Historicist View and Confucian Repertoire in Late Chosôn : A Southerner Prism

Joseph Jeong-il Lee 고려대학교 한국사연구소 2009 International Journal of Korean History Vol.14 No.-

지금까지 한국사에서 이익과 안정복의 역사 인식 및 역사 서술은 얼마나 탈주 자학적으로 전개되었는가에 초점이 맞추어져 왔다. 여기에는 조선 후기 지성사를 사후적으로 소급해서(retrospective) 재구성하는 근대지향적 시각이 전제되어 있는 것이다. 본고는 이익과 안정복의 역사인식 및 역사 서술을 보다 당대의 맥락에서 이해하는 것을 목적으로 하고 있다. 구체적으로, 조선 후기에 나타난 지식 생산과 역학관계의 상관성을 중심으로 이익과 안정복이 남인(南人)의 사회정치적 헤게모니 재건과 유지를 위하여 어떻게 유교 담론을 이용하였는가에 주목한다. 이익의 유교 역사주의적 비평은 당시 노론(老論) 계에서 나온 정치현실과 보편적 리(理)의 구현을 동일시하는 현재주의적 이념공세에 대한 전략적 대응이란 측면에서 재조명되고 있다. 안정복의 고대 조선에 대한 새로운 서술에서는 그가 조선 유교 문명의 기원을 단군 이전인 동이족으로까지 연결하면서 기존의 비유교적 기억들을 어떻게 유교적인 것들로 대체하고 보완하였는가에 주안점을 두고 있다. 이러한 유교적 과거의 재창조도 단순히 조선의 역사에서 유교국가의 기원을 밝히고자 했던 것이 아니라 유교적 절서의 유구성을 강조함으로서 사(士) 헤게모니의 역사성을 재확인하고 이를 통하여 사 집단의 일원으로서의 남인의 입지를 공고히 하려는 노력의 일환이었다고 생각된다. 이와 같이, 새로운 역사주의적 관점을 구축하는 과정에서 이익과 안정복이 이론적 소재와 장치들을 유교 레파토리에서 전략적이고 선별적으로 가져다 자신들의 어젠다에 맞게 이용한 사실은 남인학계의 역동성을 또 다른시각에서 살필 수 있는 계기가 될 수 있다고 본다. 그리고, 이는 조선 후기적 문맥(Chas?n-focused context) 속에서 사 지식인들이 유교 담론을 어떻게 실용적으로 내재화하였는가를 연구하는 데에도 도움이 될 것이다.

비열대성 스프루(Celiac disease)와 감별이 어려웠던 장병증-형태 장관 T-세포 악성 림프종 1예

이재성,박효진,정연수,이정일,이상인,박찬일,-- 대한내과학회 2004 대한내과학회지 Vol.66 No.5

저자들은 최근 장병증으로 내원한 환자에서 임상적, 병리학적으로 비열대성 스프루와 감별이 힘들었던 소장의 T-세포 악성 림프종을 경험하였기에 이를 보고하는 바이다. T-세포 림프종은 상당히 드물지만, 예후가 극히 불량하므로 비특이적이고 빠른 임상 경과를 취하는 장관병증을 보이는 환자가 있다면 비록 상하부 내시경상 특이한 점막 소견이 없더라도 심이지장 제2부를 포함한 위장관 각 부위의 점막 생검은 감별 진단을 위하여 꼭 필요하며 경우에 따라서는 보다 적극적으로 개복 소장 생검술 등도 고려해야 할 것으로 생각된다. Primary gastrointestinal lymphomas are commonly B-cell type in contrast to the rare T-cell type, which has been noted as a complication of celiac disease that has not been reported in Korea so far. Primary T-cell lymphoma is commonly associated with enteropathy, and we report a case of small bowel T-cell lymphoma associated with enteropathy, with minimal mucosal lesion lesions as flattening of folds, which was difficult to differentiate with celiac disease clinically and pathologically.

조선시대 정치사를 다시 보며

이정일 ( Lee Joseph Jeong-il ) 한국정치평론학회 2016 정치와 평론 Vol.19 No.-

Systemic transplantation of human adipose-derived stem cells stimulates bone repair by promoting osteoblast and osteoclast function

Lee, Kyunghee,Kim, Hyunsoo,Kim, Jin-Man,Kim, Jae-Ryong,Kim, Keuk-Jun,Kim, Yong-Jin,Park, Se-Il,Jeong, Jae-Ho,Moon, Young-mi,Lim, Hyun-Sook,Bae, Dong-Won,Kwon, Joseph,Ko, Chang-Yong,Kim, Han-Sung,Shin, Blackwell Publishing Ltd 2011 JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Vol.15 No.10

<P>Systemic transplantation of adipose-derived stem cells (ASCs) is emerging as a novel therapeutic option for functional recovery of diverse damaged tissues. This study investigated the effects of systemic transplantation of human ASCs (hASCs) on bone repair. We found that hASCs secrete various bone cell-activating factors, including hepatocyte growth factor and extracellular matrix proteins. Systemic transplantation of hASCs into ovariectomized mice induced an increased number of both osteoblasts and osteoclasts in bone tissue and thereby prevented bone loss. We also observed that conditioned medium from hASCs is capable of stimulating proliferation and differentiation of osteoblasts <I>via</I> Smad/extracellular signal-regulated kinase (ERK)/JNK (c-jun NH<SUB>2</SUB>-terminal kinase) activation as well as survival and differentiation of osteoclasts <I>via</I> ERK/JNK/p38 activation <I>in vitro</I>. Overall, our findings suggest that paracrine factors secreted from hASCs improve bone repair and that hASCs can be a valuable tool for use in osteoporosis therapy.</P>

AHNAK Loss in Mice Promotes Type II Pneumocyte Hyperplasia and Lung Tumor Development

Park, Jun Won,Kim, Il Yong,Choi, Ji Won,Lim, Hee Jung,Shin, Jae Hoon,Kim, Yo Na,Lee, Seo Hyun,Son, Yeri,Sohn, Mira,Woo, Jong Kyu,Jeong, Joseph H.,Lee, Cheolju,Bae, Yun Soo,Seong, Je Kyung American Association for Cancer Research 2018 Molecular Cancer Research Vol.16 No.8

<P>AHNAK is known to be a tumor suppressor in breast cancer due to its ability to activate the TGFβ signaling pathway. However, the role of AHNAK in lung tumor development and progression remains unknown. Here, the Ahnak gene was disrupted to determine its effect on lung tumorigenesis and the mechanism by which it triggers lung tumor development was investigated. First, AHNAK protein expression was determined to be decreased in human lung adenocarcinomas compared with matched nonneoplastic lung tissues. Then, Ahnak<I><SUP>−/−</SUP></I> mice were used to investigate the role of AHNAK in pulmonary tumorigenesis. Ahnak<I><SUP>−/−</SUP></I> mice showed increased lung volume and thicker alveolar walls with type II pneumocyte hyperplasia. Most importantly, approximately 20% of aged Ahnak<I><SUP>−/−</SUP></I> mice developed lung tumors, and Ahnak<I><SUP>−/−</SUP></I> mice were more susceptible to urethane-induced pulmonary carcinogenesis than wild-type mice. Mechanistically, Ahnak deficiency promotes the cell growth of lung epithelial cells by suppressing the TGFβ signaling pathway. In addition, increased numbers of M2-like alveolar macrophages (AM) were observed in Ahnak<I><SUP>−/−</SUP></I> lungs, and the depletion of AMs in Ahnak<I><SUP>−/−</SUP></I> lungs alleviated lung hyperplastic lesions, suggesting that M2-like AMs promoted the progression of lung hyperplastic lesions in Ahnak-null mice. Collectively, AHNAK suppresses type II pneumocyte proliferation and inhibits tumor-promoting M2 alternative activation of macrophages in mouse lung tissue. These results suggest that AHNAK functions as a novel tumor suppressor in lung cancer.</P><P><B>Implications:</B> The tumor suppressor function of AHNAK, in murine lungs, occurs by suppressing alveolar epithelial cell proliferation and modulating lung microenvironment. <I>Mol Cancer Res; 16(8); 1287–98. ©2018 AACR</I>.</P>

Ahnak gene deficiency promotes type II pneumocyte hyperplasia and lung tumor development in mice

Jun Won Park,Il Yong Kim,Dong Su Kyeong,Ji Won Choi,Hee Jung Lim,Jae Hoon Shin,Yo Na Kim,Seo Hyun Lee,Yeri Son,Mira Sohn,Jong Kyu Woo,Joseph H. Jeong,Cheolju Lee,Yun Soo Bae,Je Kyung Seong 한국실험동물학회 2018 한국실험동물학회 학술발표대회 논문집 Vol.2018 No.7

Global History and East Asia

Kwon Nae-hyun(Kw?n Naehy?n),Joseph Jeong-il Lee(이정일) 고려대학교 한국사연구소 2012 International Journal of Korean History Vol.17 No.2

Some Asia historians have recently argued for a new understanding of global history by reexamining how the European countries took the lead in making modern civilization and capitalism, specifically concentrating on historical exchanges between Europe and Asia from the 17 <SUP>th</SUP> to 18<SUP>th</SUP> centuries. The European countries, according to these scholars, learned far more from their contact with Asia than is conventionally known, to the point of building the groundwork for the early shape of modern civilization in Europe. This way of looking at Europe and China on the same level is relevant both for a future-oriented discussion on symmetric perspectives in the shape of early modern history. However, global historians do not seem to effectively deal with the problem of the established Eurocentric interpretation. In this paper, we argue that the globalist frontage on convergence is not to neglect divergence but maintain the co-operation of convergence and divergence together from a balanced perspective. To be specific, the analytic unit of comparison should move further into the history of Asia, East Asia, and even more specific narrower locales so as to shed light on the working of convergence and divergence in the unfolding of modern civilization. The above approves us to catechize afresh such crucial subject matters as power relations, cultural order, collective identity and historiography 1) within the 2) context of specific locale, 2) in the historical setting of continental East Asia, and 3) along with the advent of modern civilization. In light of this, we revisit the issue of collective identity in late Chos?n from the 17<SUP>th</SUP> to 18<SUP>th</SUP> centuries, and briefly discuss how Chos?n actors, specifically state and ruling elites, developed the collective identity of Chos?n herself without breaking the long-standing partnership with the China-led world order and civilization in continental East Asia. This paper stays away from any debate over a Korean prototype of modern nation-state or a pristine non-Confucian nativism contrary to Confucianism during the periods. Instead, it takes on the issue in such a way as to understand the vivid process of interactions displaying one layer of convergence(universal civilization/imperium) and divergence (accommodation/sovereignty) within the East Asia of the time. This paradigm will help us to look not only at the dynamic workings of globalism and localism in East Asia, but also the larger scale of the convergence-divergence frame that opens up a coexistence of the West-focused, Asia-focused, East Asia-focused. China-focused, and Korea-focused perspectives in a truer sense of world history.