비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

대뇌 기저핵 신경세포 일차배양에서 망간에 의해 유도된 Appoptosis : 형태학적인 소견

신동훈,김상표,정용욱,배재훈,송대규,백원기 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목적 : 본 실험은 대뇌기저핵의 신경세포를 배양하여 망간(MnCl₂)을 투여한 후 망간독성에 의한 신경세포의 apoptosis를 형태학적인 소견으로 관찰하였다. 방법 : 배양된 신경세포에 0.01에서 10μM Mnc12를 48시간동안 처리한 후 TUNEL (TdT-mediated dUTP Nick End Labelling)법 및 투과전자현미경학적으로 관찰하였다. 결과 : TUNEL방법을 이용하여 관찰한 결과 TUNEL반응에 갈색으로 양성반응을 나타내는apoptotic 세포의 수가 대조군에 비해 MnCl₂를 투여한 군에서 유의하게 높게 나타났으며(P〈0.05), 투과전자현미경학적 소견상 대조군의 신경세포들은 핵인(nucleolus)이 두드러지게 특징적으로 보이면서 핵막과 세포질내 소기관들이 잘 보존되어 있으며, 세포질내망(ER)과 사립체(mitochondria)를 특히 많이 가지고 있었다. Mnc12를 48시간 동안 처리한 군에서 이질염색질(heterochromatin)이 핵막으로 이동하면서 응집되어 있었으며, 핵내 불규칙한 형태의 염색질이 나타나 분절이 진행되는 소견을 보였고, Apoptosis의 가장 특징적인 초기 소견인 막으로 둘러싸인 반달모양의 핵내염색질의 분절편(fragment-ed chromatin)과 주위의 상대적으로 정상적인 소기관으로 구성된 apoptotic body를 관찰할 수 있었다. 결론 : 신경세포에서 망간에 의해 apoptosis가 유도됨을 형태학적인 방법으로 확인할 수 있었으며 망간에 의한 세포사망양상에 apoptosis가 하나의 기전이 될 수 있을 것이다. Objectives : Manganese is cytotoxic to the central nervous system including basal gan-glia. Its toxic mechanism is related to oxidative stress, mediated by toxic free radicals but is specultives. In the present study , we have investigated to manifest apoptosis in man-ganese-induced cytotoxicity in primary neuronal cell culture of rat basal ganglia. Methods : To detect apoptotic neuronal cells were stained by the terminal deoxynu-cleotide (TdT) -mediated dUTP nick end-labelling (TUNEL) method and apoptotic changesin nuclei of neurons were observed by electron microscopy. Results : We showed that TUNEL immunostain showed brownish signal in the nuclei of apoptotic cells and the proportions of apoptotic cells in Manganese treatment groups were more higher than controls. On transmission electron microscopy, there were chromatine condensation with margination toward nuclear membrane and condensation of cyto-plasm in the treated with luM MnCl²for 48 hours in a basal ganglia neurons. Apoptotic bodies were found and consisted of semilunar-like condensed nuclei with relatively intact cytoplasmic organelles. Conclusions : Apoptosis appears to be one mechanism in the manganese-induced net-ronal cell death. Manganese intoxication is a convenient model for apoptosis study.

건식경량벽체의 내충격성능 평가방법에 관한 연구 (Ⅰ) : 인간이 벽체에 가하는 충격하중의 분석을 위한 실험 및 고찰 An Experiment to Analyze the Human Impact Load Applied to Framed Walls

신윤호,안정업,김대희,최수경 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

The purpose of this study is to establish an evaluation method of fracture of light-weight framed walls by human impact load. In this paper, part (I), we analyzed human impact load applied to framed walls. At first, we made original measuring equipment of impact load, and carried out the experiment on human impact load in various action. After the experiment, we extracted the essential characteristics. And grasped the property of human impact load systematically based on the relation between maximum load and load velocity.

세탁페수의 효율적 처리에 관한 연구

신대윤,김근중 조선대학교 환경공해연구소 2006 環境公害硏究 Vol.19 No.1

The Conclusion that get laundry wastewater achieving effective treatment is as following. 1. The Jar- test of coagulation process experimented as alkaline aid Ca(OH) 5OO㎎/ℓ impose and at Alum 6OO㎎/ℓ as polymer coagulant at slowly mixed after pour A 101 0.5㎎/ℓ. 2. Results of chemical treatment shown that powdered activated carbon dosage O.6㎎/ℓ economical, and quality of water was the best, The quality of water of effluent SS 9.5㎎/ℓ, COD_(Mn) 14.0㎎/ℓ, COD_(Cr) 21.3㎎/ℓ, T-N 41.4㎎/ℓ and T-P 4.65㎎/ℓ, rate of removal SS 40.6%, COD_(Mn) 44.2%, COD_(Cr) 74.6%, T-N 21.9% and T-P 73.1%. 3. Using the biofilm on biochemical treatment it is HRT 18 hours when handle concentration of treatment SS 11.2㎎/ℓ, COD_(Mn)㎎/ℓ, COD_(Cr)㎎/ℓ, T-N 30.2㎎/ℓ and T-P㎎/ℓ, rate of removal COD_(Mn) 65.1%, COD_(Cr) and T-N 61.8%. 4. Biological treatment that use biofilm and chemical treatment used powdered activated carbon appeared that quality of water of powdered activated carbon treatment is better when compare quality of water that pours and does adsorption processing that SS, COD_(Cr), and T-P, quality of water of biological treatment is better COD_(Mn) and T-N. dryer, Parametric screening studies have been conducted to study optimal dryer shape and operating condition.

生物學的 燐除去機轉 및 內部返送率과 SRT가 除去率에 미치는 影響

신응배,이영대,최용수,이정욱 漢陽大學校 環境科學硏究所 1995 環境科學論文集 Vol.16 No.-

본 연구에서는 생물학적 인 제거공정의 혐기-호기-무산소 조건을 단일 반응조내에서 발생토록 고안하여 인제거 실험을 수행하였으며, 고안된 반응기내에서의 인 제거기전을 규명하고 제거효율을 평가하였으며 또한 내부반송율과 SRT 변화에 따른 유기물과 인제거 효율을 평가하였다. 고안된 공정의 종합적 인제거효율 평가를 통해 최적 운전조건을 평가·분석하였다. 실험 결과 유기물 제거율은 Aerobic recycle rate 100%, 200%에서 TOC 95% 이상, BOD와 COD 90% 이상으로 우수하였으며, 인은 Aerobic recycle rate 100%에서 폐수유입 지점 0.2일 때가 최적조건으로 분석·평가되었다. SRT 변화와 T-P, PO₄-P 제거율과의 관계는 SRT 10일에서 94%, 92% 이상으로 높은 제거효율을 나타내었다. In this investigation, phosphorus removal experiment was conducted in a single reactor combining anaerobic-aerobic-anoxic zone. Attempts have been made to delineate phosphorus removal mechanisms and to evaluate the removal efficiency. Also performed in this experiment are the removal characteristics of organic and phosphorus with different internal recycle ratios and varying SRT conditions. In addition, this study evaluates the best operation conditions in terms of phosphorus removal efficiency. The removal efficiencies of TOC, BOD and COD were observed to be higher than 95%, 90% and 90%, respectively with aerobic recycle ratios of 100% and 200%. If is further estimated that the optimal operational conditions for phosphorus removal are observed when the aerobic internal recycle rate is 100% with the wastewater inlet point being 0.2 from the bottom. The percent removal efficiencies are 92% for T-P and 90% for PO₄-P. In case of SRT, higher removal efficiencies are observed with the solid retention time of 10 days than with SRT's of 5 and 20 days. The removal rates observed are 94% for T-P and 92% for PO₄-P with the solid retention time of 10 days.

고혈압 환자에서 Leukoaraiosis 정도와 망막증과의 연관성 : 예비연구 Preliminary Results

신동익,한현정,서대희,이광훈 關東大學校 醫科大學 醫科學硏究所 2002 關東醫大學術誌 Vol.6 No.1

Changes in the cerebral white matter (leukoaraiosis;LA) are detected with increasing frequency by computed tomography (CT) and magnetic resonance imaging (MRI) in elderly patients with diabetes mellitus and hypertension. The purpose of this study is to determine whether the severity of retinopathy is correlated with degree of LA in patients with hypertension. Twenty-three consecutive patients with patients with hypertension admitted in the department of neurology were evaluated for degree of LA and severity of retinopathy. 8patients were 15female. The age distribution was between 52 and 85 years(mean 69.1years). The duration of hypertension was between 1 and 30 years(mean8.2 years). The degree of LA was correlated with severity of hypertensive retinopathy(p<0.05), especially in relatively young patient, short periods of disease, and female paitents(p<0.05). We can make a rough estimation of degree of LA with fundus examination without CT or MRI evaluations in hypertensive patients, especially in relatively young and female patients with short durations of disease. However, more broad study should be made for these value and relationship.

Cu(InGa)₃Se 결정의 구조 및 광학적 특성

신중호,김창대 木浦大學校基礎科學硏究所 1999 基礎科學硏究誌 Vol.17 No.-

The structural and optical properties of ?? (0.0≤χ≤1.0) crystals grown by the directional melting method were investigated from the measurements of XRD, optical absorption and photoluminescence. It was found from the analysis of XRD measurements that the crystal structure of ?? crystals was an ordered vacancy chalcopyrite(OVC) over a composition of 0.0≤χ≤1.0. The lattice constants a and c was linearly decreased with an increasing of a composition χ. On the other hand, the distortion factor (2-c/a_ was linearly increased with an increasing of a composition χ. The optical energy gap at 300 K of ?? crystals was varied from 1.23 eV(χ=0.0) to 1.82 eV (χ=1.0), which shows a linearly composition dependence. Photoluminescence spectrum of ?? crystals at 10 K showed a broad emission band due to donor-acceptor pair recombination. These emission bands were shifted toward a short wavelength region as a composition χ increased. The composition dependence of the emission peak energies exhibited a similarity with that of the optical energy gap.

敗醬草가 癌細胞柱에 미치는 影響

申大澈,權貞南,金瑩均,韓宗鉉,김재석,김재섭 동의대학교 한의학연구소 1997 동의한의연구 Vol.1 No.-

The purpose of this study was to investigate effect of water extract of Patriniae Herba on the poliferation of human cancer cell-lines. The effects of Patriniae Herba on the poliferation of A43l, HeLa, MOLT-4, K562 cells, Balb/c 3T3 cells, mouse thymocytes, splenocytes and human lymphocytes were estimated by MTT colorimetric assay, The results were as follows; 1. Patriniae Herbs did not effect A43l, HeLa, MOLT-4, K562 cells. 2. The cytotoxicity of mitomycin C on MOLT-4 cells was increased by the combination of Patriniae Herba. 3. Patriniae Herba inhibited the proliferation of Balb/c 3T3 cells. 4. Patriniae Herba stimulated the proliferation of thymocytes. 5. Patriniae Herba stimulated the proliferation of splenocytes. 6. Patriniae Herba stimulated the proliferation of human lymphocytes.

DSM-Ⅲ에 의한 불면증에 관한 연구 : 정신과 외래환자를 대상으로 Based on Psychiatric Outpatients

정한용,이대희,신동균 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.3

This investigation was based on the study of 247 Psychiatric patients with insomnia of at least 1 month’s duration, who had visited at the Department of Neuropsychiatry, Korea University Hae wha Hospital from January 1983 to December 1983. The results were as follows; 1. There were 101 men and 146 women with the mean age of 38.9 years. They had occupied 40.4 percent of all psychiatric patients in the same period. 2. The most common diagnoses were, in order, affective, somatoform, anxiety, schizophrenic, compulsive personality, and passive-aggressive perscalnity disorder. Also about one half of them were in the anxious of fearful cluster. 3. In the duration of insomnia, more than one half had been suffering from insomnia for at least 12 months and there were no statistical significances among diagnoses except subtypes of affective disorder. 4. Difficulty falling asleep was the most common type in this investigation. Difficulty falling asleep was more common in bipolar disorder, mania; V codes; schizophrenic; dysthymic; and compulsive personality disorder, whereas difficulty staying asleep was more common in major depression and bipolar disorder, depressed. 5. Twenty-one patients had axis Ⅲ diagnoses and also they had axis Ⅰ diagnosis as principal diagnosis. 6. In the MMPI results, the scales most elevated were, in order, hypochondriasis, conversion hysteria, depression and psychasthenia. These findings suggested that various factors such as somatic concern, depression, anxiety, fear, and obsession were correlated with insomnia.

유지 투석중인 만성 신부전환자에서 허혈성 심질환의진단 지표로서의 심장트로닌-I의 유용성

신병철,강대웅,정지용,류봉관,서영욱,김정인,김범윤,김현리,정종훈 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

Background : Coronary disease is highly prevalent in patient with end stage renal disease (ESRD) and account for much of their observed morbidity and mortality. Troponin-I consistently maintains a high sensitivity and specificity and is most sensitive marker for ischemic heart disease (IHD). Method : We examed 49 hernodialyzed patients (22 male, 27 female) without evidence of acute coronary syndrome (ACS) for 6 months. Biochemical markers were measured in serial predialysis blood samples. For analysis, we used two cardio-specific assays for troponin-T (cTnT) as well as for troponin-I (cTnI) and compared the results with CK-MB (reference value ≤ 4.0 ng/mL) concentration. Results : Myocardial ischemia was observed in 47% (23/49) of patients. cTnT level above 0.1 ng/mL. and cTnI level above 0.5 ng/mL, were observed in 22% (11/49) and 20% (10/49) of patients respectively. cTnI revealed significantly higher positive rate in patients with myocardial ischemia than the patients without myocardial ischemia (43 % vs 30%) (p<0.05). cTnT and CK-MB revealed no difference in positive rate between the patients with and without myocardial ischemia (cTnT : 30% vs 15% and CK-MB : 30% vs 19%). The sensitivity and specificity of cTnI to myocardial ischemia were higher than those of cTnT and CK-MB (sensitivity 43% vs 30% and 30%. specificity 100% vs 85% and 81%). Conclusion: Both cTnT and cTnI are useful in ruling out myocardial injury in chronic renal failure patients. But. cTnI is a more sensitivity and excellent specificity of ischemic heart disease than cTnT and CK-MB in hemodialyzed patients. In patients with ischemic heart disease, the presences of DM and advanced age were higher than those in patients without ischemic heart disease (p<0.05). Among the baseline characteristics old age, elevated LDH and diabeties were significant more frequent in the patients with elevation of cardiac troponin-I (p>0.5 ng/mL) than those with cardiac troponin-I (p<0.5 ng/mL), p=0.038, p=0.049, and p=0.045, respectively. Our results suggest that these cTnI is the potential diagnostic marker for the prediction of IHD in ESRD patients.