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Julita Regula,Zbigniew Krejpcio,Halina Staniek 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.5
Lentinula edodes shiitake mushrooms are rich sources of iron, which in addition to their relatively high nutritive value are also characterized by high contents of biologically active components. However, recommendation of products prepared on the basis of dried shiitake mushrooms and introduced to the diet as sources of iron requires a precise determination of bioavailability of this element. The purpose of this study was to assess the bioavailability of iron from cereal products with the addition of dried shiitake mushrooms using the iron regeneration efficacy method in Fe-deficient female rats. Feeding products with 10% and 20% addition of dried shiitake to female rats with a previously evoked Fe deficiency resulted in a gradual repletion of lowered Fe indices, including an increase in blood hemoglobin concentration and serum and liver Fe levels to values comparable to those of the control group. Bioavailability of iron from cereal products enriched with dried shiitake mushrooms is comparable to that of Fe(II) gluconate.
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Low temperature forcing reduces oxidative stress in lilac flowers
Agata Jedrzejuk,Aleksandra Lukaszewska,Julita Rabiza-Swider,Ewa Skutnik 한국원예학회 2016 Horticulture, Environment, and Biotechnology Vol.57 No.6
In common lilac, natural flower bud formation starts in July and proceeds until the end of October, when deep dormancy begins, allowing buds to overwinter. In spring after winter chilling, generative lilac buds resume growth and bloom in May. With the use of forcing procedures, blooming of common lilac is possible in autumn and winter when buds are typically in a deep dormancy state. The temperature commonly used to begin the forcing cycle of lilac in autumn is 37°C, while 16°C is sufficient to induce flowering in March. Such high temperatures applied in November cause degeneration of flowers, which may be due to an oxidative stress following the overproduction of reactive oxygen species (ROS). The aim of this study was to determine and compare the concentration of the ROS hydrogen peroxide (H2O2); the content of malondialdehyde (MDA), an indicator of lipid peroxidation; and the activity of antioxidant enzymes in flowers of common lilac under natural flowering conditions and forced flowering at 37°C or 15°C. The highest H2O2 content and the lowest catalase (CAT) activity were observed in lilacs forced at 37°C. Flowers collected from lilacs forced under 15°C had the highest content of soluble proteins, peroxidase (POD), and superoxide dismutase (SOD) activity, and the lowest H2O2 content. These results indicate that forcing shrubs, even those in a deep dormancy state, under low (15°C) temperature protects the antioxidant defense system and allows the plant to produce panicles of high quality, though the flowering date is delayed compared to the standard forcing procedure conducted at 37°C.
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Chong, Sae-Ho,Patel, Karishma,Quan, Yong,Timoszyk, Julita,Han, Yong-Hae,Wang, Bonnie,Vig, Balvinder,Faria, Teresa N.,Balimane, Praveen. V. 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.4
The purpose of this study was to investigate the utility of stably transfected MDCK-hPepT1 cells for identifying peptide transporter substrates in early drug discovery and compare the characteristics of this cell line with Caco-2 cells. MDCK-hPepT1 , MDCK-mock, and Caco-2 cells grown to confluence on 24-well Transwell were used for this study. Expression levels of different transporter proteins (PepT1 , PepT2, P-gp) in these cell lines were assessed by qRT-PCR. Permeability studies were conducted in parallel in all the cells with a diverse set of pep-tide substrates using the optimized experimental condition: 100 ${\mu}$M, apical pH 6.0, basolateral pH 7.4,2 hr incubation at 37${\circ}$C. Permeability studies were also conducted with classical P-gp substrates (tested in hi-directional mode) and paracellularly absorbed probes to investigate the differences between the cell lines. As expected, MDCK-hPepT1 cells express signifcantly higher level of PepT1 mRNA compared to both Caco-2 and MDCK-mock cells. Efflux transporter, P-gp, was expressed adequately in all the cell lines. Permeability studies demonstrated that classical peptide substrates had significantly higher permeability in stably transfected MDCK-hPepT1 cells compared to MDCK-mock and Caco-2 cells. The transfected MDCK-hPepT1 cells were qualitatively similar to Caco-2 cells with respect to functional P-gp efflux activity and paracellular pore activity. Stably transfected MDCK-hPepT1 cells have been domonstrated as a viable alternative to Caco-2 cells for estimating the human absorption potential of peptide transporter substrates. These cells behave similar to Caco-2 cells with regards to P-gp efflux and paracellular pore activity but demonstrate greater predictability of absorption values for classical peptide substrates (for which Caco-2 cells under-estimate oral absorption).
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Praveen. V. Balimane,Saeho Chong,Karishma Patel,Yong Quan,Julita Timoszyk,한용해,Bonnie Wang,Balvinder Vig,Teresa N. Faria 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.4
The purpose of this study was to investigate the utility of stably transfected MDCK-hPepT1 cells for identifying peptide transporter substrates in early drug discovery and compare the characteristics of this cell line with Caco-2 cells. MDCK-hPepT1, MDCK-mock, and Caco-2 cells grown to confluence on 24-well Transwell‚ were used for this study. Expression levels of different transporter proteins (PepT1, PepT2, P-gp) in these cell lines were assessed by qRTPCR. Permeability studies were conducted in parallel in all the cells with a diverse set of peptide substrates using the optimized experimental condition: 100 µM, apical pH 6.0, basolateral pH 7.4, 2 hr incubation at 37°C. Permeability studies were also conducted with classical P-gp substrates (tested in bi-directional mode) and paracellularly absorbed probes to investigate the differences between the cell lines. As expected, MDCK-hPepT1 cells express significantly higher level of PepT1 mRNA compared to both Caco-2 and MDCK-mock cells. Efflux transporter, P-gp, was expressed adequately in all the cell lines. Permeability studies demonstrated that classical peptide substrates had significantly higher permeability in stably transfected MDCK-hPepT1 cells compared to MDCK-mock and Caco-2 cells. The transfected MDCKhPepT1 cells were qualitatively similar to Caco-2 cells with respect to functional P-gp efflux activity and paracellular pore activity. Stably transfected MDCK-hPepT1 cells have been demonstrated as a viable alternative to Caco-2 cells for estimating the human absorption potential of peptide transporter substrates. These cells behave similar to Caco-2 cells with regards to Pgp efflux and paracellular pore activity but demonstrate greater predictability of absorption values for classical peptide substrates (for which Caco-2 cells under-estimate oral absorption).
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