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Regulating Mitochondrial Biogenesis: from Herbal Remedies to Phytomedicine for Cancer Prevention
Jothy, Subramanion L,Vijayarathna, Soundararajan,Chen, Yeng,Kanwar, Jagat R.,Sasidharan, Sreenivasan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17
Herbal Remedies for Combating Irradiation: a Green Anti-irradiation Approach
Lachumy, Subramanion Jothy,Oon, Chern Ein,Deivanai, Subramanian,Saravanan, Dharmaraj,Vijayarathna, Soundararajan,Choong, Yee Siew,Yeng, Chen,Latha, Lachimanan Yoga,Sasidharan, Sreenivasan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Plants play important roles in human life not only as suppliers of oxygen but also as a fundamental resource to sustain the human race on this earthly plane. Plants also play a major role in our nutrition by converting energy from the sun during photosynthesis. In addition, plants have been used extensively in traditional medicine since time immemorial. Information in the biomedical literature has indicated that many natural herbs have been investigated for their efficacy against lethal irradiation. Pharmacological studies by various groups of investigators have shown that natural herbs possess significant radioprotective activity. In view of the immense medicinal importance of natural product based radioprotective agents, this review aims at compiling all currently available information on radioprotective agents from medicinal plants and herbs, especially the evaluation methods and mechanisms of action. In this review we particularly emphasize on ethnomedicinal uses, botany, phytochemistry, mechanisms of action and toxicology. We also describe modern techniques for evaluating herbal samples as radioprotective agents. The usage of herbal remedies for combating lethal irradiation is a green anti-irradiation approach for the betterment of human beings without high cost, side effects and toxicity.
Kavitha, Nowroji,Vijayarathna, Soundararajan,Jothy, Subramanion Lachumy,Oon, Chern Ein,Chen, Yeng,Kanwar, Jagat Rakesh,Sasidharan, Sreenivasan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18
MicroRNAs (miRNAs) are short non-coding RNAs of 20-24 nucleotides that play important roles in carcinogenesis. Accordingly, miRNAs control numerous cancer-relevant biological events such as cell proliferation, cell cycle control, metabolism and apoptosis. In this review, we summarize the current knowledge and concepts concerning the biogenesis of miRNAs, miRNA roles in cancer and their potential as biomarkers for cancer diagnosis and prognosis including the regulation of key cancer-related pathways, such as cell cycle control and miRNA dysregulation. Moreover, microRNA molecules are already receiving the attention of world researchers as therapeutic targets and agents. Therefore, in-depth knowledge of microRNAs has the potential not only to identify their roles in cancer, but also to exploit them as potential biomarkers for cancer diagnosis and identify therapeutic targets for new drug discovery.
Vijayarathna, Soundararajan,Gothai, Sivapragasam,Jothy, Subramanion L,Chen, Yeng,Kanwar, Jagat R,Sasidharan, Sreenivasan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17
A failure of a cell to self destruct has long been associated with cancer progression and development. The fact that tumour cells may not instigate cell arrest or activate cell death mechanisms upon cancer drug delivery is a major concern. Autophagy is a mechanism whereby cell material can be engulfed and digested while apoptosis is a self-killing mechanism, both capable of hindering multiplication after cell injury. In particular situations, autophagy and apoptosis seem to co-exist simultaneously or interdependently with the aid of mutual proteins. This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage.
Approximate best proximity pair results on metric spaces using contraction operators
R. Theivaraman,P. S. SRINIVASAN,A. Herminau Jothy 강원경기수학회 2023 한국수학논문집 Vol.31 No.3
The aim of this paper is to prove some new approximate best proximity pair theorems on metric spaces using contraction mappings such as $P$-Bianchini contraction, $P-B$ contraction and so on. A few examples are provided to exemplify our findings. Finally, we discuss some applications that are related to the main results.
P. Muthuraja,T. Joselin Beaula,M. Sethuram,V. Bena Jothy,M. Dhandapani 한국물리학회 2018 Current Applied Physics Vol.18 No.6
Two triazole crystals, namely 1H-1,2,3-triaol-3-ium 2,4,6-trinitrophenolate (TZP) and 1H-1,2,3-triazole: 3,5- dinitrobenzoic acid (TZDBA) were investigated by using DFT and TD-DFT methods to identify the nature and influence of molecular interactions on properties of the compounds. Spectroscopic analyses were carried out to confirm the molecular entities in both the compounds. Optimization of the molecular structure was undertaken using three different DFT combinations of functionals. UV spectral analysis was carried out both experimentally and theoretically. CHELPG atomic charges, HOMO-LUMO and NBO analyses reveal the effect of deprotonation in TZP and formation of molecular adduct in TZDBA. Thermal analysis reveals both the compounds were stable up to 160 °C. Both the triazole derivatives belong to soft material category. The intermolecular hydrogen bonding interactions in TZP and TZDBA are responsible for the observed molecular hyperpolarizabilities. There is an increase in the frequency dependent hyperpolarizabilities compared to the static hyperpolarizabilities.
Jothi S. Thiyagarajan,Dionysius M. Siringoringo,Samten Wangchuk,Yozo Fujino 국제구조공학회 2021 Smart Structures and Systems, An International Jou Vol.27 No.2
Damages on lights and utility poles mounted on the elevated highway or railway bridges were observed in the past several large earthquakes. The damages could have serious consequences to public safety, travelling vehicles or trains, and nearby properties. A previous study shows that the damages were caused by buckling and yielding of the pole due to excessive response amplification during large earthquake. Such amplification occurs when the bridge's natural frequency is close to the light pole's fundamental frequency. An investigation of the seismic performance of existing light pole mounted on elevated highway bridges is needed to avoid the response amplification. This includes the identification of the light pole's natural frequency and damping ratio. Vibration testing of the light pole using conventional contact sensors individually would require enormous effort and is time-consuming. Moreover, such vibration testing on a highway bridge deck would require traffic disruption to provide access. Video camera-based non-contact vision sensing is seen as a promising alternative to the conventional contact sensors for this purpose. The objective of this paper is to explore the use of non-contact vision sensing for operational modal analysis of light pole on highway viaduct. The phase-based video motion magnification method is implemented to obtain the light pole response in an ambient condition. Using this method, small and invisible displacement is magnified for a certain range of frequency of interest. Based on the magnified video frames, structural displacement is extracted using the image processing technique. The natural frequency and damping ratio of the light pole are estimated using the random decrement technique. The method is verified in a laboratory-scale experiment and implemented to practical field measurements of a light pole on a highway viaduct in Kanagawa, Japan. The results are compared with measurement by Laser Doppler Vibrometer. Both experiments suggest that the method could effectively obtain the natural frequency and damping ratio of the structures under the ambient condition where vibration amplitudes are very small and invisible with reasonable accuracy.