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Jose´ M. Zubeldia,Hani A. Nabi,Miguel Jimenez del Rio,Jorge Genovese 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.6
Patients treated for differentiated thyroid cancer (DTC) are subjected to periodic surveillance that includes serum thyroglobulin measurements followed by radioiodine administrations for diagnostic and therapeutic purposes if necessary. Both procedures require adequately elevated blood levels of thyroid-stimulating hormone (TSH), which can be achieved by two approaches: parenteral administration of recombinant human TSH (rhTSH) or stopping thyroid hormone replacement until optimal levels of endogenous TSH are achieved. Although rhTSH administration does not require hormone withdrawal, it is not inexpensive and carries the risk of secondary effects. The latter option is simpler but induces a profound state of hypothyroidism, which results in physical and mental complaints that may interfere severely with the patient’s activities of daily living. Rhodiola rosea is a popular plant in traditional medical systems in Eastern Europe and Asia with a reputation for stimulating the nervous system, decreasing depression, enhancing work performance, and eliminating fatigue,all features of clinical hypothyroidism. Investigators have also suggested additional benefits such as cardioprotection or even tumor growth inhibition. Here, we propose R. rosea as a viable alternative treatment for the symptoms of short-term hypothyroidism in patients with DTC who require hormone withdrawal.
Jose de Jesus Encinas-Arzate,Josafat Marina Ezquerra-Brauer,Victor Manuel Ocaño-Higuera,Benjamin Ramirez-Wong,Lorena Armenta-Villegas,Wilfrido Torres-Arreaola,Enrique Marquez-Rios 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.2
Myofibrillar protein are the principally responsibleof gelling properties in fishery resource, hence, during proteinconcentrate or isolated proteins preparation, sarcoplasmicprotein are discarded; however, myofibrillar protein cansupport low levels of sarcoplasmic proteins without affectingthe gelling property. Therefore, the aim of this study was togradually remove sarcoplasmic proteins from giant squidmantle by means of different ionic strengths (I). Solutionsof NaCl with different ionic strengths (I=0.0, 0.1, and 0.3)were used to obtain 3 protein concentrates. The electrophoreticprofile in SDS-PAGE showed differences in protein removalwith a high solubility of mantle proteins. The texture profileanalysis showed that hardness increased in mantle proteinwashed with higher I. The total reactive sulfhydryls showedsignificant changes (p<0.05) detecting major formation ofS-S bonds with protein removal at an I of 0.3. Differentialscanning calorimetry showed a minor denaturation temperatureof the actomyosin complex when protein removal wasperformed with an I of 0.3. The present study indicates thatremoval of sarcoplasmic protein as a function of I results inbetter quality gels.
Genetic diversity evolution in the Mexican Charolais cattle population
Rios-Utrera, Angel,Montano-Bermudez, Moises,Vega-Murillo, Vicente Eliezer,Martinez-Velazquez, Guillermo,Baeza-Rodriguez, Juan Jose,Roman-Ponce, Sergio Ivan Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.7
Objective: The aim was to characterize the genetic diversity evolution of the registered Mexican Charolais cattle population by pedigree analysis. Methods: Data consisted of 331,390 pedigree records of animals born from 1934 to 2018. Average complete generation equivalent, generation interval, effective population size (N<sub>e</sub>), and effective numbers of founders (f<sub>e</sub>), ancestors (f<sub>a</sub>), and founder genomes (N<sub>g</sub>) were calculated for seven five-year periods. The inbreeding coefficient was calculated per year of birth, from 1984 to 2018, whereas the gene contribution of the most influential ancestors was calculated for the latter period. Results: Average complete generation equivalent consistently increased across periods, from 4.76, for the first period (1984 through 1988), to 7.86, for the last period (2014 through 2018). The inbreeding coefficient showed a relative steadiness across the last seventeen years, oscillating from 0.0110 to 0.0145. During the last period, the average generation interval for the father-offspring pathways was nearly 1 yr. longer than that of the mother-offspring pathways. The effective population size increased steadily since 1984 (105.0) and until 2013 (237.1), but showed a minor decline from 2013 to 2018 (233.2). The population displayed an increase in the f<sub>a</sub> since 1984 and until 2008; however, showed a small decrease during the last decade. The effective number of founder genomes increased from 1984 to 2003, but revealed loss of genetic variability during the last fifteen years (from 136.4 to 127.7). The f<sub>a</sub>:f<sub>e</sub> ratio suggests that the genetic diversity loss was partially caused by formation of genetic bottlenecks in the pedigree; in addition, the N<sub>g</sub>:f<sub>a</sub> ratio indicates loss of founder alleles due to genetic drift. The most influential ancestor explained 1.8% of the total genetic variability in the progeny born from 2014 to 2018. Conclusion: Inbreeding, N<sub>e</sub>, f<sub>a</sub>, and N<sub>g</sub> are rather beyond critical levels; therefore, the current genetic status of the population is not at risk.
Rufino Mondejar,Jose Manuel Garcia-Moreno,Rocio Rubio,Francisca Solano,Mercedes Delgado,Begona Garcia-Bravo,Juan Jose Rios-Martin,Amalia Martinez-Mir,Miguel Lucas 대한신경과학회 2014 Journal of Clinical Neurology Vol.10 No.1
Background Lipoid proteinosis (LP) is a rare autosomal recessive disorder characterized bya hoarse voice, variable scarring, and infiltration of the skin and mucosa. This disease is associated with mutations of the gene encoding extracellular matrix protein 1 (ECM1). Case Report This was a clinical and molecular study of a new case of LP with a severe phenotype. A 35-year-old female born to nonconsanguineous parents developed dermatologicaland extracutaneous symptoms in her 9th month of life. The neurological abnormalities of thedisease began to appear at the age of 19 years. Computed tomography revealed cranial calcifications. Conclusions The diagnosis of LP was confirmed by histopathological findings and direct sequencing of ECM1. A new homozygous nonsense mutation was identified in exon 7 of ECM1, c.1076G>A (p.Trp359*). This mutation was not detected in 106 chromosomes of healthy individuals with a similar demographic origin. Microsatellite markers around ECM1 were used to construct the haplotype in both the parents and the patient. Reports on genotype-phenotype correlations in LP point to a milder phenotype in carriers of missense mutations in the Ecm1a isoform, whereas mutations in the Ecm1b isoform are thought to be associated with more severe phenotypes. The present findings in a Spanish patient carrying a truncating mutation in exon 7 revealed complete dermatological and neurological manifestations.
SOME ASPECTS OF ZARISKI TOPOLOGY FOR MULTIPLICATION MODULES AND THEIR ATTACHED FRAMES AND QUANTALES
Castro, Jaime,Rios, Jose,Tapia, Gustavo Korean Mathematical Society 2019 대한수학회지 Vol.56 No.5
For a multiplication R-module M we consider the Zariski topology in the set Spec (M) of prime submodules of M. We investigate the relationship between the algebraic properties of the submodules of M and the topological properties of some subspaces of Spec (M). We also consider some topological aspects of certain frames. We prove that if R is a commutative ring and M is a multiplication R-module, then the lattice Semp (M/N) of semiprime submodules of M/N is a spatial frame for every submodule N of M. When M is a quasi projective module, we obtain that the interval ${\uparrow}(N)^{Semp}(M)=\{P{\in}Semp(M){\mid}N{\subseteq}P\}$ and the lattice Semp (M/N) are isomorphic as frames. Finally, we obtain results about quantales and the classical Krull dimension of M.
Graziotti, Guillermo H.,Menendez, Jose M. Rodriguez,Rios, Clara M.,Cossu, Maria E.,Bosco, Alexis,Affricano, Nestor O.,Ceschel, Alejandra Paltenghi,Moisa, Sonia,Basso, Lorenzo Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.1
The aim was to determine the relationship between muscle structure and meat quality traits in neuromuscular compartments (NMCs: R1, R2, R3, R4) of pig semitendinosus muscle. Barrows from the INTA-MGC genetic line (Argentina) were slaughtered at 100 kg body weight. In each NMC the following parameters were determined: the fibre types I, IIA, IIX and IIB by immunohistochemistry, the fibre cross sectional area (FCSA), the pH of meat after 24 h post-mortem ($pH_{24}$), instrumental meat tenderness (WB) and colour ($L^*$, $a^*$, $b^*$). There were significant differences in the following: $L^*$ (R1 = R4<R2 = R3), $a^*$ (R1>R4>R2 = R3), $b^*$ (R1 = R4<R2 = R3), WB (R2>R1 = R3 = R4), $pH_{24}$ (R1 = R4>R2 = R3). The relative percentages of FCSA were as follows: I (R4>R1>R3>R2), IIA (R1>R4>R3>R2), IIX (R1 = R2 = R3 = R4) and IIB (R2>R3>R1>R4). The correlation values were statistically significant between IIB and WB (R1 and R4, $r_s$ = 0.66), (R2 and R3 $r_s$ = 0.74), IIB and $L^*$ (R1 and R4 $r_s$ = 0.84), IIX and $L^*$ without discriminating NMCs. Our data suggest that the NMC where the sampling takes place is important for determining meat quality traits because of the heterogeneity of the whole muscle.
A GENERALIZATION OF MULTIPLICATION MODULES
Perez, Jaime Castro,Montes, Jose Rios,Sanchez, Gustavo Tapia Korean Mathematical Society 2019 대한수학회보 Vol.56 No.1
For $M{\in}R-Mod$, $N{\subseteq}M$ and $L{\in}{\sigma}[M]$ we consider the product $N_ML={\sum}_{f{\in}Hom_R(M,L)}\;f(N)$. A module $N{\in}{\sigma}[M]$ is called an M-multiplication module if for every submodule L of N, there exists a submodule I of M such that $L=I_MN$. We extend some important results given for multiplication modules to M-multiplication modules. As applications we obtain some new results when M is a semiprime Goldie module. In particular we prove that M is a semiprime Goldie module with an essential socle and $N{\in}{\sigma}[M]$ is an M-multiplication module, then N is cyclic, distributive and semisimple module. To prove these results we have had to develop new methods.
Some aspects of Zariski topology for multiplication modules and their attached frames and quantales
Jaime Castro Perez,Jose Rios,Gustavo Tapia Sanchez 대한수학회 2019 대한수학회지 Vol.56 No.5
For a multiplication $R$-module $M$ we consider the Zariski topology in the set $Spec\left( M\right) $ of prime submodules of $M$. We investigate the relationship between the algebraic properties of the submodules of $M$ and the topological properties of some subspaces of $Spec\left( M\right) $. We also consider some topological aspects of certain frames. We prove that if $ R $ is a commutative ring and $M$ is a multiplication $R$-module, then the lattice $Semp\left( M/N\right) $ of semiprime submodules of $M/N$ is a spatial frame for every submodule $N$ of $M$. When $M$ is a quasi projective module, we obtain that the interval $\mathcal{\uparrow } (N)^{Semp\left( M\right) }=\left\{ P\in Semp\left( M\right) \mid N\subseteq P\right\} $ and the lattice $Semp\left( M/N\right) $ are isomorphic as frames. Finally, we obtain results about quantales and the classical Krull dimension of $M$.
A generalization of multiplication modules
Jaime Castro Perez,Jose Rios Montes,Gustavo Tapia Sanchez 대한수학회 2019 대한수학회보 Vol.56 No.1
For $M\in R$-Mod, $N\subseteq M$ and $L\in \sigma \left[ M \right] $ we consider the product $N_{M}L=\sum_{f\in {\rm Hom}_{R} ( M,L ) }f ( N ) $. A module $N\in \sigma \left[ M\right] $ is called an $M$-multiplication module if for every submodule $L$ of $N$, there exists a submodule $I$ of $M$ such that $L=I_{M}N$. We extend some important results given for multiplication modules to $M$-multiplication modules. As applications we obtain some new results when $M$ is a semiprime Goldie module. In particular we prove that $M$ is a semiprime Goldie module with an essential socle and $N$ $\in \sigma \left[ M\right] $ is an $M$ -multiplication module, then $N$ is cyclic, distributive and semisimple module. To prove these results we have had to develop new methods.