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      • KCI등재

        Correlations of Four Genetic Single Nucleotide Polymorphisms in Brain-Derived Neurotrophic Factor with Posttraumatic Stress Disorder

        JunCheng Guo,YiJun Yang,Min Guo,XiaoDan Wang,Yang Juan,YunSuo Gao,LinQiu Fu,XiangLing Jiang,LinMei Fu,Tao Huang 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.4

        Objective-To investigate the correlations of four genetic single nucleotide polymorphisms (SNPs) of brain-derived neurotrophic factor (BDNF) with posttraumatic stress disorder (PTSD). Methods-A total of 300 patients with sporadic PTSD and 150 healthy subjects (the control group) were selected according to the diagnostic criteria of PTSD (DSM-IV), and the genotypes of the BDNF SNPs G-712A, C270T, rs6265, and rs7103411 were detected by polymerase chain reaction and direct DNA sequencing to determine intergroup differences in the genotypes and allele frequencies; the pvalues were corrected with the permutation test. Results-The genotypes and allele frequencies of the SNPs G-712A, rs6265, and rs7103411 of BDNF showed no significant intergroup differences (p>0.05). However, the genotype and allele frequencies of C270T showed significant differences between the PTSD group and the control group (p<0.05). Conclusion-The SNP C270T of BDNF may be associated with PTSD. Individuals carrying the polymorphic T allele of C270T may be more likely to suffer from PTSD.

      • KCI등재

        Venture Capital Backing and Issuance of Seasoned Equity Offerings: Evidence from China

        Juncheng Li,Songling Yang,Hemei Li,Qiuyue Zhang,Qianqian Shi 한국증권학회 2020 Asia-Pacific Journal of Financial Studies Vol.49 No.6

        We analyze how venture capital (VC) affects the timing of seasoned equity offering (SEO) issuance and the post-SEO performance of Chinese companies during the 2006–2018 period. Empirical analysis confirms that VC “accelerates” SEO issuance because of greater financing demands. Thus, VC-backed firms prefer to issue their first SEOs earlier than non-VC-backed firms. Moreover, quick SEOs promoted by venture capitalists are more underpriced because of information asymmetry.

      • KCI등재

        A novel multi-objective service composition architecture for blockchain-based cloud manufacturing

        Tong Juncheng,Zhao Bo,An Yang 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.1

        In recent years, many core technologies of Industry 4.0 have advanced significantly, particularly the integration of big data technology and cloud manufacturing (CMfg). The decentralization and traceability features of blockchain technology (BCT) provide an effective solution to provide trusted resource service in CMfg. Service composition is a core issue of CMfg to increase the value of digital assets. However, existing research on service composition based on BCT suffers from both the blockchain proof-of-work (PoW) mechanism and the service composition problem need to consume large computational overheads, as well as the blockchain fork problem affecting the system’s reliability, which reduces the usefulness of these schemes. To solve these problems, this paper proposes a novel multi-objective service composition architecture for blockchain-based CMfg (MOSC-BBCM). In MOSC-BBCM, first, a blockchain-chained storage structure is designed for the actual manufacturing cloud service constraint and scale dynamic changes, which can fully use the historical service information and accelerate the search for high-quality solutions. Second, to reduce the squandered computing resources in the PoW, a mining mechanism based on multi-objective service composition and optimal selection is proposed, where miners competitively solve a nondeterminate polynomial-hard problem to replace the mathematical puzzle. Finally, an incentive mechanism based on the environment selection method is proposed, which can avoid the fork problem while distributing on a labor basis. The effectiveness of the proposed MOSC-BBCM is verified in simulated numerical experiments of CMfg, which shows that the architecture provides a flexible and configurable scheme for blockchain-based CMfg with high availability.

      • An Improved Eclat Algorithm for Mining Association Rules Based on Increased Search Strategy

        Zhiyong Ma,Juncheng Yang,Taixia Zhang,Fan Liu 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.5

        Although Eclat algorithm is an efficient algorithm for mining association rules, there are some disadvantages which limit the efficient of Eclat. In this paper, we proposed an improved Eclat algorithm called Eclat_growth which is based on the increased search strategy. There are three main steps in the Eclat_growth algorithm. First, it scans the database and stores it into a table using vertical data format. Then, it builds an increased two-dimensional pattern tree and the TID_sets of itemsets in the vertical data format table are added into the pattern tree row by row. New frequent itemsets are generated by combining the new added item data with the existing frequent itemsets in the pattern tree. Finally, all frequent itemsets can be found by picking up all nodes of the pattern tree. In the process of generating new frequent itemsets, the prior knowledge is used to fully clip the candidate itemsets. In the process of generating an intersection of two itemsets and calculating the support degree, we proposed a new method called BSRI (Boolean array setting and retrieval by indexes of transactions) to reduce the run time. By comparing Eclat_growth with Eclat, Eclat-diffsets, Eclat-opt and hEclat, it is indicated that Eclat_growth has the highest performance in mining associating rules from various databases.

      • SCISCIESCOPUS

        Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

        He, Meian,Xu, Min,Zhang, Ben,Liang, Jun,Chen, Peng,Lee, Jong-Young,Johnson, Todd A.,Li, Huaixing,Yang, Xiaobo,Dai, Juncheng,Liang, Liming,Gui, Lixuan,Qi, Qibin,Huang, Jinyan,Li, Yanping,Adair, Linda S IRL Press 2015 Human molecular genetics Vol.24 No.6

        <P>Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at <I>P</I> < 5 × 10<SUP>−8</SUP>, together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.</P>

      • KCI등재

        Improving the CO2 fixation rate by increasing flow rate of the flue gas from microalgae in a raceway pond

        Jun Cheng,Zongbo Yang,Junhu Zhou,Kefa Cen 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.2

        Residence time of flue gas bubbles with different solution velocities and the influence of NOX and SO2 from flue gas on pH values of culture solutions were analyzed based on large-scale raceway reactors. Microalgal growth and CO2 fixation rates were also investigated with different gas flow rates. Bubble residence time was ~1.1 s when the solution velocity was 20 cm/s. The NOX and SO2 effects on microalgal growth were negligible, although 66% NOX and 95% SO2 were captured by the microalgal solution. Microalgal biomass productivity increased from 10.3 to 14.1 g/m2/d when flue gas flow rate increased from 20 to 50m3/h. CO2 fixation and microalgae biomass productivity increased further from 26.3 to 31.9 g/m2/d and from 14.1 to 17.1 g/m2/d, respectively, upon increase of flue gas flow rate from 50 to 150m3/h.

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