurred in 20-year-old female group. 2. 58 cases(87.9% ) of 66 patients with craniomandibular pain showed the thermal differences with a clinical significance 3. Craniomandibular symptoms were composed of the joint pain(31 cases : 47.0%), the joint-muscle pain(27 cases : 40.9%) and the muscle pain only(8 cases : 12.1%). 4. Clinically, Most patients with the joint pain or with the muscle pain showed thermal changes on the only pain site of temporomandibular joint area. But, patients with the joint-muscle pain showed no thermal changes on the both of joint and masseter areas. 5. By masticatory movements, the surface temperature of the working side was increased, and gradually decreased in the course of time. And then the normal temperature was observed after 40 minutes

카드뮴중독의 조기진단을 위한 생물학적 지표탐색 : 요중 Metallothionein 배설량의 의의

홍연표,장임원,박정덕 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.2

Metallothionein(MT) is a low molecular weight protein that is induced as a defence mechanism for cadmium(Cd) toxicity. In present study, urinary MT was determined using a competitive ELISA in Cd-exposed rats. In addition, measured the urinary, blood and renal Cd concentration and the urinary excretion of total protein, β₂-microglobulin(MG) and Nacetyl-β-D-glucosaminidase(NAG) at 1, 3, 7, 14, 28 days after Cd injection in Cd-exposed rats with doses of 0.8 and 1.6㎎ Cd/㎏ body weight, respectively. The urinary, blood and renal Cd were specific for Cd-exposure, that increased in proportional to dose of Cd. The urinary and blood Cd tended to slightly decrease, while renal Cd tended to increase by lapse of time after Cd exposure. This finding indicates that renal Cd is more specific than urinary and blood Cd for Cd exposure. The urinary excretion of MT showed a statistically significant increase in Cd exposed rats(0.8 and 1.6 ㎎ Cd/㎏ body weight). The increase of urinary excretion of MT was more evident at 7, 14, 28 days after Cd exposure than the changes of urinary excretion of total protein, β₂-MG and NAG. The Pearson's correlation coefficients between urinary Cd and urinary MT, β₂-MG, NAG and total protein were 0.4344, 0.3727, 0.3307 and 0.2099, respectively. These findings indicate that the urinary MT is more sensitive and specific than total protein, β₂-MG and nag for Cd exposure. The present results suggest that the urinary MT, using a simple and rapid competitive ELISA, is a valuable index and screening test in epidemiologic study for Cd exposed group.

製品 開發에 關한 디자인 프로세스 메니지먼트

洪正杓 全北大學校 1993 論文集 Vol.35 No.-

The economic environment of the world growth into the serious situation since the competition with enterprises and nations is considered as the vigorous fight. The market power and the innovation of technology are essential for the survival of corporation. To do this international competition power has to be forced through the revolutionary innovation of the technology and the creation of design. The roles of design involves the mediatory role of information and knowledgy in organization creative the role of processor making valuable and meaningful information and connective role between man and enterprise. Therefor, industrial design deal with not only the shape of product but also the function of product. It also contents the requirement of the objectivity relationality and necessary in solving the problems and decision making. Design management had required in the systemetic organization, human resource management. Invention of product, and product evaluation. Now the concept of design is not only the creation of beautiful, cheap, and practical product but also the creation of the culture of human life to cope with the change of generation. So design management is necessary to participate social activity and creation new culture. Today the enterprise is using design for making the product whitch has the market power and the competition power. Design management could be interpretated as the methodology of aiding design management. The design management, the top issue design area, should be first understand to prevention the problem that is caused by the various design method, the character of design project, and unnecessary time. To do this, design process should be built in a systemetic way by adaption the various technique of management.

혈액 내 구리, 아연 및 ceruloplasmin 농도에 흡연, 음주 및 신체적 활동이 미치는 영향

홍연표,강은용,신인철,최병선,박정덕,장임원,박진완 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.4

Objectives : To investigate the influence of smoking, alcohol ingestion, and physical activity on copper and zinc in RBC and serum and serum ceruloplasmin, this study was performed in a cross-sectional study in 113 healthy men aged 20 to 40 years who had no symptomatic liver, heart, gastrointestinal, and other chronic diseases. Methods : At the men's entry into the study, blood samples were drawn from each subject and immediately centrifuged for analysis of copper, zinc, iron, ceruloplasmin, total cholesterol, and hematocrit. Each man completed a questionnaire that provided information on smoking, amount of alcohol intake, and physical activity. Partial regression analysis was performed on confounding variables such as age, body mass index, hematocrit, serum cholesterol, and serum iron. Results : In general linear models, adjustment for confounding variables did not show statistical differences, and there was only an increasing tendency in serum copper in heavy smoker(P=0.0678). There was no difference between high physical activity with mild smokers and lower physical with heavy smokers. Conclusions : This study suggested that copper, zinc and ceruloplasmin were not good biomarker for early effect by smoking, alcohol intake and physical activity in young adult. However, selection bias should be considered in evaluation of this result, and a large prospective study will be needed in advance on usefulness of copper, zinc and ceruloplasmin as a marker for risk factors and early change of atherosclerosis.

'90年代 冷藏庫 디자인 戰略樹立을 위한 硏究

洪正均 全北大學校 1992 論文集 Vol.34 No.-

Goods and service get supply to the market have a begining of variety and a large size, as well a new product and technique have developing by the economic growth and industrial development. In the field of home we have a replenished a may of house hold furnishing for a standard of living elevation and a life of scientifically. This thesis will briefly review about the which, refrigerator have make a necessaries of home and a saturation goods of market, namely, a extension late of 90%. Three company on domestic home applicances have been carry out design policy that make a selection refrigerator a central sale goods, because promote in phase of goods, Major purpose of this thesis are that the companies establish design policy which is coincident with needs of consummer, as present of logical solution throught the environmental analysis of refrigerator which accupying the first place, and have called the major term of house hold goods, in the scale of an offering amount.

新製品 開發을 위한 造形要素 發掘과 形態 創出에 대한 硏究 : 팬코일유니트(Fancoil Unit)디자인개발 CASE STUDY A Case Study of Fancoil Unit Design Research

홍정표 全北大學校 1996 論文集 Vol.42 No.-

This study is for a new product style creative. Until now, we have been doing on the designer's sensitivity(qualitative analysis) for the new style creat But now we will be deal with a quantity analysis (by the data) And then, this study First, sampling a symbol model from a connect with assumption model and association of image by at first-hand subway of user. Second, approach to design throught the quantity data make appraisal of consummer about the assumption model. Third, present a definite model, applyed consequence of conjoint analysis in the fancoil.

버팀보로 지지된 흙막이벽의 거동에 관한 연구

홍원표,여규권,윤중만,조용상 중앙대학교 기술과학연구소 1997 기술과학연구소 논문집 Vol.27 No.-

버팀보 축력으로부터 산정된 측방토압은 지표면에서 굴착깊이의 17%에 해당되는 깊이까지 선형적으로 증가하다가 그 깊이 아래로부터는 일정토압분포를 보이는 사다리꼴모양의 분포를 보였다. 이 일정토압 분포부분의 토압 크기는 평균적으로 최종굴착깊이에서의 Rankine 주동토압의 58%에 해당하거나 연직상재압의 17%에 해당하였다. 또한 흙막이벽의 수평변위와 굴착깊이와의 관계로부터 흙막이구조물의 안정성을 판단할 수 있는 시공관리기준을 설정하였다. 흙막이벽의 수평변위량이 굴착깊이의 0.20%보다 작으면 흙막이벽과 굴착배면지반은 안정된 상태에 있다. 그러나 벽체의 수평변위가 굴착깊이의 0.20%보다 크게 발생하면 굴착공사의 안정성을 주의깊게 관찰해야만 하며, 필요하다면 흙막이 구조물을 보강해야만 한다. The lateral earth pressures on braced earth retaining walls, which are estimated form the measured strut force, shows a trapezoidal distribution that the earth pressure increases linearly with depth from the ground surface to 17% of the final excavation depth, and then keeps constant value. The maximum lateral earth pressure was same to 58% of Rankine's active earth pressure or 17% of the vertical overburden pressure at the final excavation depth. Also, empirical criterion is established for construction management to monitor and ensure the stability of deep excavation from the relationship between horizontal displacement of wall and excavated depth. If the horizontal displacement of wall measured from inclinometer shows less than 0.20 percent of the excavated depth, the retention wall and surrounding ground exist under stable state. When the horizontal displacement is developed more than 0.20 percent of the excavated depth, excavation works should be carefully observed and reinforced the earth retention wall, if necessary.